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Nickel-Catalyzed Enantioselective Desymmetrizing Aza-Heck Cyclization of Oxime Esters

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CCS Chemistry 2021年第12期3卷 421-430页

作者： Hong-Cheng Shen Ying Chen Ying zhang He-Ming Jiang wen-qian zhang wen-Ao Li Mostafa Sayed Xinhao zhang Yun-Dong Wu Liu-Zhu Gong Hefei National Laboratory for Physical Sciences at the Microscale Department of ChemistryCenter for Excellence in Molecular Synthesis of CASUniversity of Science and Technology of ChinaHefei 230026 Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055 Shenzhen Bay Laboratory Shenzhen 518055

Densely functionalized chiral nitrogen-containing heterocycles are ubiquitous in bioactive synthetic compounds and natural ***,we report a nickel(Ni)-catalyzed enantioselective desymmetrizing aza-Heck cyclization of oxime esters with a commercially available chiral pyridinebis(oxazoline)(pybox)*** reaction proceeds under mild reaction conditions,tolerates various functional groups,and leads to chiral 2-substituted-3,7a-dihydro-3aH-indoles.

关键词： nickel catalysis enantioselective desymmetrization aza-Heck reaction oxime esters DFT calculations

Promotion of right ventricular outflow tract reconstruction using a novel cardiac patch incorporated with hypoxia-pretreated urine-derived stem cells

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Bioactive Materials 2022年第8期7卷 206-218页

作者： Long-Mei Zhao Long Wang wen-qian zhang Rui Wang Xiu-Zhen zhang Xiong-Xin Lei Yan Liang Yu-Ting Song Qing-Yi zhang Ke Lin Hui-Qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan610041China Department of Cardiovascular Surgery West China HospitalSichuan UniversityChengduSichuan610041China Department of Cardiovascular Surgery Shandong Provincial HospitalShandong First Medical UniversityJinanShandong250021China Research Core Facility West China HospitalSichuan UniversityChengduSichuan610041China

Approximately 25%of patients with congenital heart disease require implantation of patches to ***,most of the currently available patches are made of inert materials with unmatched electrical conductivity and mechanical properties,which may lead to an increased risk for arrhythmia and heart *** this study,we have developed a novel Polyurethane/Small intestinal submucosa patch(PSP)with mechanical and electrical properties similar to those of the native myocardial tissue,and assessed its feasibility for the reconstruction of right ventricular outflow tract.A right ventricular outflow tract reconstruction model was constructed in 40 *** with commercially available bovine pericardium patch,the PSP patch has shown better histocompatibility and biodegradability,in addition with significantly improved cardiac *** tackle the significant fibrosis and relatively poor vascularization during tissue remodeling,we have further developed a bioactive patch by incorporating the PSP composites with urine-derived stem cells(USCs)which were pretreated with *** results showed that the hypoxia-pretreated bioactive patch could significantly inhibit fibrosis and promote vascularization and muscularization,resulting in better right heart *** findings suggested that the PSP patch combined with hypoxia-pretreated USCs may provide a better strategy for the treatment of congenital heart disease.

关键词： Congenital heart disease Polypyrrole Polyurethane/small intestinal submucosa Hypoxia Urine-derived stem cells

Application of metabolomics in urolithiasis:the discovery and usage of succinate

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Signal Transduction and Targeted Therapy 2023年第2期8卷 771-783页

作者： Xiu-zhen zhang Xiong-xin Lei Yan-lin Jiang Long-mei Zhao Chen-yu Zou Yun-jin Bai Ya-xing Li Rui Wang qian-jin Li Qiu-zhu Chen Ming-hui Fan Yu-ting Song wen-qian zhang Yi zhang Jesse Li-Ling Hui-qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteDepartment of OrthopedicsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengduSichuan 610041China Research Core Facility of West China Hospital Sichuan UniversityChengduSichuan 610041China Department of Medical Genetics West China Second University HospitalChengduSichuan 610041China

Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic stone *** has been shown that the occurrence of calcium oxalate monohydrate(COM)during stone formation is regulated by crystal growth *** crystallization inhibitors have been recognized as a therapeutic modality for decades,limited progress has been made in the discovery of effective modifiers to intervene with stone *** this study,we have used metabolomics technologies,a powerful approach to identify biomarkers by screening the urine components of the dynamic progression in a bladder stone *** in-depth mining and analysis of metabolomics data,we have screened five differential *** density functional theory studies and bulk crystallization,we found that three of them(salicyluric,gentisic acid and succinate)could effectively inhibit nucleation in *** thereby assessed the impact of the inhibitors with an EG-induced rat model for kidney ***,succinate,a key player in the tricarboxylic acid cycle,could decrease kidney calcium deposition and injury in the *** analysis further showed that the protective effect of succinate was mainly through anti-inflammation,inhibition of cell adhesion and osteogenic *** findings indicated that succinate may provide a new therapeutic option for urinary stones.

关键词： crystallization thereby protective

Determination of trace arsenic(V) by catalytic solid substrate-room temperature phosphorescence quenching method

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Chinese Chemical Letters 2007年第6期18卷 711-713页

作者： Guo Hui Zhu Zhi Ming Li Xiao Hua Chen Jia Ming Liu Tian Long Yang wen qian zhang Shao Xian Lin Ping Zhou Department of Food and Biological Engineering Zhangzhou Institute of Technology Zhangzhou 363000 China Department of Chemistry and Environmental Science Zhangzhou Normal College Zhangzhou 363000 China

In the H2SO4 medium and in the presence of dodecylbenzene sulfonic acid sodiumsalt (DBS), dimethyl yellow (R) could emit strong and stable solid substrate room temperature phosphorescence (RTP) on filter paper. And NaIO4 could oxidize R to cause the RTP quenching. Arsenic(V) could catalyze the reaction of NaIO4 oxidizing R, which caused the RTP sharply quenching. The reducing value of phosphorescence intensity (ΔIp) for the system with DBS is 3.3 times higher than that without DBS. Moreover, the ΔIp is proportional to the concentration of As(V). Based on the facts above, a new RTP quenching method for the determination of trace As(V) has been established.

