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Properties of a New Dental Photocurable Resin based on the Expanding Monomer and Threecomponent Photoinitiator System

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Journal of Wuhan University of Technology(Materials Science) 2014年第2期29卷 384-390页

作者：付静 LIU Wenjia LIU Xiaoqing Sapna laxmi tuladhar wan qianbing 王航 State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Department of Prosthodontics West China College of Stomatology Sichuan University

The purpose of this study was to use. a three-component photoinitiation system comprising 1wt% CQ （camphorquinone）, 2wt% DMAEMA （2-（dimethylamino） ethyl meth acrylate） and 2wt% ph^2I^＋PF6^- （diphenyliodonium hexafluorophosphate） to initiate the copolymerization of the matrix resins which combine bisphenol-S-bis （3-methacrylate-2-hydroxy propyl） ether （BisS-GMA） with the expanding monomer unsaturated spiro orthoesters 2-methylene-l,4,6-tdspiro[4,4] nonane （MTOSN）, for minimizing the volumetric shrinkage that generally occurs during polymerization. It was hypothesized that MTOSN would expand volumetrically during polymerization under the three-component photoinitiator system and further reductions in volumetric shrinkage would be obtained. The performance study which consists of degree of conversion and condition of the ring-opening reactions of MTOSN, volumetric shrinkage and mechanical properties including tensile bond strength, compressive strength and Vicker＇s hardness were carried out respectively by Fourier transfer infrared, the dilatometer and the universal testing machine. The results supported that the dental composites based on the expanding monomer and three-component photoinitiator system engendered a greater decrease of volumetric shrinkage and better mechanieal properties.

关键词： 2-methylene-1, 4, 6-trispiro [4, 4] nonane light-curing dental matrix resin volumetric shrinkage mechanical properties

Synthesis and potential osteogenic applications of Wnt3a-loaded ZIF-8 nanoparticles

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Chinese Chemical Letters 2024年第3期35卷 399-405页

作者： Hengfei wang Song Chen Zihan He Junyu Chen Zhou Zhu qianbing wan Jian wang Xibo Pei State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of ProsthodonticsWest China Hospital of StomatologySichuan UniversityChengdu 610041China Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher EducationStomatological Hospital of Chongqing Medical UniversityChongqing 400016China

The Wnt signaling pathway plays a critical role in bone homeostasis,and the related protein therapy strategies have been reported to have great potential in osseointegration;however,they face formidable challenges such as complex external environments and unavoidable protein *** this work,we report a novel approach combining the synthesis of metal–organic frameworks(MOFs)and protein encapsulation in a one-pot process based on zeolitic imidazolate framework-8(ZIF-8)and Wnt3a protein,with improved biomechanical behavior and enhanced protein biological *** combination was designed to enhance the Wnt3a protein function through the improved chemical stability provided by the ZIF-8 ***,the zinc ions contained in the ZIF-8 crystals induced bone homeostasis,further favoring the *** results showed that the Wnt3a protein-loaded ZIF-8 crystals served as efficient drug delivery vehicles to promote osteogenesis,preventing protein *** particular,Wnt3a-loaded ZIF-8 nanoparticles(Wnt3a@ZIF-8 NPs)had higher efficacy on bone marrow mesenchymal stem cells(BMSCs)than ZIF-8 NPs or Wnt3a proteins,contributing to the osteogenesis through ZIF-8 crystals and intracellular Wnt3a proteins released from Wnt3a@ZIF-8 ***,polymerase chain reaction(PCR)analysis showed that the osteogenic pathways were ***,the present one-pot process can open up new avenues to develop signaling protein-delivery systems for applications in protein therapy strategies.

