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Memristive feature and mechanism induced by laser-doping in defect-free 2D semiconductor materials

Journal of Semiconductors 2024年第7期45卷 85-91页

作者： Xiaoshan Du Shu Wang Qiaoxuan Zhang Shengyao Chen Fengyou Yang Zhenzhou Liu Zhengwei fan Lijun Ma Lei Wang Lena Du Zhongchang Wang Cong Wang Bing Chen qian Liu College of Electronic and Information Engineering Shandong University of Science and TechnologyQingdao 266590China National Center for Nanoscience and Technology&University of Chinese Academy of Sciences Beijing 100190China Hebei University of Water Resources and Electric Engineering Electrical Automation Department Cangzhou 061001China The MOE Key Laboratory of Weak-Light Nonlinear Photonics and International Sino-Slovenian Join Re-search Center on Liquid Crystal Pho-tonics TEDA Institute of Applied Physics and School of PhysicsNankai UniversityTianjin 300457China College of Mathematics and Physics Shandong Advanced Optoelectronic Materials and Technologies Engineering LaboratoryQingdao Uni-versity of Science and TechnologyQingdao 266061China Department of Physics Capital Normal UniversityBeijing 100048China Department of Advanced Materials and Computing International Iberian Nanotechnology Laboratory(INL)4715-330 BragaPortugal College of Mathematics and Physics Beijing University of Chemical TechnologyBeijing 100029China

Memristors as non-volatile memory devices have gained numerous attentions owing to their advantages in storage,in-memory computing, synaptic applications, etc. In recent years, two-dimensional(2D) materials with moderate defects have been discovered to exist memristive feature. However, it is very difficult to obtain moderate defect degree in 2D materials, and studied on modulation means and mechanism becomes urgent and essential. In this work, we realized memristive feature with a bipolar switching and a configurable on/off ratio in a two-terminal MoS_(2) device(on/off ratio ~100), for the first time, from absent to present using laser-modulation to few-layer defect-free MoS_(2)(about 10 layers), and its retention time in both high resistance state and low resistance state can reach 2×10^(4) s. The mechanism of the laser-induced memristive feature has been cleared by dynamic Monte Carlo simulations and first-principles calculations. Furthermore, we verified the universality of the laser-modulation by investigating other 2D materials of TMDs. Our work will open a route to modulate and optimize the performance of 2D semiconductor memristive devices.

关键词： 2D-material memristor laser doping laser direct writing memristive mechanism

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Numerical Study on Comparison of Negative and Positive Surface Discharge in c-C_(4)F_(8)/CF_(3)I/CO_(2) Gas Mixture

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Journal of Shanghai Jiaotong university(Science) 2024年第2期29卷 202-215页

作者：范彬海周小丽钱勇臧奕茗 Academy for Engineering&Technology Fudan UniversityShanghai 200433China Department of Light Sources and Iluminating Engineering School of Information Science and TechnologyFudan UniversityShanghai 200433China Department of Electronic Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The dynamics of negative surface discharges in c-C_(4)F_(8)/CF_(3)I/CO_(2) gas mixture is investigated here with a 2D fuid *** distributions of ion concentration,electric field strength and photon flux during the propagation of the streamer are obtained by solving the drift-diffusion equations of particles and Poisson's equation,and the photon flux variation function during the propagation is also *** is found that the streamer branches occur when the streamer transitions from the upper surface of the insulator to the side surface,and then when the streamer approaches the plane electrode,the photon flux will increase *** this basis,the positive and negative surface discharge models are compared in terms of streamer characteristics,particle characteristics and streamer *** is found that the streamer has a higher electron concentration and electric field in the positive *** streamer develops“floating”in the positive surface discharge,while it is close to the surface of the insulator in the negative *** addition,the negative streamer branch has a wider width and develops further.

关键词： streamer branch surface discharge c-C_(4)F_(8)/CF_(3)I/CO_(2)gas mixture positive and negative models

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Scorpiones,Scolopendra and Gekko Inhibit lung Cancer Growth and Metastasis by Ameliorating Hypoxic Tumor Microenvironment via PI3K/AKT/mTOR/HIF-1αSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第9期30卷 799-808页

作者： MAO Qi-yuan WANG Xue-qian LIN Fei YU Ming-wei fan Hui-ting ZHENG Qi LIU Lan-chun ZHANG Chu-chu LI Dao-rui LIN Hong-sheng Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Department of Oncology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Institute of Traditional Chinese Medicine Information China Academy of Chinese Medical SciencesBeijing100700China

