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Unleashing the Power of Bio-based Thermotropic Liquid Crystal Modifiers:Toughening and Reinforcing Petroleum-based Epoxy Resin without Compromising Other Properties

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Chinese Journal of Polymer Science 2024年第8期42卷 1093-1102页

作者： Qing-Yun Lu Hong-Wei Gu Jia-Hui Li qian-qian fan Bei-Tao Liu Yan Kou Xi-Gao Jian Zhi-Huan Weng State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsLiaoning Technology Innovation Center of High Performance Resin MaterialsDepartment of Polymer Science&EngineeringDalian University of TechnologyDalian 116024China Thermochemistry Laboratory Liaoning Province Key Laboratory of Thermochemistry for Energy and MaterialsDalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Toughening the petroleum-based epoxy resin blends with bio-based modifiers without compromising their modulus,mechanical strength,and other properties is still a big challenge in view of the *** this study,a bio-based liquid crystal epoxy resin(THMT-E P)with an s-triazine ring structure was utilized to modify a petroleum-based bisphenol A epoxy resin(E51)with 4,4'-diaminodiphenylsulfone(DDS)as a curing agent,and the blended systems were evaluated for their thermal stability,mechanical properties,and flame *** results showed that the impact strength of the blended system initially increased and then decreased with the increase in THMT-EP content,and it reached the a maximum value of 26.5 kJ/m^(2)when the THMT-EP content was 5%,which was 31.2%higher than that of E51/***,the flexural strength,modulus,and glass transition tem perature of the blended system were all simultaneously improved with the addition of *** the same time,the addition of THMT-EP enhanced the flame retardancy of the system by increasing the char yield at 700℃and decreasing the peak heat release rate and total heat release *** work paves the way for a more sustainable improvement in the comprehensive performance of epoxy resin.

关键词： Epoxy resin Toughening Bio-based Thermotropic liquid crystal

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Up-regulated Wnt1-inducible signaling pathway protein 1 correlates with poor prognosis and drug resistance by reducing DNA repair in gastric cancer

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World Journal of Gastroenterology 2019年第38期25卷 5814-5825页

作者： Li-Hua Zhang Yan Wang qian-qian fan Yan-Kui Liu Long-Hai Li Xiao-Wei Qi Yong Mao Dong Hua Department of Oncology Affiliated Hospital of Jiangnan UniversityJiangnan UniversityWuxi 214062Jiangsu ProvinceChina School of Pharmaceutical Sciences Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Wuxi Medical College Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Gynecology Zaozhuang Maternal and Child Health HospitalZaozhuang 277100Shandong ProvinceChina Department of Pathology Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina

BACKGROUND Wnt1-inducible signaling pathway protein 1(WISP1)is upregulated in several types of human cancer,and has been implicated in cancer ***,its clinical implications in gastric cancer(GC)remain *** To explore the expression pattern and clinical significance of WISP1 in *** Public data portals,including Oncomine,The Cancer Genome Atlas database,Coexpedia,and Kaplan-Meier plotter,were analyzed for the expression and clinical significance of WISP1 mRNA levels in *** hundred and fifty patients who underwent surgery for GC between February 2010 and October 2012 at the Affiliated Hospital of Jiangnan University were selected for validation ***1 levels were measured at both the mRNA and protein levels by RTqPCR,Western blot analysis,and immunohistochemistry(IHC).In addition,the in situ expression of WISP1 in the GC tissues was determined by IHC,and the patients were accordingly classified into high-and low-expression *** correlation of WISP1 expression status with patient prognosis was then determined by univariate and multivariate Cox regression ***1 was knocked down by RNA *** 50%inhibitory concentration of oxaliplatin was detected by CellTiter-Blue *** WISP1 levels at both the mRNA and protein levels were remarkably upregulated in GC tissues compared to normal ***,IHC revealed that WISP1 expression was associated with T stage and chemotherapy outcome,but not with lymph node metastasis,age,gender,histological grade,or histological *** patients with high WISP1 expression showed a poor overall *** survival analysis indicated that WISP1 was an important prognostic factor for GC ***,knock-down of WISP1 expression enhanced sensitivity to oxaliplatin by reducing DNA repair and enhancing DNA *** Significantly upregulated WISP1 expression is associated with cancer progression,chemotherapy outcome,and prognosis in ***

关键词： Wntl-inducible signaling pathway protein 1 Biomarker Bioinformatics analysis Chemotherapy outcome Gastric cancer

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Rational modulation of fluorophosphate cathode by anionic groups to reduce the polarization behavior for fast-charging sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang fan Zhang Xingyu Zhou qian Wang Changyu Liu Yangyang Liu Hui Wang Xiaojie Liu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

Na3V2（PO4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge ***,the average Na+diffusion coefficient of Na3V2（PO4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation Polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode

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Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： qian Yin fan Wen Zhigang Tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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Comparison of two vasopressor protocols for preventing hypotension post-spinal anesthesia during cesarean section: a randomized controlled trial

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Chinese Medical Journal 2021年第7期134卷 792-799页

作者： qian-qian fan Yong-Hui Wang Jing-Wen Fu Hai-Long Dong Man-Ping Yang Duo-Duo Liu Xiao-fan Jiang Zhi-Xin Wu Li-Ze Xiong Zhi-Hong Lu Department of Anesthesiology and Perioperative Medicine Xijing HospitalFourth Military Medical UniversityXi’anShaanxi 710032China Department of Gynecology and Obstetrics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi 710032China Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi 710032China Department of Anesthesiology and Translational Research Institute of Brain and Brain-like Intelligence Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200081China.

Background:Norepinephrine infusion decreases hypotension after spinal anesthesia during cesarean *** study aimed to compare the efficacy of norepinephrine infusion and ephedrine bolus against post-spinal hypotension in ***:In this double-blinded,randomized controlled clinical trial,parturients scheduled for elective cesarean section were randomly allocated to receive norepinephrine infusion(0.05μg·kg^(-1)·min^(-1))just before spinal anesthesia continuing for 30 min or ephedrine bolus(0.15 mg/kg)just before spinal anesthesia.A rescue bolus(5μg norepinephrine for the norepinephrine group,and 5 mg ephedrine for the ephedrine group)was administered whenever hypotension *** primary outcome was the incidence of hypotension within 30 min of spinal anesthesia *** outcomes included maternal and neonatal outcomes 30 min after spinal block,and neonatal cerebral oxygenation 10 min after ***:In total,190 patients were enrolled;of these patients,177 were included in the final *** patients suffered hypotension in the norepinephrine group than in the ephedrine group(29.5%vs.44.9%,odds ratio[OR]:0.51,95%confidence interval[CI]:0.28-0.95,P=0.034).Moreover,the tachycardia frequency was lower in the norepinephrine group than in the ephedrine group(OR:0.22,95%CI:0.11-0.44,P<0.001),and patients suffered less nausea and vomiting(OR:0.28,95%CI:0.11-0.70,P=0.004).There was no difference in Apgar scores and umbilical arterial blood gas analysis between the two ***,neonatal cerebral regional saturations were significantly higher after birth in the norepinephrine group than in the ephedrine group(mean difference:2.0%,95%CI:0.55%-3.45%,P=0.008).Conclusion:In patients undergoing elective cesarean section with spinal anesthesia,norepinephrine infusion compared to ephedrine bolus resulted in less hypotension and tachycardia,and exhibited potential neonatal benefits.

关键词： Hypotension Spinal anesthesia Norepinephrine Ephedrine Cesarean section

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利用外接CO_2激光源的中红外ATR光谱仪原位无创探测人体血糖浓度

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光谱学与光谱分析 2017年第1期37卷 85-88页

作者：张芊茜范玉玲何秀全孙渝明济南大学信息科学与工程学院山东济南250022 山东大学医学院山东济南250012 山东大学信息科学与工程学院山东济南250100

糖尿病是一种严重威胁人类健康的疾病,取血检测人体血糖浓度造成病患痛苦甚至感染。因此人体血糖浓度的无创检测技术在糖尿病的临床诊断、监测和治疗上具有重要的意义,也是一个具有挑战性的热点研究课题。在目前报道的各种测试方法中,... 详细信息

糖尿病是一种严重威胁人类健康的疾病,取血检测人体血糖浓度造成病患痛苦甚至感染。因此人体血糖浓度的无创检测技术在糖尿病的临床诊断、监测和治疗上具有重要的意义,也是一个具有挑战性的热点研究课题。在目前报道的各种测试方法中,中红外光谱测试技术受到了广泛重视。利用常规光源的中红外ATR光谱仪进行无创血糖检测时,由于探测光在人体组织中穿透深度低,难以到达含有体液的间质层乃至含有血液信息的真皮层,结果导致测试数据与人体实际血糖浓度的相关性差,限制了临床应用。考虑到高强、高纯的中红外激光在人体组织中具有较深的穿透深度,且CO2激光器的1 035cm-1的发射光非常接近葡萄糖在1 029cm-1处的基频特征吸收峰,因此本文使用外接CO2激光器作为中红外ATR光谱仪的自定义外接光源,组装了新型中红外测试系统。利用此设备,测试了人手指在1 035cm-1激光辐照下的吸光度,同时利用普通光源扫描了人手指的中红外吸收光谱,记录其在1 492cm-1的吸光度。利用常规医学方法测定了人体实际血糖值。结果显示,人手指处受1 035cm-1激光辐照的吸光度与常规光源的红外光谱中1 492cm-1处吸光度的相对强度与人体血糖浓度同步改变,两波数处吸光度的比值与人体实际血糖浓度具有一定的正相关性(R=0.812 5)。测量结果可作为人体血糖值的一个新型指标,显示了外接CO2激光源的中红外ATR光谱仪在无创探测人体血糖浓度方面的临床诊断潜力。

