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High-quality genomes of Bombax ceiba and Ceiba pentandra provide insights into the evolution of Malvaceae species and differences in their natural fiber development

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Plant Communications 2024年第5期5卷 189-207页

作者： Lei Shao Shangkun jin jinwen Chen Guangsui Yang Rui Fan Zhiyuan Zhang qian Deng jin Han Xiaowei Ma Zeyu Dong Hejun Lu Wanying Hu Kai Wang Lisong Hu Zhen Shen Surong Huang Ting Zhao Xueying Guan Yan Hu Tianzhen Zhang Lei Fang Zhejiang Provincial Key Laboratory of Crop Genetic Resources Institute of Crop SciencePlant Precision Breeding AcademyCollege of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China Hainan Institute of Zhejiang University Sanya 572025China Tropical Crop Germplasm Research Institute Chinese Academy of Tropical Agricultural SciencesHaikou 571101China Spices and Beverages Research Institute Chinese Academy of Tropical Agricultural SciencesWanning 571533China School of Life Sciences Nantong UniversityNantong 226019China

Members of the Malvaceae family,including Corchorus spp.,Gossypium spp.,Bombax spp.,and Ceiba spp.,are important sources of *** the past decade,the genomes of several Malvaceae species have been assembled;however,the evolutionary history of Malvaceae species and the differences in theirfiber development remain to be ***,we report the genome assembly and annotation of two nat-uralfiber plants from the Malvaceae,Bombax ceiba and Ceiba pentandra,whose assembled genome sizes are 783.56 Mb and 1575.47 Mb,*** analysis revealed that whole-genome duplication and Gypsy long terminal repeat retroelements have been the major causes of differences in chromosome number(2n=14 to 2n=96)and genome size(234 Mb to 2676 Mb)among Malvaceae *** also used comparative genomic analyses to reconstruct the ancestral Malvaceae karyotype with 11 proto-chromo-somes,providing new insights into the evolutionary trajectories of Malvaceae ***-MIXTA-like 3 is relatively conserved among the Malvaceae and functions infiber cell-fate determination in the *** appears to perform this function in any tissue where it is expressed,*** on the endo-carp of *** and in ovulefibers of *** identified a structural variation in a cellulose synthase gene and a higher copy number of cellulose synthase-like genes as possible causes of thefiner,less spinnable,weakerfibers of *** study provides two high-quality genomes of naturalfiber plants and offers insights into the evolution of Malvaceae species and differences in their naturalfiber formation and devel-opment through multi-omics analysis.

关键词： Malvaceae species genome evolution ancestral karyotype fiber differentiation

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TOPMODEL模型在长江上游无资料地区的水文模拟

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水电能源科学 2018年第9期36卷 44-47页

作者：金倩芳周建中严冬孙娜华中科技大学水电与数字化工程学院湖北武汉430074

针对无资料地区水文模拟精度不高的问题,以长江上游李庄、朱沱、寸滩、宜昌四个子流域为例,假定其中一个流域无实测资料,其余流域为参证流域,分别选择TOPMODEL模型和新安江模型,以多目标算法MOCSCDE进行模型参数率定后,移用于无资料流域... 详细信息

针对无资料地区水文模拟精度不高的问题,以长江上游李庄、朱沱、寸滩、宜昌四个子流域为例,假定其中一个流域无实测资料,其余流域为参证流域,分别选择TOPMODEL模型和新安江模型,以多目标算法MOCSCDE进行模型参数率定后,移用于无资料流域,开展水文模拟研究工作与结果分析。结果表明,TOPMODEL模型径流模拟结果与实际具有更高的拟合度,更适用于无资料情况下的流域水文模拟,为TOPMODEL模型在无资料地区的应用提供一定依据。

关键词： TOPMODEL模型无资料地区水文模拟参数移植

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Mitigated reaction kinetics between lithium metal anodes and electrolytes by alloying lithium metal with low-content magnesium

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Journal of Energy Chemistry 2024年第8期95卷 644-650,I0014页

作者： Yang-Yang Wang Ya-Nan Wang Nan Yao Shu-Yu Sun Xiao-Qing Ding Chen-Xi Bi qian-Kui Zhang Zhao Zheng Cheng-Bin jin Bo-Quan Li Xue-qiang Zhang Jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018ZhejiangChina

Lithium(Li)metal is regarded as a promising anode candidate for high-energy-density rechargeable ***,Li metal is highly reactive against electrolytes,leading to rapid decay of active Li metal ***,alloying Li metal with low-content magnesium(Mg)is proposed to mitigate the reaction kinetics between Li metal anodes and *** atoms enter the lattice of Li atoms,forming solid solution due to the low amount(5 wt%)of *** atoms mainly concentrate near the surface of Mg-alloyed Li metal *** reactivity of Mg-alloyed Li metal is mitigated kinetically,which results from the electron transfer from Li to Mg atoms due to the electronegativity *** on quantitative experimental analysis,the consumption rate of active Li and electrolytes is decreased by using Mgalloyed Li metal anodes,which increases the cycle life of Li metal batteries under demanding ***,a pouch cell(1.25 Ah)with Mg-alloyed Li metal anodes delivers an energy density of 340 Wh kg^(-1)and a cycle life of 100 *** work inspires the strategy of modifying Li metal anodes to kinetically mitigate the side reactions with electrolytes.

