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Chinese Journal of Integrative Medicine 2023年第7期29卷 626-633页

作者： li Xing-xing li Dong CUI Xiao-yun ZHOU Kun liU Jing LU Jin-jin WU Yang liN qian li Yan Department of Cardiology Dongfang HospitalBeijing University of Chinese MedicineBeijing100078China Department of Cardiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China

Objective:To explore the cardioprotective effects of astragaloside Ⅳ(AS-Ⅳ) in heart failure(HF).Methods:PubMed,Excerpta Medica Database(EMBASE),Cochrane library,Web of Science,Wanfang Database,Chinese Bio-medical literature and Retrieval System(SinoMed),China Science and Technology Journal Database(VIP),and China National Knowledge Infrastructure(CNKI) were searched from inception to November 1,2021for animal experiments to explore AS-Ⅳ in treating HF in rats or mice. The left ventricular ejection fraction(LVEF),left ventricular fractional shortening(LVFS),left ventricular end-diastolic dimension(LVEDD),left ventricular endsystolic dimension(LVESD),left ventricular weight-to-body weight(LVW/BW) and B-type brain natriuretic peptide(BNP) were *** qualities of included studies were assessed by the risk of bias according to the Cochrane ***-analysis was performed using Stata ***:Twenty-one articles involving 558 animals were *** with the control group,AS-Ⅳ improved cardiac function,specifically by increasing LVEF(mean difference(MD)=6.97,95% confidence interval(CI)=5.92 to 8.03,Plinically validated in the future.

关键词： astragaloside IV heart failure pre-clinical evidence systematic review

Stability analysis of large-scale stope using stage subsequent filling mining method in Sijiaying iron mine

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Journal of Rock Mechanics and Geotechnical Engineering 2015年第1期7卷 87-94页

作者： Zhiqiang Yang Shuhua Zhai qian Gao Maohui li Key Laboratory of High-efficient Mining and Safety of Metal Mine Ministry of EducationUniversity of Science and Technology Beijing Jinchuan Group Co. Ltd.

To improve mining production capacity, a stage subsequent filling mining(SSFM) method is employed for Sijiaying iron mine. The height of the stage stope is approximately 100 m. As there are farmlands and villages on the surface of the mine, the surface deformation should be controlled when the ore is mined out for the purpose of stope stability and minimizing surface subsidence. In this paper, according to the site-specificgeological conditions, the self-stability of the stagefi lling body was analyzed, and the failure mechanism of back filling body was defined. Thus the relationship between the exposed height of filling body and the required strength was obtained. Next, the stability of back filling body and the characteristics of surface subsidence due to mining of 450 m level were analyzed using physical ***, a three-dimensional numerical model was established using FLAC3 D, with which the surface subsidence and the stability of stope were achieved. The results show that the stope basically remains stable during the two-step recovery process. The maximum magnitude of the incline is 10.99 mm/m, a little larger than the permissible value of 10 mm/m, and the horizontal deformation is 5.9 mm/m,approaching the critical value of 6.0 mm/m, suggesting that the mine design is feasible for safety mining.

关键词： Stage subsequent filling mining(SSFM) method Self-stability analysis of filling body Physical modeling Three-dimensional numerical model

Design,Synthesis and Anticancer Activity Evaluation of Novel Quinazoline Derivatives as EFGR Inhibitors

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Chinese Journal of Structural Chemistry 2021年第7期40卷 933-941,841页

作者： li Hong-Xia qian Yu-Mei XU li-Sheng School of life and Food Engineering Suzhou UniversitySuzhou 234000China

Malignant tumor is one of the major diseases that seriously threaten human health *** with traditional chemotherapy,targeted drug therapy has become a new idea of tumor *** EGFR(epidermal growth factor receptor)is highly expressed in many human tumor cell lines,which is a biomarker of tumor *** this paper,small molecule tyrosine kinase inhibitors with quinazoline structure aiming at EGFR were studied.A series of novel quinazoline derivatives(4a~4l)have been designed and synthesized from 4-hydroxyquinazoline as the parent *** of target compounds were characterized by 1H NMR and 13C NMR *** in vitro anticancer activity of compounds 4a~4l was evaluated by MTT assay against Hela,MCF-7 and A549 tumor cell lines,and apoptosis-inducing capacity was investigated by Annexin-V/PI staining *** results showed that all compounds had good antitumor activity against the test tumor cell ***,compound 4a exhibited the best anticancer activity(IC_(50)=10.23μM)against Hela cell lines,remarkable ability to induce apoptosis,and low toxicity,which identified 4a as a promising anticancer drug aiming at EFGR.

