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Neural Regeneration Research 2012年第3期7卷 187-190页

作者： Wentao fan qian Wang Yongmei Yan Shaanxi University of Chinese Medicine Xianyang 712000 Shaanxi Province China

The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection of a small dose of reserpine. After intragastric perfusion with 45 mg/100 g, 15 mg/100 g, and 7.5 mg/100 g of Xingnao Jieyu for 7, 14 and 21 days, neuronal morphology in the frontal lobe and hippocampus was improved, depression state and voluntary behaviors were also effectively improved in rats with post-stroke depression. Moreover, the effects of Xingnao Jieyu at a dose of 45 and 15 mg/100 g were similar to the traditional antidepressant Prozac.

关键词： Xingnao Jieyu capsule poststroke depression hippocampus neuron traditional Chinese medicine neural regeneration

Group-based user pairing for virtual MIMO in LTE

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The Journal of China Universities of Posts and Telecommunications 2007年第3期14卷 38-42页

作者： qian Yu fan Bin ZHENG Kan Wireless Signal Processing and Network Laboratory Beijing University ofPosts and Telecommunications Beijing 100876 China

A user pairing method is proposed to improve the throughput gain of virtual multiple input multiple output （virtual MIMO） in 3G long-term evolution（LTE）. The approach taken in this study separated the user pairing into four steps： 1） the users are divided into two groups according to their signal-to-noise ratio （SNR）, and different user pairing metrics are proposed for each group; 2） the scheduler chooses a user for transmitting by a given rule; 3） the scheduler searches the pairing candidate for the selected user in each group; 4） the scheduler chooses the final pairing user from the co-group and crossover-group candidates by using a marginal utility function, to balance fairness and efficiency. The method can improve the throughput of users with high SNR, and guarantee fairness for users with low SNR, so it can be used in 3G LTE systems. The article provides both theoretical analysis and simulation results to support the idea.

关键词： virtual MIMO user pairing 3G LTE space division multiple access (SDMA)

Cancer metabolism and dietary interventions

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Cancer Biology & Medicine 2022年第2期19卷 163-174页

作者： Lin qian fan Zhang Miao Yin Qunying Lei Fudan University Shanghai Cancer Center&Institutes of Biomedical Sciences Cancer InstitutesKey Laboratory of Breast Cancer in ShanghaiShanghai Key Laboratory of Radiation OncologyShanghai Key Laboratory of Medical EpigeneticsShanghai Medical CollegeFudan UniversityShanghai 200030China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200030China State Key Laboratory of Medical Neurobiology Fudan UniversityShanghai 200030China Lead Contact Shanghai 200030China

Metabolic remodeling is a key feature of cancer *** of cancer metabolism has greatly expanded since the first observation of abnormal metabolism in cancer cells,the so-called Warburg *** cells tend to modify cellular metabolism to favor specialized fermentation over the aerobic respiration usually used by most normal ***,targeted cancer therapies based on reprogramming nutrient or metabolite metabolism have received substantial attention both conceptually and in clinical *** particular,the management of nutrient availability is becoming more attractive in cancer *** this review,we discuss recent findings on tumor metabolism and potential dietary interventions based on the specific characteristics of tumor ***,we present a comprehensive overview of changes in macronutrient ***,amino acids,and lipids,are rewired in the cancer microenvironment individually or ***,we summarize recent progress in cancer interventions applying different types of diets and specific nutrient restrictions in pre-clinical research or clinical trials.

