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四川农业大学学报 2003年第3期21卷 237-240页

作者：唐茜单虹丽杨安四川农业大学林学园艺学院四川雅安625014

分析了四川苦丁茶氨基酸组成以及多酚类、可溶性糖和无机元素等含量,并和大叶冬青苦丁茶、贵州苦丁茶和绿茶进行了对比。结果表明,四川苦丁茶植物是一种内含物较丰富,代谢类型、品质特征等有别于大叶冬青苦丁茶、贵州苦丁茶和绿茶的营... 详细信息

分析了四川苦丁茶氨基酸组成以及多酚类、可溶性糖和无机元素等含量,并和大叶冬青苦丁茶、贵州苦丁茶和绿茶进行了对比。结果表明,四川苦丁茶植物是一种内含物较丰富,代谢类型、品质特征等有别于大叶冬青苦丁茶、贵州苦丁茶和绿茶的营养保健型饮料资源。

关键词：四川苦丁茶紫茎女贞序梗女贞化学成分

Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-lin li Xin-Ran Song qian-qian Wan Yu-Ming Wang Han-Zhou li Wei-Quan Xu Jia-Bao liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Multi-area detection sensitivity calculation model and detection blind areas influence analysis of photoelectric detection target

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Defence Technology（防务技术） 2022年第4期18卷 547-556页

作者： Han-shan li Xiao-qian Zhang Hui Guan School of Electronic and Information Engineering Xi’an Technological UniversityXi’an710021China

Multi-element array photoelectric detector is the core devices to form a photoelectric detection target with a large field of *** photoelectric detection target brings about the problem of uneven detection sensitivity distribution in the detection *** improve the uneven detection sensitivity of this photoelectric detection target,this paper analyzes the distribution law of the uneven detection sensitivity of the photoelectric detection target using the multi-element array photoelectric detector,dissects the main factors affecting the detection sensitivity according to the photoelectric detection principle,establishes the calculation model of detection sensitivity of the photoelectric detection target in the different detection areas and proposes a method to improve the detection sensitivity by compensating the gain of each unit photoelectric *** analysis of simulation and experimental results show that the proposed method of photoelectric detection target can effectively improve the output signal amplitude of the projectile under the certain detection distance,in particular,the output signal amplitude of the projectile is significantly increased when the projectile passes through the detection blind *** experimental results are consistent with the simulation results,which verify the effectiveness of the proposed improvement method.

关键词： Projectile Photoelectric detection target Multi-element array photoelectric detector Detection sensitivity Detection screen

Molecule‑Level Multiscale Design of Nonflammable Gel Polymer Electrolyte to Build Stable SEI/CEI for lithium Metal Battery

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Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi Sun Zelong Gong Tao Zhang Jiafeng li Xianli Zhu Ruixiao Zhu lingxu Wang Leyuan Ma Xuehui li Miaofa Yuan Zhiwei Zhang Luyuan Zhang Zhao qian Longwei Yin Rajeev Ahuja Chengxiang Wang Key Laboratory for liquid‑Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed Matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability is an unavoidable issue for gel polymer electrolytes(GPEs).Usually,flameretardant solvents are necessary to be used,but most of them would react with anode/cathode easily and cause serious interfacial instability,which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by in situ polymerizing trifluoroethyl methacrylate(TFMA)monomers with flame-retardant triethyl phosphate(TEP)solvents and liTFSI–liDFOB dual lithium *** is strongly anchored to PTFMA matrix via polarity interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electrolyte interface/cathode electrolyte interface *** coordination structure changes li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The li|SGPE|li cell presents highly reversible li stripping/plating performance for over 1000 h at 0.1 mA cm^(−2),and 4.2 V liCoO_(2)|SGPE|li battery delivers high average specific capacity>120 mAh g^(−1) over 200 *** study paves a new way to make nonflammable GPE that is compatible with li metal anode.

关键词： Anchoring effect Nonflammable gel electrolyte In situ cross-linked Electrode-electrolyte interface li metal battery

Effect of Interaction of Non-residual Fractions on Adsorption of Atrazine onto Surficial Sediments and Natural Surface Coating Samples

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Chemical Research in Chinese Universities 2011年第2期27卷 212-216页

作者： li Yu li shan-shan GAO qian WANG Ao Sino-Canada Research Academy of Energy and Environmental Studies North China Electric Power University Beijing 102206 P. R. China Jilin Provincial Center for Sanitary Inspection and Test Changchun 130062 P. R. China College of Environment and Resources Jilin University Changchun 130012 P. R. China

To quantify the effect of the interaction of non-residual fractions[Fe oxides（Fe）, Mn oxide（Mn）, organic materials（OMs）] in the surficial sediments and the natural surface coating samples on the adsorption of atrazine（AT）, an AT multiple regression adsorption model（AT-MRAM） was developed. The AT-MRAM improves upon the previous AT additional adsorption model（AT-AAM） with superior goodness-of-fit test（adjusted R2=ca.1.000）, F-test and t-test（P〈0.01）, and reveals the effect of the interaction among the components in the surficial sediments（SSs） and na- tural surface coatings samples（NSCSs） on the adsorption of AT, which was neglected by the AT-AAM. Meanwhile, the AT-MRAM was also verified through adsorption experiments of AT and the relative deviation between predicted maximum adsorption of AT and the experimental one is less than 15%. The resulted information shows that Mn is prone to interact with other non-residual components, the total maximum adsorption of AT is inversly proportional to the level of Mn, and Fe and OMs facilitate the adsorption of AT. The results also indicate that the adsorption of AT is not only dominated by Fe, OMs, Fe/OMs, but also restrained by Fe/Mn, Fe/Mn/OMs, with lesser roles attributed to Mn, and the estimated AT distributions among the components do not agree with that previously predicted by the AT-AAM, especially with the relative contribution of Mn to the adsorption of AT, revealing significant contribution of the interactions among non-residual components in controlling the behavior of AT in aquatic environments.

