检索结果-南通市图书馆

Creatine kinase in the diagnosis and prognostic prediction of amyotrophic lateral sclerosis:a retrospective case-control study

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第3期16卷 591-595页

作者： Xue-Ping Chen qian-qian wei Ru-wei Ou Yan-Bing Hou Ling-Yu Zhang Xiao-Qin Yuan Yun-qian Yao De-Sheng Jia qian Zhang wei-Xue Li Hui-Fang Shang Department of Neurology West China Hospital of Sichuan UniversityChengduSichuan ProvinceChina

Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral *** the present retrospective case-control study,we included 582 patients with amyotrophic lateral sclerosis and 582 age-and sexmatched healthy *** amyotrophic lateral sclerosis participants received treatment in the Department of Neurology,West China Hospital,China,between May 2008 and December *** creatine kinase levels in patients with amyotrophic lateral sclerosis were significantly higher than those in healthy *** analysis revealed that serum creatine kinase levels in men were higher than those in women in both amyotrophic lateral sclerosis patients and healthy *** with patients with bulbar-onset amyotrophic lateral sclerosis,patients with limb-onset amyotrophic lateral sclerosis had higher creatine kinase ***'s correlation analysis revealed that serum creatine kinase levels were not correlated with body mass index,Amyotrophic lateral Sclerosis Functional Rating ScaleRevised score,or progression *** adjusting for prognostic covariates,higher log creatine kinase values were correlated with higher overall survival in the amyotrophic lateral sclerosis *** also investigated the longitudinal changes in serum creatine kinase levels in 81 amyotrophic lateral sclerosis patients;serum creatine kinase levels were decreased at the second blood test,which was sampled at least 6 months after the first blood ***,our results suggest that serum creatine kinase levels can be used as an independent factor for predicting the prognosis of amyotrophic lateral sclerosis *** study received ethical approval from the Ethics Committee of West China Hospital,China(approval No.2015(236))on December 23,2015.

关键词： amyotrophic lateral sclerosis biomarker creatine kinase diagnosis epidemiological study prognosis serology survival

Effective Response of Nonlinear Spherical Coated Composites Under External AC and DC Electric Field

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2009年第4期51卷 743-747页

作者： SHEN Yu-Yan CHEN Xiao-Gang LI qian-qian CUI wei HAO Yan-Hua College of Science Inner Mongolia University of Technology Hohhot 010051 China

Under the external AC and DC electric field, the effective response of nonlinear spherical coated composites, which obey the constitutive relation of electric displaeement and electric field, is investigated in the dilute limit by using the perturbation method. The local potentials in inclusion and host regions are derived at all harmonics. Moreover, the formulae of the effective linear and nonlinear responses are given in the dilute limit.

关键词： nonlinear composites effective response AC electric field

Neutrophil-to-lymphocyte ratio in sporadic amyotrophic lateral sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第4期17卷 875-880页

作者： qian-qian wei Yan-Bing Hou Ling-Yu Zhang Ru-wei Ou Bei Cao Yong-Ping Chen Hui-Fang Shang Department of Neurology Laboratory of Neurodegenerative DisordersWest China HospitalSichuan UniversityChengduSichuan ProvinceChina

The neutrophil-to-lymphocyte ratio(NLR)is considered a robust prognostic biomarker for predicting patient survival outcomes in many ***,it remains unclear whether it can be used as a biomarker for amyotrophic lateral sclerosis(ALS).To correlate NLR with disease progression and survival in sporadic ALS,1030 patients with ALS between January 2012 and December 2018 were included in this *** patients were assigned into three groups according to their NLR values:Group 1(NLR3,n=172[16.7%]).All patients were followed up until April *** in Group 3 had a significantly older onset age,a lower score on the Revised ALS Functional Rating Scale,and rapidly progressing disease ***,faster disease progression rates were associated with higher NLR values(odds ratio=1.211,95%confidence interval[CI]:1.090–1.346,P<0.001)after adjusting for other risk *** with Groups 1 and 2,the survival time in Group 3 was significantly shorter(log-rank P=0.002).The NLR value was considered an independent parameter for the prediction of survival in ALS patients after normalizing for all other potential parameters(hazard ratio[HR]=1.079,95%CI:1.016–1.146,P=0.014).The effects on ALS survival remained significant when adjusted for treatment(HR=1.074,95%CI:1.012–1.141,P_(trend)=0.019)or when considering the stratified NLR value(HR=1.115,95%CI:1.009–1.232,P_(trend)=0.033).Thus,the NLR may help to predict the rate of disease progression and survival in patients with sporadic *** study was approved by the Institutional Ethics Committee of West China Hospital of Sichuan University,China(approval No.2015(236))on December 23,2015.

关键词： amyotrophic lateral sclerosis Cox analysis inflammation lymphocytes monocytes neutrophils prognosis survival rate

Multivariable clinical-genetic model for predicting dyskinesia in early-onset Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2021年第3期10卷 343-345页

作者： Yong-Ping Chen Ru-wei Ou Xiao-Jing Gu Ling-Yu Zhang Bei Cao Yan-Bing Hou Kun-Cheng Liu Jun-Yu Lin qian-qian wei Bi Zhao Ying Wu Hui-Fang Shang Department of Neurology Laboratory of Neurodegenerative DisordersRare Disease CenterWest China HospitalSichuan UniversityChengdu 610041China

Main text The levodopa-induced dyskinesias(LIDs)in Parkinson’disease(PD)patients during levodopa treatment can lead to significant *** evidence has suggested that the younger the age of onset,the more likely the development of LIDs[1].Till now,most of the studies on clinical or genetic risk factors for LIDs were cross-sectional[2],or included limited sample size[3],or mainly included late-onset PD patients[4].Here,we investigated the incidence of LIDs in the early stage of early-onset PD(EOPD),including the first 5 years of duration and the first 5 years of dopamine replacement therapy(DRT),and established and validated clinicalgenetic models for LID *** methods are provided in Supplementary File 1.

