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Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes

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Nuclear Science and Techniques 2024年第4期35卷 208-220页

作者： Ao-Yan Cheng Hao Cai Shi Chen Tian-Lu Chen xiang dong You-liang Feng Qi Gao Quan-Bu Gou Yi-Qing Guo Hong-Bo Hu ming-ming Kang hai-Jin li Chen liu Mao-Yuan liu Wei liu Fang-Sheng Min Chu-Cheng Pan Bing-qiang Qiao xiang-li qian Hui-Ying Sun Yu-Chang Sun Ao-Bo wang Xu wang Zhen wang Guang-Guang Xin Yu-Hua Yao qiang Yuan Yi zhang School of Physics and Technology Wuhan UniversityWuhan 430072China School of Physics and Astronomy Yunnan UniversityKunming 650091China Ministry of Education The Key Laboratory of Cosmic Rays(Tibet University)Lhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences 19 A Yuquan RoadShijingshan DistrictBeijing 100049China College of Physics Sichuan UniversityChengdu 610064China School of Intelligent Engineering Shandong Management UniversityJinan 250357China Tsung‑Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China Suzhou Aerospace Information Research Institute Suzhou 215123China College of Physics Chongqing UniversityNo.55 Daxuecheng South RoadHigh‑tech DistrictChongqing 401331China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210008China

The High Altitude Detection of Astronomical Radiation(HADAR)experiment,which was constructed in Tibet,China,combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity advantages of focused Cherenkov *** objective is to observe transient sources such as gamma-ray bursts and the counterparts of gravitational *** study aims to utilize the latest AI technology to enhance the sensitivity of HADAR *** datasets and models with distinctive creativity were constructed by incorporating the relevant physical theories for various *** models can determine the type,energy,and direction of the incident particles after careful *** obtained a background identification accuracy of 98.6%,a relative energy reconstruction error of 10.0%,and an angular resolution of 0.22°in a test dataset at 10 *** findings demonstrate the significant potential for enhancing the precision and dependability of detector data analysis in astrophysical *** using deep learning techniques,the HADAR experiment’s observational sensitivity to the Crab Nebula has surpassed that of MAGIC and *** energies below 0.5 TeV and remains competitive with conventional narrow-field Cherenkov telescopes at higher *** addition,our experiment offers a new approach for dealing with strongly connected,scattered data.

关键词： Vhe gamma-ray astronomy HADAR Deep learning Convolutional neural networks

Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao zhang Sen Luo hai li Shu-Ning Sun Xian-Bo wang Xin Zheng Yan Huang Bei-ling li Yan-Hang Gao Zhi-Ping qian Feng liu Xiao-Bo Lu Jun-Ping liu Hao-Tang Ren Yu-Bao Zheng Hua-dong Yan Guo-Hong Deng liang Qiao Yan zhang Wen-Yi Gu Xiao-Mei xiang Yi Zhou Yi-Xin Hou Qun zhang Yan Xiong Cong-Cong Zou Jun Chen Ze-Bing Huang Xiu-Hua Jiang Ting-Ting Qi Yuan-Yuan Chen Na Gao Chun-Yan liu Wei Yuan Xue Mei Jing li Tao li Rong-Jiong Zheng Xin-Yi Zhou Jun Zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure liver cirrhosis Clinical features Prognosis

Anα/βhydrolase family member negatively regulates salt tolerance but promotes flowering through three distinct functions in rice

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Molecular Plant 2022年第12期15卷 1908-1930页

作者： You-Huang xiang Jia-Jun Yu Ben liao Jun-xiang Shan wang-Wei Ye Nai-qian dong Tao Guo Yi Kan hai zhang Yi-Bing Yang Ya-Chao li huai-Yu Zhao Hong-Xiao Yu Zi-Qi Lu Hong-Xuan lin National Key Laboratory of Plant Molecular Genetics CAS Centre for Excellence in Molecular Plant Sciences and Collaborative Innovation Center of Genetics&DevelopmentShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China Guangdong Laboratory for lingnan Modern Agriculture Guangzhou 510642China University of the Chinese Academy of Sciences Beijing 100049China School of life Science and Technology ShanghaiTech UniversityShanghai 201210China