Objective:To investigate whether Buthus martensii karsch(Scorpiones),Scolopendra subspinipes mutilans ***(Scolopendra)and Gekko gecko Linnaeus(Gekko)could ameliorate the hypoxic tumor microenvironment and inhibit lung cancer growth and metastasis by regulating phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α(PI3K/AKT/mTOR/HIF-1α)signaling ***:Male C57BL/6J mice were inoculated with luciferase labeled LL/2-luc-M38 cell suspension to develop lung cancer models,with rapamycin and cyclophosphamide as positive *** methyl cellulose solutions of Scorpiones,Scolopendra and Gekko were administered intragastrically as 0.33,0.33,and 0.83 g/kg,respectively once daily for 21 *** expression were detected every 7 days after inoculation,and tumor growth curves were *** was performed to determine CD31 and HIF-1αexpressions in tumor tissue and microvessel density(MVD)was *** blot was performed to detect the expression of PI3K/AKT/mTOR/HIF-1αsignaling pathway-related ***-linked immunosorbent assay was performed to detect serum basic fibroblast growth factor(bFGF),transforming growth factor-β1(TGF-β1)and vascular endothelial growth factor(VEGF)in ***:Scorpiones,Scolopendra and Gekko prolonged the survival time and inhibited lung cancer metastasis and expression of HIF-1α(all Plusion:Scorpiones,Scolopendra and Gekko all showed beneficial effects on lung cancer by ameliorating the hypoxic tumor microenvironment via PI3K/AKT/mTOR/HIF-1αsignaling pathway.

关键词： Scorpiones Scolopendra Gekko dredging collaterals and activating blood Chinese medicine of worms lung cancer hypoxic tumor microenvironment phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α signaling pathway

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Gas microchannel plate-pixel detector for X-ray polarimetry

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Nuclear Science and Techniques 2024年第5期35卷 60-73页

作者： Huan-Bo Feng Hong-Bang Liu Dong Wang Zi-Li Li Shu-Lin Liu qian Liu Hang-Zhou Li Bin-Long Wang Yan-Jun Xie Zong-Wang fan Hui Wang Ran Chen Di-fan Yi Rui-Ting Ma Fei Xie Bo Peng Xiang-Ming Sun Jin Li En-Wei Liang Present Address:Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Science Huzhou UniversityHuzhou 313000China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physical Science University of Chinese Academy of SciencesBeijing 100049China The 13th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050057China

POLAR-2 is a gamma-ray burst(GRB)polarimeter that is designed to study the polarization in GRB radiation emissions,aiming to improve our knowledge of related ***-2 is expected to utilize an on-board polarimeter that is sensitive to soft X-rays(2-10 keV),called low-energy polarization *** have developed a new soft X-ray polari-zation detector prototype based on gas microchannel plates(GMCPs)and pixel chips(Topmetal).The GMCPs have bulk resistance,which prevents charging-up effects and ensures gain stability during *** detector is composed of low outgassing materials and is gas-sealed using a laser welding technique,ensuring long-term stability.A modulation factor of 41.28%±0.64% is obtained for a 4.5 keV polarized X-ray beam.A residual modulation of 1.96%±0.58% at 5.9 keV is observed for the entire sensitive area.

关键词： X-ray polarimetry Gas microchannel plate-pixel detector Gamma-ray bursts

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Self-rectifying magnetoelectric device for remote neural regeneration and function restoration

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Biomaterials Translational 2024年第2期5卷 197-199页

作者： Yuanhao Tong Yuanming Ouyang Cunyi fan Yun qian Department of Orthopedics National Center for OrthopedicsShanghai Sixth People’s Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration ShanghaiChina

Recently,Joshua ***,Gauri Bhave,and Jacob *** from Rice University reported a magnetoelectric nonlinear metamaterial(MNM)for neural signal transmission and nerve function restoration.1 Nonlinear charge transport between the semiconductor layers enabled this magnetoelectric(ME)metamaterial to have a nonlinear ME coupling coefficient,which allowed for self-rectification(Figure 1).

关键词： function magneto nonlinear

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cNPAS2 inducedβcell dysfunction by regulating KANK1 expression in type 2 diabetes

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World Journal of Diabetes 2024年第9期15卷 1932-1941页

作者： Yan-Bin Yin Wei Ji Ying-Lan Liu qian-Hao Gao Dong-Dong He Shi-Lin Xu Jing-Xin fan Li-Hai Zhang Department of General Surgery The First Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Anesthesiology Yantai Affiliated Hospital of Binzhou Medical UniversityYantai 264199Shandong ProvinceChina Operating Room The First Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Anesthesiology Huazhong University of Science and Technology Union Jiangbei HospitalWuhan 430100Hubei ProvinceChina Department of Endocrinology The First Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina

BACKGROUND Diabetes mellitus type 2(T2DM)is formed by defective insulin secretion with the addition of peripheral tissue resistance of insulin *** has been affecting over 400 million people all over the *** To explore the pathogenesis of T2DM and to develop and implement new prevention and treatment strategies for *** Receiver operating characteristic(ROC)curve analysis was used to conduct diagnostic *** expression level of genes was determined by reverse transcription-PCR as well as Western *** proliferation assays were performed by cell counting kit-8(CCK-8)*** last,T2DM mice underwent Roux-en-Y gastric bypass *** We found that NPAS2 was significantly up-regulated in isletβcell apoptosis of *** ROC curve revealed that NPAS2 was capable of accurately diagnosing ***2 overexpression did increase the level of *** addition,the CCK-8 test revealed knocking down NPAS2 and KANK1 increased the proliferation of MIN6 *** last,we found that gastric bypass may treat type 2 diabetes by down-regulating NPAS2 and *** This study demonstrated that NPAS2 inducedβcell dysfunction by regulating KANK1 expression in type 2 diabetes,and it may be an underlying therapy target of T2DM.

关键词： Diabetes mellitus type 2 KANK1 NPAS2 Gastric bypass

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趋化因子CXCL14在SLE患者外周血单个核细胞中的表达及启动子甲基化分析

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中国应用生理学杂志 2017年第3期33卷 197-201页

作者：王金丹黄茜茜叶璐璐范超凡郭刚强徐玲娟薛向阳盛秀胜温州医科大学检验医学院、生命科学院浙江温州325035 温州医科大学第二临床医学院浙江温州325035 温州医科大学微生物学和免疫学教研室分子病毒与疫苗研究所热带医学研究所浙江温州325035 金华市中医医院检验科浙江金华321017 金华职业技术学院医学院浙江金华321017

目的:分析趋化因子CXCL14在系统性红斑狼疮(SLE)患者外周血单个核细胞(PBMC)中的表达及其启动子甲基化特征。方法:收集28例SLE患者和20名健康人外周血单个核细胞(PBMC)标本,抽提细胞中RNA,逆转录后,以GAPDH为内参,通过定量PCR检测PBMC中... 详细信息

目的:分析趋化因子CXCL14在系统性红斑狼疮(SLE)患者外周血单个核细胞(PBMC)中的表达及其启动子甲基化特征。方法:收集28例SLE患者和20名健康人外周血单个核细胞(PBMC)标本,抽提细胞中RNA,逆转录后,以GAPDH为内参,通过定量PCR检测PBMC中CXCL14的表达,统计分析CXCL14表达水平与SLE各种临床资料的相关性,探讨PBMC中CXCL14表达与SLE的关系,通过重亚硫酸盐修饰的全基因组DNA用以BSP测序来明确不同标本中CXCL14启动子中甲基化位点的甲基化率。结果:CXCL14在SLE患者和正常人PBMC中的表达量存在显著差异(P<0.05)。与健康人PBMC中CXCL14的含量相比较,CXCL14在SLE患者PBMC中表达量显著降低。与进一步CXCL14表达水平与SLE各种临床资料的相关性分析显示,CXCL14表达水平与SSB抗体(干燥综合征B抗体)、蛋白尿及血小板计数相关。与SSB抗体阴性SLE患者比较,SSB抗体阳性患者CXCL14表达水平更低(P<0.05);与蛋白尿阴性SLE患者相比,蛋白尿阳性患者CXCL14表达水平更低(P<0.05);而血小板升高患者的CXCL14表达水平更高(P<0.05)。CXCL14表达水平与SLE活动、肾损害指标、抗ds-DNA、C反应蛋白(CRP)、补体C3水平等指标未见显著相关性。CXCL14启动子区甲基化分析显示,SLE患者Cp G岛甲基化明显高于正常对照。结论:PBMC中低表达的CXCL14与SLE发生发展相关,其启动子区Cp G岛过度甲基化是SLE患者CXCL14低表达的重要机制。

关键词：系统性红斑狼疮趋化因子 CXCL14 甲基化

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数字技术赋能全过程人民民主的独特优势与风险防范

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东北师大学报（哲学社会科学版） 2024年第5期 25-34页

作者：张等文樊倩倩东北师范大学政法学院吉林长春130117

大数据、云计算、区块链、人工智能等数字技术的发展,为发展全过程人民民主提供了技术支撑。在发展全过程人民民主过程中运用数字技术,有利于拓宽全过程人民民主实践的时空边界,克服民主运行过程中的规模难题,降低民主运行成本。然而,... 详细信息

