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Net effect of air pollution controls on health risk in the Beijing-Tianjin-Hebei region during the 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： Changqing Lin peter K.K.Louie Alexis K.H.Lau Jimmy C.H.Fung Zibing Yuan Minghui Tao Xuguo Zhang Md.Shakhaoat Hossain Chengcai Li Xiang qian Lao Division of Environment and sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of Environment and Energy South China University of TechnologyGuangzhou 510006China Hubei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public Health and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reducing the emission of nitrogen oxides(NO_(x))may increase O_(3) *** the counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous when the assessments focus on the changes in pollutant *** this study,a risk-based method was used to gauge the net effect of air pollution controls on mortality risk in the Beijing–Tianjin–Hebei(BTH)region during the 2022 Winter Olympics and Paralympics(WOP).This mega-event presents a unique opportunity to investigate the efficacy of deep cuts in pollutant *** show that O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in the *** to the active photochemical formations,O_(3) became the dominant pollutant that affected human health during the *** the substantial O_(3) increases,the health benefits of NO_(2) reductions overwhelmed the adverse health effects of O_(3) increases in most regions of the BTH(at 81 out of 112 stations).After considering the impacts of particulate matter,the integrated health risk of air pollution mixtures declined almost everywhere in the *** results underscore the great necessity of changing the assessment paradigm of pollution control from using concentration-based methods to using risk-based *** with the carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to achieve synergistic control solutions for air pollution and climate change.

关键词： Ozone Nitrogen dioxide Health risk Carbon neutrality Mega-events

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Phase II study of novel orally PI3Kα/δinhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2193-2201页

作者： Huaqing Wang Jifeng Feng Yanyan Liu Zhengzi qian Da Gao Xuehong Ran Hui Zhou Lihong Liu Binghua Wang Meiyun Fang Hebing Zhou Zhenqian Huang Shi Tao Zhuowen Chen Liping su Hang su Yu Yang Xiaobao Xie Huijing Wu Ping sun Guoyu Hu Aibin Liang Zhiming Li Department of Oncology Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China The Institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China Department of Medical Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009PR China Department of Medical Oncology Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003PR China Department of Medical Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Hematology The Affiliated Hospital of Inner Mongolia Medical College010050 HohhotPR China Department of Hematology Weifang People’s HospitalThe First Affiliated Hospital of Weifang Medical University261000 WeifangPR China Department of Lymphoma&Hematology Hunan Cancer HospitalThe Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University410013 ChangshaPR China Department of Hematology The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital050011 ShijiazhuangPR China Department of Lymphoma Weihai Central Hospital264400 WeihaiPR China Department of Hematology and Rheumatology The Affiliated Zhongshan Hospital of Dalian University116001 DalianPR China Department of Hematology Beijing Luhe Hospital101199 BeijingPR China Department of Hematology The First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouPR China Department of Hematology The First Affiliated Hospital of Hainan Medical College570102 HaikouPR China Department of Hematology The First People’s Hospital of Foshan528000 FoshanPR China Department of Hematology Shanxi Cancer Hospital030013 TaiyuanPR China Department of Lymphoma Senior Department of HematologyThe Fifth Medical Center of Chinese PLA General Hospital100039 BeijingPR China Department of Lymphoma and Head and Neck Cancer Fujian Cancer Hospital350014 FuzhouPR China Department of Hematology The First People’s Hospit

This registration study assessed clinical outcomes of TQ-B3525,the dual phosphatidylinositol-3-kinase(PI3K)α/δinhibitor,in relapsed and/or refractory follicular lymphoma(R/R FL).This phase II study(*** *** March 27,2020)comprised run-in stage and stage 2.R/R FL patients after≥2 lines therapies received oral 20 mg TQ-B3525 once daily in a 28-day cycle until intolerable toxicity or disease *** endpoint was independent review committee(IRC)-assessed objective response rate(ORR).Based on results(ORR,88.0%;duration of response[DOR],11.8 months;progression-free survival[PFS],12.0 months)in 25 patients at run-in stage,second stage study was initiated and included 82 patients for efficacy/safety *** received prior-line(median,3)therapies,with 56.1%refractory to previous last therapies;73.2%experienced POD24 at *** stage 2,ORR was 86.6%(71/82;95%CI,77.3-93.1%),with 28(34.2%)complete *** control rate was 95.1%due to 7(8.5%)stable *** time to response was 1.8 *** 71 responders,median DOR was not reached;18-month DOR rate was 51.6%.with median follow-up of 13.3 months,median PFS was 18.5(95%CI,10.2-not estimable)*** overall survival(OS)was not reached by cutoff date;24-month OS rate was estimated as 86.1%.Response rates and survival data were consistent across all *** 3 or higher treatment-related adverse events were observed in 63(76.8%)cases,with neutropenia(22.0%),hyperglycemia(19.5%),and diarrhea(13.4%)being ***-B3525 showed favorable efficacy and safety for R/R FL patients after≥2 lines prior therapies.