关键词： Arsenic(V) Dimethyl yellow Catalytic solid substrate-room temperature phosphorescence quenching method

State of polar climate in 2023

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Advances in Climate Change Research 2024年第5期15卷 769-783页

作者： Ming-Hu DING Xin WANG Lin-Gen BIAN Zhi-Na JIANG Xiang LIN Zhi-Feng Qu Jie Su Sai WANG Ting WEI Xiao-Chun ZHAI Dong-Qi zhang Lei zhang wen-qian zhang Shou-Dong ZHAO Kong-Ju ZHU State Laboratory of Server Weather Chinese Academy of Meteorological SciencesBeijing 100081China Ocean University of China Qingdao 266100China National Satellite Meteorological Centre Beijing 100081China Key Laboratory of Polar AtmosphereOceanlce System for Weatherand Climate Ministry of EducationShanghai200438China

The year 2023 has become the warmest year on global *** the Antarctic and Arctic are sensitive regions to global warming,the climate changes in 2023 in these regions have attracted widespread *** this study,using observations,reanalysis and remote sensing data,we reported detailed polar climate changes in 2023,including warming,sea ice,atmospheric composition and extreme *** exhibited large east-west regional differences and the coexistence of extreme warm and cold *** Coats Land,Queen Maud Land and the Antarctic Peninsula,three and seven stations recorded the second and third highest autumn air temperatures in history,*** Amundsen-Scott station experienced extreme warming event in July,with the temperature increasing by 40℃ in one *** cooling was evident in the Ross Sea and neighboring regions which were predominantly winter(June-August)cold anomalies,with Marylin Station reaching the lowest winter temperature in *** Arctic experienced the warmest summer after 1979,with an overall distribution of warm land-cold sea'on annual *** with the 1991-2020 average,the annual air temperature anomalies reached more than 2℃in northern Canada and the Barents Sea-Kara Sea *** high summer temperature caused most severe wildfires in Canada on record and second largest daily cumulative melt area over the Greenland ice Sheet daily *** sea ice continued to decrease rapidly,with minimum sea ice extent in Antarctic and Arctic ranking the first and sixth lowest *** melt season,Arctic Ocean sea ice began to melt later in 2023 than the 2011-2023 average,and freeze onset was delayed due to high temperatures in summer and ***,the status of polar atmospheric greenhouse gases remains bleak,and major greenhouse gas concentrations continue to *** Antarctic ozone hole in 2023 formed approximately 10 d earlier and lasted longer than the 1979-2023 average,with a ma

关键词： Antarctic Arctic Climate changes Extreme events

Attenuated Total Reflection Surface-Enhanced Infrared Absorption Spectroscopy: a Powerful Technique for Bioanalysis

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Journal of Analysis and Testing 2017年第1期1卷 71-83页

作者： Jian Li Bo Zheng qian-wen zhang Yang Liu Cai-Feng Shi Feng-Bin Wang Kang Wang Xing-Hua Xia State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China

Attenuated total reflection surface-enhanced infrared absorption spectroscopy(ATR-SEIRAS)has recently been proven to be a powerful tool for *** enables in situ and in real-time observation of dynamic processes occurring on specific interface,revealing rich structural and functional information of biomolecules at sub monolayer *** aim of this general review was to give an overview of the cutting edge applications of *** start with description of the basic configuration of the standard ATR-SEIRAS *** enhanced mechanisms and methods to fabricate enhanced substrates are then *** discuss the recent developments,challenges and applications of ATR-SEIRAS in bioanalysis,mainly focusing on DNA analysis,protein behavior and cell ***,further development of the ATRSEIRAS technique with enhanced sensitivity,improved time and spatial resolutions will be prospected.

关键词： Surface-enhanced infrared absorption spectroscopy ATR-SEIRAS Bioanalysis DNA Protein Cell

A Theoretical and Empirical Research on the Mediating Effect of Internal Entrepreneurial Environment

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研究与发展管理 2009年第1期21卷 112-112页

作者： LI qian-wen,zhang Yu-li

The intensity of external uncertain environments has urged more and more companies to adopt theentrepreneurial orientation strategy. But to translate the corporate entrepreneurial orientation intoorganizational perfor... 详细信息

关键词： external rged more environment internalentrepreneurial

N-donor ligands Effect on Diverse Complexes and Luminescent Properties

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N-donor ligands Effect on Diverse Complexes and Luminescent ...

Coordinating-Carbonyl Solvent-Induced Transformations of 3D Mn（Ⅱ） Double-Walled Open-Frameworks

第七届全国物理无机化学学术会议

作者： Quan-Quan Li wen-qian zhang Ping Liu College of Chemistry ＆ Materials Science Northwest University

＜正＞The goal for crystal engineering,in the field of modern chemistry and materials science,is to design and synthesize crystals to govern the molecular ordering of building blocks and acquire preferable materials with intriguing frameworks and desired properties.[1-3]Until now,obtaining predetermined structures and desired properties of complexes are still tremendous scientific challenges for their

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Coordinating-Carbonyl Solvent-Induced Transformations of 3D ...