大数据、云计算、区块链、人工智能等数字技术的发展,为发展全过程人民民主提供了技术支撑。在发展全过程人民民主过程中运用数字技术,有利于拓宽全过程人民民主实践的时空边界,克服民主运行过程中的规模难题,降低民主运行成本。然而,在数字技术赋能全过程人民民主过程中,也产生了民主运行的“圈层化”困境、“民主遗民”现象、民主行为“伦理缺位”以及“指尖上的形式民主”等风险。为更好地推进数字技术赋能全过程人民民主,必须坚持以人民为中心的价值理念,不断缩小和弥合数字鸿沟,健全数字技术的法律法规,加快数字人大和数字政协等数字民主样板建设,推动数字民主高质量发展。

关键词：民主数字技术全过程人民民主民主规模

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重型燃气轮机通流部分热力特性计算与仿真研究

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汽轮机技术 2017年第1期59卷 26-30页

作者：卢绪祥肖依倩李录平范润宇刘瑞长沙理工大学能源与动力工程学院长沙410114

以某F级单轴重型燃气轮机通流部分热力特性为研究对象,通过模块化建模方法在MATLAB/Simulink平台中建立燃机系统仿真模型,对燃气轮机典型截面上压缩空气和高温燃气沿转子轴向的特性进行仿真研究。提出了一种结合表征压气机级特性的基元... 详细信息

以某F级单轴重型燃气轮机通流部分热力特性为研究对象,通过模块化建模方法在MATLAB/Simulink平台中建立燃机系统仿真模型,对燃气轮机典型截面上压缩空气和高温燃气沿转子轴向的特性进行仿真研究。提出了一种结合表征压气机级特性的基元级算法和根据抽气点位置划分的压缩级建模方法的压气机仿真模型。由于燃机通流部分工质的温度变化较大,而且伴随着燃烧反应及燃气与冷却空气混流问题,为保证仿真精度,该模型采用变比热容公式计算空气和燃气的热力参数,并对工质组分质量分数进行详细计算,还考虑了容积惯性和转动惯性对整个系统模型的影响。结果表明,该仿真模型在实际应用中能够满足建模精度的要求。

关键词：燃气轮机通流部分热力特性基元叶栅法系统仿真模型

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Chlorinated Polyfluoroalkyl Ether Sulfonic Acids(Cl-PFESAs)Are Associated with Eye Diseases in Humans and Eye Toxicity in Zebrafish

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Environment & Health 2024年第6期2卷 390-400页

作者： lu-Yin Wu Li-Xia Liang Yang Zhou Zeeshan Mohammed Zhengmin Min qian Stephen Edward McMillin Maya Tabet Chu Chu Yuan-Yuan fan Jia-Xin Zhou Jing-Wen Huang Wei-Hong Tan Guang-Hui Dong Li-Zi Lin Joint International Research Laboratory of Environment and Health Ministry of EducationGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Environmental ProtectionGuangzhou 510655China Department of Developmental Biology&Genetics School of Biological SciencesIndian Institute of ScienceBangalore 400060India Department of Epidemiology and Biostatistics College for Public Health&Social JusticeSaint Louis UniversitySt.LouisMissouri 63104United States School of Social Work Saint Louis UniversitySt.LouisMissouri 63103United States College of Global Population Health University of Health Sciences and Pharmacy in St.LouisSt.LouisMissouri 63110United States Guangdong Cardiovascular Institute Department of Reproductive MedicineDepartment of Obstetrics and GynecologyGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Reproductive Medicine and Genetics Center The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China

Evidence from animal experiments has shown that chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs)can induce vision dysfunction in ***,environmental epidemiological evidence supporting this hypothesis remains *** our case−control study,samples collected from 270 individuals(135 controls and 135 cases)from the Isomers of C8 Health Project data were analyzed for *** also repeated our analysis on zebrafish to support our findings in humans and to decipher the mechanism underlying Cl-PFESA eye *** serum levels of per-and polyfluoroalkyl substances(PFASs)and alternatives were significantly higher in the cases than in the *** serum Cl-PFESA levels were associated with greater odds of eye diseases,and the trend showed a statistically significant dose-dependent *** Shapley additive explanations(SHAP)value indicated that 8:2 Cl-PFESA was the dominant eye disease risk factor among the 13 studied *** zebrafish experiments,Cl-PFESAs induced eye toxicity in adult zebrafish by oxidative damage and cell *** to the control group,there was significantly reduced thicknesses of the inner plexiform layer(IPL),outer plexiform layer(OPL),and retinal tissue in the zebrafish exposed to *** study provides human clinical and animal experimental data,showing that exposure to PFASs increases the odds of the development of eye toxicity.

关键词： eye diseases chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs) case−control study shapley additive explanations(SHAP) zebrafish experiment

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