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Hangzhou criteria as downstaging criteria in hepatocellular ca

Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 349-357页

作者： Qi-Fan Zhan Sun-Bin Ling Yi-Nan Deng Qiao-Nan Shan qian-wei ye Sheng-Jun Xu Guang-Jiang Jiang Di Lu Xu-Yong wei Li Zhuang Wu Zhang Tian Shen Bei-Ni Cen Hai-Yang Xie Ji-Min Liu Jian Wu Shu-Sen Zheng Yang Yang Xiao Xu Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China NHC Key Laboratory of Combined Multi-organ Transplantation Key Laboratory of the Diagnosis and Treatment of Organ TransplantationCAMSHangzhou 310003China Department of Hepatic Surgery and Liver Transplantation Center the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 310000China Department of Pathology and Molecular Medicine Faculty of Health SciencesMcMaster UniversityHamiltonOntario L8S 4K1Canada

Background:The downstaging of hepatocellular carcinoma(HCC)has been confirmed to benefit liver transplantation(LT)patients whose tumors are beyond the transplantation *** criteria(MC),a tumor size and number-based assessment,is currently used as the endpoint in these ***,many studies believe that tumor biological behavior should be added to the evaluation criteria for downstaging ***,this study aimed to explore the feasibility of Hangzhou criteria(HC),which introduced tumor grading and alpha-fetoprotein in addition to tumor size and number,as an endpoint of ***:We performed a multicenter and retrospective study of 206 patients accepted locoregional therapy(LRT)as downstaging/bridge treatment prior to LT in three centers of ***:Recipients were divided into four groups:failed downstaging to the HC(group A,n=46),successful downstaging to the HC(group B,n=30),remained within the HC all the time(group C,n=113),and tumor progressed(group D,n=17).The 3-year HCC recurrence probabilities of groups B and C were not significantly different(10.3%vs.11.6%,P=0.87).The HCC recurrent rate was significantly higher in group A(52.3%)compared with that in group B/C(P<0.05).Seven patients(7/76,9.2%)whose tumor exceeded the the HC were successfully downstaged to the MC,and 39.5%(30/76)to the the *** group B,23 patients remained beyond the MC and their survivals were as well as those of patients within the ***:Compared to the MC,HC downstaging criteria can give more HCC patients access to LT and furthermore,the outcome of these patients is the same as those matching MC downstaging *** downstaging criteria therefore is applicable in clinical practice.

关键词： Hepatocellular carcinoma Liver transplantation Downstaging

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夫妻个人特有财产问题探讨

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中华女子学院山东分院学报 2009年第5期 29-35页

作者：钱叶卫中国政法大学北京100088

建国以来,我国夫妻财产制的立法经历了从1950年婚姻法到1980年婚姻法再到2001年修正的婚姻法的立法推进过程。2001年修正的婚姻法中关于夫妻财产制的规定有了很大的跨越,专门规定了属于夫妻一方财产的情况。在婚后所得共同制中,夫妻共... 详细信息

建国以来,我国夫妻财产制的立法经历了从1950年婚姻法到1980年婚姻法再到2001年修正的婚姻法的立法推进过程。2001年修正的婚姻法中关于夫妻财产制的规定有了很大的跨越,专门规定了属于夫妻一方财产的情况。在婚后所得共同制中,夫妻共有财产与夫妻个人特有财产共同存在,两者并不矛盾:这符合财产法律关系变动理论;体现了意思自治原则;是保护夫妻个人债务的债权人利益的需要;是综合平衡个体利益和婚姻共同体利益的需要。现行《婚姻法》第18条和《解释(二)》第13条对我国夫妻个人特有财产范围进行了界定。目前,有关夫妻个人特有财产还有一些有争议的问题需要我们探讨。

关键词：夫妻个人特有财产

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Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： wei Xiong Xuan ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

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Protective effects of Ligustrazine,Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2011年第6期10卷 632-637页

作者： Xi-Ping Zhang,Jun Jiang,Qi-Hui Cheng,qian ye,wei-Juan Li,Hua Zhu and Jun-Ya Shen Department of General Surgery,Department of Gynecology and Obstetrics and Central Laboratory Department,Hangzhou First People’s Hospital,Hangzhou 310006,China Zhejiang Chinese Medical University,Hangzhou 310053,China Department of General Surgery Hangzhou First People's Hospital Hangzhou 310006 China Zhejiang Chinese Medical University Hangzhou 310053 China Department of Gynecology and Obstetrics Hangzhou First People's Hospital Hangzhou 310006 China Central Laboratory Department Hangzhou First People's Hospital Hangzhou 310006 China