Ongoing soil salinization drastically threatens crop growth,development,and yield *** is therefore crucial that we improve salt tolerance in rice by exploiting natural genetic ***,many salt-responsive genes confer undesirable phenotypes and therefore cannot be effectively applied to practical agricultural *** this study,we identified a quantitative trait locus for salt tolerance from the African rice species Oryza glaberrima and named it as Salt Tolerance and heading Date 1(STH1).We found that STH1 regulates fatty acid metabolic homeostasis,probably by catalyzing the hydrolytic degradation of fatty acids,which contributes to salt ***,we demonstrated that STH1 forms a protein complex with D3 and a vital regulatory factor in salt tolerance,OsHAL3,to regulate the protein abundance of OsHAL3 via the 26S proteasome ***,we revealed that STH1 also serves as a co-activator with the floral integrator gene heading date 1 to balance the expression of the florigen gene heading date 3a under different circumstances,thus coordinating the regulation of salt tolerance and heading ***,the allele of STH1 associated with enhanced salt tolerance and high yield is found in some African rice accessions but barely in Asian *** of the STH1HP46 allele from African rice into modern rice cultivars is a desirable approach for boosting grain yield under salt ***,our discoveries not only provide conceptual advances on the mechanisms of salt tolerance and synergetic regulation between salt tolerance and flowering time but also offer potential strategies to overcome the challenges resulted from increasingly serious soil salinization that many crops are facing.

关键词： rice salt tolerance flowering time grain yield fatty acid

Effect of cooling parameters on the microstructure and properties of Mo-bearing and Cr-bearing steels

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International Journal of Minerals,Metallurgy and Materials 2011年第5期18卷 551-556页

作者： xiang-dong Huo Yu-qian li Yu-tao Zhao hai-wang zhang Zhao-hui li School of Material Science and Engineering Jiangsu University Zhenjiang 212013 China Technology Center of Handan Iron and Steel Corp. Handan 056002 China

To develop low-cost low carbon bainitic steel, Mo-bearing and Cr-bearing steels were melted in a vacuum induction furnace and were researched by thermal simulation and hot rolling at the laboratory. As the cooling rate increases from 0.2 to 50°C/s, the transformation temperatures of two steels lie between 650 and 400°C, and the final microstructures of them change from quasi-polygonal ferrite and granular bainite to lath bainite. Compared with cooling in air or by interrupted cooling, Mo-bearing and Cr-bearing steel plates cooled by sprayed water boast higher strength and superior toughness, for large-size islands are responsible for the poor mechanical properties. Compared to Mo, Cr is effective to isolate the bainitic reaction in low carbon steel, and the bainitic microstructure can also be obtained in Cr-bearing steel cooled at a wide range of cooling rate.

关键词： low carbon steel bainite phase transformations chromium microstructure mechanical properties

Development of Oligo-GISH kits for efficient detection of chromosomal variants in peanut

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The Crop Journal 2023年第1期11卷 238-246页

作者： Pei Du liuyang Fu qian wang Tao Lang Hua liu Suoyi Han Chenyu li Bingyan Huang li Qin Xiaodong Dai Wenzhao dong Xinyou zhang henan Academy of Crop Molecular Breeding/State Industrial Innovation Center of Biological Breeding/The Shennong Laboratory/Key Laboratory of Oil Crops in Huang-huai-hai Plains Ministry of Agriculture/Henan Provincial Key Laboratory for Oil Crops ImprovementHenan Academy of Agricultural SciencesGraduate T&R Base of Zhengzhou UniversityZhengzhou 450002HenanChina Institute of Biotechnology and Nuclear Technology Sichuan Academy of Agricultural SciencesChengdu 610061SichuanChina

Oligo probe staining is a low-cost and efficient chromosome identification *** this study,oligo genomic in situ hybridization(Oligo-GISH)technology was established in *** A and B subgenome-specific interspersed repeat(IR)oligo probe sets were developed based on clustering and electronic localization of tandem repeat sequences in the reference genome of *** OligoGISH kit was then used to perform staining of 15 Arachis *** A-subgenome probe set stained the chromosomes of A-and E-genome Arachis species,the B-subgenome probe set stained those of B-,F-,K-,and E-genome species,and neither set stained those of H-genome *** results indicate the relationships among the genomes of these Arachis *** Oligo-GISH kit was also used for batch staining of the chromosomes of 389 seedlings from the irradiated M1generation,allowing 67 translocation and deletion lines to be *** Oligo-FISH karyotyping,FISH using single-copy probe libraries,and trait investigation identified seven homozygous chromosomal variants from the M3generation and suggested that there may be genes on chromosome 4B controlling seed number per *** findings demonstrate that the IR probe sets and method developed in this study can facilitate research on distant hybridization and genetic improvement in peanut.