关键词： Cancer metabolism diet intervention carbohydrate amino acid lipid

2016年中国植物科学若干领域重要研究进展

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植物学报 2017年第4期52卷 394-452页

作者：王小菁萧浪涛董爱武王台钱前漆小泉陈凡左建儒杨淑华顾红雅陈之端姜里文白永飞孔宏智种康华南师范大学湖南农业大学复旦大学中国科学院植物研究所中国农业科学院水稻研究所中国科学院遗传与发育生物学研究所中国农业大学北京大学香港中文大学

2016年中国植物科学持续稳步发展,表现在中国植物科学家在国际主流高影响力学术期刊发表文章的数量稳中有升,中国植物科学领域的期刊逆风出行,进入研究性期刊世界前三甲行列。中国科学家在植物学诸多领域取得了丰硕的成果。水稻(Oryza s... 详细信息

2016年中国植物科学持续稳步发展,表现在中国植物科学家在国际主流高影响力学术期刊发表文章的数量稳中有升,中国植物科学领域的期刊逆风出行,进入研究性期刊世界前三甲行列。中国科学家在植物学诸多领域取得了丰硕的成果。水稻(Oryza sativa)产量性状杂种优势的分子遗传机制解析入选2016年中国科学十大进展;植物受精过程中雌雄配子体信号识别机制的研究和独脚金内酯的受体感知机制入选2016年生命科学十大进展。我国植物科学,特别是以水稻为代表的作物研究在国际学术界已占有一席之地。例如,在水稻组学(如基因组和转录组等)资源和技术平台的建立、重测序的开发及功能基因的克隆和调控网络的解析方面取得了系列重要成果(如揭示了独脚金内酯信号转导的"去抑制化激活"机制、从分子水平上阐释了水稻籼粳杂种不育和广亲和性基因S5的作用机理及发现了控制水稻耐冷的基因组位点),已经引领世界水稻乃至作物科学研究。该文对2016年中国本土植物科学若干领域取得的重要研究进展进行了概括性评述,旨在全面追踪当前中国植物科学领域的发展前沿和研究热点,与读者共享我国科学家所取得的杰出成就。

关键词：中国植物科学研究进展 2016年

Selection of suitable internal controls for gene expression normalization in rats with spinal cord injury

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Neural Regeneration Research 2022年第6期17卷 1387-1392页

作者： Wei Liu Jie Yu Yi-fan Wang qian-qian Shan Ya-Xian Wang Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNational Medical Products Administration(NMPA)Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Department of Nursing The Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Clinical Medicine Medical School of Nantong UniversityNantongJiangsu ProvinceChina Department of Radiotherapy and Oncology The Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

There is a lack of systematic research on the expression of internal control genes used for gene expression normalization in real-time reverse transcription polymerase chain reaction in spinal cord injury *** this study,we used rat models of spinal cord hemisection to analyze the expression stability of 13 commonly applied reference genes:Actb,Ankrd27,CypA,Gapdh,Hprt1,Mrpl10,Pgk1,Rictor,Rn18s,Tbp,Ubc,Ubxn11,and *** results show that the expression of Ankrd27,Ubc,and Tbp were stable after spinal cord injury,while Actb was the most unstable internal control ***27,Ubc,Tbp,and Actb were consequently used to investigate the effects of internal control genes with differing stabilities on the normalization of target gene *** gene expression levels and changes over time were similar when Ankrd27,Ubc,and Tbp were used as internal controls but different when Actb was used as an internal *** recommend that Ankrd27,Ubc,and Tbp are used as internal control genes for real-time reverse transcription polymerase chain reaction in spinal cord injury *** study was approved by the Administration Committee of Experimental Animals,Jiangsu Province,China(approval No.20180304-008)on March 4,2018.

关键词： geNorm analysis reference genes internal control genes normalization NormFinder analysis reverse transcription-quantitative polymerase chain reaction spinal cord injury stability of gene expression

Electronic Structures and Chemical Bonding of NbS6^(-/0)Clusters

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Chinese Journal of Structural Chemistry 2016年第2期35卷 175-184页

作者： WANG Bin LI qian-qian WANG Jian-Fu HUANG Xin ZHANG Yong-fan Department of Chemistry Fuzhou UniversityFuzhou 350116China Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry Xiamen 361005China

Density functional theory（DFT） and coupled cluster theory（CCSD（T）） calculations were employed to investigate the structural and electronic properties of Nb S6^- and Nb S6 clusters. Generalized Koopmans＇ theorem was applied to predict the vertical detachment energies and simulate the photoelectron spectra（PES）. The current study indicated that various types of sulfur ligands（i.e., S^（2-）, S^（2-）, S2^（2-） and S3^（2-）） were presented in the lowest-energy structures of Nb S6^（-/0）. The ground-state structure of Nb S6^- is shown to be Cs（~1A＇） symmetry with a terminal S^（2-）, a side-on bound S2^（2-） and a S3^（2-） ligands. Molecular orbital analyses were performed to analyze the chemical bonding in NbS6^（-/0） clusters and elucidate their structural and electronic properties.