关键词： lymphoma assessed initiated

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AutoQNN: An End-to-End Framework for Automatically Quantizing Neural Networks

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Journal of Computer Science & Technology 2024年第2期39卷 401-420页

作者：龚成卢冶代素蓉邓倩杜承昆李涛 College of Software Nankai UniversityTianjin 300350China College of Computer Science Nankai UniversityTianjin 300350China State Key Laboratory of Processors Institute of Computing TechnologyChinese Academy of Sciences Beijing 100190China

Exploring the expected quantizing scheme with suitable mixed-precision policy is the key to compress deep neural networks(DNNs)in high efficiency and *** exploration implies heavy workloads for domain experts,and an automatic compression method is ***,the huge search space of the automatic method introduces plenty of computing budgets that make the automatic process challenging to be applied in real *** this paper,we propose an end-to-end framework named AutoQNN,for automatically quantizing different layers utilizing different schemes and bitwidths without any human *** can seek desirable quantizing schemes and mixed-precision policies for mainstream DNN models efficiently by involving three techniques:quantizing scheme search(QSS),quantizing precision learning(QPL),and quantized architecture generation(QAG).QSS introduces five quantizing schemes and defines three new schemes as a candidate set for scheme search,and then uses the Differentiable Neural Architecture Search(DNAS)algorithm to seek the layer-or model-desired scheme from the *** is the first method to learn mixed-precision policies by reparameterizing the bitwidths of quantizing schemes,to the best of our *** optimizes both classification loss and precision loss of DNNs efficiently and obtains the relatively optimal mixed-precision model within limited model size and memory *** is designed to convert arbitrary architectures into corresponding quantized ones without manual intervention,to facilitate end-to-end neural network *** have implemented AutoQNN and integrated it into *** experiments demonstrate that AutoQNN can consistently outperform state-of-the-art *** 2-bit weight and activation of AlexNet and ResNet18,AutoQNN can achieve the accuracy results of 59.75%and 68.86%,respectively,and obtain accuracy improvements by up to 1.65%and 1.74%,respectively,compared with state-of-the-art ***,c

关键词： automatic quantization mixed precision quantizing scheme search quantizing precision learning quan-tized architecture generation

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The Relationship Between NLRP3 Inflammasome and Its Downstream Inflammatory Factors in Obstructive Sleep Apnea Patients with Carotid Atherosclerosis Under Cigarette Exposure

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Journal of Clinical and Nursing Research 2024年第9期8卷 249-260页

作者： qian Lv Qiaoli Yu Lihua Wei Jili su Yan Zhou Department of Respiratory and Critical Care Medicine Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi ProvinceChina Laboratory of Respiratory Disease Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi ProvinceChina

Aim:To study the relationship between NLRP3(nucleotide oligomerization domain[NOD]-,leucine-rich repeats[LRR]-,and pyrin domain-containing protein 3)inflammasome and its downstream inflammatory factors in obstructive sleep apnea(OSA)patients with carotid atherosclerosis(CAS)under cigarette exposure,further exploring the risk factors of CAS in OSA ***:A total of 109 adult males who underwent polysomnography and carotid artery ultrasonography in our hospital from October 2019 to December 2021 were *** to the detection results,they were divided into the OSA group,the CAS group,and the OSA combined CAS group;additionally,29 healthy subjects who underwent a physical examination were also *** to whether they were smoking,the groups were further divided into smoking and non-smoking *** age,body mass index(BMI),blood pressure,apnea-hypopnea index(AHI),lowest blood oxygen saturation(LSaO2),carotid intima-media thickness(CIMT),levels of blood sugar,blood low-density lipoprotein cholesterol(LDLc),and serum NLRP3,interleukin-1β(IL-1β),and interleukin-18(IL-18)of all subjects were ***:The OSA combined CAS group had higher LDLc levels and AHI and lower LSaO2 than the OSA group and CAS *** levels of serum NLRP3,IL-1β,and IL-18 in the OSA group were higher than those in the normal control group(Psure,serum NLRP3,IL-1β,and IL-18 levels were higher in the OSA,CAS,and OSA combined CAS smoking groups than those in the non-smoking group(Psure,AHI,LDLc,NLRP3,IL-1β,and IL-18 were significantly positively correlated(P<0.05),and LSaO2 was negatively correlated with CAS in OSA(P<0.05).AHI,LSaO2,LDLc,NLRP3,and IL-1βare the risk factors for OSA combined with ***:LSaO2,AHI,LDLc,NLRP3,and IL-1βare the important risk factors for OSA co

