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Adoptive therapy with CAR redirected T cells for hematological malignancies

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Science China(life Sciences) 2016年第4期59卷 370-378页

作者： Shiqi li Zhi Yang Junjie Shen Juanjuan shan Cheng qian Institute of Pathology and Southwest Cancer Center Southwest Hospital Third Military Medical University

The survival of patients with hematological malignancies has been significantly improved due to the development of new therapeutic agents. However, relapse remains a major matter for concern. Recently, T cells engineered with chimeric antigen receptor(CAR) were reported to show unprecedented responses in a range of hematological malignancies. The persistence of the CAR-T cell can last for years and tends toward long-term antitumor memory by which relapses can be effectively prevented. The primary side effects that appear in most clinical trials are cytokine release syndrome and neurotoxicity. However, these symptoms can be treated and reversed. In this review, we describe CAR structure and function and summarize recent advances in CAR-T cell therapy in hematological malignancies.

关键词： cancer hematological malignancies immunotherapy chimeric antigen receptor T-cell therapy

An Elastic Shell Model for the Human Tricuspid Valve

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Acta Mathematicae Applicatae Sinica 2019年第1期35卷 111-128页

作者： Xiao-qin SHEN qian YANG lin-jin li li CAI Xiao-shan CAO Xi’an University of Technology NPU-UoG International Cooperative Lab for Computation & Application in Cardiology Northwestern Polytechnical University Department of Mathematical University of Delaware

The human tricuspid valve, one of the key cardiac structures, plays an important role in the circulatory system. However, there are few mathematical models to accurately simulate *** this paper, firstly, we consider the tricuspid valve as an elastic shell with a specific shape and establish its novel geometric model. Concretely, the anterior, the posterior and the septal leaflets of the valve are supposed to be portions of the union of two interfacing semi-elliptic cylindrical shells when they are fully ***, we use Koiter's linear shell model to describe the tricuspid valve leaflets in the static case, and provide a numerical scheme for this elastostatics model. Specifically, we discretize the space variable, i.e., the two tangent components of the displacement are discretized by using conforming finite elements(linear triangles) and the normal component of the displacement is discretized by using conforming Hsieh-Clough-Tocher triangles(HCT triangles).Finally, we make numerical experiments for the tricuspid valve and analyze the outcome. The numerical results show that the proposed mathematical model describes well the human tricuspid valve subjected to applied forces.

关键词： tricuspid valve geometric model parametric equation Koiter model conforming finite element

Recognition model and algorithm of projectiles by combining particle swarm optimization support vector and spatial-temporal constrain

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Defence Technology（防务技术） 2023年第9期27卷 273-283页

作者： Han-shan li School of Electronic and Information Engineering Xi'an Technological UniversityXi'an710021China

In order to improve the recognition rate and accuracy rate of projectiles in six sky-screens intersection test system,this work proposes a new recognition method of projectiles by combining particle swarm optimization support vector and spatial-temporal constrain of six sky-screens detection *** on the measurement principle of the six sky-screens intersection test system and the characteristics of the output signal of the sky-screen,we analyze the existing problems regarding the recognition of *** order to optimize the projectile recognition effect,we use the support vector machine and basic particle swarm algorithm to form a new recognition *** set up the particle swarm algorithm optimization support vector projectile information recognition model that conforms to the six sky-screens intersection test *** also construct a spatial-temporal constrain matching model based on the spatial geometric relationship of six sky-screen intersection,and form a new projectile signal recognition algorithm with six sky-screens spatial-temporal information constraints under the signal classification mechanism of particle swarm optimization algorithm support vector *** on experiments,we obtain the optimal penalty and kernel function radius parameters in the PSO-SVM algorithm;we adjust the parameters of the support vector machine model,train the test signal data of every sky-screen,and gain the projectile signal classification ***,according to the signal classification results,we calculate the coordinate parameters of the real projectile by using the spatial-temporal constrain of six sky-screens detection sensor,which verifies the feasibility of the proposed algorithm.

