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Cytoplasmic FKBPs are involved in molting and metamorphosis through regulating the nuclear localization of EcR

Insect Science 2024年第3期31卷 759-772页

作者： Xian Zhang Qiao-Ran Wang qian Wu Jun Gu Li-Hua huang Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology School of Life SciencesSouth China Normal UniversityGuangzhouChina Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouChina

Molting and metamorphosis are important physiological processes in insects that are tightly controlled by ecdysone receptor(EcR)through the 20-hydroxyecdysone(20E)signaling *** is a steroid nuclear receptor(SR).Several FK506-binding proteins(FKBPs)have been identified from the mammal SR complex,and are thought to be involved in the subcellular trafficking of ***,their roles in insects are poorly *** explore whether FKBPs are involved in insect molting or metamorphosis,we injected an FKBP inhibitor(FK506)into a lepidopteran insect,Spodoptera litura,and found that molting was inhibited in 61.11%of the larvae,and that the time for larvae to pupate was significantly extended.A total of 10 FKBP genes were identified from the genome of *** and were clustered into 2 distinct groups,according to their subcellular localization,with FKBP13 and FKBP14 belonging to the endoplasmic reticulum(ER)group and with the other members belonging to the cytoplasmic(Cy)*** the CyFKBPs were significantly upregulated in the prepupal or pupal stages,with the opposite being observed for the ER group ***506 completely blocked the transfer of EcR to the nucleus under 20E induction,and significantly downregulated the transcriptional expression of many 20E signaling genes.A similar phenomenon was observed after RNA interference of2 CyFKBPs(FKBP45 and FKBP12b),but not for *** together,our data indicate that the cytoplasmic FKBPs,especially FKBP45 and FKBP12b,mediate the nuclear localization of EcR,thereby regulating the 20E signaling and ultimately affecting molting and metamorphosis in insects.

关键词： EcR FKBP metamorphosis molting RNAi subcellular localization

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High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-Yuan Qu Ying Lei Qi Chen Yu-Xiu Chen Meng-Lin Li Xue-Yan Sun Ye-Jun Wu Qiu-Sha huang Hai-Xia Fu Yuan Kong Yue-Ying Li qian-Fei Wang xiao-Jun huang xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

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How aging affects bone health via the intestinal micro-environment

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BIOCELL 2024年第3期48卷 353-362页

作者： HUAN HU YUE huang FANGZHOU LIU qian WANG YANZI YAO School of Stomatology Zunyi Medical UniversityZunyiChina Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution Zunyi Medical UniversityZunyiChina Department of Stomatology Luoyang Maternal and Child Health HospitalLuoyangChina

Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more *** conditions represent a common,costly and chronic burden,not only for elderly but also to society at ***,elucidating the pathophysiology and developing effective therapies for these diseases is of paramount *** advances in research have identiﬁed the gut as a novel and promising target for addressing bone disorders,giving rise to the concept of the“gut-bone axis”.An in-depth review of the latest insights into the effects of age-related physiological changes in the gastrointestinal tract on bone health is presented in this *** examines how the“gut-bone”axis interacts with bone aging across various domains,including metabolism,nutrition,intestinal permeability,immunity,and oxidative stress.

关键词： Gut barrier Skeletal system Senescent Gut-bone axis Gut microbiota

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Increased N6-methyladenosine is related to the promotion of the methyltransferase METTL14 in ovarian aging

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Genes & Diseases 2024年第3期11卷 151-154页

作者： Chunfeng qian Zhenxing Liu Yonghong qian Jie Ding Rulei Chen Han Su Minghong Shen Hong Li Boxian huang State Key Laboratory of Reproductive Medicine and Offspring Health Suzhou Affliated Hospital of Nanjing Medicine and Offspring HealthSuzhou Affiliated Hospital of Nanjing Medical UniversitySuzhouMunicipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215002China Department of Gynecology Affliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu School of Nanjing Medical UniversitySuzhouJiangsu 215002China Department of Pathology Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu School of Nanjing Medical UniversitySuzhouJiangsu 215002China

The ovary is a vital female reproductive organ that functions to produce oocyte gametes and cyclically expressed sex hormones to maintain reproductive capacity and hormone *** aging,characterized by declines in follicle quantity and oocyte quality,leads to premature ovarian failure,premature ovarian insufficiency,or diminished ovarian reserve,thus contributing to female *** gene-expression signatures from RNA transcriptional level and post-transcriptional regulation are relative to oocyte quality and reproductive age.

