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Removal of particulate matter and dissolved organic matter from sedimentation sludge water during pre-sedimentation process:Performances and mechanisms

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Journal of Environmental Sciences 2025年第2期148卷 409-419页

作者： Shule Duan Huiyu Dong Caifang Jiang Hong Liang Ling Jiang qian xu Xiaoyu Cheng Zhimin qiang Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Guangxi Nanning Water Co. Ltd.Nanning 530029China

Sedimentation sludge water(SSW),a prominent constituent of wastewater from drinking water treatment plants,has received limited attention in terms of its treatment and utilization likely due to the perceived difficulties associated with managing SSW *** study comprehensively evaluated the water quality of SSW by comparing it to a well-documented wastewater(filter backwash water(FBW)).Furthermore,it investigated the pollutant variations in the SSW during pre-sedimentation process,probed the underlying reaction mechanism,and explored the feasibility of employing a pilot-scale coagulation-sedimentation process for SSW *** levels of most water quality parameters were generally comparable between SSW and *** the pre-sedimentation of SSW,significant removal of turbidity,bacterial counts,and dissolved organic matter(DOM)was *** characterization of DOM components,molecular weight distributions,and optical properties revealed that the macromolecular proteinaceous biopolymers and humic acids were preferentially *** characterization of particulates indicated that high surface energy,zeta potential,and bridging/adsorption/sedimentation/coagulation capacities in aluminum residuals of SSW,underscoring its potential as a coagulant and promoting the generation and sedimentation of inorganic-organic *** coagulation-sedimentation process could effectively remove pollutants from low-turbidity SSW([turbidity]0<15 NTU).These findings provide valuable insights into the water quality dynamics of SSW during the pre-sedimentation process,facilitating the development of SSW quality management and enhancing its reuse rate.

关键词： Sedimentation sludge water Filter backwash water Reuse Health risk Coagulation-sedimentation

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第1期68卷 377-384页

作者： Shiwen Liu xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan qian xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of EducationSchool of Public HealthSoutheast UniversityNanjing 210009China Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and DetectionSchool of Public HealthNanjing Medical UniversityNanjing 211166China Department of Psychosomatics and Psychiatry Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009China

The measurement of amino acid and monoamine neurotransmitters(NTs)in serum plays a central role in the identification and monitoring of clinical panic disorder(PD).However,the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely ***,we developed a strategy that integrated solid phase extraction based on magnetic Fe_(3)O_(4)coated with polydopamine(Fe_(3)O_(4)@PDA)and direct analysis of mass spectrometry in real time(DART-MS)for quantification of 10 *** systematically investigated the optimal conditions of this strategy to achieve good accuracy and *** with existing magnetic solid phase extraction methods for NTs detection in biological samples,this strategy could adsorb more targets while having similar adsorption efficiencies,and the total process time was reduced by an average of 69.42%.We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic *** addition,an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this *** results highlighted the potential ability of Fe_(3)O_(4)@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

关键词： neurotransmitters panic disorder magnetic solid phase extraction direct analysis of mass spectrometry in real time

Development and validation of a nomogram model for predicting overall survival in patients with gastric carcinoma