关键词： hydroxyquinazoline EFGR antitumor activity toxicity apoptosis

Extraction of metals from complex sulfide nickel concentrates by low-temperature chlorination roasting and water leaching

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International Journal of Minerals,Metallurgy and Materials 2017年第4期24卷 377-385页

作者： Cong Xu Hong-wei Cheng Guang-shi li Chang-yuan Lu Xiong-gang Lu Xing-li Zou qian Xu State Key Laboratory of Advanced Special Steel & School of Materials Science and Engineering Shanghai University Shanghai 200072 China

The recovery of valuable metals from complex sulfide concentrates was investigated via chlorination roasting followed by water leaching. A reaction process is proposed on the basis of previous studies and the results of our preliminary experiments. During the process, various process parameters were studied, including the roasting temperature, the addition of NH4Cl, the roasting time, the leaching time, and the liquid-to-solid ratio. The roasted products and leach residues were characterized by X-ray diffraction and vibrational spectroscopy. Under the optimum condition, 95% of Ni, 98% of Cu, and 88% of Co were recovered. In addition, the removal of iron was studied in the water leaching stage. The results demonstrate that this process provides an effective approach for extracting multiple metals from complex concentrates or ores. © 2017, University of Science and Technology Beijing and Springer-Verlag Berlin Heidelberg.

关键词： Calcination Chemicals removal (water treatment) Chlorination Leaching Metal recovery Nickel Rare earths Sulfur compounds Temperature X ray diffraction

PMCMC for Term Structure of Interest Rates under Markov Regime Switching and Jumps

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Journal of Systems Science and Information 2020年第2期11卷 159-169页

作者： Xiangdong liU Xianglong li Shaozhi ZHENG Hangyong qian Department of Statistics Jinan UniversityGuangzhou 510632China

A parameter estimation method,called PMCMC in this paper,is proposed to estimate a continuous-time model of the term structure of interests under Markov regime switching and *** is a closed form solution to term structure of interest rates under Markov ***,the model is extended to be a CKLS model with non-closed form solutions which is a typical nonlinear and non-Gaussian state-space model(SSM)in the case of adding *** the difficulty of parameter estimation greatly prevents from researching models,we prove that the nonlinear and non-Gaussian state-space model has better performances in studying *** method proposed in this paper will be implemented in simulation and empirical study for *** results illustrate that the PMCMC algorithm has powerful advantages in tackling the models.

关键词： PMCMC term structure of interest rates state-space models regime switching jump-diffusion

压力作用下高压电缆缓冲层表面电阻特性及等效模型

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南方电网技术 2024年第2期18卷 133-141页

作者：吴照国黄会贤王谦吴海涛包健康李勇刘佳徐扬国网重庆市电力公司电力科学研究院重庆401123 国网重庆市电力公司重庆400014 重庆邮电大学重庆400065

针对缓冲层导电特性测试中未考虑压力影响的问题开展了压力作用下高压电缆半导电缓冲阻水带的表面电阻特性研究。首先开展了缓冲层表面电阻测试,并从缓冲层微观结构特征以及纳米填料导电机理两方面对测试的表面电阻数据统计特征进行了... 详细信息

针对缓冲层导电特性测试中未考虑压力影响的问题开展了压力作用下高压电缆半导电缓冲阻水带的表面电阻特性研究。首先开展了缓冲层表面电阻测试,并从缓冲层微观结构特征以及纳米填料导电机理两方面对测试的表面电阻数据统计特征进行了分析。通过在表面电阻测试电极以及电极之间的缓冲层表面上施加不同重量的载荷研究了缓冲层表面电阻值与外界压力的关系。基于n阶电阻网络以及差分方程组建立了压力作用下的缓冲层表面电阻模型,利用缓冲层微观压阻特性以及模型仿真计算分析了缓冲层表面电阻测试特性以及该特性随压力作用而变化的规律。研究成果有助于掌握高压电缆缓冲层在真实运行压力环境下的导电特性。

关键词：高压电缆缓冲层表面电阻压阻特性差分方程组模型

枯草芽孢杆菌与屎肠球菌对蛋鸡生产性能、蛋品质、血清生化、免疫指标和肠道微生物的影响

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饲料研究 2024年第2期47卷 31-35页

作者：李安东孙新堂肖华平孙茜王成森山东畜牧兽医职业学院潍坊市家禽抗菌药使用减量化工程技术研究中心潍坊市兽用生物发酵技术重点实验室山东潍坊261061

试验旨在研究枯草芽孢杆菌与屎肠球菌对蛋鸡生产性能、蛋品质、血清生化指标、免疫指标及肠道微生物的影响。选取38周龄400只海兰褐蛋鸡,随机分为4组,每组5个重复,每个重复20只鸡。试验1组(对照组)饲喂基础饲粮;试验2组在基础饲粮中添加... 详细信息