关键词： promotion signature maintain

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Experimental study on wax deposition of highly paraffinic oil in intermittent gas-oil flow in pipelines

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Petroleum Science 2024年第3期21卷 2080-2088页

作者： Chuan-Shuo Wang qian-Li Ma xiao-Fang Lv Jie Zhang Yang Liu Shi-Dong Zhou Jiangsu Key Laboratory of Oil and Gas Storage and Transportation Technology Changzhou UniversityChangzhou213164JiangsuPR China Hade Oil and Gas Development Department Tarim Oilfield BranchKorla841000XinjiangPR China

Oil-gas two phase wax deposition is a fairly common and open-ended question in flow assurance of multiphase transportation *** paper investigated the two main aspects of oil-gas two phase wax deposition layer:apparent thickness and crystal structure characteristics.A typical highly paraffinic oil in Bohai Sea,China,was used as the experimental material to investigate the wax deposition thickness in oil-gas two phase under the influence of different oil temperatures,superficial gas/liquid phase velocities and gas-oil ratios by using multiphase flow loop experimental *** as in the classical theory of wax molecular diffusion,it showed that wax deposition thickness of oil-gas two phase increased with increasing oil *** of the impact of different superficial phase velocities found that the actual liquid flow heat transfer and shear stripping was the gas phase dominant mechanisms determining wax deposit *** addition,the crystal structure of the wax deposition layer was characterized with the help of small-angle X-ray scattering(SAXS)for different circumferential positions,flow rates and gas-oil *** bottom deposition layer had a complex crystal structure and high hardness,which were subject to change over flow rate ***,the SAXS results provided evidence that the indirect effect of the actual liquid velocity modified by the gas phase was the main *** study of the effect of gas phase on the wax deposition of oil-gas two phase will help shed light onto the mechanism by which this important process *** findings address a very urgent need in the field of wax deposition of highly paraffinic oil to understand the flow security of oilgas two phase that occurs easily in multiphase field pipelines.

关键词： Oil-gas two phase Highly paraffinic oil Wax deposition SAXS

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Iodine Nutrition, Thyroid-stimulating Hormone, and Related Factors of Postpartum Women from three Different Areas in China: A Cross-sectional Survey

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Biomedical and Environmental Sciences 2024年第3期37卷 254-265页

作者： SHAN xiao Yun ZOU Yan huang Li Chun JIANG Shan ZHOU Wei Wen QIN Qiu Lan LIU Chang Qing LUO xiao Yan LU Jia Xi MAO De qian LI Min YANG Zhen Yu YANG Li Chen Key Laboratory of Trace Element Nutrition of National Health Committee National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 241001HunanChina Zhejiang Provincial Center for Disease Prevention and Control Hangzhou 310051ZhejiangChina Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning 530028GuangxiChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang 050021HebeiChina

Objective Studies on the relationship between iodine,vitamin A(VA),and vitamin D(VD)and thyroid function are *** study aimed to analyze iodine and thyroid-stimulating hormone(TSH)status and their possible relationships with VA,VD,and other factors in postpartum *** A total of 1,311 mothers(896 lactating and 415 non-lactating)from Hebei,Zhejiang,and Guangxi provinces were included in this *** urinary iodine concentration(UIC),TSH,VA,and VD were *** The median UIC of total and lactating participants were 142.00µg/L and 139.95µg/L,*** median TSH,VA,and VD levels in all the participants were 1.89 mIU/L,0.44μg/mL,and 24.04 ng/mL,*** differences in the UIC were found between lactating and non-lactating *** and TSH levels were significantly different among the three *** rural UIC was higher than the urban *** mothers had a higher UIC and a higher prevalence of excessive *** UICs and TSHs levels were observed in both the VD deficiency and insufficiency groups than in the VD-sufficient *** adjustment,no linear correlation was observed between UIC and VA/*** interaction was found between vitamins A/D and UIC on TSH *** The mothers in the present study had no iodine ***,area type,BMI,and VD may be related to the iodine status or TSH levels.

