检索结果-南通市图书馆

Dark matter search at colliders and neutrino floor

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2020年第11期44卷 70-78页

作者： Qing-Hong Cao An-Kang Wei qian-fei xiang Department of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China Center for High Energy Physics Peking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China

The sensitivity of the direct detection of dark matter(DM)approaches the so-called neutrino floor,below which it is difficult to disentangle the DM candidate from the neutrino *** this work,we consider the scenario that no DM signals are reported in various DM direct detection experiments and explore whether collider searches could probe DM below the neutrino *** adopt several simplified models in which the DM candidate couples to electroweak gauge bosons or leptons in the standard model only through high-dimensional *** including the RGE running effect,we investigate the constraints of direct detection,indirect detection,and collider *** collider search can probe light DM below the neutrino ***,for the effective interaction of χχBμνB^μν,current data from the mono-photon channel at the 13 TeV LHC has already covered the entire parameter space of the neutrino floor.

关键词： dark matter collider direct detection

Exploring fermionic multiplet dark matter through precision measurements at the CEPC

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2022年第9期46卷 159-172页

作者： Lin-Qing Gao Xiao-Jun Bi Jin-Wei Wang qian-fei xiang Peng-fei Yin Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Scuola Internazionale Superiore di Studi Avanzati(SISSA) via Bonomea 26534136 TriesteItaly INFN Sezione di Triestevia Valerio 234127 TriesteItaly Institute for Fundamental Physics of the Universe(IFPU) via Beirut 234151 TriesteItaly Center for High Energy Physics Peking UniversityBeijing 100871China

New physics could be explored through loop effects using the precision measurements at the Circular Electron Positron Collider(CEPC)owing to its clean collision environment and high *** this paper,we focus on two dark matter models that involve additional electroweak fermionic *** calculate their one-loop corrections in five processes,i.e.,e^(+)e^(-)→μ^(+)μ^(-),Zh,W^(+)W^(-),ZZ,and,Zγ,and investigate the corresponding signatures at the CEPC with the projected *** observe that the detectable parameter regions of these processes are *** combined analysis shows that the mass of dark matter m_(χ^(0)_(1))in these two models can be probed up to-150GeV and-450GeV,respectively,at a 95%confidence level.

关键词： CEPC dark matter loop correction

Epigenetic regulation of the inflammatory response in stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi Liang fei Yang Zixiao Li qian Li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie qian Hao xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词：

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

流团模型在洪水计算中的应用

水动力学研究与进展（A辑） 1997年第2期12卷 196-208页

作者：邵颂东王光谦费祥俊清华大学水利系北京100084

作者在已论证平面二维L-E法可行性的基础上,对水流计算模型作了进一步简化,即提出将牛顿第二运动定律直接作用于各个流体质团来获得整体流动规律,并给出其基本方程与相应的数值处理方法,经过1954年荆江分洪区实际洪水过程的检验,并通过... 详细信息

作者在已论证平面二维L-E法可行性的基础上,对水流计算模型作了进一步简化,即提出将牛顿第二运动定律直接作用于各个流体质团来获得整体流动规律,并给出其基本方程与相应的数值处理方法,经过1954年荆江分洪区实际洪水过程的检验,并通过对1954年型百年一遇洪水分洪过程的预测,均证实了该流团模型计算类似分洪区洪水问题的合理性与可靠性,可用于分洪过程及洪水演进的预报.

关键词：洪水节点量流团量分洪区流团模型

High-resolution imaging through dynamic scattering media: Iterative optimization based on polarimetric characteristics

在线全文

学校读者我要写书评

暂无评论

Science China Technological Sciences 2025年第1期 82-84页

作者： Meng xiang Kai DENG Tianyu WANG Jinpeng LIU Xue DONG Teli XI fei LIU Xiaopeng SHAO School of Optoelectronic Engineering Xidian University Xi'an Key Laboratory of Computational Imaging National Key Laboratory of Infrared Detection Technologies

High-resolution imaging through randomly dynamic scattered fields and highly scattered walls is an extensively sought-after capability with potential applications in various fields such as underwater imaging, biomedical imaging, and seeing through fog. Numerous methods have been proposed to unscramble object information from degraded scattered images, resulting in considerable improvements in image contrast in degraded scenarios [1].