关键词： Lithium metal anodes Alloying Anode/electrolyte interface Reaction kinetics Pouch cell

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Design of SiNridge-slot micro-ring resonator and generation of dual-comb based on orthogonally bicolor pumping

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Optoelectronics Letters 2024年

作者： Wen jin Wang qian Yu Huimin Wu Zhengwei Zhang Hui School of Science， Xi'an Shiyou University Shaanxi Engineering Research Center of Oil and Gas Resource Optical Fiber Detection Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas wells

A novel high quality-factor （Q） micro-ring resonator （MRR） structure based on the Si3N4ridge-slot waveguide is proposed， and the MRR is pumped by orthogonally polarized bicolor pumping to generate dual-comb. We optimized the structure of MRR by the finite element method and precise dispersion engineering， which finally obtained the suitable MRR geometry with negative dispersion characteristics at 1550 nm， having Q of 1.7×107and the absorption loss as low as 2.6×10-5dB/cm. The simulation model of generating dual-comb is established as coupled Lugiato-Lefever equation （LLE）， which takes into account the higher order dispersion， cross-phase modulation （XPM）， multiphoton absorption， and external pumping. Solved by the split-step Fourier method （SSFM） and the fourth-order Runge-Kutta （RK4） method， the numerical results show that the generated dual-comb is periodically equally spaced distribution but with slightly different intensities in the time domain. In the frequency domain， there are 64 comb teeth with intensities higher than -100 dBm with a bandwidth of 120 nm. Particularly， in the case of bicolor orthogonal polarization pumping， a smaller amount of detuning does not greatly affect the bandwidth of the dual-comb.

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Participant Heterogeneity of Systemic Scleroderma Interventional Trials Worldwide

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International Journal of Dermatology and Venereology 2024年第2期7卷 99-107页

作者： Li-Qing Shi Shi-Hang zhou Ping-Lang Ruan Bo Zhang Yue Xin Cheng Zhao Xu Yao jing-Ru Tian qian-jin Lu Hospital for Skin Diseases(Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases Chinese Academy of Medical SciencesNanjingJiangsu 210042China Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs NanjingJiangsu 210042China Department of Dermatology Hunan Key Laboratory of Medical Epigenomicsthe Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China

Objective:Heterogeneity of participants in clinical trials distorts intervention ***,factors associated with participant heterogeneity in randomized clinical trials(RCTs)focusing on systemic sclerosis(SSc)are not *** conducted this systematic review to establish normative standards for future research and help develop management ***:Three databases and 4 registries were searched to identify characteristics of SSc RCTs across different *** of bias was assessed by the Cochrane Collaboration’s tool and logistic regression was performed to calculate crude and adjusted odds ***:In total,261 trials met our inclusion *** quality of SSc RCTs worldwide was relatively poor,with no trend of improvement in recent years,and only 12.2%were ranked as having a low risk of *** with a low risk of bias as well as single-center,single-country,or open-label trials tended to have better participant adherence than trials with a high risk of bias and multiple-center,multiple-country,or double-blind ***,trial registration and primary outcome definition contributed to high *** income was also relevant;participant adherence in high-income countries,but not in upper-and lower-middle-income countries,was significantly altered by different ***:Overall,the risk of bias,national income,and trial design may lead to participant heterogeneity of SSc RCTs and ultimately confound the general clinical utility of the *** with a rigorous design and transparent conduction protocol are crucial for obtaining unbiased data that can serve as a reference and for maintaining the fundamental repeatability of SSc RCTs.

关键词： systemic sclerosis randomized clinical trials heterogeneity participant adherence national income risk of bias

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Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1302-1316页

作者： Xinyuan Xu qian Zhang Xufeng Wang jing jin Chengwei Wu Li Feng Xiuyan Yang Mingzhu Zhao Yingyi Chen Shaoyong Lu Zhen Zheng Xiaobing Lan Yi Wang Yan Zheng Xuefeng Lu Qiufen Zhang Jian Zhang State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Medicinal Chemistry and BioinformaticsCenter Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Basic Medicine and Medical CenterUniversity of Science and Technology of ChinaHefei 230026China Department of Assisted Reproduction Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Pharmacy Ningxia Medical UniversityYinchuan 750004China Department of Pancreatic Surgery Shanghai General HospitalShanghai Key Laboratory of Pancreatic DiseaseInstitute of Pancreatic DiseaseShanghai Jiao Tong University School of MedicineShanghai 200080China

Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour ***6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic ***,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be ***,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/***,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/*** allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural ***,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver *** our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic *** not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer.