关键词： Median urinary iodine concentration Thyroid-stimulating hormone Vitamin A Vitamin D Postpartum women

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Value of multiple models of diffusion-weighted imaging to predict hepatic lymph node metastases in colorectal liver metastases patients

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World Journal of Gastroenterology 2024年第4期30卷 308-317页

作者： Hai-Bin Zhu Bo Zhao xiao-Ting Li xiao-Yan Zhang qian Yao Ying-Shi Sun Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of RadiologyPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND About 10%-31% of colorectal liver metastases(CRLM)patients would concomitantly show hepatic lymph node metastases(LNM),which was considered as sign of poor biological behavior and a relative contraindication for liver *** to now,there’s still lack of reliable preoperative methods to assess the status of hepatic lymph nodes in patients with CRLM,except for pathology examination of lymph node after *** To compare the ability of mono-exponential,bi-exponential,and stretchedexponential diffusion-weighted imaging(DWI)models in distinguishing between benign and malignant hepatic lymph nodes in patients with CRLM who received neoadjuvant chemotherapy prior to *** In this retrospective study,97 CRLM patients with pathologically confirmed hepatic lymph node status underwent magnetic resonance imaging,including DWI with ten b values before and after *** parameters,such as the apparent diffusion coefficient from the mono-exponential model,and the true diffusion coefficient,the pseudo-diffusion coefficient,and the perfusion fraction derived from the intravoxel incoherent motion model,along with distributed diffusion coefficient(DDC)andαfrom the stretched-exponential model(SEM),were *** parameters before and after chemotherapy were compared between positive and negative hepatic lymph node groups.A nomogram was constructed to predict the hepatic lymph node *** reliability and agreement of the measurements were assessed using the coefficient of variation and intraclass correlation *** Multivariate analysis revealed that the pre-treatment DDC value and the short diameter of the largest lymph node after treatment were independent predictors of metastatic hepatic lymph nodes.A nomogram combining these two factors demonstrated excellent performance in distinguishing between benign and malignant lymph nodes in CRLM patients,with an area under the curve of ***,parameters from SEM sho

关键词： Colorectal cancer Individualized treatment Diffusion magnetic resonance imaging Intravoxel incoherent motion Liver

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A Study on Idea Adoption Prediction Model Based on SMOTE-AdaBoost: Taking Salesforce Platform as an Example

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Journal of Systems Science and Information 2024年第4期12卷 476-490页

作者： Yunjiang XI Futao huang Lu huang xiao LIAO Juan YU School of Business Administration South China University of Technology School of Internet Finance and Information Engineering Guangdong University of Finance School of Economics and Management Fuzhou University

In the context of information overload, companies often struggle to effectively identify valuable ideas on their open innovation platforms. In this article, we propose an idea adoption strategy based on machine learning. We used data from a well-known open innovation platform, Salesforce, and extracted characteristic variables using the Information Adoption Model. Four classification models were then constructed based on AdaBoost, Random Forest, SVM and Logistic Regression models. Due to significant differences in the number of positive and negative samples in the OIP, we used the SMOTE method to address the problem of data imbalance. The results of the study showed that the ensemble learning models were more accurate in identifying valuable ideas than the individual machine learning models. When comparing the two ensemble learning models, AdaBoost outperformed Random Forest in predicting both positive and negative class samples. The SMOTE-AdaBoost model achieved a recall of 0.93, a precision of 0.92 and an impressive AUC of 0.98 in identifying adopted ideas, which could well identify valuable ideas and has implications for improving the efficiency and quality of idea adoption in OIP. The shortcoming of this work is that it only investigated a single platform. In the future, we will consider extending this method to different platforms and multiple classification problems.