关键词： Metal–organic frameworks Nanoparticle Drug release Osteogenesis Bone defects

Micro or nano:Evaluation of biosafety and biopotency of magnesium metal organic framework-74 with different particle sizes

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Nano Research 2020年第2期13卷 511-526页

作者： Zhou Zhu Shaokang Jiang Yanhua Liu Xiaomeng Gao Shanshan Hu Xin Zhang Chao Huang qianbing wan Jian wang Xibo Pei State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of ProsthodonticsWest China Hospital of StomatologSichuan UniversityChengdu 610041China College of Chemistry Sichuan UniversityChengdu 610064China

In recent years,various particulate materials have played important roles in medical ***,nano-and micron-sized particles of the same material could exhibit distinct properties due to different particle *** finding provided a simple and effective way to improve the biological applications of particulate ***,as a highly promising member,the effect of the particle size change of the magnesium metal organic framework-74(Mg-MOF74)was well worth *** we firsth assessed the in vitro and in vivo toxicity of micron/nanoscale Mg-MOF74(m-Mg-MOF74/n-Mg-MOF74)in *** in vitro study revealed that compared to micron-sized subjects,n-Mg-MOF74 provided a wider range of safe ***,both micron/nanoscale Mg-MOF74 showed good biocompatibility and allowed all the rats under the treatment to survive through the expected experimental periods,with n-Mg-MOF74 still showing lower *** advantages of nanoscale Mg-MOF74might benefit from its sustainable and balanced release of Ma^2+both inside and outside the *** on the biosafety evaluation,advanced bio-functional assessments of m/n-Mg-MOF74 including early osteogenesis and angiogenesis were ***,the suitable dose groups of n-Mg-MOF74 achieved optimal early osteogenic promotion and angiogenic stimulation ***,our combined data delineated the toxicity and biological behaviors of Ma-MOF74 of different scales,and sugqested nanoscale Mg-MOF74 as a better choice for future *** result revealed that particle size reductior might be a viable strategy to improve and expand medical applications of MOFs or other particulate materials.

关键词： magnesium metal organic framework-74 micron/nanoscale biological applications osteogenesis angiogenesis

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Janus微/纳米颗粒在生物医学中的应用

中国组织工程研究 2025年第28期29卷 6101-6109页

作者：陈森林朱舟万乾炳四川大学华西口腔医院修复科口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川省成都市610041

背景:Janus微/纳米颗粒因具有形状、结构、功能各向异性被广泛应用于组织工程、药物递送、癌症治疗、生物影像和传感等医学领域。目的:阐述Janus微/纳米颗粒在生物医学的前沿应用。方法:通过计算机检索中国知网、万方、PubMed、Web of S... 详细信息

背景:Janus微/纳米颗粒因具有形状、结构、功能各向异性被广泛应用于组织工程、药物递送、癌症治疗、生物影像和传感等医学领域。目的:阐述Janus微/纳米颗粒在生物医学的前沿应用。方法:通过计算机检索中国知网、万方、PubMed、Web of Science数据库中2010-2024年发表的相关文献,分别以“Janus纳米颗粒,Janus颗粒,双面神颗粒,药物递送,癌症治疗,生物影像,生物传感,组织工程”和“Janus nanoparticle,Janus particle,Drug delivery,Cancer therapy,Biosensing,Bioimaging,Tissue engineering”为中、英文检索词,进行筛选、整理、归纳、总结,最终纳入69篇文献进行综述。结果与结论:Janus微/纳米颗粒可根据基础材料性质分为有机、无机、有机-无机复合三大类,其合成策略有遮蔽、自组装、相分离、微流控和成核生长等。Janus微/纳米颗粒可通过高负载率、门控释放、自主运动等特性进行高效率药物递送。Janus微/纳米颗粒除了增强传统癌症治疗措施(放化疗)的治疗效果外,还可以应用于细胞免疫、蛋白药物、细胞铁死亡等新兴癌症治疗方法;可应用于增强生物影像(CT、MRI、超声)的增敏剂,实现高质量成像,用于指导诊断和治疗;可通过运载生长因子、增强生物支架机械性能和抗菌效果,应用于组织工程。综合目前的研究,研究者们通过集合不同有机聚合物、无机材料的物化特性以不同的合成策略合成功能定制的Janus微/纳米颗粒,应用于复杂的生物医学领域。目前Janus微/纳米颗粒应用于组织再生领域、大规模生产和人体临床试验的报道较少,因此该类材料的开发、合成策略、临床安全评估和转化仍需投入更大的研究力度。