关键词： Six sky-screens intersection test system Pattern recognition Particle swarm optimization Support vector machine Projectile

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基于二次均值阴影集的FCM聚类算法

华北理工大学学报（自然科学版） 2025年第1期47卷 116-124页

作者：闫珊珊李文焱李丽红华北理工大学理学院河北唐山063210 河北省数据科学与应用重点实验室河北唐山063210 唐山市数据科学重点实验室河北唐山063210

为减少五区域阴影集中使用常数值来定义阴影集的五值隶属函数而造成的划归误差,利用平均值隶属度构建了一种基于二次均值阴影集的FCM聚类算法(FCM-5QSS)。首先,通过FCM算法得到对象与簇之间的隶属度矩阵;然后,使用平均值隶属度来定义阴... 详细信息

为减少五区域阴影集中使用常数值来定义阴影集的五值隶属函数而造成的划归误差,利用平均值隶属度构建了一种基于二次均值阴影集的FCM聚类算法(FCM-5QSS)。首先,通过FCM算法得到对象与簇之间的隶属度矩阵;然后,使用平均值隶属度来定义阴影集的五值隶属函数,同时通过模糊度性质及不确定性平衡原理得到两对阈值,进而将隶属度对应的对象划分到5个区域中;最后,通过划分核心区域和次核心区域中隶属度μ≥ηfalse的对象簇,得到聚类结果。在8个UCI公开数据集上的实验结果表明了所提出方法的有效性。

关键词：三支决策五区域阴影集平均值隶属度三支聚类

维普期刊数据库博看期刊

Encapsulating manganese oxide nanoparticles within conducting polypyrrole via in situ redox reaction and oxidative polymerization for long-life lithium-ion batteries

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Rare Metals 2021年第9期40卷 2415-2423页

作者： He-liang Yao shan-shan Gao Zheng-qian Fu Wei-Chao Bao Zhong-Hui Cui Yi-Qiu li Fang-Fang Xu State Key Laboratory of High Performance Ceramics and Superﬁne Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

Manganese oxides(MnO_(x)) have been extensively investigated due to their extremely high theoretical capacities for application as conversion anodes in lithiumion batteries. However, fully performing their theoretical performance still faces poor electric conductivity and serious volume change upon lithium insertion/***, we demonstrate encapsulating manganese oxide nanoparticles within a conducting polymer polypyrrole(PPy) shell as a facile strategy to overcome such flaws through in situ redox reaction and oxidative polymerization process. Such an in situ method combines the redox reaction between potassium permanganate and tetrahydrofuran to form MnO_(x)nanoparticles and the subsequent oxidative polymerization of pyrrole to form a conductive polypyrrole coating shell by the oxidant KMnO_(4) into one step. For the as-fabricated products(MnO_(x)@PPy), this tenderly introduced conductive PPy shell highly favors the fast electron transfer and preserves the electrode structure integrity upon repeated cycling. As the anode for liBs, MnO_(x)@PPy exhibits superior lithium storage performance with a high reversible capacity(1538 mAh·g^(-1)), long-life cyclability(747 mAh·g^(-1) after 1000 cycles at 1.0 C) and durable ratability(574 mAh·g^(-1) at 2.0 C). This work demonstrates that the convenient in situ strategy to form conductive polymer coating shell is effective to improve the performance of conversion anodes and can be extended to other materials for energy storage applications.

关键词： Manganese oxide Polypyrrole High cycling performance lithium-ion battery

Prognostic relevance of number and ratio of metastatic lymph nodes in resected carcinoma of the ampulla of Vater

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Chinese Journal of Cancer Research 2013年第6期25卷 735-742页

作者： Jianguo Zhou qian Zhang Peng li Yi shan Dongbing Zhao Jianqiang Cai Department of Abdominal Surgery Cancer HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of General Surgery Aerospace Central Hospital

Objectives： To explore the prognostic relevance of the number and ratio of metastatic lymph nodes in resected Carcinoma of the ampulla of Vater （CAV）. Methods： The clinical data of 155 patients who underwent pancreaticoduodenectomy （PD） for cancer of the ampulla of Vater between January 1990 and December 2010 were retrospectively analyzed. Kaplan- Meier method was used in survival analysis and Log rank method in comparison. Multivariate analysis was performed using Cox proportional hazards model. Results： Among these 155 patients, the in-hospital mortality rate was 4.5%, lymph node positive disease was 21.3%, and the 5-year survival rate was 51.6%. Patients with a lymph node ratio （LNR）〉20% were more likely to have tumor differentiation, depth of duodenal involvement, depth of pancreatic invasion, T-stage and TNM-Stage. The number of the metastatic lymph nodes is important prognostic factors of the CAV. Univariate analysis showed that the factors associated with the prognosis included tumor size （P=0.036）, tumor differentiation （P=0.019）, LNR （P=0.032）, mtmber of metastatic lymph nodes （P=0.024）, lymph node metastasis （P=0.03）, depth of pancreatic invasion （P=0.001）, T-stage （P=0.002）, TNM stage （P=0.001）, elevated CA 19-9 （P=0.000）, and jaundice （P=0.021）. Multivariate analysis showed that the factors associated with the prognosis were the number of metastatic lymph nodes （P=0.032; RR： 1.283; 95% CI： 1.022-1.611）, tumor size （P=0.043; RR： 1.736; 95% CI： 1.017-2.963）, and elevated CA 19-9 （P=0.003; RR： 3.247; 95% CI： 1.504-7.010）. Conclusions： LNR is a useful factor for predicting the prognosis of the radical treatment for CAV,, whereas the number of metastatic lymph nodes is the most important factor. Further research on the locations, number, and LNR will be clinically meaningful to improve survival in patients with CAV.