关键词：

Cu/Al浇铸界面连接及拉伸性能的分子动力学模拟

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国有色金属学报 2020年第12期30卷 2886-2900页

作者：钱相飞郭巧能杨仕娥王明星刘强王杰芳郑州大学物理学院郑州450001

基于分子动力学方法研究不同浇铸温度和浇铸时间对Cu/Al多层膜连接过程界面扩散的影响,从力学性能和位错滑移方面,对比研究不同浇铸时间和浇铸温度下Cu/Al多层膜的拉伸变形,揭示微观原子结构对金属薄膜力学性能的影响。结果表明:随着浇... 详细信息

基于分子动力学方法研究不同浇铸温度和浇铸时间对Cu/Al多层膜连接过程界面扩散的影响,从力学性能和位错滑移方面,对比研究不同浇铸时间和浇铸温度下Cu/Al多层膜的拉伸变形,揭示微观原子结构对金属薄膜力学性能的影响。结果表明:随着浇铸温度和浇铸时间增加,界面区域的Cu、Al原子相互扩散数目增多,过渡层厚度增大,Cu/Al多层膜屈服强度和抗拉强度随浇铸时间增加先增加后降低,在浇铸温度为1013 K、浇铸时间为0.2 ns时,Cu/Al多层膜的力学性能最佳。

关键词：分子动力学浇铸 Cu/Al多层膜界面扩散

在线全文

学校读者我要写书评

暂无评论

制动器试验台的控制方法分析

南通职业大学学报 2011年第1期25卷 62-66页

作者：张扬李豪钱祥飞南京大学南京210093

针对测试汽车制动器优劣的模拟试验,建立数学模型,解决模拟载荷车轮转动惯量的计算,并提供了确定试验台电动机驱动电流的加权移动平均法、指数平滑法和增量PID控制法;给出评价试验的能量误差指标和收敛性指标,设计了电流值计算机控制的... 详细信息

针对测试汽车制动器优劣的模拟试验,建立数学模型,解决模拟载荷车轮转动惯量的计算,并提供了确定试验台电动机驱动电流的加权移动平均法、指数平滑法和增量PID控制法;给出评价试验的能量误差指标和收敛性指标,设计了电流值计算机控制的反馈补偿算法和时频变换算法。

关键词：制动器试验台指数平滑 PID控制反馈补偿 Z变换

循环载荷下纳米铜/铝薄膜孔洞形核、生长及闭合的分子动力学模拟

在线全文

学校读者我要写书评

暂无评论

物理学报 2019年第13期68卷 95-106页

作者：刘强郭巧能钱相飞王海宁郭睿林肖志杰裴海蛟郑州大学物理工程学院郑州450001 郑州大学国际学院郑州450001

本文运用分子动力学模拟了在应变幅比为R=–1的循环载荷条件下,扩散焊纳米铜/铝双层薄膜内部孔洞形核、生长以及闭合的演化机理.研究发现,在循环载荷条件下,孔洞主要在铜/铝双层膜的铝侧内部形核,且有孔洞Ⅰ和孔洞Ⅱ两种演化方式.孔洞... 详细信息

本文运用分子动力学模拟了在应变幅比为R=–1的循环载荷条件下,扩散焊纳米铜/铝双层薄膜内部孔洞形核、生长以及闭合的演化机理.研究发现,在循环载荷条件下,孔洞主要在铜/铝双层膜的铝侧内部形核,且有孔洞Ⅰ和孔洞Ⅱ两种演化方式.孔洞Ⅰ在铜-铝相互扩散形成双层膜时在因柯肯达尔效应所产生出的空隙缺陷位置处形核,这种形核方式下,空隙缺陷形成空位后,空位在铝侧无序结构内部向铜原子数相对密集的区域移动.当空位聚集形成孔洞时,孔洞在固定位置生长.孔洞Ⅱ在压杆位错被克服所形成的空隙缺陷位置处形核,在铝侧形核后的孔洞没有发生移动.与孔洞Ⅰ相比,孔洞Ⅱ在应变加载过程中孔洞形核时的应力大、孔洞生长速度较快且尺寸稍大,在应变卸载阶段孔洞闭合速度也较快.两种孔洞在形核、生长和闭合过程中有两方面的共同特点:1)两种孔洞都是在铝侧无序结构内部的空隙缺陷处形核.2)两种孔洞在其生长、闭合过程中外形变化相同.在孔洞生长阶段,两种孔洞在外形上都是先沿应变加载方向拉伸长大,然后沿与应变加载相垂直的方向长大,最后趋向球形发展.在孔洞闭合阶段,两种孔洞在外形上首先沿应变加载方向压缩成椭球状,然后沿与应变加载相垂直的方向从孔洞两端向孔洞中心闭合消失.在随后的循环加载过程中,孔洞消失位置处没有再次出现新孔洞,而是在铝侧其它位置无序结构内部的空隙缺陷处形核.

关键词：分子动力学铜/铝薄膜循环载荷孔洞