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Current Medical Science 2021年第6期41卷 1198-1204页

作者： qian liU Yang liU shu-e li Jin-huan GENG Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China

Objective:Autophagy is a programmed cell death procedure,which has essential functions in ***,its temporal expression and function under different status are yet to be *** study aims to investigate the temporal expression of autophagy and its possible function in 7,12-dimethylbenz[a]anthracene(DMBA)-induced hamster buccal-pouch cancer model(HBPCM).Methods:A total of 50 hamster buccal-pouch tumorigenesis models were established by painting DMBA for 4,8,10 and 13 *** expression and subcellular localization of LC3,Beclin 1 and Bcl-2 in buccal lesions were evaluated by immunohistochemical staining and Western *** damage was observed by immunohistochemical staining of *** relationship between Beclin 1 and Bcl-2 was analyzed by immunofluorescence ***:The expression levels of LC3 and Beclin 1 associated with autophagy in the experimental buccal pouch of HBPCM were significantly upregulated after 4 weeks(Plized regions of Bcl-2 and Beclin 1 peaked after 4 weeks and then decreased *** DNA damage in epithelial cells increased slightly after 4 weeks,and then rapidly decreased over the next 2 ***:Autophagy is motivated by a tumor suppressor that diminishes carcinogen-induced DNA ***,autophagy is gradually suppressed,which may be attributed to the interaction between Bcl-2 and Beclin *** result indicates that the promotion of autophagy may suppress malignant transformation and provide new insights on future potential treatments of HBPCM.

关键词： tumorigenesis autophagy DNA damage Beclin 1 and Bcl-2

Quantitative determination of metaxalone in human plasma by LC-MS and its application in a pharmacokinetic study

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Asian Journal of Pharmaceutical Sciences 2016年第5期11卷 668-672页

作者： Lanting Zhao qian li Chang shu Keli Wang li Ding China Pharmaceutical University

A simple and rapid method using liquid chromatography–mass spectrometry(LC-MS) for the determination of metaxalone in human plasma has been developed and *** was used as the internal standard(IS). The plasma samples were simply treated with acetonitrile which allowed the precipitation of plasma proteins. The chromatographic separation was achieved on a Sapphire C18(2.1 mm × 150 mm, 5 μm, Newark, USA)column using the mobile phase(5 mM ammonium acetate containing 0.01% formic acid:acetonitrile(45:55, v/v)) at a flow rate of 0.3 ml/min. The selected ion monitoring(SIM) in the positive mode was used for the determination of [M + H]+m/z 222.1 and 286.1 for metaxalone and letrozole, respectively. The standard curve obtained was linear(r2≥ 0.99)over the concentration range of 30.24-5040 ng/ml. Meanwhile, no interfering peaks or matrix effect was observed. The method established was simple and successfully applied to a pharmacokinetic study of metaxalone in healthy Chinese volunteers after a single oral dose administration of 800 mg metaxalone. The main pharmacokinetic parameters of metaxalone were as follow: Cmax,(1664 ± 1208) ng/ml and(2063 ± 907) ng/ml;AUC0-36,(13925 ± 6590) ng/ml h and(18620 ± 5717) ng/ml h;t1/2,(13.6 ± 7.7) h and(20.3 ± 7.7) h for the reference and test tablets, respectively. These pharmacokinetic parameters of metaxalone in healthy Chinese volunteers were reported for the first time.

关键词： Metaxalone LC-MS Pharmacokinetics

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跨境生鲜供应链金融创新模式研究

管理案例研究与评论 2024年第3期17卷 467-480页

作者：朱盼盼曲英冯书倩刘昆大连理工大学经济管理学院大连116024 北京微冷创新科技股份有限公司北京100016

在网络生态与金融科技导向下,信任链重构被认为是供应链金融创新的关键,但关于如何通过信任链重构实现供应链金融创新尚缺乏理论探讨。基于信任链重构视角,以首农供应链(大连)有限公司为研究对象,揭示跨境生鲜供应链金融创新的前因、过... 详细信息