关键词： clinical dopamine younger

TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： Fei-Yu Zhao Guo-wei Si Nian-Song qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China Senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study by Zuo et *** focus is on the efficacy of he-patic arterial infusion chemotherapy combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy,in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2021年第6期134卷 690-698页

作者： Jun-Yu Lin Ling-Yu Zhang Bei Cao qian-qian wei Ru-wei Ou Yan-Bing Hou Kun-Cheng Liu Xin-Ran Xu Zheng Jiang Xiao-Jing Gu Jiao Liu Hui-Fang Shang Department of Neurology West China HospitalSichuan UniversityChengduSichuan 610041China

Background: Sleep disorders are common but under-researched symptoms in patients with multiple system atrophy (MSA). We investigated the frequency and factors associated with sleep-related symptoms in patients with MSA and the impact of sleep disturbances on disease ***: This cross-sectional study involved 165 patients with MSA. Three sleep-related symptoms, namely Parkinson’s disease (PD)-related sleep problems (PD-SP), excessive daytime sleepiness (EDS), and rapid eye movement sleep behavior disorder (RBD), were evaluated using the PD Sleep Scale-2 (PDSS-2), Epworth Sleepiness Scale (ESS), and RBD Screening Questionnaire (RBDSQ), respectively. Disease severity was evaluated using the Unified MSA Rating Scale (UMSARS).Results: The frequency of PD-SP (PDSS-2 score of ≥18), EDS (ESS score of ≥10), and RBD (RBDSQ score of ≥5) in patients with MSA was 18.8%, 27.3%, and 49.7%, respectively. The frequency of coexistence of all three sleep-related symptoms was 7.3%. Compared with the cerebellar subtype of MSA (MSA-C), the parkinsonism subtype of MSA (MSA-P) was associated with a higher frequency of PD-SP and EDS, but not of RBD. Binary logistic regression revealed that the MSA-P subtype, a higher total UMSARS score, and anxiety were associated with PD-SP;that male sex, a higher total UMSARS score, the MSA-P subtype, and fatigue were associated with EDS;and that male sex, a higher total UMSARS score, and autonomic onset were associated with RBD in patients with MSA. Stepwise linear regression showed that the number of sleep-related symptoms (PD-SP, EDS, and RBD), disease duration, depression, fatigue, and total Montreal Cognitive Assessment score were predictors of disease severity in patients with ***: Sleep-related disorders were associated with both MSA subtypes and the severity of disease in patients with MSA, indicating that sleep disorders may reflect the distribution and degree of dopaminergic/non-dopaminergic neuron degeneration in MSA.

关键词： Multiple system atrophy Sleep disorders Disease severity Subtype

在线全文

学校读者我要写书评

暂无评论

机油类产品激光诱导荧光时间特性的研究

物理学报 2002年第5期51卷 1031-1034页

作者：王茜蒨魏光辉北京理工大学光电工程系北京100081

介绍了一种由三倍频Nd∶YAG激光器、单色仪、光电倍增管以及信号采集处理系统构成的激光荧光谱寿命测量系统及其测量原理和方法 ,讨论了如何去除激发光脉冲宽度和探测系统响应速度对测量结果的影响 ,并实际测量了一种应用广泛的燕山机... 详细信息

介绍了一种由三倍频Nd∶YAG激光器、单色仪、光电倍增管以及信号采集处理系统构成的激光荧光谱寿命测量系统及其测量原理和方法 ,讨论了如何去除激发光脉冲宽度和探测系统响应速度对测量结果的影响 ,并实际测量了一种应用广泛的燕山机油的荧光谱寿命 .本系统具有简便、快捷、准确以及成本低等优点。

关键词：激光诱导荧光荧光寿命 Nd:YAG激光器光电倍增值环境监测油类污染物水质监测机油类产品时间特性

在线全文

学校读者我要写书评

暂无评论

基于UWB优化配置的室内行人导航方法

中国惯性技术学报 2017年第2期25卷 186-191页

作者：曾庆化王敬贤孟骞熊智钱伟行南京航空航天大学导航研究中心南京210016 卫星通信与导航协同创新中心南京210016 南京师范大学电气与自动化工程学院南京210094

在卫星信号无法覆盖的室内条件下,行人的精确导航问题是当前研究的热点。为解决基于MEMS的微惯性导航系统误差随时间发散、航向角发散快的问题,提出了一种利用UWB辅助修正惯性导航系统,实现室内较高精度定位的方法。该方法采用基于零速... 详细信息

在卫星信号无法覆盖的室内条件下,行人的精确导航问题是当前研究的热点。为解决基于MEMS的微惯性导航系统误差随时间发散、航向角发散快的问题,提出了一种利用UWB辅助修正惯性导航系统,实现室内较高精度定位的方法。该方法采用基于零速修正的微惯导系统进行导航,以抑制惯导误差随时间发散,并在建筑内拐角、楼梯口等关键节点处优化配置UWB设备,采用UWB信息与微惯导数据进行卡尔曼滤波,实现对微惯导航向及位置的修正。与大规模使用UWB系统进行室内定位相比,该方法降低了系统布设成本,避免了UWB出现问题时对整体导航结果的影响,有效地保证了系统的定位精度。行走实验表明:直线行走时,微惯导最终定位误差为1.8%;转弯行走时,在UWB辅助定位下,微惯导最终定位误差小于1.0%。

关键词：室内定位惯性导航系统超宽带无线技术组合导航

Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi Yu Xi Zheng Xiao-Sheng Li qian-Jie Xu wei Zhang Zhong-Li Liao Hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model