关键词：中红外光谱自定义外接激光源人体血糖无创探测

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Co@C-N as an electronic mediator anchored with Cu2O nanoparticles enables efficient photoreduction of CO2 to CO with nearly 100% selectivity

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Science China Chemistry 2025年

作者： Xingbin Pan Xiuzheng Deng Jingshan fan Jiangchuan Liu Changhai Liu Zhongyu Li qian Liang Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology CNPC-CZU Innovation Alliance School of Petrochemical Engineering Changzhou University School of Materials Science & Engineering Changzhou University

Solar-driven CO2conversion into value-added chemical provides an attractive strategy for sustainable development. However,the enhanced CO2photoreduction performance with target product selectivity remains a major challenge. Here, we develop a novel strategy involving Cu2O nanoparticles in situ grown on the surface of ZIF-67-derived Co@C-N nanocages （CC） to create abundant active sites and appropriate heterointerfaces. A remarkable CO selectivity of 95.7%with a yield of 117.39μmol g-1h-1and an apparent quantum efficiency as high as 1.88%at 420 nm was obtained over CC-60 catalyst in pure water, which was 87.6times higher than that of pure Cu2O. Theoretical calculations and experiments indicated that Co@C-N nanocages as charge mediator not only rapidly trap photogenerated electrons to promote charge separation efficiency, but also regulate the d-band center of Cu atoms to move to the Fermi energy level, thereby optimizing the reaction kinetics to facilitate the highly selective conversion of the key intermediate *CO desorption to CO.

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Charaterization of Citrus Hybrid ＂Huangguogan＂ through the Combination of Morphological and Molecular Markers

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Journal of Life Sciences 2013年第4期7卷 348-352页

作者： Xue-Fei Wang Xi-Rui Xiong Xue-Li Pu Qiao-Qiao Yan Bo Xiong Feng-Ling Liao qian-qian fan Zhi-Hui Wang College of Horticulture Sichuan Agricultural University Ya 'An 625014 SiChuan China

Huangguogan, an obvious Citrus hybrid, is suitable for transportation and export and ripens in March or April. Because of late season, it may playa significant role in fruit market. However, its origin is still unconfirmed. The aim of this study was to clarify the possible parentage of Huangguogan via the combination of morphological and molecular markers including simple sequence repeat （SSR） and chloroplast simple sequence repeat （cpSSR）. Analysis of morphological traits including leaf stalk length, phylliform index and fruit shape index indicated that Huangguogan had similarities in morphology with Sweet orange. The SSR Cluster Analysis showed that Huangguogan was clustered together with Hongju tangerine and revealed -80% genetic similarity. They illustrated a close genetic distance between Huangguogan and Hongju tangerine. In addition, the bands of2 polymorphic cpSSR were identical in Huangguoggan and Sweet orange. Consequently, it is likely that its female parentage was the sweet orange （Citrus sinensis （L.） Osbeck） and its male parentage was the tangerine （Citrus reticulata Blanco）.

关键词： Citrus natural hybrid huangguogan morphological and molecular markers.

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Chiral phosphoramidite ligand-modulated palladium auto-tandem catalysis for asymmetric dehydrogenative dienylation of imines with α-alkenes

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Science China Chemistry 2025年

作者： Zhong-Sheng Nong Hao-fan qian Ying-Chun Chen Pu-Sheng Wang Liu-Zhu Gong Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China Key Laboratory of Drug Targeting and Drug Delivery System (Sichuan University) Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University School of Materials and Chemistry Southwest University of Science and Technology

The development of efficient processes allowing rapid access to complex chiral molecules from easily available alkenes is a long-term pursuit in the synthetic chemistry community. Transition metal-catalyzed asymmetric functionalization of allylic C–H bond represents a unique alternative toward this goal. However, enantioselective dehydrogenative transformation of olefins to value-added optically enriched molecules remains yet to be discovered. Here, we report a highly enantioselective dehydrogenative dienylation of imines with unactivated α-alkenes driven by the synergistic action of palladium complex and carboxylic acid. Chiral phosphoramidite ligands turned out to be superior in modulating the performance of palladium autotandem catalysis and allowed a broad range of α-alkenes and imines to be transformed into chiral dienylamines. Mechanistic studies suggest that the dienes could be in situ generated from α-alkenes through a palladium(0)-mediated dehydrogenative process in the presence of excess benzoquinone oxidants, and then participated in the Pd-chiral phosphoramidite-catalyzed intermolecular vinylogous-type addition to the imines activated by the carboxylic acid co-catalyst. Notably, the second β-H elimination occurring in the dienylation event might be the turnover-limiting step.

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui fan Li Chen Jie Wang Xiao-qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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