关键词： Obstructive sleep apnea Smoking NLRP3 Carotid atherosclerosis

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Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis

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World Journal of Gastroenterology 2024年第15期30卷 2143-2154页

作者： Sen Li qian-Jun Ren Can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang su Li Xing-Qiu Liang Bin Wen Ming-Kun Liang Xiao-Fang Zhao Department of Basic Science Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Traditional Chinese Medicine Specialty Office Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina

BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury,and finally leads to liver cirrhosis or even hepatocellular *** pathogenesis of hepatic fibrosis is associated with the progressive accumulation of activated hepatic stellate cells(HSCs),which can transdiffer-entiate into myofibroblasts to produce an excess of the extracellular matrix(ECM).Myofibroblasts are the main source of the excessive ECM responsible for hepatic ***,activated hepatic stellate cells(aHSCs),the principal ECM producing cells in the injured liver,are a promising therapeutic target for the treatment of hepatic *** To explore the effect of taurine on aHSC proliferation and the mechanisms *** Human HSCs(LX-2)were randomly divided into five groups:Normal control group,platelet-derived growth factor-BB(PDGF-BB)(20 ng/mL)treated group,mmol/L,respectively)with PDGF-BB(20 ng/mL)treated *** Counting Kit-8 method was performed to evaluate the effect of taurine on the viability of ***-linked immunosorbent assay was used to estimate the effect of taurine on the levels of reactive oxygen species(ROS),malondialdehyde,glutathione,and iron *** electron microscopy was applied to observe the effect of taurine on the autophagosomes and ferroptosis features in *** real-time polymerase chain reaction and Western blot analysis were performed to detect the effect of taurine on the expression ofα-SMA,Collagen I,Fibronectin 1,LC3B,ATG5,Beclin 1,PTGS2,SLC7A11,and *** Taurine promoted the death of aHSCs and reduced the deposition of the *** with taurine could alleviate autophagy in HSCs to inhibit their activation,by decreasing autophagosome formation,downregulating LC3B and Beclin 1 protein expression,and upregulating p62 protein ***,treatment with taurine triggered ferroptosis and ferritinophagy to eliminate aHSCs characterized b

关键词： Hepatic stellate cells Autophagy Ferroptosis Molecular docking Taurine

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Ambient formaldehyde concentrations in summer in 30 Chinese cities and impacts on air cleaning of built environment

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Energy and Built Environment 2024年第4期5卷 493-499页

作者： Shuolin Qiu Zirui He Guangdong Liu Zhen Ding Zhongming Bu Jianping Cao Wenjing Ji Wei Liu Chunxiao su Xinke Wang Fan Liu Ting Li Hua qian Cong Liu School of Energy and Environment Southeast UniversityNanjingJiangsu210096China China Green Development Investment Group Co.LTD Beijing100000China Department of Environmental Health Jiangsu Provincial Center for Disease Control and PreventionNanjingJiangsu210009China Department of Energy and Environmental System Engineering Zhejiang University of Science and TechnologyHangzhouZhejiang310023China School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong510006China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing100083China Institute for Health and Environment Chongqing University of Science and TechnologyChongqing401331China School of Environment and Architecture University of Shanghai for Science and TechnologyShanghai200093China School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an710049ShaanxiChina Tsinghua University Beijing100084China

