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边缘信息引导的伪装目标检测

光电子．激光 2024年第10期35卷 1024-1031页

作者：吴涛林葛斌钱亚红夏晨星裴佳佳安徽理工大学计算机科学与工程学院安徽淮南232001 合肥综合性国家科学中心能源研究院安徽合肥230031 河南中烟工业有限责任公司安阳卷烟厂河南安阳455004

伪装目标检测(camouflaged object detection,COD)旨在检测隐藏在复杂背景中的伪装目标。由于伪装目标的特点:前景与背景纹理相似、边缘对比度低,导致现有方法得到的预测图像边缘模糊、小目标区域缺失。因此,本文提出了边缘信息引导的... 详细信息

伪装目标检测(camouflaged object detection,COD)旨在检测隐藏在复杂背景中的伪装目标。由于伪装目标的特点:前景与背景纹理相似、边缘对比度低,导致现有方法得到的预测图像边缘模糊、小目标区域缺失。因此,本文提出了边缘信息引导的伪装目标检测网络(edge information guided network,EIGNet)。首先,通过低层特征和高层特征对目标的边缘进行显式建模,充分提取目标的边缘特征指导后续特征表示。然后,通过双分支结构处理不同维度的伪装目标。其中,全局分支用以提取全局上下文信息强调大目标的全局贡献,局部分支用以挖掘丰富的局部低级线索增强小目标的特征表示。最后,采用自顶向下的方式实现相邻层特征的逐步融合,得到具有精细边缘和完整区域的预测图像。在3个伪装数据集上的实验结果表明本文方法优于其他15个模型,在NC4K数据集上平均绝对误差(mean absolute error,MAE)降至0.044。

关键词：伪装目标检测(COD) 边缘语义特征增强特征聚合

音乐声的音色感知特征与图像的纹理特征的关联研究

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复旦学报（自然科学版） 2020年第3期59卷 314-321页

作者：蒋伟张筱艺刘京宇钱亚红蒋玉暕中国传媒大学现代演艺技术北京市重点实验室北京100024 中国传媒大学视听技术与智能控制系统文化和旅游部重点实验室北京100024 中国传媒大学信息与通信工程学院北京100024

本文主要研究音乐声的音色感知特征与图像的纹理之间的关联关系并建立音色与纹理的匹配模型.首先对Brodatz纹理库中的图片提取纹理特征,然后利用纹理特征对纹理图片进行系统聚类和多维尺度分析,挑选出18张用来做主观评价实验的纹理图片... 详细信息

本文主要研究音乐声的音色感知特征与图像的纹理之间的关联关系并建立音色与纹理的匹配模型.首先对Brodatz纹理库中的图片提取纹理特征,然后利用纹理特征对纹理图片进行系统聚类和多维尺度分析,挑选出18张用来做主观评价实验的纹理图片.通过主观评价实验,得到音色感知特征值以及音色和纹理的匹配关系数据,并基于此数据分别计算了匹配(或不匹配)的音色感知特征纹理特征之间的皮尔逊相关系数,相关系数绝对值最高达0.75,证明了二者之间存在强烈关联.最后使用逻辑回归、随机森林、多层感知神经网络对音色感知特征和纹理之间的匹配关系进行预测,得到了准确率较高的预测模型,说明通过音色感知特征和纹理特征预测二者匹配关系是可行的.

