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Biodistribution and Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles In Vitro and In Vivo

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Current Medical Science 2018年第6期38卷 1096-1102页

作者： Qin YU Xiao-qin XIONG Lei ZHAO Ting-ting XU Hao BI Rong fu qian-hua wang Department of Clinical Laboratory Wuhan Blood CenterWuhan 430000China School of Chemistry and Life Science Hubei University of EducationWuhan 430205China Department of Obstetrics and Gynecology Union HospitalHuazhong University of Science and TechnologyWuhan 430022China

Biodistribution and toxicity assessment are critical for safe clinical use of newly developed *** iron oxide nanoparticles (SPION)are effective carriers for targeted drug *** study aimed to examine the toxicity and biodistribution of SPION coated with polyethylenimine (PEI)(SPION-PEI)designed for small interfering RNA (siRNA) delivery both in vitro and in ***-PEI/siRNA complexes were prepared at different weight *** effects of SPION-PEI/siRNA on HSC-T6 cell viability were determined by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT).Rats were divided into three groups:a control group,a normal-saline group and a SPION-PEI/siRNA *** a single intravenous injection,in vivo nanoparticle biodistribution and accumulation were evaluated by Prussian blue staining in the heart,liver,spleen,lung and kidney 8 h,24 h,and 7 days after the *** distribution was histologically studied at the three time points by measuring ironpositive areas (μm2)in organ sections stained with Prussian *** same organs were analyzed by H&E staining for any possible histopathological ***,biochemical indexes such as alanine amino transaminase (ALT),aspartate transaminase (AST),blood urea nitrogen (BUN)and creatinine (CREA)were also assessed at all experimental time *** exhibited that the SPION-PEI could retard siRNA altogether at weight ratios above *** assay showed that SPION-PEI loaded with siRNA had low *** vivo study revealed that the liver and spleen were the major sites of SPION-PEI/siRNA *** iron content was significantly increased in the liver and spleen,peaking 24 h after intravenous injection and then declining *** evidence was found of irreversible histopathological damage to any of the organs *** results suggested that most SPION-PEI/siRNA complexes were distributed in the liver and spleen,which might be the targ

关键词： superparamagnetic iron oxide nanoparticles toxicity biodistribution Prussian blue staining

Double-layer microwave absorber of nanocrystalline strontium ferrite and iron microfibers

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Chinese Physics B 2012年第2期21卷 541-547页

作者： Wei Chun-Yu Shen Xiang-qian Song fu-Zhan School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China

Microwave absorption properties of the nanocrystalline strontium ferrite （SrFe12O19） and iron （α-Fe） microfibers for single-layer and double-layer structures are investigated in a frequency range of 2 GHz 18 GHz. For the singlelayer absorbers, the nanocrystalline SrFe12O19 microfibers show some microwave absorptions at 6 GHz 18 GHz, with a minimum reflection loss （RL） value of -11.9 dB at 14.1 GHz for a specimen thickness of 3.0 mm, while for the nanocrystalline α-Fe microfibers, their absorptions largely take place at 15 GHz-18 GHz with the RL value exceeding -10 dB, with a minimum .RL value of about -24 dB at 17.5 GHz for a specimen thickness of 0.7 mm. For the doublelayer absorber with an absorbing layer of α-Fe microfibers with a thickness of 0.7 mm and matching layer of SrFe12O19 microfibers with a thickness of 1.3 ram, the minimum RL value is about -63 dB at 16.4 GHz and the absorption band width is about 6.7 GHz ranging from 11.3 GHz to 18 GHz with the RL value exceeding -10 dB which covers the whole Ku-band （12.4 GHz 18 GHz） and 27% of X-band （8.2 GHz 12.4 GHz）.

关键词： nanocrystalline microfibers microwave absorber double-layer structure

Modified calcination conditions of rare alkali metal Rb-containing muscovite(KAl_2[AlSi_3O_(10)](OH)_2)

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Rare Metals 2013年第6期32卷 632-635页

作者： Zhi-qiang Shan Xin-qian Shu Ji-fu Feng Wei-Ning Zhou School of Chemical and Environmental Engineering China University of Mining & Technology Comprehensive Utilization Research Institute of Resource Guilin Research Institute Geology for Mineral Resources

Muscovite mineral was roasted in different *** leaching rate was a standard to examine the impact of various factors on calcination effect,including the agent types,roasting time,mass ratio,and roasting *** results indicate that the best agent is the combination of sodium chloride and calcium chloride,and its mass ratio of muscovite/NaCl/CaCl2is1.00:0.25:*** at 850℃ for 30 min,the rubidium leaching rate is up to 90.12%.The reaction of muscovite ore with the chlorinating agent CaCl2was studied by TG/DSC,and the surface morphology before and after leaching was characterized by *** chloride products can be obtained using t-BAMBP extraction,hydrochloric acid re-extraction,and purification.