关键词： niobium sulfide cluster density functional theory(DFT) simulated photoelectron spectroscopy chemical bonding

Targeting STAT3 with SH-4-54 suppresses stemness and chemoresistance in cancer stem-like cells derived from colorectal cancer

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World Journal of Clinical Oncology 2025年第2期16卷 63-75页

作者： Xu-fan Zhang qian Chen Qin Jiang Qiong-Ying Hu Department of Nuclear Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Laboratory Medicine Hospital of Mianyang Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Over the years,the numbers of treatment options for colorectal cancer(CRC)have increased,leading to notable improvements in the overall survival of CRC *** therapy may initially yield positive results,the development of drug resistance can result in treatment failure and cancer *** resistance is often attributed to the presence of cancer stem cells(CSCs).These CSCs not only contribute to therapeutic resistance but also play crucial roles in the initiation and development of tumor *** To investigate the antitumor effects of SH-4-54,which are mediated by targeting CSCs relative to treatment *** CSCs were enriched by culturing CRC cells in serum-free *** of stemness and IL-6/JAK2/STAT3 signaling were detected by Western *** of CSC malignancy,including proliferation,invasion,and tumor formation,were *** In this study,we employed SH-4-54,which exhibits anticancer activity in solid tumors through targeting the SH2 domain of both the signal transducer and activator of transcription(STAT)3 and the STAT5,and evaluated its effects on stemness and chemoresistance in colorectal *** expected,SH-4-54 treatment inhibited the phosphorylation of STAT3(p-STAT3)and decreased the percentage of ALDH1A1-positive CRC *** addition of SH-4-54 dissociated colorectal spheroids and decreased the expression of stemness markers,including ALDH1A1,CD44 and ***-4-54 treatment decreased IL-6/JAK2/STAT3 signaling by inhibiting p-STAT3 and thus inhibited spheroid formation by SW480 and LoVo ***,SH-4-54 treatment inhibited indicators of malignancy,including cell proliferation,invasion,and tumor formation,in CSCs in vitro and in ***,SH-4-54 treatment significantly increased chemosensitivity to *** Taken together,these results indicate that SH-4-54 is a promising molecule that exerts antitumor effects on colorectal CSCs by inhibiting STAT3 signaling.

关键词： SH-4-54 Colorectal cancer Cancer stem-like cells Stemness Chemosensitivity

Effects of long-term fast charging on a layered cathode for lithium-ion batteries

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Journal of Energy Chemistry 2022年第4期31卷 604-612页

作者： Jingwei Hu Fengsong fan qian Zhang Shengwen Zhong Quanxin Ma Jiangxi Key Laboratory of Power Battery and Materials Faculty of Materials Metallurgy and ChemistryJiangxi University of Science and TechnologyGanzhou 341000JiangxiChina

Fast charging, which aims to shorten recharge times to 10–15 min, is crucial for electric vehicles(EVs),but battery capacity usually decays rapidly if batteries are charged under such severe *** the failure mechanism is a prerequisite to improving the charging performance of lithium(Li)-ion batteries. Previous studies have focused less on cathode materials while also mostly focusing on their early changes. Thus, the cumulative effect of long-term fast charging on cathode materials has not been fully studied. Here, we study the changes in a layered cathode material during 1000 cycles of 6 C charging based on 1.6 Ah LiCoO_(2)/graphite pouch cells. Postmortem analysis reveals that the surface structure, charge transfer resistance and Li-ion diffusion coefficient of the cathode degenerate during repeated fast charging, causing a large increase in polarization. This polarization-induced poor utilization of the Li inventory is an important reason for the rapid capacity fading of batteries. These findings deepen the understanding of the aging mechanism for cells undergoing fast charging and can be used as benchmarks for the future development of high-capacity, fast-charging layered cathode materials.