关键词：音色纹理特征提取

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原子荧光法测定植物样品中的硒

广东微量元素科学 2008年第3期15卷 46-50页

作者：李晓春潘金德毛春国钱亚红浙江省地质矿产研究所浙江杭州310007

研究建立了氢化物发生-原子荧光光谱法测定植物样品中硒的方法,对样品处理、干扰及消除进行了探讨。结果表明,该法的检出限为0.56ng/g,回收率为93.6%~99.2%,RSD为2.8%~5.2%。

关键词：植物原子荧光光谱法硒

全谱直读发射光谱测定植物样中全硼的方法研究

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广东化工 2022年第16期49卷 181-184页

作者：钱亚红金晨江陈燕芳陈玲霞浙江省地矿科技有限公司浙江杭州310007 浙江省地质矿产研究所浙江杭州310007

采用全谱直读发射光谱法测定植物样品中硼,调整碳粉和硫粉比例改良缓冲剂,使用深孔石墨电极作为激发载体,优化激发条件,确立干扰扣除方式,建立有效地测定植物样品中全硼的方法。方法检出限为0.93 mg/kg,方法精密度3.77%~5.62%,通过生物... 详细信息

采用全谱直读发射光谱法测定植物样品中硼,调整碳粉和硫粉比例改良缓冲剂,使用深孔石墨电极作为激发载体,优化激发条件,确立干扰扣除方式,建立有效地测定植物样品中全硼的方法。方法检出限为0.93 mg/kg,方法精密度3.77%~5.62%,通过生物成分分析标准物质验证,得到满意的结果,方法准确度高、实用高效、环保,可在植物样品的检测工作中起到积极作用。

关键词：植物样硼全谱直读发射光谱固体进样

Contribution of non-Saccharomyces yeasts to aroma-active compound production,phenolic composition and sensory profile in Chinese Vidal icewine

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Food Bioscience 2022年第2期46卷 658-669页

作者： qian Ge Chunfeng Guo Yue Yan Xiangyu Sun Tingting Ma Jing Zhang Caihong Li Chunlin Gou Tianli Yue yahong Yuan College of Food Science and Engineering Northwest A&F UniversityYangling712100China Institute of Quality Standard and Testing Technology for Agro-products of Ningxia Yinchuan750002China Laboratory of Quality&Safety Risk Assessment for Agro-products(Yangling) Ministry of AgricultureYangling712100China

To acquire candidate non-Saccharomyces strains for preparation of high-quality Vidal icewine,11 representative indigenous non-Saccharomyces strains were selected for analyzing their production of organic acids,phenolic compounds,aroma-active compounds and evaluating their sensory profile in Vidal *** results showed that the contents of organic acids in the wines were controlled and balanced well by the non-Saccharomyces strains as well as polyphenol concentrations were well improved during the *** strains differed from each other in their ability to produce aroma compounds,causing diversity and complexity of aroma characteristics in *** by Saccharomycopsis crataegensis YC30(Sc)and Hanseniaspora uvarum QTX22(Hu)could enhance the sweet and floral notes in Vidal icewine,especially Sc,which has never been reported *** can not only enrich the aroma categories,but also increase the content ofδ-decalactone,γ-decalactone,ethyl isobutyrate,ethyl butyrate,phenethyl acetic acid,*** evaluation and optimization of non-Saccharomyces yeast strains could provide theoretical basis for the improvement of ice wine quality,and supply new ideas and strategies for the brewing of ice wine.

关键词： Vidal icewine Non-Saccharomyces yeast Saccharomycopsis crataegensis Sensory characterization Aromatic profile Odor activity values

Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1150-1165页

作者： Yuzhen qian Yixuan Sun Peishang Shi Xiuman Zhou Qiongqiong Zhang Qingyu Dong Shengzhe Jin Lu Qiu Xiaoshuang Niu Xiaowen Zhou Wenshan Zhao yahong Wu Wenjie Zhai Yanfeng Gao School of Life Sciences Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China International Joint Laboratory for Protein and Peptide Drugs of Henan Province Zhengzhou UniversityZhengzhou 450001China

