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Solid phase synthesis of fatty acid modified glucagon-like peptide-1(7-36) amide under thermal and controlled microwave irradiation

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Chinese Chemical Letters 2010年第1期21卷 27-30页

作者： ni, Shuai Han Zhang, Hui Bin Huang, wen Long Zhou, Jin Pei qian, Hai China Pharmaceut Univ Ctr Drug Discovery Nanjing 210009 Peoples R China

Fatty acid modified glucagon-like peptide-1(7-36) amide was synthesized efficiently on Rink-Amide-MBHA resin by microwave-assisted solid phase *** method of thermal and controlled microwave irradiation provided impressive enhancements in product yield,selectivity,and reaction *** coupling time was dramatically decreased to 6 min,and the desired products were obtained in high yield and purity.

关键词： Glucagon-like peptide-1 GLP-1 Microwave Solid phase Fatty acid modification

Monte Carlo Hamiltonian： Inverse Potential

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Communications in Theoretical Physics 2004年第4期41卷 509-512页

作者： LUOXiang-qian CHENGXiao-ni HelmutKROeGER DepartmentofPhysics ZhongshanUniversityGuangzhou510275China DépartementdePhysique UniversitéLavalQuébecQuébecG1K7P4Canada

The Monte Carlo Hamiltonian method developed recently allows to investigate the ground state and low-lying excited states of a quantum system,using Monte Carlo(MC)algorithm with importance ***,conventional MC algorithm has some difficulties when applied to inverse *** propose to use effective potential and extrapolation method to solve the *** present examples from the hydrogen system.

关键词： Monte Carlo method quantum mechanics computational physics

Mechanism of separating pyrite and dolomite by flotation

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Journal of University of Science and Technology Beijing 2007年第4期14卷 291-296页

作者： Anping Liu wen ni Wei Wu Civil and Environmental Engineering School University of Science and Technology Beijing Beijing 100083 China Nanjing Meishan Mining Co. Ltd. Baosteel Group Nanjing 210041 China Key Lab of the Ministry of Education of China for Nanomaterials Beijing University of Chemical Technology Beijing 100029 Chin

To study the mechanism of separating pyrite and dolomite by flotation, the acting mechanisms of WHL depressor and both the minerals were studied by means of thermogravimetric and differential thermal analysis （TG-DTA）, Fourier transform infrareddiffuse reflection spectroscopy （PTIR-DRS）, and X-ray photoelectron spectroscopy （XPS）. The results indicated that WHL formed metal salts with metal ions dissolved in water from dolomite and pyrite, which then deposited on their surfaces. Both of the minerals could be depressed by WHL. In the process of flotation, sulfur was created besides the WIlL being absorbed on the surface of the sulfur concentrate, and its recovery rate was slightly affected.

关键词： flotation dolomite pyrite depressor mechanism

Modification of Wirsching’s Model for Fatigue Reliability Analysis

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China Ocean Engineering 1998年第2期13卷 163-172页

作者： ni, Kan Zhang, Shengkun qian, Renjie Shanghai Jiao Tong Univ Sch Naval Architecture & Ocean Engn Shanghai 200030 Peoples R China

First, Wirsching's model, which is widely employed in fatigue reliability anlysis of marine and offshore structures, is analysed systematically. It is found that the very important random variable A in Wirsching's model can not be directly determined from fatigue experiment because of the irreversibility of fatigue test, and in fact, what Wirsching studied from testing results is not A but a of the statistical Miner's rule. Second, by use of the statistical Miner's rule, a modified Wirsching's model is proposed. Thirdly and more importantly, based on the two-dimensional probabilistic Miner's rule, a new model is established for fatigue reliability analysis of structural components subjected to specified cyclic loading of variable amplitude or stochastic time history. In the end, an example is presented, from which it will be seen that this new model is very convenient to use and feasible to engineering practice.

关键词： variable amplitude stochastic loading time history fatigue reliability Wirsching's model two-dimensional probabilistic Miner's rule

美国华裔文学族裔性书写新范式探究——以《唐人街内部》《反抗者》和《我们失去的心》为例

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佳木斯大学社会科学学报 2025年第1期43卷 134-138页

作者：纪翠萍温州大学外国语学院浙江温州325035

21世纪20年代前后,美国华裔文学出现了回归族裔性书写传统的现象,通过研读在此期间发表的族裔性书写代表作品《唐人街内部》《反抗者》和《我们失去的心》,可以发现新世纪族裔性书写在继承传统的基础上,呈现出了新的书写范式。在写作对... 详细信息

21世纪20年代前后,美国华裔文学出现了回归族裔性书写传统的现象,通过研读在此期间发表的族裔性书写代表作品《唐人街内部》《反抗者》和《我们失去的心》,可以发现新世纪族裔性书写在继承传统的基础上,呈现出了新的书写范式。在写作对象上突破单一种族关怀,采用跨族群书写;在创作方式上,将作品的文学性与族裔性有机融合,在文学追求中体现族裔诉求;在写作主题上,在审视全球发展和美国社会相关问题的同时,从多角度关注和反思少数族裔和边缘群体的生存现状和未来发展。新的书写范式体现了美国华裔作家捕捉最新国际、国内形势的敏锐和文学创作上的不断创新,也有助于美国华裔文学开疆拓土,更好融入美国主流文学市场和世界文学领域。