在网络生态与金融科技导向下,信任链重构被认为是供应链金融创新的关键,但关于如何通过信任链重构实现供应链金融创新尚缺乏理论探讨。基于信任链重构视角,以首农供应链(大连)有限公司为研究对象,揭示跨境生鲜供应链金融创新的前因、过程和结果。研究发现:融资规模有限,融资成本高,具有融资性贸易、弃货与存货减值风险是跨境生鲜供应链金融创新的前因。依托供应链金融服务平台,通过可信交易链、可信物流链、可信行为链与可信制度链构建的跨境生鲜供应链金融创新模式,可有效提升金融服务可得性,实现全过程风险管控。研究结论对我国跨境生鲜供应链金融创新与风险控制具有参考价值。

关键词：跨境生鲜行业供应链金融创新信任链重构风险控制案例研究

微种植钉支抗与平面导板在下前牙过长型深覆■矫治中的效果评价

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上海口腔医学 2024年第3期33卷 301-305页

作者：王静孙一凡路茜庞淑婷沧州市人民医院口腔正畸科河北沧州061000 华北理工大学口腔医学院河北唐山063000 沧州市人民医院口腔内科河北沧州061000

目的:对比分析微种植钉支抗与平面导板对下前牙过长型深覆■的矫治效果。方法:选择2022年1月—2023年6月接诊的下前牙过长型深覆■患者82例,采用随机数字表法分为2组(各41例),采用直丝弓矫治技术,并分别通过微种植钉支抗(微种植钉组)和... 详细信息

目的:对比分析微种植钉支抗与平面导板对下前牙过长型深覆■的矫治效果。方法:选择2022年1月—2023年6月接诊的下前牙过长型深覆■患者82例,采用随机数字表法分为2组(各41例),采用直丝弓矫治技术,并分别通过微种植钉支抗(微种植钉组)和固定式平面导板(平面导板组)压低前牙。比较2组下前牙压低效果、覆■变化量、根尖吸收量等。采用SPSS 25.0软件包对数据进行统计学分析。结果:2组矫治前后的SNA角、SNB角、ANB角、U1-PP、U6-PP及L6-MP变化不明显(P>0.05)。2组矫治后L1-MP比矫治前减小,差异有统计学意义(P0.05)。微种植钉组下颌中切牙及侧切牙根尖吸收量显著低于平面导板组(P0.05)。结论:微种植钉支抗和平面导板用于成人前牙深覆■矫治,能有效压低下颌前牙,矫治效果良好,但后者可导致牙根吸收增加。

关键词：深覆■ 微种植钉支抗平面导板直丝弓矫治牙根吸收

产脂肪酶多粘类芽胞杆菌的产酶条件和固定化优化及对模拟油污废水的降解研究

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微生物学杂志 2024年第4期44卷 31-39页

作者：王娜赵文倩张盈盈蔡灏漾李泽舒褚衍亮江苏科技大学生物技术学院江苏镇江212100

以筛选自健康桑树叶片的内生细菌多粘类芽胞杆菌(Paenibacillus polymyxa)为实验菌株,对其产脂肪酶进行分析,探讨菌株在油污废水净化领域的应用潜力。在透明圈法定性分析的基础上,研究了影响菌株产酶的因素,优化了产酶条件;采用壳聚糖-... 详细信息

以筛选自健康桑树叶片的内生细菌多粘类芽胞杆菌(Paenibacillus polymyxa)为实验菌株,对其产脂肪酶进行分析,探讨菌株在油污废水净化领域的应用潜力。在透明圈法定性分析的基础上,研究了影响菌株产酶的因素,优化了产酶条件;采用壳聚糖-戊二醛固定的方法对脂肪酶进行固定,探讨了固定化酶对模拟油污废水的降解能力。结果表明,菌株具有产脂肪酶特性,所产脂肪酶的最适反应温度为39℃,最适反应pH值为7.0。通过碳氮源筛选发现,蔗糖(60 g/L)和菜籽饼粉(15 g/L)最适合作为菌株培养基发酵产酶。设置培养基初始pH为7.0,培养温度32℃,发酵培养2 d,脂肪酶活性即可达到最大值。脂肪酶可有效固定在壳聚糖-戊二醛载体上。降解模拟油污废水时,游离酶在反应48 h时降解度达638.88 mg/mgprot,而后持续下降;固定化酶在反应36 h时,降解度达4174.44 mg/mgprot,且在60 h内,一直保持在相对恒定的水平。60 h后,固定化酶的降解度虽然显著下降,但相比于游离酶仍然保持较高的降解能力。内生细菌多粘类芽胞杆菌具有良好的产脂肪酶及降解油污能力,在废水净化领域有潜在的应用前景。