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 132-143页

作者： Guan-Zhong Liang Xiao-Sheng Li Zu-Hai Hu qian-Jie xu Fang Wu Xiang-Lin Wu Hai-Ke Lei Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China Research Center for Medicine and Social Development School of Public HealthChongqing Medical UniversityChongqing 400016China The Research Center of Big Data Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND The prevalence and mortality rates of gastric carcinoma are disproportionately elevated in China,with the disease's intricate and varied characteristics further amplifying its health *** forecasting of overall survival(OS)is of paramount importance for the clinical management of individuals afflicted with this *** To develop and validate a nomogram model that provides precise gastric cancer prevention and treatment guidance and more accurate survival outcome prediction for patients with gastric *** Data analysis was conducted on samples collected from hospitalized gastric cancer patients between 2018 and *** absolute shrinkage and selection operator,univariate,and multivariate Cox regression analyses were employed to identify independent prognostic factors.A nomogram model was developed to predict gastric cancer patient *** model's predictability and discriminative ability were evaluated via receiver operating characteristic *** evaluate the clinical utility of the model,Kaplan-Meier and decision curve analyses were *** A total of ten independent prognostic factors were identified,including body mass index,tumor-node-metastasis(TNM)stage,radiation,chemotherapy,surgery,albumin,globulin,neutrophil count,lactate dehydrogenase,and platelet-to-lymphocyte *** area under the curve(AUC)values for the 1-,3-,and 5-year survival prediction in the training set were 0.843,0.850,and 0.821,*** AUC values were 0.864,0.820,and 0.786 for the 1-,3-,and 5-year survival prediction in the validation set,*** model exhibited strong discriminative ability,with both the time AUC and time C-index exceeding *** with TNM staging,the model demonstrated superior clinical ***,a nomogram was developed via a web-based *** This study established and validated a novel nomogram model for predicting the OS of gastric cancer patients,which demonstrat

关键词： Gastric carcinoma Prediction Overall survival Nomogram Prospective

Development and validation of a nomogram prediction model for overall survival in patients with rectal cancer

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 93-104页

作者： Ling Liang Xiao-Sheng Li Ze-Jun Huang Zu-Hai Hu qian-Jie xu Yu-Liang Yuan Wei Zhang Hai-Ke Lei Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multiomics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Rectal cancer is prevalent and associated with substantial morbidity and *** To develop a nomogram prediction model for overall survival(OS)in patients with rectal cancer by leveraging a comprehensive analysis of demographic,clinicopathological,haematological,and follow-up data to identify independent prognostic *** We conducted a prospective cohort study in China involving rectal cancer patients and applied Cox regression and least absolute shrinkage and selection operator regression to assess the significance of various variables as independent prognostic factors for *** identified factors were integrated into a nomogram model,which was evaluated for predictive accuracy via the C-index,area under the curve(AUC),calibration curve,and decision curve analysis(DCA).RESULTS Multivariate analysis revealed independent predictors of OS,including the Karnofsky performance status,age,sex,TNM stage,chemotherapy,surgery,targeted therapy,β2-microglobulin,lactate dehydrogenase,and the neutrophil-to-lymphocyte *** nomogram demonstrated a C-index of 0.80 for the training and validation cohorts,with AUC values indicating high predictive accuracy for 1-year,3-year,and 5-year *** calibration curves confirmed the model's excellent agreement with the observed survival rates,and DCA revealed the superior clinical utility of the nomogram over the TNM staging *** In this study,a novel prognostic model that accurately predicts the OS of rectal cancer patients was *** model exhibited excellent discriminatory and calibration capabilities,thus offering a reliable tool for health care professionals to estimate patient survival.

关键词： Rectal cancer Overall survival Nomogram Prognosis

Revolutionizing photothermal CO_(2)hydrogenation with ceria-based catalysts

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Nano Research 2025年第1期18卷 30-49页

作者： Zhaorui Zhang Xiao Han Junhong Zhang Yunyun Dong Jinsheng Zhao qian xu Ningqiang Zhang School of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng 252059China Institute for Catalysis Hokkaido UniversityN-21W-10Sapporo 001-0021Japan National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China

In the context of achieving carbon neutrality,CO_(2)catalytic conversion technologies are effective in reducing atmospheric CO_(2)concentrations while simultaneously producing renewable *** approach is seen as a viable method for constructing a new carbon cycle,thereby effectively addressing the issue of global *** CO_(2)conversion has recently emerged as a promising research focus due to its high energy utilization efficiency,superior CO_(2)conversion,excellent product selectivity,mild operating conditions,low energy consumption and minimal operating *** oxide(CeO_(2))has been widely used in photothermal catalysis due to its unique chemical properties,particularly when used as a support material with supported metals,creating distinctive interfacial sites for catalytic *** an emerging star support in photothermal CO_(2)conversion,its contributions are equally significant and should not be ***,to our knowledge,there has been no comprehensive review of CeO_(2)applications in catalytic hydrogenation of CO_(2).In this paper,we summarize and discuss CeO_(2)-based materials for photothermal CO_(2)conversion to value-added *** research particularly focuses on the synthesis methods of CeO_(2)-supported catalysts,the history of CeO_(2)in photothermal catalysis,types of photothermal catalytic reactors,unique characterization methods for the photothermal catalysts and the photothermal CO_(2)hydrogenation reactions by CeO_(2)-based *** related to further challenges and future directions for photothermal CO_(2)hydrogenation are also provided.