Aside from antibodies,peptides show great potential as immune checkpoint inhibitors(ICIs)due to several advantages,such as better tumor penetration and lower ***-activation gene 3(LAG-3)is an immune checkpoint which can induce T cell dysfunction through interaction with its soluble ligand fibrinogen like protein-1(FGL1).Here,we found that LAG-3 expression was higher than programmed cell death protein 1(PD-1)in multiple human cancers by TCGA databases,and successfully identified a LAG-3 binding peptide LFP-6 by phage display bio-panning,which specifically blocks the interaction of LAG-3/FGL1 but not LAG-3/***,D-amino acids were introduced to substitute the N-and C-terminus of LFP-6 to obtain the proteolysis-resistant peptide LFP-D1,which restores T cell function in vitro and inhibits tumor growth in ***,a bispecific peptide LFOP targeting both PD-1/PD-L1 and LAG-3/FGL1 was designed by conjugating LFP-D1 with PD-1/PD-L1blocking peptide OPBP-1(8-12),which activates T cell with enhanced proliferation and IFN-γ *** importantly,LFOP combined with radiotherapy significantly improve the T cell infiltration in tumor and elevate systemic antitumor immune *** conclusion,we developed a novel peptide blocking LAG-3/FGL1 which can restore T cell function,and the bispecific peptide synergizes with radiotherapy to further enhance the antitumor immune response.

关键词： LAG-3 FGL1 PD-1 PD-L1 Peptide Immune checkpoint Radiotherapy Cancer immunotherapy

MINS, a Novel Naphthalimide-Polyamine Conjugate, Induced Apoptosis Depending on p53 Status in Human Colon Cancer Cells

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Open Journal of Apoptosis 2014年第4期3卷 59-69页

作者： Ming Li Tao Yang Fujun Dai qian Li yahong Zhang Songqiang Xie Chaojie Wang Institute of Chemical Biology Pharmaceutical College of Henan University Kaifeng China The Key Laboratory of Natural Medicine and Immuno-Engineering Henan University Kaifeng China

Natural polyamine is an ideal antitumor drug carrier because of the great requirement difference between cancer cells and normal cells. Previous data demonstrated that many cytotoxic drugs conjugated with natural or synthetic polyamines have potent antitumor effects. Up to now, the antitumor mechanism of conjugates of naphthalimides with polyamine remains poorly understood in human colon cancer cells. The aim of this study is to evaluate the effect of MINS (a novel naph-thalimide-polyamine conjugate) and mechanism of MINS in human colon cancer cells. Mitochondrial toxicity, which was generated by ROS from mitochondria electron transport chain, might be a major factor in MINS-inducted apoptosis. Our data also demonstrated that MINS-mediated cell apoptosis depend on p53 status, for MINS induced Caco-2 cells (p53 null) only necrosis but not apoptosis. Furthermore, the apoptotic effect of MINS is stronger than that of Amonafide, the parent drug of MINS. Our data suggested that the MINS-mediated cell apoptosis depend on p53 in human colon cancer cells.

关键词： Naphthalimide-Polyamine Conjugates Apoptosis p53 Mitochondrial Transmembrane Potential Oxidative Stress

Modulation of nitrate-induced phosphate response by the MYB transcription factor RLI1/HINGE1 in the nucleus

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Molecular Plant 2021年第3期14卷 517-529页

作者： Zhihua Zhang Zhao Li Wei Wang Zhimin Jiang Liping Guo Xiaohan Wang Yangwen qian Xiahe Huang Yongqiang Liu Xiujie Liu yahong Liu Aifu Li Yu Yan Junpeng Xie Shouyun Cao Stanislav Kopriva Legong Li Fanjiang Kong Baohui Liu Yingchun Wang Bin Hu Chengcai Chu State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biologythe Innovative Academy for Seed DesignChinese Academy of SciencesBeijingChina School of Life Sciences Guangzhou University.GuangzhouChina College of Plant Science Jilin UniversityChangchunChina Biogle Genome Editing Center ChangzhouChina State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biologythe Innovative Academy for Seed DesignChinese Academy of SciencesBeijingChina College of Advanced Agricultural Science University of Chinese Academy of SciencesBeijingChina Botanical Institute Cluster of Excellence on Plant SciencesUniversity of CologneCologneGermany College of Life Sciences Capital Normal UniversityBeijingChina