关键词： Atrazine Interaction adsorption Mn oxide Surficial sediment Multiple linear regression

Research on Novel Targets Regulating Cardiac Ischemic Arrhythmias

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中国药理通讯 2008年第2期25卷 16-16页

作者： Yang Bao-Feng Lu Yan-Jie Zhang Yong Xu Chao-qian shan Hong-li Pan Zhen-Wei li Bao-Xin Department of Pharmacology Incubator of State-Province Key Laboratories ofBiomedicine-Pharmaceutics of China Harbin MediCal University Harbin 150081

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing liu li-Fei Song Zheng-Zhi Wu qian-qian Jiang Shao-Yu liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

乳腺微创旋切手术治疗乳腺多发性肿块的临床效果

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临床医学研究与实践 2017年第23期2卷 58-59页

作者：罗海涛梁海元单千里兴平市一四五医院微创外科陕西咸阳713106

目的探讨乳腺微创旋切手术治疗乳腺多发性肿块的临床效果。方法选取我院2014年2月至2016年2月收治的110例乳腺多发性肿块患者,按照手术方法分为观察组和对照组,每组55例。对照组患者采用传统手术进行治疗,观察组患者则采用乳腺微创旋切... 详细信息

目的探讨乳腺微创旋切手术治疗乳腺多发性肿块的临床效果。方法选取我院2014年2月至2016年2月收治的110例乳腺多发性肿块患者,按照手术方法分为观察组和对照组,每组55例。对照组患者采用传统手术进行治疗,观察组患者则采用乳腺微创旋切手术,观察两组治疗效果和不良反应发生情况。结果观察组患者的手术时间、术中出血量以及瘢痕长度均优于对照组(P<0.05);观察组满意度为85.45%,明显高于对照组的38.18%(P<0.05);观察组并发症发生率为5.45%,明显低于对照组的18.18%(P<0.05)。结论临床上采用乳腺微创旋切手术治疗乳腺多发性肿块的手术时间短、出血少且瘢痕较小,术后并发症发生率低且患者满意度高,整体临床治疗效果较好。

关键词：微创旋切手术多发性肿块瘢痕

Rare earth element Ce enables high thermoelectric performance in n-type SnSe polycrystals

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Journal of Materials Science & Technology 2023年第12期143卷 234-241页

作者： shan li li Yin Yijie liu Xiaodong Wang Chen Chen qian Zhang School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072China School of Materials Science and Engineering and Institute of Materials Genome&Big DataHarbin Institute of TechnologyShenzhen 518055China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

SnSe exhibits excellent thermoelectric performance in both n-and p-type single crystals,but its n-type polycrystals are restricted because of the lower electrical ***,we dually introduced rare earth element Ce and PbTe to optimize the thermoelectric properties of n-type SnSe *** is demonstrated that Ce is an effective cationic dopant to convert SnSe from p-to n-type conductor,and an enhanced peak zT value of∼0.9 at 823 K was obtained in Sn 0.97 Ce 0.03 Se due to the improved power ***,PbTe alloying not only reduced the band gap to increase the carrier concentration,but also enhanced the density-of-states effective mass,and hence further increased the power factor in the whole measured temperature ***,the lattice thermal conductivity was significantly reduced owing to the enhanced phonon scattering by the mass and strain *** a result,the peak zT value was increased to∼1.3 for Sn 0.9 Pb 0.07 Ce 0.03 Se 0.93 Te 0.07 together with a high average zT value of∼0.52 in the temperature range of 300 to 823 K.

关键词： Thermoelectric N-type SnSe Ce doping PbTe alloying

Revisiting the X-ray emission of the asynchronous polar V1432 Aql

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Research in Astronomy and Astrophysics 2021年第12期21卷 499-508页

作者： Qi-shan Wang Sheng-Bang qian li-Ying Zhu Yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory of the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100101China

As the only eclipsing asynchronous polar,V1432 Aql provides an excellent laboratory to study the interaction between the accreted matter and the magnetic ***,we report an analysis of the X-ray data from the contemporaneous NuSTAR and Swift-XRT *** X-ray data present a profile with a low-intensity state for almost half an orbital period,a dip at 0.6 phase,and a peak at 0.75 phase,which suggests that there was only one accretion region during the observation and the claim is supported by the spectral *** comparison with the previous data indicates that the X-ray data have an orbital modulation,as the case in BeppoSAX,rather than a spin one observed in *** attribute the orbit and spin modulations to the different accretion geometries at *** spectral analysis of the wide-band data presents a significant reflection effect,a commonly observed soft X-ray temperature,and the energy balance in V1432 ***,we obtained a low total accretion rate of 1.3×10~(-10)M yr~(-1)and a high specific accretion rate of 3.8 g cm~(-2)s~(-1)which explains the strong reflection from the surface of the white ***,due to its complex emission,a more physical understanding of its accretion geometry is still outstanding.

关键词： stars:individual(V1432 Aql) cataclysmic variables:asynchronous polars