关键词： Modified calcination Muscovite ore Chlorinating agent

重症超声在基层重症病房临床诊断中的应用价值研究

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实用医院临床杂志 2017年第4期14卷 194-196页

作者：邬艺渊尹万红李希苏舟李晓茜付轶王君龚娟四川省乐山市人民医院重症医学科四川乐山614000 四川大学华西医院重症医学科四川成都610041

目的探讨重症超声在基层重症病房中临床诊断的应用价值。方法对既往没有学习过重症超声的市级中心医院重症医学科一线医务人员进行短期超声培训,根据其临床情况自主决定并使用重症超声对患者进行入科检查及临床问题导向检查。记录重症... 详细信息

目的探讨重症超声在基层重症病房中临床诊断的应用价值。方法对既往没有学习过重症超声的市级中心医院重症医学科一线医务人员进行短期超声培训,根据其临床情况自主决定并使用重症超声对患者进行入科检查及临床问题导向检查。记录重症超声的使用情况及发现的超声征象、能否为临床诊治提供帮助,分析统计超声提供的有用信息和不同使用方式下对确立诊断的作用。比较流程化与非流程化检查对于临床诊断的有用性。结果研究期间共行床旁超声检查56例次。可提供有用临床信息49例次(87.5%),其中进行重症急会诊超声检查(CCUE)方案化检查21例次(21/49),单项问题导向重点检查28例次(28/49)。帮助确立诊断23例次。使用CCUE、腹腔出血创伤评估(FAST)流程化检查者有15例次帮助确立诊断,而非流程化检查只有8例次帮助确立诊断,流程化检查较非流程化检查能明显有助于诊断(P=0.003)。结论通过简短的培训后,重症超声可以在基层医院快速掌握后应用于临床诊断工作中,对临床快速诊断和治疗提供很大的帮助;流程化检查比非流程化检查更能提供帮助,需要加强培训。

关键词：重症超声基层,ICU 诊断流程化检查

Analysis on composition and inclusions of ballpoint pen tip steel

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International Journal of Minerals,Metallurgy and Materials 2018年第4期25卷 420-428页

作者： qian-kun Yang Ping Shen Dong Zhang Yan-xin Wu Jian-xun fu State Key Laboratory of Advanced Special Steel Shanghai Key Laboratory of Advanced Ferrometallurgy School of Materials Science and Engineering Shanghai University

Ballpoint pen tip steel, a super free-cutting stainless steel, exhibits excellent corrosion resistance and good machining properties. In this study, inductively coupled plasma spectroscopy, metallographic microscopy, and scanning electron microscopy were used to determine the elemental contents in five ballpoint pen tips and their components, morphologies, and inclusion distributions. The results showed that the steels were all S–Pb–Te super free-cutting ferritic stainless steel. The free-cutting phases in the steels were mainly Mn S, Pb, and small amounts of Pb Te. Mn S inclusions were in the form of chain distributions, and the aspect ratio of each size inclusion in the chain was small. The stress concentration effect could substantially reduce the cutting force when the material was machined. Some of the Pb was distributed evenly in the steel matrix as fine particles（1–2 μm）, and the rest of the Pb was distributed at the middle or at both ends of the Mn S inclusions. The Pb plays a role in lubrication and melting embrittlement, which substantially increases the cutting performance. Pb Te was also usually distributed in the middle and at both ends of the Mn S inclusions, and Te could convert the sulfides into spindles, thereby improving the cutting performance of the steel.