Formaldehyde is an important carcinogen commonly found *** indoor sources have been intensively *** study on outdoor formaldehyde concentration,which is potentially an important source to indoors,remains *** study attempts to characterize temporal and spatial distribution of the atmospheric formalde-hyde concentration in Chinese *** variation of ambient formaldehyde was examined in 6 cities and peak hours were identified between 12:00 pm and 3:00 ***,outdoor formaldehyde concentrations were measured in the peak hours in 30 cities during the summer months of Jul.-Aug.,*** formaldehyde concentrations in the peak hours fell into a range of 0.005-0.087 mg/m^(3)(median value is 0.027 mg/m^(3)),87.7%of which have exceeded the chronic reference exposure criteria of 0.009 mg/m^(3) set by Office of Environmental Health Hazard *** risk analysis suggests that exposure to ambient formaldehyde could cause a median carcinogenic risk of 1.9×10^(−5)(3.17×10^(−6)-6.13×10^(−5)),higher than threshold limit of 10−*** correlation analysis of the 30 cities shows that ambient summertime atmospheric formaldehyde concentrations of the city are positively correlated with its Gross Domestic Product(r=0.48).We also found that the outdoor formaldehyde concentrations in urban areas(median:0.017 mg/m^(3))is slightly higher than those in suburban areas(median:0.013 mg/m^(3)).Results here prove that outdoor formaldehyde is ubiquitous in Chinese cities and reduces effectiveness of ventilation in dilution indoor *** it would underestimate air cleaner capacity needed by a factor of about *** should be accounted for in health analysis and air quality engineering control design of built environment in the future.

关键词： Atmospheric formaldehyde Temporal distribution Health risk Ventilation efficiency

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Ablation behaviour and mechanical performance of ZrB_(2)-ZrC-SiC modified carbon/carbon composites prepared by vacuum infiltration combined with reactive melt infiltration

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新型炭材料（中英文） 2024年第4期39卷 633-644页

作者： ZHANG Jia-ping su Xiao-xuan LI Xin-gang WANG Run-ning FU qian-gang Shaanxi Key Laboratory of Fiber Reinforced Light Composite Materials Northwestern Polytechnical UniversityXi’an 710072China

The development of advanced aircraft relies on high performance thermal-structural materials,and carbon/carbon com-posites(C/C)composited with ultrahigh-temperature ceramics are ideal ***,the traditional routes of compositing are either inefficient and expensive or lead to a non-uniform distribution of ceramics in the *** with the traditional C/C-ZrC-SiC composites prepared by the reactive melt infiltration of ZrSi_(2),C/C-ZrB_(2)-ZrC-SiC composites prepared by the vacuum infiltration of ZrB_(2) combined with reactive melt infiltration have the higher content and more uniform distribution of the introduced ceramic *** mass and linear ablation rates of the C/C-ZrB_(2)-ZrC-SiC composites were respectively 68.9%and 29.7%lower than those of C/C-ZrC-SiC composites prepared by reactive melt *** ablation performance was improved because the volatilization of B_(2)O_(3),removes some of the heat,and the more uniformly distributed ZrO_(2),that helps produce a ZrO2-SiO2 continu-ous protective layer,hinders oxygen infiltration and decreases ablation.

关键词： C/C composites ZrB_(2)-ZrC-SiC Vacuum filtration Reactive melt infiltration Ablation.

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Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint:A Retrospective Analysis

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Current Medical Science 2024年第4期44卷 741-747页

作者： su-guo WANG Yong-gang WANG Guo-wei qian Li-na TANG Xin ZHOU Dong-dong CHENG Chen-liang ZHOU Qing-cheng YANG Zan SHEN Gao-zhong HUANG Hong-tao LI Department of General Medicine Shenzhen Third People's HospitalShenzhen 518112China Department of VIP Clinic Shanghai Jiao Tong University Afiliated Sixth People's HospitalShanghai 200233China Department of Oncology Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Cancer Research Institute of Jilin University the First Hospital of Jilin UniversityChangchun 130021China Department of Orthopedics Shanghai Jiao Tong University Afiliated Sixth People's HospitalShanghai 200233China

Objective To investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant *** After retrospectively screening the data of 742 patients between January 2007 and July 2020,50 patients aged 13 to 39 years with Enneking stage II disease were included in the *** lipid levels,including total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),lipoprotein-α[Lp(a)],and apolipoprotein A1,B,and E(ApoA1,ApoB,and ApoE),and clinicopathological characteristics were collected before and after neoadjuvant *** The mean levels of TC,TG,and ApoB were significantly increased following neoadjuvant chemotherapy(16%,38%,and 20%,respectively,*** values;Psurvival(DFS)was observed in patients with decreased TG and increased LDL-C following chemotherapy,although this difference was not statistically significant(P=0.23 and P=0.24,respectively).Conclusion Significant elevations in serum lipids were observed after neoadjuvant chemotherapy in patients with localized *** was no prognostic significance of pretreatment serum lipid levels on histologic response to neoadjuvant *** scale of increase in serum Lp(a)might have a potential prognostic role in *** with increased LDL-C or reduced TG after chemotherapy seem to exhibit a trend toward favorable DFS.