关键词： open innovation platform AdaBoost information adoption ensemble learning

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Development of RPA-Cas12a-fluorescence assay for rapid and reliable detection of human bocavirus 1

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Animal Models and Experimental Medicine 2024年第2期7卷 179-188页

作者： Weidong qian Xuefei Wang Ting Wang Jie huang qian Zhang Yongdong Li Si Chen School of Food and Biological Engineering Shaanxi University of Science and TechnologyXi'anP.R.China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenP.R.China Ningbo Municipal Center for Disease Control and Prevention NingboP.R.China Medical College of Shenzhen University ShenzhenP.R.China

Human bocavirus(HBoV)1 is considered an important pathogen that mainly affects infants aged 6–24 months,but preventing viral transmission in resource-limited regions through rapid and affordable on-site diagnosis of individuals with early infection of HBoV1 remains somewhat ***,we present a novel faster,lower cost,reliable method for the detection of HBoV1,which integrates a recombinase polymerase amplification(RPA)assay with the CRISPR/Cas12a system,designated the RPA-Cas12a-fluorescence *** RPA-Cas12a-fluorescence system can specifically detect target gene levels as low as 0.5 copies of HBoV1 plasmid DNA per microliter within 40 min at 37℃without the need for sophisticated *** method also demonstrates excellent specificity without cross-reactivity to non-target ***,the method was appraised using 28 clinical samples,and displayed high accuracy with positive and negative predictive agreement of 90.9%and 100%,***,our proposed rapid and sensitive HBoV1 detection method,the RPA-Cas12a-fluorescence assay,shows promising potential for early on-site diagnosis of HBoV1 infection in the fields of public health and health *** established RPA-Cas12a-fluorescence assay is rapid and reliable method for human bocavirus 1 *** RPA-Cas12a-fluorescence assay can be completed within 40 min with robust specificity and sensitivity of 0.5 copies/μl.

关键词： CRISPR-Cas12a detection human bocavirus 1 on-site diagnosis recombinase polymerase amplification

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Interactive effects of soils,local environmental conditions and herbivores on secondary chemicals in tallow tree

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Journal of Plant Ecology 2024年第4期17卷 167-180页

作者： Li xiao Wei huang Juli Carrillo Jianqing Ding Evan Siemann College of Life and Environmental Science Central South University of Forestry and TechnologyChangsha 410004China National Engineering Laboratory of Applied Technology for Forestry&Ecology in Southern China Central South University of Forestry and TechnologyChangsha 410004China CAS Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China Faculty of Land and Food Systems Centre for Sustainable Food SystemsBiodiversity Research CentreUniversity of British ColumbiaVancouver V6T 1Z4Canada State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China Biosciences Department Rice UniversityHoustonTX 77005USA

Plants produce secondary chemicals that may vary along with latitude due to changing abiotic and biotic stress gradients and local environmental *** apart the individual and combined effects of these different abiotic,such as soil nutrients,and biotic factors,such as soil biota and herbivores,on secondary chemicals is critical for understanding plant responses to changing *** conducted an experiment at different latitudes in China,using tallow tree(Triadica sebifera)seedlings sourced from a population at 31°*** seedlings were cultivated in gardens located at low,middle and high latitudes,with either local soil or soil from the original seed collection site(origin soil).The seedlings were exposed to natural levels of aboveground herbivores or had them *** secondary chemicals(both foliar and root),aboveground herbivores and soil characteristics were *** showed that most leaf and root secondary metabolites depended on the interaction of the experimental site and soil *** and root phenolic and tannin concentrations were higher at the middle latitude site,especially in the origin *** and foliar flavonoid concentrations increased when aboveground herbivores were *** communities depended strongly on soil *** different responses of tannins versus flavonoids suggest that these two chemical classes differ in their responses to the varying abiotic and biotic factors in these sites along *** together,our results emphasize the importance of considering the interactive effects of local environmental conditions,soil properties and herbivory in regulating plant chemical defenses.

关键词： phenolics tannins flavonoids abiotic factors soil characteristics Triadica sebifera

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