关键词：内生细菌脂肪酶多粘类芽胞杆菌固定化油污废水

1例初始表现为急性弥散性血管内凝血的胃低分化腺癌伴多发转移:^(18)F-FDG PET/CT显像所见

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中国医学影像技术 2024年第4期40卷 634-635页

作者：杨红杰孙倩刘军王子阳胡疏董孟杰北京大学深圳医院核医学科广东深圳518036 北京大学深圳医院病理科广东深圳518036

患者女,20岁,无明显诱因阵发性下腹部疼痛伴牙龈出血、皮肤散在瘀斑及肛门坠胀感9天;既往体健。查体:贫血貌,全身皮肤散在片状瘀斑,四肢皮肤干燥;腹部柔软,无压痛及反跳痛。实验室检查:红细胞2.49×10^(12)/L,血小板36×10^(9)/L,血红蛋... 详细信息

患者女,20岁,无明显诱因阵发性下腹部疼痛伴牙龈出血、皮肤散在瘀斑及肛门坠胀感9天;既往体健。查体:贫血貌,全身皮肤散在片状瘀斑,四肢皮肤干燥;腹部柔软,无压痛及反跳痛。实验室检查:红细胞2.49×10^(12)/L,血小板36×10^(9)/L,血红蛋白70 g/L,血浆鱼精蛋白副凝固实验(+),D-二聚体>20 mg/L,纤维蛋白原降解产物>150.00 mg/L,糖类抗原12573.40 U/ml。

关键词：弥散性血管内凝血胃肿瘤体层摄影术,X线计算机正电子发射断层显像

PN/A工艺在热水解污泥消化液处理工程中的应用研究

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中国环境科学 2024年第7期44卷 3698-3706页

作者：王晓聪韩晓宇张树军李伟黄京焦佳童王倩王之敏曲之明北京排水集团有限责任公司北京市资源化工程技术研究中心北京100044

利用短程硝化厌氧氨氧化(PN/A)工艺在北京某污水处理厂成功启动了处理热水解污泥消化液的工程,调试运行结果表明:在接种生物膜填料数占总填料数18%和生物膜上厌氧氨氧化菌(AnAOB)占比为6.8%的情况下可快速启动PN/A系统,并在3个月内可以... 详细信息

利用短程硝化厌氧氨氧化(PN/A)工艺在北京某污水处理厂成功启动了处理热水解污泥消化液的工程,调试运行结果表明:在接种生物膜填料数占总填料数18%和生物膜上厌氧氨氧化菌(AnAOB)占比为6.8%的情况下可快速启动PN/A系统,并在3个月内可以达到设计处理水量,总氮去除负荷为0.26kg/(m^(3)·d),总氮去除率达到80%以上.通过定量PCR检测和高通量数据发现AOB和AnAOB丰度不同的空间分布特点,项目调试过程中氨氧化菌(ammonia oxidizing bacteria,AOB)和AnAOB均呈稳定增长的趋势,经过3个月启动培养后絮体中AOB丰度达到1011数量级,生物膜中的AnAOB达到1012数量级.实际运行数据证明该旁侧处理系统对水厂主流区产生积极影响,可降低日处理量为40×10^(4) t的污水厂2.9mg/L的进水总氮.另外,在该项目后期运行过程中出现反应池缺氧段和末端游离氨(free ammonia,FA)浓度不足的情况,导致短程硝化过程不稳定,通过控制反应池首端与末端FA浓度及剩余氨氮浓度,可实现对短程硝化过程的快速恢复.

