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Surgical management of Zollinger-Ellison syndrome: Classical considerations and current controversies

World Journal of Gastroenterology 2019年第32期25卷 4673-4681页

作者： qian-qian shao Bang-Bo Zhao Liang-Bo Dong Hong-Tao Cao Wei-Bin Wang Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences/Peking Union Medical College

Zollinger-Ellison syndrome(ZES)is characterized by gastric acid hypersecretion causing severe recurrent acid-related peptic *** secretion of gastrin can now be effectively controlled with powerful proton pump inhibitors,but surgical management to control gastrinoma itself remains *** on a thorough literature review,we design a surgical algorithm for ZES and list some significant consensus findings and recommendations:(1)For sporadic ZES,surgery should be routinely undertaken as early as possible not only for patients with a precisely localized diagnosis but also for those with negative imaging *** surgical approach for sporadic ZES depends on the lesion location(including the duodenum,pancreas,lymph nodes,hepatobiliary tract,stomach,and some extremely rare sites such as the ovaries,heart,omentum,and jejunum).Intraoperative liver exploration and lymphadenectomy should be routinely performed;(2)For multiple endocrine neoplasia type 1-related ZES(MEN1/ZES),surgery should not be performed routinely except for lesions>2 *** attempt to perform radical resection(pancreaticoduodenectomy followed by lymphadenectomy)can be *** ameliorating effect of parathyroid surgery should be considered,and parathyroidectomy should be performed first before any abdominal surgery for ZES;and(3)For hepatic metastatic disease,hepatic resection should be routinely ***,liver transplantation is still considered an investigational therapeutic approach for ***-designed prospective studies are desperately needed to further verify and modify the current considerations.

关键词： Zollinger-Ellison syndrome Sporadic gastrinomas Multiple endocrine neoplasia type 1 Hepatic metastatic disease Surgical treatment

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Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou qian Lu Mingcong Tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu Xiaomin Xu Xiao Zhang Zongping shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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A new strain of Omono River Virus has fiber-like protrusions

A new strain of Omono River Virus has fiber-like protrusions

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第六届全国冷冻电子显微学与结构生物学专题研讨会

作者： Zhe LIU qian-qian shao Yuan-zhu GAO Xu-dong JIA Qin-fen ZHANG Guangdong Provincial Center for Disease Control and Prevention Guangdong Provincial Institution of Public Health State Key Lab for Biocontrol School of Life Sciences Sun Yat-sen University

Most reported members of totiviridae lack an extracellular life cycle stage and are transmitted by cytoplasmic interchange. However, several novel unassigned viruses related to Totiviridae were reported in recent years to exhibit the extracellular transmission pathway, including the previously reported Omono River Virus(OmRV) with no protrusions separated from *** a new OmRV strain assigned OmRV-LZ was identified and structurally determined by Cryoelectron microscopy reconstruction. Two 3-dimensional(3-D) maps with or without fiber-like protrusions were obtained by 3-D classification. Our results demonstrated the protrusion that has a weak connection with capsid protein subunit A and may be easily broken. It is suggested that the protrusion is formed by the ORF1-encoded small protein, and may play roles in cell entry.

关键词： Omono River Virus(OmRV) Totivirus Fiber-like protrusion Cryo-electron microscopy Single particle reconstruction

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Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： Zhen-Nan Pan Hao-Lin Zhang Kun-Huan Zhang Jia-qian Ju Jing-Cai Liu shao-Chen Sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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我国农村土地流转价格问题与对策建议

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价格月刊 2017年第10期 76-80页

作者：高宇林倩倩邵周岳山东财经大学山东济南250010 山东省土地调查规划院山东济南250014

农村土地流转价格是影响土地流转顺利进行的重要因素,它受自然因素、社会因素及流转主体自身因素的影响。目前,我国农村土地定价理论尚不完善,未能综合考虑所有因素,使得在土地流转实践中流转价格存有许多问题。为解决农村土地流转价格... 详细信息

农村土地流转价格是影响土地流转顺利进行的重要因素,它受自然因素、社会因素及流转主体自身因素的影响。目前,我国农村土地定价理论尚不完善,未能综合考虑所有因素,使得在土地流转实践中流转价格存有许多问题。为解决农村土地流转价格问题,政府要加强土地流转信息的传递、完善监督机制,立足政府引导、增强农户法律意识,增加土地流入方利益、建立合理的土地流转价格机制以及完善土地流转价格评估体系、实行分批流转。

关键词：农村土地流转价格实际价格理论价格地区差异

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu qian-qian Jiang shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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雌、孕激素对人早孕蜕膜基质细胞中B淋巴细胞激活因子受体(BAFFR)表达的影响

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生殖与避孕 2009年第3期29卷 157-161页

作者：魏艳秋董白桦邓碧萍李泽武刘瑾董召刚邵倩倩孔北华曲迅山东大学齐鲁医院妇产科济南250012 山东大学齐鲁医院临床基础研究所济南250012 山东大学医学院济南250012

目的:初步探讨B淋巴细胞激活因子受体(Bcells-activating factor receptor,BAFFR)在胚胎植入调控中的作用。方法:选取正常早孕妇女人工流产蜕膜组织,分离、提纯早孕蜕膜基质细胞(decidual stromal cells,DSC),培养于含10%去激素胎牛血... 详细信息

