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Clinical study on Salvia Miltiorrhiza + calcium dobesilate treatment of early retinopathy of type 2 diabetes mellitus

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Journal of Hainan Medical University 2019年第18期25卷 57-61页

作者： Du-Qin wang Rui-Juan Guan qian-han wang Ling Li Li Wan Traditional Chinese Medicine Hospital of Shijingshan District Beijing 100043China Teaching and Research Section of Traditional Chinese Medicine Department of Sports MedicineChengdu Sports UniversityChengduSichuan Province610075

Objective:To study the efficacy of Salvia Miltiorrhiza+calcium dobesilate for early retinopathy of type 2 diabetes ***:The patients with non-proliferative diabetic retinopathy admitted to our hospital between August 2016 and February 2018 were chosen and randomly divided into the observation group receiving Salvia Miltiorrhiza+calcium dobesilate treatment and the control group receiving calcium dobesilate *** treatment and 3 months after treatment,ophthalmologic examination was conducted to measure the hemangioma volume,macular thickness and blood spot area,and serum was collected to measure the contents of angiogenesis molecules,inflammation molecules and oxidative stress ***:The hemangioma volume,macular thickness and blood spot area as well as serum hypoxia-inducible factor-1α(HIF-1α),vascular endothelial growth factor(VEGF),erythropoietin(EPO),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),intercellular adhesion molecule-1(ICAM-1),malondialdehyde(MDA)and advanced oxidation protein product(AOPP)levels of both groups were significantly lower whereas serum pigment epithelium-derived factor(PEDF),heme oxygenase-1(HO-1),vitamin E(VitE)and total antioxidant capacity(TAC)levels were significantly higher after treatment,and the hemangioma volume,macular thickness and blood spot area as well as serum HIF-1α,VEGF,EPO,IL-1β,TNF-α,ICAM-1,MDA and AOPP levels of observation group after treatment were significantly lower than those of control group whereas serum PEDF,HO-1,VitE and TAC levels were significantly higher than those of control ***:Salvia Miltiorrhiza+calcium dobesilate treatment of early retinopathy of type 2 diabetes mellitus is more effective than calcium dobesilate alone in improving the condition and inhibiting the angiogenesis,inflammation and oxidative stress.

关键词： Type 2 diabetes mellitus Diabetic retinopathy Salvia Miltiorrhiza Angiogenesis Inflammation Oxidative stress

Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer

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Science China Chemistry 2025年第1期 35-45页

作者： Xinyu Peng qian Ma Da han School of Life Science Shanghai University Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine State Key Laboratory of Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Department of Research and Development Intellinosis Biotechnologies Co.Ltd.

Gastric cancer(GC) is a prevalent and lethal malignancy worldwide, and the 5-year survival rate is less than 30%. The absence of distinctive symptoms often leads to late-stage diagnosis, contributing to a grim prognosis. Early detection is pivotal for improving the survival rates and outcomes of GC patients. Traditional diagnostic methods, including gastroscopy and histopathological examination, are restricted in the early diagnosis of GC. Conventional protein biomarkers, such as carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9), and carbohydrate antigen 72-4(CA72-4), exhibit insufficient sensitivity and specificity for GC screening, which diminishes their clinical value. Recently, novel circulating biomarkers, such as circulating tumor cells(CTCs), circulating tumor cell DNA(ct DNA), and circulating free RNA(cf RNA), have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and specificity. This review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.

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粗号无捻转杯纱的开发技术要点

棉纺织技术 2017年第3期45卷 44-47页

作者：刘倩韩冰王贵宁河北宏润新型面料有限公司河北保定071500

探讨粗号无捻转杯纱生产中应采取的技术措施。介绍了116.6tex转杯纱的生产工艺,并就其中技术难点,如转杯速度的实现,相应报警参数的设置,与9.7tex水溶丝倍捻工艺优选,水溶纤维溶解工艺等做了相关阐述,最终实现了116.6tex无捻纱的批量生... 详细信息

探讨粗号无捻转杯纱生产中应采取的技术措施。介绍了116.6tex转杯纱的生产工艺,并就其中技术难点,如转杯速度的实现,相应报警参数的设置,与9.7tex水溶丝倍捻工艺优选,水溶纤维溶解工艺等做了相关阐述,最终实现了116.6tex无捻纱的批量生产。认为:粗号无捻纱的生产需要综合考虑转杯直径、转杯速度、捻度设计等参数的设定,才能使其达到风格独特、手感柔软的效果。

关键词：转杯纺无捻纱退捻水溶丝粗号纱倍捻

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影响体外鼠胚试验标准化的要素分析

中国比较医学杂志 2017年第7期27卷 102-106页

作者：史建峰韩倩倩王春仁中国食品药品检定研究院医疗器械检定所生物材料室北京102629

不孕症已成为影响人类生殖健康的全球性问题,作为治疗不孕症的一种重要治疗手段,辅助生殖技术经过几十年的发展已经获得长足进步。辅助生殖技术用医疗器械产业快速发展,对此类产品进行风险管理,制定相应的安全性评价检测方法已势在必行... 详细信息

不孕症已成为影响人类生殖健康的全球性问题,作为治疗不孕症的一种重要治疗手段,辅助生殖技术经过几十年的发展已经获得长足进步。辅助生殖技术用医疗器械产业快速发展,对此类产品进行风险管理,制定相应的安全性评价检测方法已势在必行。2016年行业标准YY/T 1434-2016《人类体外辅助生殖技术用医疗器械体外鼠胚试验》已经发布,本文就体外鼠胚试验中的关键节点和试验体系要素进行简要综述。