关键词： ballpoint pen tip free-cutting stainless steel inclusions lead tellurium

Altered functional connectivity of prefrontal cortex in chronic heroin abusers

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Neural Regeneration Research 2011年第28期6卷 2193-2197页

作者： Yinbao Qi Xianming fu Ruobing qian Chaoshi Niu Xiangpin Wei Department of Neurosurgery Anhui Provincial Hospital Anhui Medical University Hefei 230001 Anhui Province China

In this study, we investigated alterations in the resting-state functional connectivity of the prefrontal cortex in chronic heroin abusers using functional magnetic resonance imaging. We found that, compared with normal controls, in heroin abusers the left prefrontal cortex showed decreased functional connectivity with the left hippocampus, right anterior cingulate, left middle frontal gyrus, right middle frontal gyrus and right precuneus. However, the right prefrontal cortex showed decreased functional connectivity with the left orbital frontal cortex and the left middle frontal gyrus in chronic heroin abusers. These alterations of resting-state functional connectivity in the prefrontal cortices of heroin abusers suggest that their frontal executive neural network may be impaired, and that this may contribute to their continued heroin abuse and relapse after withdrawal.

关键词： heroin abuse resting-state functional magnetic resonance imaging prefrontal cortex functional connectivity cognitive control

Application of tellurium in free-cutting steels

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Journal of Iron and Steel Research International 2018年第8期25卷 787-795页

作者： Ping Shen qian-kun Yang Dong Zhang Yan-xin Wu Jian-xun fu State Key Laboratory of Advanced Special Steel Shanghai Key Laboratory of Advanced Ferrous Metallurgy School of Materials Science and Engineering Shanghai UniversityShanghai 200444 China Institute of Material Science and Engineering National Taiwan University Taipei 10617 Taiwan China

Te is widely used in iron and steel industry. After adding a certain amount of Te in the steel, many physical and chemical properties can be improved. As a free-cutting element, a small amount of Te can significantly improve the machinability of steel. The existing form of Te in the steel, the modification law of MnS inclusion by Te and the influence rule and mechanism of Te on the machinability of steel are summarized and expounded in detail, providing a reference for further study and development of Te-containing free-cutting steels.

关键词： Tellurium - Inclusion Sulfide modification Free-cutting steel

Energy-Level Splitting Measurement by Time-Delayed Laser-Induced Double Gratings

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Chinese Physics Letters 1994年第10期11卷 620-622页

作者： fu Panming MI Xin YU Zuhe LI Xiaofeng JIANG qian Institute of Physics Academia SinicaBeijing 100080

We have studied theoretically a time-delayed laser-induced double gratings(TDLIDG)in a Doppler-broadened three-level *** have shown that the overall accuracy of using TDLIDG for the energy-level splitting measurement ... 详细信息

关键词： system. splitting TDL

Unsteady state precipitation of M_(23)C_(6)carbides during thermal cycling in reduced activation steel manufactured by laser melting deposition

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Journal of Iron and Steel Research International 2023年第3期30卷 557-568页

作者： Ji-xin Hou fu-lin Zhang Zhi-xin Xia Yun-he Yu Hai-ying fu Shu-hai Huang qian An Chi Zhang Shagang School of Iron and Steel Soochow UniversitySuzhou 215021JiangsuChina School of Material Science and Engineering Tsinghua UniversityBeijing 100084China Center for fusion Science Southwestern Institute of PhysicsChengdu 610225SichuanChina Southwest Technology and Engineering Research Institute Chongqing 400050China

The temperature field distribution and thermal history of Fe-9Cr2WVTa reduced activation steel prepared by laser melting deposition(LMD)have been calculated with Gaussian and Ring laser beams,and the nucleation and growth behaviors of M_(23)C_(6)precipitates in the 1st,7th and 19th layers have been calculated using the modified classical nucleation theory and Svoboda Fischer Fratzl Kozeschnik *** energy distribution shows W-shape with Ring laser beam while it shows V-shape with Gaussian laser beam,which results in the more uniform M_(23)C_(6)size in the same layer with Ring laser *** in the bottom(i.e.,the 1st layer)have the minimum size and the size increases with the layer number with Gaussian and Ring laser *** temperature history,the instantaneous nucleation rate and the size evolution of M_(23)C_(6)have been systematically *** results indicate that the nucleation,growth and re-dissolution of precipitates in reduced activation steel depend on the amount of energy absorbed in the thermal cycle during *** continuous accumulation of energy during the thermal cycle leads to larger M_(23)C_(6)at the top *** unsteady state precipitation dynamics of M_(23)C_(6)carbides during thermal cycling are consistent with the simulation results.

关键词： Laser melting deposition Reduced activation steel Unsteady state precipitation Heat source model