关键词： Ampulla of vater lymph nodes metastasis carcinoma prognosis

Synthesis of(S) and(R)-tilisolol hydrochloride

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Chinese Chemical Letters 2009年第6期20卷 648-650页

作者： shan qian Xiao Juan Ye Fan Zheng li Yang Yong Wu Key Laboratory of Drug Targeting West China School of Pharmacy Sichuan University Chengdu Sichuan 610041 China

Tilisolol hydrochloride 1, a non-selective β-adrenoceptor blocker, was developed as a drug for the treatment of hypertension and angina pectoris. The optical active forms of 1, la and lb were synthesized from inexpen... 详细信息

关键词： Tilisolol hydrochloride Optical Synthesis

Clinical analysis of Wernicke encephalopathy after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 352-357页

作者： li-Min Ding li-shan Deng Jun-Jie qian Gang liu lin Zhou Shu-Sen Zheng Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China NHFPC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Key Laboratory of the Diagnosis and Treatment of Organ Transplantation Chinese Academy of Medical SciencesHangzhou 310003China Key Laboratory of Organ Transplantation Research Center for Diagnosis and Treatment of Hepatobiliary DiseasesHangzhou 310003China Culture and Sports Center for the Disabled of Jiangxi Province Nanchang 330000China Department of Transplantation Jiangxi Provincial People’s HospitalNanchang 330000China Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases Hangzhou 310003China

Background:Wernicke encephalopathy(WE)is an acute neurological disease resulting from vitamin B1 deficiency,and there are only very few case reports of WE after liver *** present study aimed to investigate the clinical characteristics,etiology,magnetic resonance imaging(MRI)features,treatment and prognosis of patients with WE after liver ***:Twenty-three patients with WE after liver transplantation from the First Affiliated Hospital,Zhejiang University School of Medicine and Jiangxi Provincial People’s Hospital between January 2011 and December 2021 were retrospectively ***:Among the 23 patients diagnosed with WE after liver transplantation,6(26%)had a classic triad of impaired consciousness,oculomotor palsy and ataxia,and 17(74%)had two *** misdiagno-sis rate was 65%.After treatment with high-dose vitamin B1,19(83%)patients showed improvement,whereas 4(17%)showed no improvement,including 3 with residual short-term memory impairments and 1 with residual spatial and temporal disorientation and ***:The misdiagnosis rate is high in the early stage of WE,and the prognosis is closely asso-ciated with whether WE is diagnosed early and treated ***-dose glucose or glucocorticoids can trigger WE and cannot be administered before vitamin B1 *** B1 is suggested to be used as a prophylactic treatment for patients with WE after liver transplantation.

关键词： liver transplantation Wernicke encephalopathy Vitamin B1 Clinical presentations Imaging features Diagnosis Treatment Prognosis

A wireless solution for greenhouse monitoring and control system based on ZigBee technology

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第10期8卷 1584-1587页

作者： ZHANG qian YANG Xiang-long ZHOU Yi-ming WANG li-ren GUO Xi-shan School of Biosystem Engineering and Food Science. Zhejiang University. Hangzhou 310029 China

With the rapid development of wireless technologies, it is possible for Chinese greenhouses to be equipped with wireless sensor networks due to their low-cost, simplicity and mobility. In the current study, we compared the advantages of ZigBee with other two similar wireless networking protocols, Wi-Fi and Bluetooth, and proposed a wireless solution for green- house monitoring and control system based on ZigBee technology. As an explorative application of ZigBee technology in Chinese greenhouse, it may promote Chinese protected agriculture.

关键词： Greenhouse Monitoring and control Wireless ZigBee IEEE802.15.4 JN5121