The coordinated utilization of nitrogen(N)and phosphorus(P)is vital for plants to maintain nutrient balance and achieve optimal ***,we revealed a mechanism by which nitrate induces genes for phosphate utilization;this mechanism depends on NRT1.1B-facilitated degradation of cytoplasmic SPX4,which in turn promotes cytoplasmic-nuclear shuttling of PHR2,the central transcription factor of phosphate signaling,and triggers the nitrate-induced phosphate response(NIPR)and N-P coordinated utilization in *** this study,we unveiled a fine-tuning mechanism of NIPR in the nucleus regulated by Highly Induced by Nitrate Gene 1(HINGE1,also known as RLI1),a MYB-transcription factor closely related to ***1/HINGE1,which is transcriptionally activated by PHR2 under nitrate induction,can directly activate the expression of phosphate starvation-induced *** importantly,RLI1/HINGE1 competes with PHR2 for binding to its repressor proteins in the nucleus(SPX proteins),and consequently releases PHR2 to further enhance phosphate ***,RLI1/HINGE1 amplifies the phosphate response in the nucleus downstream of the cytoplasmic SPX4-PHR2 cascade,thereby enabling fine-tuning of N-P balance when nitrate supply is sufficient.

关键词： rice NIPR RLI1/HINGE1 PHR2 SPXs nucleus

Skin derived precursors induced Schwann cells mediated tissue engineering-aided neuroregeneration across sciatic nerve defect

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Bioactive Materials 2024年第3期33卷 572-590页

作者： Chengbin Xue Hui Zhu Hongkui Wang Yaxian Wang Xi Xu Songlin Zhou Dong Liu yahong Zhao Tianmei qian Qi Guo Jin He Kairong Zhang Yun Gu Leilei Gong Jian Yang Sheng Yi Bin Yu Yongjun Wang Yan Liu Yumin Yang Fei Ding Xiaosong Gu Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Research Center of Clinical MedicineAffiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNantong UniversityNantongJS226001PR China Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJS226001PR China Department of Hand Surgery China-Japan Union HospitalJilin UniversityChangchunPR China Medical School of Nantong University NantongJS226001PR China

A central question in neural tissue engineering is how the tissue-engineered nerve(TEN)translates detailed transcriptional signals associated with peripheral nerve regeneration into meaningful biological ***,we report a skin-derived precursor-induced Schwann cell(SKP-SC)-mediated chitosan/silk fibroin-fabricated tissue-engineered nerve graft(SKP-SCs-TEN)that can promote sciatic nerve regeneration and functional restoration nearly to the levels achieved by autologous nerve grafts according to behavioral,histological,and electrophysiological *** achieving better effect of neuroregeneration,this is the first time to jointly apply a dynamic perfusion bioreactor and the ascorbic acid to stimulate the SKP-SCs secretion of extracellular matrix(ECM).To overcome the limitation of traditional tissue-engineered nerve grafts,jointly utilizing SKP-SCs and their ECM components were motivated by the thought of prolongating the effect of support cells and their bioactive cues that promote peripheral nerve *** further explore the regulatory model of gene expression and the related molecular mechanisms involved in tissue engineering-aided peripheral nerve regeneration,we performed a cDNA microarray analysis of gene expression profiling,a comprehensive bioinformatics analysis and a validation study on the grafted segments and dorsal root ganglia tissues.A wealth of transcriptomic and bioinformatics data has revealed complex molecular networks and orchestrated functional regulation that may be responsible for the effects of SKP-SCs-TEN on promoting peripheral nerve *** work provides new insights into transcriptomic features and patterns of molecular regulation in nerve functional recovery aided by SKP-SCs-TEN that sheds light on the broader possibilities for novel repair strategies of peripheral nerve injury.

关键词： SKP-SCs-TEN Transcriptomic feature Reconstruction of regenerative microenvironment Molecular regulation Molecular regenerative-medicine