关键词： CO_(2)neutrality hydrogenation photothermal catalysis ceria C1 chemistry

Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi Yu Xi Zheng Xiao-Sheng Li qian-Jie xu Wei Zhang Zhong-Li Liao Hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model

类别条件噪声下的半监督AUC优化理论与算法

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计算机学报 2025年第1期48卷 136-155页

作者：姜阳邦彦许倩倩杨智勇郝前秀操晓春黄庆明中国科学院大学计算机科学与技术学院北京101408 中国科学院计算技术研究所智能信息处理重点实验室北京100190 中山大学网络空间安全学院广东深圳518107

现有半监督AUC优化方法通常假设数据标注是准确的。然而在许多实际应用中,研究者往往会同时面临标注量不足和不准确的问题。为此,该文首次尝试在不完整和不准确的数据标注情况下优化AUC指标。具体而言,通过分析,对称替代损失在某些情况... 详细信息

现有半监督AUC优化方法通常假设数据标注是准确的。然而在许多实际应用中,研究者往往会同时面临标注量不足和不准确的问题。为此,该文首次尝试在不完整和不准确的数据标注情况下优化AUC指标。具体而言,通过分析,对称替代损失在某些情况下可以在半监督问题中具有噪声鲁棒性。在此基础上,该文构建了一个鲁棒半监督AUC优化框架,其导出的经验风险无需估计噪声率。此外,通过紧致泛化上界的分析表明,当模型基于足够大的训练数据集进行学习时,其在未见数据上能够很好地泛化。随后,使用Barrier hinge损失对该框架进行实例化。为加快训练过程,进一步开发了一种加速算法,将损失和梯度估计的复杂度从O(n^(2))降低至O(nlogn),在实验中可获得高达200倍的加速。最后,通过在15个基准数据集上进行实验验证,证明了所提方法的有效性。

关键词：半监督学习 AUC优化标签噪声二分类问题不平衡数据学习

慢性乙型肝炎患者microRNA表达及其对肝纤维化分期的诊断价值

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中华医院感染学杂志 2025年第1期35卷 35-39页

作者：钟雷章勇徐芊许伟连云港市立东方医院检验科江苏连云港222042 连云港市立东方医院感染科江苏连云港222042

目的探讨慢性乙型肝炎(CHB)患者微小核糖核酸(miR)表达及其诊断肝纤维化(HF)分期的临床价值。方法选取2021年1月-2023年10月连云港市立东方医院接受治疗的85例CHB患者作为病例组,并根据纤维化分期进一步分为无或轻度HF组53例(S0~S1期)... 详细信息