关键词： Fast charging Layered cathode Failure mechanism Lithium-ion batteries Capacity fading

Biotransformation of quercetin by Gliocladium deliquescens NRRL 1086

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Chinese Journal of Natural Medicines 2017年第8期15卷 615-624页

作者： XU Jia-Qi fan Ni YU Bo-Yang WANG qian-qian ZHANG Jian Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Research China Pharmaceutical UniversityNanjing 210009China Institute of Biotechnology for TCM Research School of Traditional Chinese MedicineChina Pharmaceutical UniversityNanjing 211198China

With an attempt to synthesize high-value isoquercitrin(quercetin-3-O-β-D-glucopyranoside), we carried out the biotransformation of quercetin(1) by Gliocladium deliquescens NRRL 1086. Along with the aimed product quercetin 3-O-β-D-glycoside(2), three additional metabolites, 2-protocatechuoyl-phlorogucinol carboxylic acid(3), 2,4,6-trihydroxybenzoic acid(4), and protocatechuic acid(5), were also isolated. The time-course experiments revealed that there were two metabolic routes, regio-selectivity glycosylation and quercetin 2,3-dioxygenation, co-existing in the culture. Both glycosylation and oxidative cleavage rapidly took place after quercetin feeding; about 98% quercetin were consumed within the initial 8 h and the oxdized product(2-protocatechuoyl-phlorogucinol carboxylic acid) was hydrolyzed into two phenolic compounds(2,4,6-trihydroxybenzoic acid and protocatechuic acid). We also investigated the impact of glucose content and metal ions on the two reactions and found that high concentrations of glucose significantly inhibited the oxidative cleavage and improved the yield of isoquercitrin and that Ca^(2+), Fe^(2+), Mn^(2+), Mg^(2+), and Zn^(2+) inhibited glycosylation. To test the promiscuity of this culture, we selected other four flavonols as substrates; the results demonstrated its high regio-selectivity glycosylation ability towards flavonols at C-3 hydroxyl. In conclusion, our findings indicated that the versatile microbe of G. deliquescens NRRL 1086 maitained abundant enzymes, deserving further research.

关键词： Gliocladium deliquescens NRRL 1086 Quercetin Biotransformation Glycosylation Quercetin-2,3-dioxygenase

Multiple input self-organizing-map ResNet model for optimization of petroleum refinery conversion units

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Frontiers of Chemical Science and Engineering 2023年第6期17卷 759-771页

作者： Jiannan Zhu Vladimir Mahalec Chen fan Minglei Yang Feng qian Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China Department of Chemical Engineering McMaster UniversityHamiltonOntario L8S 4L8Canada Engineering Research Center of Process System Engineering Ministry of EducationEast China University of Science and TechnologyShanghai 200237China

This work introduces a deep-learning network,i.e.,multi-input self-organizing-map ResNet(MISR),for modeling refining units comprised of two reactors and a separation *** model is comprised of self-organizing-map and the neural network *** self-organizing-map part maps the input data into multiple two-dimensional planes and sends them to the neural network *** the neural network part,residual blocks enhance the convergence and accuracy,ensuring that the structure will not be overfitted *** of the MISR model of hydrocracking unit also benefits from the utilization of prior knowledge of the importance of the input variables for predicting properties of the *** results show that the proposed MISR structure predicts more accurately the product yields and properties than the previously introduced self-organizing-map convolutional neural network model,thus leading to more accurate optimization of the hydrocracker ***,the MISR model has smoother error convergence than the previous *** operating conditions have been determined via multi-round-particle-swarm and differential evolution *** experiments show that the MISR model is suitable for modeling nonlinear conversion units which are often encountered in refining and petrochemical plants.

关键词： hydrocracking convolutional neural networks self-organizing map deep learning data-driven optimization