关键词：污水处理厌氧氨氧化脱氮污泥消化液

Evaluation of residual stress and corrosion behaviour of electroless plated Ni-P/Ni-Mo-P coatings

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Transactions of Nonferrous Metals Society of China 2018年第12期28卷 2499-2510页

作者： Hong liU Dai-shu qian School of Mechanical and Automotive Engineering Qilu University of Technology (Shandong Academy of Sciences)Ji'nan 250353China

Single Ni-P and Ni-Mo-P coatings as well as duplex Ni-P/Ni-Mo-P coatings with the same compositions were prepared by electroless *** residual stresses of the coatings on the surface and cross sections were measured by nanoindentation and AFM analysis,and the corrosion behaviour of the coatings in10%HCl solution was evaluated by electrochemical methods,to establish the correlation between the residual stresses and corrosion behaviour of the *** results showed that the single Ni-P and duplex Ni-P/Ni-Mo-P coatings presented residual compressive stresses of241and206MPa respectively,while the single Ni-Mo-P coating exhibited a residual tensile stress *** residual compressive stress impeded the growth of the pre-existing porosity in the coatings,protecting the integrity of the *** duplex Ni-P/Ni-Mo-P coatings had better corrosion resistance than their respective single *** addition,the stress states affect the corrosive form of coatings.

关键词： electroless plating Ni-P/Ni-Mo-P duplex coatings residual stress nano indentation corrosion resistance

Design and implementation of a high-efficiency concurrent dual-band power amplifier

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The Journal of China Universities of Posts and Telecommunications 2014年第6期21卷 94-99页

作者： YANG qian-kun liU Yuan-an YU Cui-ping li shu-lan li Jiu-chao Beijing Key Laboratory of Work Safety Intelligent Monitoring Beijing University of Posts and Telecommunications School of Electronic Engineering Beijing University of Posts and Telecommunications

This paper studies the behaviors of power amplifier（PA） driven by a single-carrier continuous wave（CW） signal and a two-carrier CW signal both in theory and simulation, and explains why the traditional dual-band PA failed to perform satisfactory results when a two-carrier CW signal is applied to, called concurrently. Besides that, an evaluation standard of concurrent dual-band PA was presented to value its performance. Solution was given with design and fabrication of a concurrent 1.85 GHz/2.65 GHz class F PA, employing a 10 W GaN HEMT device from Cree, CGH40010, whose measurement shows the saturated output power is 40.6 d Bm and 40.8dB m with drain efficiencies（DE） of 77.4% and 75.3% at 1.85 GHz and 2.65 GHz, respectively. On the other hand, we see that the peak DE achieves 59.7% with an output power of 39.9 dB m in concurrent mode, which follows up with the standard.

关键词： PA concurrent dual-band intermodulation and harmonic high efficiency

Summed volume region selection based three-dimensional automatic target recognition for airborne liDAR

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Defence Technology（防务技术） 2020年第3期16卷 535-542页

作者： Qi-shu qian Yi-hua Hu Nan-xiang Zhao Min-le li Fu-cai Shao State Key Laboratory of Pulsed Power Laser Technology National University of Defense TechnologyHefei230037China Anhui Province Key Laboratory of Electronic Restriction National University of Defense TechnologyHefei230037China The Military Representative Bureau of the Ministry of Equipment Development of the Central Military Commission in Beijing Beijing100191China

Airborne liDAR can flexibly obtain point cloud data with three-dimensional structural information,which can improve its effectiveness of automatic target recognition in the complex *** with 2D information,3D information performs better in separating objects and ***,an aircraft platform can have a negative influence on liDAR obtained data because of various flight attitudes,flight heights and atmospheric disturbances.A structure of global feature based 3D automatic target recognition method for airborne liDAR is proposed,which is composed of offline phase and online *** performance of four global feature descriptors is *** the summed volume region(SVR) discrepancy in real objects,SVR selection is added into the pre-processing operations to eliminate mismatching clusters compared with the interested *** reliable simulated data are obtained under various sensor’s altitudes,detection distances and atmospheric *** final experiments results show that the added step increases the recognition rate by above 2.4% and decreases the execution time by about 33%.

关键词： 3D automatic target recognition Point cloud liDAR Airborne Global feature descriptor