目的探讨慢性乙型肝炎(CHB)患者微小核糖核酸(miR)表达及其诊断肝纤维化(HF)分期的临床价值。方法选取2021年1月-2023年10月连云港市立东方医院接受治疗的85例CHB患者作为病例组,并根据纤维化分期进一步分为无或轻度HF组53例(S0~S1期)和显著HF组32例(≥S2期),另选取同期于医院体检的健康者89名为对照组,比较三组肝功能指标、HF指标及miR-34a、miR-29b、miR-21、miR-122水平,采用受试者工作特征(ROC)曲线分析血清miR-34a、miR-29b、miR-21、miR-122水平评估CHB患者纤维化分期≥S2期的诊断效能。结果三组肝功能指标血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBil)等及HF指标透明质酸(HA)、层黏连蛋白(LN)、Ⅳ型胶原(C-Ⅳ)、Ⅲ型前胶原(PC-Ⅲ)比较均有统计学差异(P<0.05),且显著HF组各指标水平更高(P<0.05)。三组血清miR-34a、miR-29b、miR-21、miR-122水平比较差异有统计学意义(P<0.05),其中显著HF组血清miR-34a、miR-29b水平更低(均P<0.05),血清miR-21水平更高(P<0.05),显著HF组和无或轻度HF组血清miR-122水平均高于对照组(P<0.05),但显著HF组低于无或轻度HF组(P<0.05)。miR-34a、miR-29b、miR-21、miR-122联合检测诊断CHB患者纤维化分期≥S2期的曲线下面积(AUC)为0.830,敏感度和特异度分别为78.12%和77.36%。结论CHB患者肝功能异常与HF程度存在一定联系,且miR-34a、miR-29b、miR-21、miR-122对CHB患者纤维化分期≥S2期具有较高的评估价值,且联合检测评估价值更高。

关键词：乙型肝炎病毒慢性乙型肝炎肝功能微小核糖核酸肝纤维化

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基于倾向性评分匹配方法探讨子宫体积与宫腔粘连发生的相关性

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中华妇产科杂志 2025年第1期60卷 18-23页

作者：许阡段华安圆圆甘露首都医科大学附属北京妇产医院北京妇幼保健院妇科微创中心北京100006

目的研究子宫体积与子宫内膜损伤所致宫腔粘连之间的相关性。方法回顾性收集2018年6月至2019年11月期间于首都医科大学附属北京妇产医院妇科微创中心门诊所有行宫腔镜检查的7007例育龄期患者的临床资料,选取无子宫肌瘤、子宫腺肌病的宫... 详细信息

目的研究子宫体积与子宫内膜损伤所致宫腔粘连之间的相关性。方法回顾性收集2018年6月至2019年11月期间于首都医科大学附属北京妇产医院妇科微创中心门诊所有行宫腔镜检查的7007例育龄期患者的临床资料,选取无子宫肌瘤、子宫腺肌病的宫腔粘连患者为宫腔粘连组,同期无子宫肌瘤、子宫腺肌病的非宫腔粘连育龄期患者为对照组。采用SPSS 26.0软件对两组患者以倾向性评分匹配方法进行1∶1匹配,匹配变量包括年龄、身高、体重、体重指数(BMI)、孕次、产次、流产刮宫次数。比较两组患者子宫体积是否存在差异,并探讨子宫体积是否为宫腔粘连的影响因素。另将宫腔粘连组患者分为轻度、中度、重度,探讨子宫体积是否影响宫腔粘连的严重程度。结果(1)本研究按入组标准共纳入宫腔粘连组患者351例,对照组患者2986例,经倾向性评分匹配,最终宫腔粘连组和对照组各327例患者,匹配后两组患者的年龄、身高、体重、BMI、孕次、产次、流产刮宫次数分别比较,差异均无统计学意义(P均>0.05)。(2)倾向性评分匹配后,宫腔粘连组患者的子宫体积中位数为44.23 cm^(3),对照组的子宫体积中位数为57.20 cm^(3),两组间子宫体积存在显著差异(P<0.001)。(3)子宫体积减小(OR=0.961,95%CI为0.952~0.970)是宫腔粘连形成的独立危险因素(P<0.001)。(4)子宫体积对宫腔粘连的严重程度有显著影响(P<0.001),子宫体积越大(B=-0.030,95%CI为-0.044~-0.017)宫腔粘连的严重程度越轻。结论子宫体积减小是宫腔粘连形成的独立危险因素,且子宫体积对于宫腔粘连的严重程度有显著影响,对于子宫体积较小的患者,应重视宫腔粘连的一级预防和二级预防。

关键词：宫腔粘连子宫体积相关性危险因素倾向性评分宫腔镜检查