关键词： Janus微/纳米颗粒组织工程药物运输癌症治疗生物影像生物传感工程化材料

Drug-loading ZIF-8 for modification of microporous bone scaffold to promote vascularized bone regeneration

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Chinese Chemical Letters 2024年第6期35卷 358-364页

作者： Xin Zhang Junyu Chen Xiang Pei Linxin Yang Liang wang Luona Chen Guangmei Yang Xibo Pei qianbing wan Jian wang State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesChengdu 610041China Department of Prosthodontics West China Hospital of StomatologySichuan UniversityChengdu 610041China

Surface modification of microporous bone scaffolds using nanoparticles has been broadly studied in bone tissue *** at improving vascularized bone regeneration(VBR),zeolitic imidazolate framework-8(ZIF-8)was encapsulated with dimethyloxallyl glycine(DMOG)and the drug-carrying nanoparticles(D@Z)could be uniformly coated onto the surface of the bone *** osteogenic and angiogenic actions of D@Z are closely correlated with the amount of slowly released DMOG,and in general,exhibited a favorable ***,the D7.5@Z group,which showed the greatest capacity to induce in vitro osteogenesis-angiogenesis coupling,was utilized for surface modification of the bone *** processes including phosphate-containing compound metabolic process,cell differentiation,cell proliferation and cell motility might contribute to enhanced ability to induce VBR by the coated scaffold and signaling pathways such as Rap1,Ras,phosphatidylinositol 3-kinase/protein kinase B(PI3K-AKT)and vascular endothelial growth factor(VEGF)signaling pathways participated in these ***,as depicted by in vitro real time-polymerase chain reaction(RT-PCR),Western blot(WB)and in vivo cranial bone defect model,the microporous scaffold coated with nano-D7.5@Z greatly promoted *** conclude,nano-D@Z has significant promise for practical application in modification of microporous bone scaffolds to enhance VBR,and DMOG loading quantity has a beneficial influence on D@Z to improve osteogenesis-angiogenesis coupling.

关键词： Drug-loading nanoparticles Surface coating Microporous bone scaffold Vascularization bone regeneration

Influence of Alumina Addition on the Optical Property of Zirconia/Alumina Composite Dental Ceramics

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Journal of Wuhan University of Technology(Materials Science) 2011年第4期26卷 690-695页

作者：蒋丽李伟 State Key Laboratory of Oral Diseases Sichuan University

The influence of various alumina additions on the optical property of zirconia/alumina composite ceramics was investigated. The relative sintered densities, transmittances, color and the microstructure of the composite ceramics were studied. The experimental results showed that the relative sintered densities and transmittances decreased with alumina addition. The lightness increased obviously but the chroma change was small. Pure zirconia nanopowders sintered densely could obtain the relatively high transmittance, while the transmittance and the lightness of slight addition changed significantly. The zirconia/alumina composite ceramics with alumina addition less than 7.5wt% could achieve the relatively stable and reliable optical properties.

关键词： alumina addition zirconia/alumina ceramics transmittance color optical properties

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基质金属蛋白酶抑制剂的研究进展

华西口腔医学杂志 2017年第2期35卷 208-214页

作者：贾玲玲万乾炳口腔疾病研究国家重点实验室国家口腔疾病临床研究中心四川大学华西口腔医院口腔修复科成都610041

牙本质粘接混合层的长期稳定性不佳,基质金属蛋白酶等内源性酶降解胶原是导致混合层破坏的重要因素。使用酶抑制剂抑制胶原降解,维持胶原结构的完整性,是提高混合层稳定性的关键。本文重点总结了基质金属蛋白酶抑制剂(包括氯己定、乙二... 详细信息