目的:初步探讨B淋巴细胞激活因子受体(Bcells-activating factor receptor,BAFFR)在胚胎植入调控中的作用。方法:选取正常早孕妇女人工流产蜕膜组织,分离、提纯早孕蜕膜基质细胞(decidual stromal cells,DSC),培养于含10%去激素胎牛血清培养基内,分为雌二醇(E2)组、孕酮(P4)组、E2+P4组和空白对照(C)组,培养96h。MTT检测细胞的增殖能力;Real-time PCR检测BAFFR mRNA;流式细胞仪检测BAFFR蛋白表达。结果:与C组比较,各实验组DSC增殖能力及BAFFR mRNA水平均无明显变化(P>0.05);BAFFR蛋白定位于DSC胞内,且E2+P4可显著上调其表达(P<0.05)。结论:正常人早孕DSC表达高水平的BAFFR,雌、孕激素联合对其有显著的上调作用,提示BAFFR可能参与胚胎植入的调控及早孕期母-胎界面的免疫调节。

关键词：蜕膜基质细胞孕酮(P4) 雌二醇(E2) B淋巴细胞激活因子受体(BAFFR)

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Robust tuning method for modified smith predictor

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Journal of Systems Engineering and Electronics 2007年第1期18卷 89-94页

作者： Zhang Guanghui qian Feng shao Huihe Inst. of Automation East China Univ. of Science and Technology Shanghai 200237 P. R. China Inst. of Automation Shanghai Jiaotong Univ. Shanghai 200030 P. R. China

A robust tuning method for ο^Astroem＇s two-degree of Freedom Modified Smith Predictor （MSP） is proposed, and it can achieve the fast setpoint and load disturbance responses independently. The tuning rules may meet the requirements within a certain delay margin according to the robustness theory. The simulation results illustrate that the tuning method is efficient compared with other controllers. Finally, the MSP controller is applied to the 15L batch fermentation system for controlling the temperature in bioreactor, and the experiment results further verify that the robust tuning rules may achieve good performance.

关键词： Tuning Smith Predictor Robusmess Integrating processes Temperature control

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A Variational Model for Two-Phase Immiscible Electroosmotic Flow at Solid Surfaces

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Communications in Computational Physics 2012年第3期11卷 831-862页

作者： Sihong shao Tiezheng qian Joint KAUST-HKUST Micro/Nanofluidics Laboratory Hong Kong University of Science and TechnologyClear Water BayHong KongLMAMand School ofMathematical SciencesPeking UniversityBeijing 100871China Department of Mathematics and Joint KAUST-HKUST Micro/Nanofluidics Laboratory Hong Kong University of Science and TechnologyClear Water BayHong Kong

We develop a continuum hydrodynamic model for two-phase immiscible flows that involve electroosmotic effect in an electrolyte and moving contact line at solid *** model is derived through a variational approach based on the Onsager principle of minimum energy *** approach was first presented in the derivation of a continuum hydrodynamic model for moving contact line in neutral two-phase immiscible flows(qian,Wang,and Sheng,*** Mech.564,333-360(2006)).Physically,the electroosmotic effect can be formulated by the Onsager principle as well in the linear response ***,the same variational approach is applied here to the derivation of the continuum hydrodynamic model for charged two-phase immiscible flows where one fluid component is an electrolyte exhibiting electroosmotic effect on a charged surface.A phase field is employed to model the diffuse interface between two immiscible fluid components,one being the electrolyte and the other a nonconductive fluid,both allowed to slip at solid *** model consists of the incompressible Navier-Stokes equation for momentum transport,the Nernst-Planck equation for ion transport,the Cahn-Hilliard phase-field equation for interface motion,and the Poisson equation for electric potential,along with all the necessary boundary *** particular,all the dynamic boundary conditions at solid surfaces,including the generalized Navier boundary condition for slip,are derived together with the equations of motion in the bulk *** examples in two-dimensional space,which involve overlapped electric double layer fields,have been presented to demonstrate the validity and applicability of the model,and a few salient features of the two-phase immiscible electroosmotic flows at solid *** wall slip in the vicinity ofmoving contact line and the Smoluchowski slip in the electric double layer are both investigated.

关键词： Electroosmotic flow moving contact line slip boundary condition

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HIV Cure and HIV Reservoirs

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Biomedical and Environmental Sciences 2014年第6期27卷 478-480页

作者： YIN qian qian shao Yi Ming MA Li Ying State Key Laboratory for Infection Disease Prevention and Control National Center for AIDS/STD Control and Prevention (NCAIDS) Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseas Chinese Center for Disease Control and Prevention (China-CDC)

The success of combined antiretroviral therapy （cART） has dramatically improved the clinical outcomes of HIV infection and made HIV infection a chronic disease. Nonetheless, cART alone cannot eliminate viral reservoirs and fully recover patients＇ health, so the patients have to receive this treatment for lifetime. Therefore, researchers have focused their efforts on the cure for HIV infection. In recent years, some intriguing and inspiring cases indicated that the cure of HIV infection （HIV cure） or durable alleviation of HIV infection may not be a dream any more. ＇Berlin Patient＇＇Mississippi Baby＇, and probably ＇Long Beach Baby＇ have brought great hope to the HIV cure. Many scientists believe that the HIV cure is just a question of time.

关键词： HIV Cure and HIV Reservoirs ZFN

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