关键词： SIRT6 Inhibitor Allosteric Selectivity Cocrystal Pancreatic cancer metastasis

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Robust free-space optical frequency transfer in time-varying link distances conditions

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Chinese Physics B 2024年第2期33卷 271-276页

作者：童周刘雷王家亮操前金志成应康韩申生韩正甫桂有珍 School of Physical Sciences University of Science and Technology of ChinaHefei 230000China Key Laboratory for Quantum Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Space Laser Communication and Detection Technology Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China

Future inter-satellite clock comparison on high orbit will require optical time and frequency transmission technology between moving ***,we demonstrate robust optical frequency transmission under the condition of variable link *** variable link is accomplished by the relative motion of a single telescope fixed on the experimental platform to a corner-cube reflector(CCR)installed on a sliding *** acousto–optic modulators with different frequencies are used to separate forward signal from backward *** active phase noise suppression,when the CCR moves back and forth at a constant velocity of 20 cm/s and an acceleration of 20 cm/s^(2),we achieve the best frequency stability of 1.9×10^(-16) at 1 s and 7.9×10^(-19) at 1000 s *** work paves the way for future studying optical frequency transfer between ultra-high-orbit satellites.

关键词： free-space optical frequency transfer variable link distance

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卫生基础设施与健康人力资本

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中国经济问题 2024年第2期 91-105页

作者：王奇赵钊周倩晋晓姝四川大学商学院华北水利水电大学管理与经济学院西南财经大学经济与管理研究院中共四川省委党校区域经济教研部

农村厕所革命工程是健康中国行动和乡村振兴战略的重要内容。本文基于该工程在行政村层面上的政策冲击,利用2017年中国乡村治理调查与中国家庭金融调查数据,研究卫生基础设施建设对个体健康水平的影响及其作用机制。研究发现,行政村实... 详细信息

农村厕所革命工程是健康中国行动和乡村振兴战略的重要内容。本文基于该工程在行政村层面上的政策冲击,利用2017年中国乡村治理调查与中国家庭金融调查数据,研究卫生基础设施建设对个体健康水平的影响及其作用机制。研究发现,行政村实施卫生改厕显著提高了个人自评健康水平,在考虑选择性偏误导致的内生性问题后该结论依然稳健。机制分析表明,降低疾病传播是农村卫生改厕提升健康水平的重要渠道。同时,这一健康效应在医疗可得性差、国家级贫困县以及年龄较大的组别中更为显著。本文为厕所革命促进健康中国建设提供了有力的经验证据支撑。

关键词：卫生基础设施健康人力资本厕所革命疾病传播

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Highly selective growth of(6,5)single-walled carbon nanotubes from sigma phase alloy catalyst

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Nano Research 2024年第3期17卷 1999-2003页

作者： Liantao Xin Chen Ma qianru Wu Shaokang Liu Linhai Li Xiuyun Zhang Liu qian Maoshuai He Dong Li Fangqian Han Shulan Hao Lihu Feng Yahan Li Huaping Liu Lili Zhang Chang Liu jin Zhang College of Chemistry and Molecular Engineering Qingdao University of Science and TechnologyQingdao 266042China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China College of Physics Science and Technology Yangzhou UniversityYangzhou 225002China Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The chirality structure of a single-walled carbon nanotube(SWNT)strongly depends on the composition of catalyst used in the chemical vapor deposition *** this study,we develop a porous magnesia supported manganese-rhenium(MnRe/MgO)catalyst for chirality-selective synthesis of *** characterizations reveal that(6,5)tubes with a selectivity higher than 70%are grown from the Re-rich MnRe/MgO *** comparing the SWNT growth results with those of monometallic Mn or Re,the formation of sigma phase,an intermetallic compound occurring in transition-metal alloy systems,is revealed to be crucial for the dominant synthesis of(6,5)*** work not only extends the application of sigma phase alloy for catalytic synthesis of SWNTs,but also sheds lights on the growth of SWNTs with a high chirality selectivity.

关键词： single-walled carbon nanotubes sigma phase manganese-rhenium catalyst selective growth transition-metal alloy

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胺碘酮治疗急诊快速性心律失常的疗效与安全性

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中国医院用药评价与分析 2017年第4期17卷 479-481页

作者：吴礼文钱进周清东莞市黄江医院急诊科广东东莞523750

目的:探讨胺碘酮治疗急诊快速性心律失常的疗效和安全性。方法:选取2014年9月—2016年6月东莞市黄江医院急诊收治的快速性心律失常患者70例,按随机数字表法分为观察组和对照组,每组35例。观察组患者给予胺碘酮治疗,对照组患者给予利多... 详细信息

目的:探讨胺碘酮治疗急诊快速性心律失常的疗效和安全性。方法:选取2014年9月—2016年6月东莞市黄江医院急诊收治的快速性心律失常患者70例,按随机数字表法分为观察组和对照组,每组35例。观察组患者给予胺碘酮治疗,对照组患者给予利多卡因治疗。比较两组患者的临床疗效与不良反应发生情况,并监测患者治疗前后血压及心率变化情况。结果:观察组患者的总有效率为94.29%(33/35),明显高于对照组的77.14%(27/35),差异有统计学意义(P0.05)。结论:胺碘酮治疗急诊快速性心律失常的疗效较好,可明显改善患者的血压、心率,安全性较高。

关键词：快速性心律失常胺碘酮治疗效果

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