BACKGROUND:Severe acute pancreatitis (SAP) is characterized by fatal pathogenic conditions and a high *** is important to study SAP complicated with multiple organ *** this study we compared the protective effects of three traditional Chinese medicines (Ligustrazine,Kakonein and Panax Notoginsenoside) on the small intestine and immune organs (thymus,spleen and lymph nodes) of rats with SAP and explored their mechanism of ***:One hundred forty-four rats with SAP were randomly divided into model control,Ligustrazine-treated,Kakonein-treated,and Panax Notoginsenoside-treated groups (n=36 per group).Another 36 normal rats comprised the sham-operated *** to the different time points after operation,the experimental rats in each group were subdivided into 3-,6-and 12-hour subgroups (n=12).At various time points after operation,the mortality rate of rats and pathological changes in the small intestine and immune organs were recorded and the serum amylase levels were ***:Compared to the model control groups,the mortality rates in all treated groups declined and the pathological changes in the small intestine and immune tissues were relieved to different *** serum amylase levels in the three treated groups were significantly lower than those in the model control group at 12 *** pathological severity scores for the small intestinal mucosa,thymus and spleen (at 3 and 12 hours) in the Ligustrazine-treated group,for the thymus (at 3 and 12 hours) and spleen (at 3 and 6 hours) in the Kakonein-treated group,and for the thymus (at 3 hours)and spleen (at 3 hours) in the Panax Notoginsenoside-treated group were significantly lower than those in the model control *** pathological severity scores of the small intestinal mucosa (at 6 and 12 hours) and thymus (at 6 hours) in the Ligustrazine-treated group were significantly lower than those in the Kakonein-and Panax Notoginsenoside-treated ***:All the t

关键词： severe acute pancreatitis traditional Chinese medicine small intestine multiple organs apoptosis

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从非婚同居现象看我国婚姻制度的立法缺陷

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山西省政法管理干部学院学报 2009年第3期22卷 91-93页

作者：钱叶卫中国政法大学民商经济法学院北京100088

我国非婚同居现象日益突出,由于其不受相关法律规范,引起了大量的社会纠纷。要树立人们对婚姻的信心,应建立婚前财产保护制度,设立婚姻教育制度和示范性的契约婚姻制度,建立维护完整婚姻和保障离婚自由的价值平衡机制,通过完善这些相关... 详细信息

我国非婚同居现象日益突出,由于其不受相关法律规范,引起了大量的社会纠纷。要树立人们对婚姻的信心,应建立婚前财产保护制度,设立婚姻教育制度和示范性的契约婚姻制度,建立维护完整婚姻和保障离婚自由的价值平衡机制,通过完善这些相关制度以减少非婚同居现象的发生。

关键词：非婚同居婚姻制度立法缺陷

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夫妻个人特有财产问题探讨

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盐城师范学院学报（人文社会科学版） 2009年第3期29卷 33-37页

作者：钱叶卫中国政法大学民商经济法学院北京100088

2001年修正的婚姻法关于夫妻财产制的规定有了很大的跨越,专门规定了属于夫妻一方财产的情况,这对调整夫妻财产关系,保障婚姻家庭中个人的经济独立和调动个人的积极性发挥了重要作用。探究我国夫妻财产制的立法推进过程,分析夫妻个人特... 详细信息

2001年修正的婚姻法关于夫妻财产制的规定有了很大的跨越,专门规定了属于夫妻一方财产的情况,这对调整夫妻财产关系,保障婚姻家庭中个人的经济独立和调动个人的积极性发挥了重要作用。探究我国夫妻财产制的立法推进过程,分析夫妻个人特有财产存在的法理,界定我国夫妻个人特有财产范围,有助于区分夫妻个人财产特有和共有原则的确立。

关键词：夫妻财产制特有财产《婚姻法》

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科学研究纲领指导下的科学合理重建

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遵义师范学院学报 2006年第6期8卷 7-9页

作者：钱玮烨贵州大学人文学院贵州贵阳550025

伊姆雷·拉卡托斯,英国著名的数学哲学家和科学哲学家,他博取波普尔和库恩学说的合理成分建立了“科学研究纲领方法论”,提出了新的解决科学与非科学的划界标准,以及如何判断科学理论的进步问题。

关键词：拉卡托斯科学研究纲领合理性

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浙江经济的文化诠释

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金华职业技术学院学报 2006年第4期6卷 14-17页

作者：钱微叶奉化工贸实业总公司浙江奉化315500

改革开放以来,浙江经济尤其是民营经济持续高速增长,出现了“浙江现象”。本文从浙江人的重商传统、务实精神、开放意识等方面,对浙江经济或“浙江现象”进行文化诠释和解读。

关键词：重商传统务实精神开放意识

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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song qian-qian Wan Yu-Ming Wang Han-Zhou Li wei-Quan Xu Jia-Bao Liao wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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