牙本质粘接混合层的长期稳定性不佳,基质金属蛋白酶等内源性酶降解胶原是导致混合层破坏的重要因素。使用酶抑制剂抑制胶原降解,维持胶原结构的完整性,是提高混合层稳定性的关键。本文重点总结了基质金属蛋白酶抑制剂(包括氯己定、乙二胺四乙酸、季铵盐类、锌离子和氧化锌、四环素类及其衍生物、异羟肟酸类抑制剂、二磷酸盐衍生物、交联剂等)的研究进展,并对未来的发展进行展望。

关键词：基质金属蛋白酶半胱氨酸组织蛋白酶牙本质酶抑制剂生物降解耐久性

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口腔氧化锆修复材料分代之我见

国际口腔医学杂志 2021年第2期48卷 125-128页

作者：万乾炳口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院修复科成都610041

氧化锆全瓷材料由于具有良好的生物相容性和美学性能,逐渐取代金-瓷修复体广泛用于修复领域。传统的氧化锆全瓷修复体需要在氧化锆基底表面塑堆饰面瓷,但饰面瓷容易崩瓷。近些年来,临床上出现了使用全氧化锆修复体的趋势,但是,临床上可... 详细信息

氧化锆全瓷材料由于具有良好的生物相容性和美学性能,逐渐取代金-瓷修复体广泛用于修复领域。传统的氧化锆全瓷修复体需要在氧化锆基底表面塑堆饰面瓷,但饰面瓷容易崩瓷。近些年来,临床上出现了使用全氧化锆修复体的趋势,但是,临床上可供医生选择的全锆修复材料较多,如何选择适当的氧化锆材料成为修复医生的挑战。氧化锆全瓷修复材料根据材料组成和透光性能等分为4代。本综述介绍了4代氧化锆全瓷材料的材料组成、力学性能、透光性能、临床适应证等。

关键词：氧化锆分代全瓷

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不对称伤口敷料的研究进展与生物应用

中国组织工程研究 2023年第3期27卷 434-440页

作者：周洁裴锡波万乾炳四川大学华西口腔医院修复科四川省成都市610000

背景:使用伤口敷料对清创后的伤口进行保护已是许多学者的共识,但目前仍缺乏能模拟皮肤结构的理想多功能敷料。不对称伤口敷料能尽可能模拟天然皮肤结构,具有抗感染、促伤口渗出液排出等功能,有较大的潜力成为理想的伤口敷料。目的:总... 详细信息

背景:使用伤口敷料对清创后的伤口进行保护已是许多学者的共识,但目前仍缺乏能模拟皮肤结构的理想多功能敷料。不对称伤口敷料能尽可能模拟天然皮肤结构,具有抗感染、促伤口渗出液排出等功能,有较大的潜力成为理想的伤口敷料。目的:总结不对称敷料的最新研究进展及生物应用。方法:利用计算机在PubMed、Web of Science、中国知网、万方数据库中进行文献检索,英文检索关键词为“asymmetric dressing,wound asymmetric membrane,wound asymmetric film”,中文检索关键词为“不对称敷料,伤口不对称膜”,根据纳入排除标准对文章进行筛选,最终纳入53篇文献进行综述。结果与结论:不对称敷料除可仿生天然皮肤的不对称结构外,其致密疏水层还能防止外界细菌侵入,控制创面水汽交换,亲水层能负载并释放需要的药物,多孔结构也利于细胞的黏附增殖,进而促进伤口愈合;其不对称特性并不能显著影响敷料的物理性能,但不对称敷料常由多种材料复合而成,所得的敷料性能常优于单一材料。目前的不对称敷料依照结构特点可分为单层改性不对称敷料、双层不对称敷料、梯度不对称敷料3种类型,今后的研究还会赋予不对称敷料更多、更智能的功能,使其作为一种可能的理想伤口敷料进一步发展,解决目前传统敷料在临床运用中所面临的问题。

关键词：不对称敷料新型伤口敷料梯度敷料抗感染载药系统 Janus膜伤口愈合综述