试验旨在研究枯草芽孢杆菌与屎肠球菌对蛋鸡生产性能、蛋品质、血清生化指标、免疫指标及肠道微生物的影响。选取38周龄400只海兰褐蛋鸡,随机分为4组,每组5个重复,每个重复20只鸡。试验1组(对照组)饲喂基础饲粮;试验2组在基础饲粮中添加200 g/t的枯草芽孢杆菌;试验3组在基础饲粮中添加200 g/t的屎肠球菌;试验4组在基础饲粮中添加由100 g/t枯草芽孢杆菌与100 g/t屎肠球菌组成的复合益生菌。试验期56 d。结果显示,与对照组相比,所有试验组蛋鸡产蛋率均升高(P<0.05),死淘率和料蛋比均降低(P<0.05);蛋壳厚度、蛋黄颜色均升高(P<0.05);蛋鸡血清中的总蛋白及球蛋白含量均增加(P<0.05),血清中免疫球蛋白G、免疫球蛋白M和γ干扰素含量均增加(P<0.05);蛋鸡的盲肠食糜中乳酸菌数量升高(P<0.05),而大肠杆菌和沙门氏菌数量降低(P<0.05)。研究表明,枯草芽孢杆菌与屎肠球菌能够提高蛋鸡的生产性能,维持肠道健康,改善血清生化指标和免疫指标。

关键词：枯草芽孢杆菌屎肠球菌蛋鸡生产性能蛋品质血清生化指标免疫性能肠道微生物

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GPU based real-time simulation of massive falling leaves

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Computational Visual Media 2015年第4期1卷 351-358页

作者： Chengyang li Jingye qian Ruofeng Tong Jian Chang Jianjun Zhang Department of Computer Science Zhejiang University National Centre for Computer Animation Bournemouth University

As an important autumn feature,scenes with large numbers of falling leaves are common in movies and games. However,it is a challenge for computer graphics to simulate such scenes in an authentic and efficient manner. This paper proposes a GPU based approach for simulating the falling motion of many leaves in real time. Firstly,we use a motionsynthesis based method to analyze the falling motion of the leaves,which enables us to describe complex falling trajectories using low-dimensional features. Secondly,we transmit a primitive-motion trajectory dataset together with the low-dimensional features of the falling leaves to video memory,allowing us to execute the appropriate calculations on the GPU.

关键词： real-time simulation falling leaves GPU acceleration

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基于国家药品抽检的川牛膝质量问题及建议

中国药学杂志 2024年第3期59卷 275-280页

作者：高必兴齐景梁李倩耿昭钟恋高驰邓曦王颖包小红杨蕾苟琰四川省药品检验研究院国家药品监督管理局中成药质量评价重点实验室成都611731

目的基于2022年国家药品抽检工作,分析市场上不同厂家川牛膝质量差异,分析问题并提出建议,为川牛膝的质量监管及标准提高提供依据。方法针对所抽取川牛膝样品按照相应标准进行检测,出具检验报告书。针对检验中所发现的质量问题、标准... 详细信息

目的基于2022年国家药品抽检工作,分析市场上不同厂家川牛膝质量差异,分析问题并提出建议,为川牛膝的质量监管及标准提高提供依据。方法针对所抽取川牛膝样品按照相应标准进行检测,出具检验报告书。针对检验中所发现的质量问题、标准问题及前期调研发现的相关问题进行有针对性的探索性研究,进行质量评价分析,发现问题,提出建议。结果共抽取川牛膝样品334批。标准检验,2批样品性状不合格,存在用麻牛膝充当川牛膝使用的情况,同时发现标准收载含量测定方法过于复杂,且限度过低。探索性研究,27批川牛膝检出麻牛膝特有成分牛膝皂苷Ⅰ,7批超出规定限度,存在麻牛膝混用的情况;270批川牛膝检出植物生长调节剂(多效唑)。114批重金属及有害元素镉(Cd)检测超出限度。最后提升了川牛膝质量标准、建立了补充检验方法、提出风险警示。结论通过此次全国抽检发现川牛膝饮片和标准中的相关问题,提示需完善标准并加强川牛膝的质量监管。

关键词：川牛膝麻牛膝国家药品抽检质量分析多效性

基于数据挖掘中医药治疗儿童青少年抑郁症用药规律研究

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光明中医 2024年第12期39卷 2323-2327页

作者：李倩曹玉莹李庆华陈果覃雪静魏巍四川省卫生健康发展研究中心四川成都610041

目的研究分析中医药治疗儿童青少年抑郁症的用药规律。方法收集中国生物医学文献服务系统、万方数据知识服务平台、中国知网、维普等中文数据库建库至2023年3月发表的中医药治疗儿童青少年抑郁症的处方,筛选导入中医传承计算平台V 3.0... 详细信息

目的研究分析中医药治疗儿童青少年抑郁症的用药规律。方法收集中国生物医学文献服务系统、万方数据知识服务平台、中国知网、维普等中文数据库建库至2023年3月发表的中医药治疗儿童青少年抑郁症的处方,筛选导入中医传承计算平台V 3.0,对录入处方的药物使用频次、四气五味及归经进行分析,采用关联规则、K-means聚类算法进行演算分析。结果共收集47首有效方剂,涉及中药87味,性温、寒、平,味苦甘辛为主,归经以脾经为主,通过K-means聚类分析得到3种药物聚类群。结论中药治疗儿童青少年抑郁症原则为健脾益气、疏肝解郁、宁心安神。

关键词：郁证抑郁症数据挖掘用药规律中医药儿童青少年