关键词：辅助生殖技术体外鼠胚试验 2-细胞阻滞医疗器械

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song qian-qian Wan Yu-Ming wang han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

IEEE 802.15.4中信道利用率的分析与改进

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计算机工程 2014年第4期40卷 103-107页

作者：孙启钱汉望刘建坡邱云周中国科学院上海微系统与信息技术研究所上海200050

在分析IEEE 802.15.4网络中为时延敏感应用提供的保护时隙(GTS)分配策略后,指出GTS分配中信道利用率低等不足。为此,对IEEE 802.15.4中的GTS进行改进。将GTS时隙再次划分为微时隙,与标准GTS申请命令不同,节点无须指定所需的GTS长度,而... 详细信息

在分析IEEE 802.15.4网络中为时延敏感应用提供的保护时隙(GTS)分配策略后,指出GTS分配中信道利用率低等不足。为此,对IEEE 802.15.4中的GTS进行改进。将GTS时隙再次划分为微时隙,与标准GTS申请命令不同,节点无须指定所需的GTS长度,而是提供需要发送的数据数量和数据长度,通过协调节点来决定所分配的GTS长度。仿真实验结果表明,改进后协议能提高信道利用率和网络吞吐量。

关键词： IEEE 802 15 4标准无线传感器网络介质访问控制保护时隙信道利用率

Motion Control and Optimal Design of a Biomimetic Manipulator Based on Snake Coiling and Stretching

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Journal of Bionic Engineering 2023年第4期20卷 1514-1531页

作者： Jiangjie han Yongshang wang Mengbo qian Zhejiang A&F University LinanHangzhou311300China

The traditionally articulated manipulator had a single control method,and the limited motion trajectory space was unsuitable for working in an unstructured *** paper introduces a control method and optimization for a multijoint manipulator Inspired by snakes'curling and stretching ***,we analyze the manipulator’s connection mode and motion planning and propose a new motion *** addition,we calculated the relevant positions and angles and subdivided the motion of some joints based on the principle of the meta-heuristic ***,the manipulator in this mode has a larger workspace and more flexible motion *** experimental results are consistent with the theoretical analysis,which further proves the feasibility and scalability of the scheme.

关键词： Bio-inspired robotic system Manipulator motion control Continuum robots Flexible robots Snake-like

Bionic iontronics based on nano-confined structures

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Nano Research 2023年第9期16卷 11718-11730页

作者： han qian Di Wei Zhong Lin wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

The Moore’s law in silicone-based electronics is reaching its limit and the energy efficiency of the most sophisticated electronics to mimic the iontronic logic circuit in single-celled organisms is still inferior to their natural *** electronics,iontronics is widely present in nature,and provides the fundamentals for many life activities through the transmission and conversion of information and energy via ***,as nanotechnology and fabrication processes continue to advance,highly efficient iontronics could be enabled by creation of asymmetry from nano-confined unipolar ion transport through various nanohierarchical structures of *** introduction of bionic design and nanostructures has made it possible for ions to demonstrate numerous anomalous behaviours and entirely new mechanisms,which are governed by complex interfacial *** this review,we discuss the origins,development,mechanism,and applications of bionic iontronics and analyze the unique benefits as well as the practicality of iontronics from a variety of ***,as an emerging field of research with innumerable challenges and opportunities for exploring the theory and applications of ions as transport carriers,promises to provide new insights in many subjects covering energy and sensing,etc.,and establishes a new paradigm in investigating the ionic-electric signal transduction interface for futuristic iontronic logic circuit and neuromorphic computing.

关键词： iontronics electronics nano-confined ion transport nanofluidic asymmetry

Mechanistic insights into stepwise activation of malachite for enhancing surface reactivity and flotation performance

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2159-2172页

作者： Qicheng Feng Wanming Lu han wang qian Zhang State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Faculty of Land Resource EngineeringKunming University of Science and TechnologyKunming 650093China Yunnan Key Laboratory of Green Separation and Enrichment of Strategic Mineral Resources Kunming University of Science and TechnologyKunming 650093China

Malachite is a common copper oxide mineral that is often enriched using the sulfidization-xanthate flotation ***,the direct sulfidization method cannot yield copper concentrate ***,a new sulfidization flotation process was developed to promote the efficient recovery of *** this study,Cu^(2+) was used as an activator to interact with the sample surface and increase its reaction sites,thereby strengthening the mineral sulfidization process and *** to single copper ion activation,the flota-tion effect of malachite significantly increased after stepwise Cu^(2+) *** potential,X-ray photoelectron spectroscopy(XPS),time-of-flight secondary ion mass spectroscopy(ToF-SIMS),scanning electron microscopy and energy dispersive spectrometry(SEM-EDS),and atomic force microscopy(AFM)analysis results indicated that the adsorption of S species was significantly enhanced on the mineral surface due to the increase in active Cu sites after Cu^(2+) stepwise ***,the proportion of active Cu-S spe-cies also increased,further improving the reaction between the sample surface and subsequent ***-transform infrared spec-troscopy(FT-IR)and contact angle tests implied that the xanthate species were easily and stably adsorbed onto the mineral surface after Cu^(2+) stepwise activation,thereby improving the hydrophobicity of the mineral ***,the copper sites on the malachite sur-face after Cu^(2+) stepwise activation promote the reactivity of the mineral surface and enhance sulfidization flotation of malachite.

关键词： malachite copper ions stepwise activation flotation mechanism enhanced sulfidization