关键词：美国华裔文学族裔性书写新范式反思

CHAOTIC TRANSIENTS IN A CURVED FLUID CONVEYING TUBE

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Acta Mechanica Solida Sinica 2005年第3期18卷 207-214页

作者： ni Qiao Wang Lin qian Qin Department of Mechanics Huazhong University of Science and Technology Wuhan 430074 China

The chaotic transients of a curved fluid conveying tube subjected to a nonlinear foundation are investigated. The assumption of the inextensibility of the tube is applied to derive the nonlinear differential equation of motion via the Newtonian approach, with the differential quadrature method used to discretize the curved tube model in the spatial domain. And the nonlinear dynamic motion equation is obtained. The numerical analysis shows that, the final steady states are sensitive to the initial system conditions in a large parameter region of the fluid speed. This phenomenon of chaotic transients is infrequent for fluid conveying tubes.

关键词： curved fluid conveying tube chaotic transient nonlinear dynamics DQM

VIBRATION AND STABILITY OF VERTICAL UPWARD-FLUID-CONVEYING PIPE IMMERSED IN RIGID CYLINDRICAL CHANNEL

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Acta Mechanica Solida Sinica 2008年第5期21卷 431-440页

作者： Qin qian Lin Wang Qiao ni Department of Mechanics Huazhong University of Science and Technology Wuhan 430074 China

A theoretical model is developed for the vibration and stability of a vertical pipe subjected concurrently to two dependent axial flows. The external fluid, after exiting the outer annular region between the pipe and a rigid cylindrical channel, is conveyed upwards inside the pipe. This configuration thus resembles of a pipe that aspirating fluid. The equation of planar mo- tion is solved by means of the differential quadrature method （DQM）. Calculations are conducted for a slender drill-string-like and a bench-top-size system, for different confinement conditions of the outer annular channel. It is shown that the vibrations of these two systems are closely related to the degree of confinement of the outer annular channel. For a drill-string-like system with narrow annuli, buckling instability may occur in the second and third modes. For a bench-top-size system, however, both buckling and flutter may occur in the lowest three modes. The form of instability depends on the annuli size.

关键词： pipe conveying fluid annular flow axial flow drill-string stability critical flow velocity

Clinical characteristics and beta-cell function of Chinese children and adolescents with type 2 diabetes from 2009 to 2018

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World Journal of Pediatrics 2019年第4期15卷 405-411页

作者： Zhen-Ran Xu Miao-Ying Zhang Jin-wen ni Ruo-qian Cheng Zhang-qian Zheng Li Xi Fei-Hong Luo Department of Pediatric Endocrinology and Inherited Metabolic Diseases Children's Hospital of Fudan University399 Wan Yuan RoadShanghai 201102China

Background The limited available studies have unveiled different natural histories and prognosis associated with pediatric type 2 diabetes (T2D) and adult *** date,data on the clinical features,metabolic profiles and beta-cell function characteristics are still limited in the Chinese pediatric T2D *** A total of 56 children with T2D,31 with prediabetes and 159 with obesity were *** characteristics,metabolic profiles,beta-cell function and insulin resistance were *** The mean onset age of T2D was 12.35 ± 1.99 (7.9-17.8) years,and 7% of children were younger than 10 years;55% of them were male,57% had a family history of diabetes and 64% had classic symptoms,and 25% had a low or high birth weight.89% of T2D patients were obese or overweight.A total of 58% of the patients with prediabetes were *** fast serum C-peptide level was highest in the obesity group (P nificant difference between the T2D and prediabetes *** mean homeostatic model of assessment of beta-cell function was the highest in the obesity group and was lowest in the T2D group (P ning and intervention program for T2D is recommended in high-risk or obese Chinese pediatric populations starting at 7 years.

关键词： Diabetes mellitus,type 2 Obesity Prediabetic state

Self-adaptive learning based discrete differential evolution algorithm for solving CJWTA problem

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Journal of Systems Engineering and Electronics 2014年第1期25卷 59-68页

作者： Yu Xue Yi Zhuang Tianquan ni Siru ni Xuezhi wen College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics School of Computer and Software Nanjing University of Information Science and Technology No.723 Research Institute of China Shipbuilding Industry Corporation

Cooperative jamming weapon-target assignment （CJWTA） problem is a key issue in electronic countermeasures （ECM）. Some symbols which relevant to the CJWTA are defined firstly. Then, a formulation of jamming fitness is presented. Final y, a model of the CJWTA problem is constructed. In order to solve the CJWTA problem efficiently, a self-adaptive learning based discrete differential evolution （SLDDE） algorithm is proposed by introduc-ing a self-adaptive learning mechanism into the traditional discrete differential evolution algorithm. The SLDDE algorithm steers four candidate solution generation strategies simultaneously in the framework of the self-adaptive learning mechanism. Computa-tional simulations are conducted on ten test instances of CJWTA problem. The experimental results demonstrate that the proposed SLDDE algorithm not only can generate better results than only one strategy based discrete differential algorithms, but also outper-forms two algorithms which are proposed recently for the weapon-target assignment problems.

关键词： global optimization self-adaptive discrete differentialevolution weapon-target assignment (WTA) cooperative jamming.