关键词： osteosarcoma neoadjuvant chemotherapy serum lipids

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Corneal nerve changes by anti-glaucoma medications examined by in vivo confocal microscopy

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1645-1653页

作者： Xin-Yuan Zhu Qing-Shu Ge Zong-Yi Li Long-Fang Zhou qian-Wen Bu Ying su Xin-Jie Wang Qing-Jun Zhou Xiao-Jing Pan Die Hu School of Clinical Medicine Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Eye Institute of Shandong First Medical University Qingdao Eye Hospital of Shandong First Medical UniversityQingdao 266071Shandong ProvinceChina State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyQingdao 266071Shandong ProvinceChina School of Ophthalmology Shandong First Medical UniversityQingdao 266071Shandong ProvinceChina

AIM:To evaluate the effects of antiglaucoma eye drops on corneal nerves by in vivo confocal microscopy(IVCM).METHODS:This study comprised 79 patients diagnosed with glaucoma and 16 healthy control *** the glaucoma patients,54 were treated with medication,while 25 remained *** corneal images were evaluated by IVCM,and then ACCMetrics was used to calculate the following parameters:corneal nerve fiber density(CNFD),branch density(CNBD),fiber length(CNFL),total branch density(CTBD),fiber area(CNFA),fiber width(CNFW),and fractal dimension(CNFrD).The correlation between IVCM parameters and drugs was evaluated using non-parametric measurements of Spearman’s rank correlation ***:The CNFD was reduced in glaucoma groups compared to healthy subjects(P<0.01).Patients using anti-glaucoma medications exhibited poorer confocal parameters compared to untreated *** the number of medications and usage count increased,CNFD,CNBD,CNFL,CTBD,CNFA,and CNFrD experienced a decline,while CNFW increased(all P<0.01).For the brinzolamide-therapy group,there was a significant decrease in CNFD and CNFL compared to the other monotherapy groups(P<0.001).In the absence of medication,CNFD in males was lower than that in females(P<0.05).Among patients under medication therapy,CNFD remained consistent between males and ***:Antiglaucoma eye drops affect the microstructure of corneal *** and ACCMetrics are useful tools that could be used to evaluate the corneal nerve changes.

关键词： glaucoma therapy corneal nerve fibers in vivo confocal microscopy ACCMetrics

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基于RBF的油气水段塞流流型超声识别方法

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化工进展 2024年第2期43卷 628-636页

作者：苏茜夏志飞刘振兴武汉科技大学信息科学与工程学院/人工智能学院湖北武汉430081 武汉科技大学冶金自动化与检测技术教育部工程研究中心湖北武汉430081

石油管道内的多相流流型识别主要集中在气液两相流和油水两相流方向且准确识别流型范围有限,为了解决油气水段塞流流型识别问题,本文提出一种基于RBF神经网络和超声传播规律的油气水段塞流流型识别方法。根据油气水段塞流的相分布特点,... 详细信息

石油管道内的多相流流型识别主要集中在气液两相流和油水两相流方向且准确识别流型范围有限,为了解决油气水段塞流流型识别问题,本文提出一种基于RBF神经网络和超声传播规律的油气水段塞流流型识别方法。根据油气水段塞流的相分布特点,建立了流型识别超声测试仿真模型。采用超声透射衰减技术和反射回波技术研究水平管道油气水三相段塞流超声响应特性,提取透射衰减信号区分段塞流液膜区、气泡夹带区和稳定液塞区。利用反射信号时间序列数据中的回波能量等统计特征,通过RBF神经网络对油气水段塞流进行流型识别。结果表明,基于超声传播机理以及RBF神经网络三相段塞流流型识别率为95.7%。基于RBF神经网络的流型识别算法研究为超声技术实现水平管油气水段塞流流型识别提供了理论基础。

关键词：多相流瞬态响应油气水段塞流超声衰减 RBF网络流型识别

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