关键词： Peanut Oligo-GISH Genomic relationship Variants Chromosome identification

Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated Chinese and Western Medicine

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Chinese Journal of Integrative Medicine 2023年第4期29卷 308-315页

作者： QU Yi-lun dong Zhe-yi CheNG hai-mei liU qian wang qian YANG Hong-tao MAO Yong-hui li Ji-jun liU Hong-fang GENG Yan-qiu HUANG Wen liU Wen-hu XIE Hui-di PENG Fei li Shuang JIANG Shuang-shuang li Wei-zhen DUAN Shu-wei FENG Zhe zhang Wei-guang liU Yu-ning TIAN Jin-zhou CheN xiang-mei Department of Nephrology First Medical Center of Chinese People's Liberation Army General HospitalNephrology Institute of the Chinese People's Liberation ArmyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Key Laboratory of Glucolipid Metabolic DisorderMinistry of Education of ChinaInstitute of Chinese MedicineGuangdong Pharmaceutical UniversityGuangdong Traditional Chinese Medicine Key Laboratory for Metabolic DiseasesGuangzhou 510006China Department of Nephrology The First Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Department of Nephrology Beijing HospitalBeijing 100730China Department of Nephrology The Forth Medical Center of People's Liberation Army General HospitalBejing 100039China Department of Endocrinology Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBejing 100700China Department of Nephrology The Third Medical Center of PLA General HospitalBeijing 100039China Department of Nephrology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Nephrology Beijing Friendship HospitalFaculty of Kidney DiseasesCapital Medical UniversityBeijing 100050China Department of Nephrology Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBeijing 100700China Three Departments of Encephalopathy Dongzhimen Hospital of Beijing University of Chinese MedicineBeijing 100700China

Objective:To investigate the factors related to renal impairment in patients with diabetic kidney disease(DKD)from the perspective of integrated Chinese and Western ***:Totally 492 patients with DKD in 8 Chinese hospitals from October 2017 to July 2019 were *** to Kidney Disease Improving Global Outcomes(KDIGO)staging guidelines,patients were divided into a chronic kidney disease(CKD)1-3 group and a CKD 4-5 *** data were collected,and logistic regression was used to analyze the factors related to different CKD stages in DKD ***:Demographically,male was a factor related to increased CKD staging in patients with DKD(OR=3.100,P=0.002).In clinical characteristics,course of diabetes>60 months(OR=3.562,P=0.010),anemia(OR=4.176,Pherosclerosis(OR=2.153,P=0.007)and blood deficiency syndrome(OR=1.945,P=0.020)were factors related to increased CKD staging in patients with ***:Male,course of diabetes>60 months,anemia,hyperuricemia,massive proteinuria,atherosclerosis,and blood deficiency syndrome might indicate more severe degree of renal function damage in patients with DKD.(Registration ***03865914).

关键词： diabetickidney disease integrated Chinese and Western medicine Chinese medicine syndrome

基于非局部位错密度晶体塑性有限元模型的金属晶体薄膜微弯曲变形特点(英文)

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Transactions of Nonferrous Metals Society of China 2013年第11期23卷 3362-3371页

作者：章海明董湘怀王倩李河宗上海交通大学模具CAD国家工程研究中心上海200030 河北工程大学机电工程学院邯郸056038

采用考虑非均匀微观结构的非局部位错密度晶体塑性有限元模型,研究金属晶体薄膜材料微弯曲塑性变形的特点。该模型采用统计存储位错密度和几何必需位错密度作为其内部状态变量,通过几何必须位错密度的演化来预测单晶体金属薄膜材料微弯... 详细信息

采用考虑非均匀微观结构的非局部位错密度晶体塑性有限元模型,研究金属晶体薄膜材料微弯曲塑性变形的特点。该模型采用统计存储位错密度和几何必需位错密度作为其内部状态变量,通过几何必须位错密度的演化来预测单晶体金属薄膜材料微弯曲中的应变梯度效应。采用不同晶粒大小的CuZn37α-黄铜多晶体薄膜进行微弯曲实验,并测量试样微弯曲变形后的微硬度分布图。将模拟得到的位错密度分布与实验测得的微硬度分布进行对比,发现粗晶试样和细晶试样微硬度分布的不同主要是由统计存储位错密度和几何必须位错密度引起的。基于微观物理机理,研究微弯曲变形的特点和位错密度的演化。

关键词：晶体塑性微弯曲统计存储位错几何必需位错

金属箔厚向为一个或几个晶粒时微塑性成形的本构模型(英文)

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Transactions of Nonferrous Metals Society of China 2013年第5期23卷 1428-1434页

作者：王倩董湘怀章海明李河宗申昱上海交通大学模具CAD国家工程研究中心上海200030 河北工程大学机电工程学院邯郸056038

为了描述4个因素(晶粒尺寸d、材料厚度t、厚度方向的晶粒数目(t/d)以及表面特性)对金属箔流动应力的影响,将表面层模型和位错密度结合,定量分析厚度方向晶粒数目对纯铜箔流动应力的影响,提出临界晶粒数目的判断准则。预测结果表明,当t/... 详细信息

为了描述4个因素(晶粒尺寸d、材料厚度t、厚度方向的晶粒数目(t/d)以及表面特性)对金属箔流动应力的影响,将表面层模型和位错密度结合,定量分析厚度方向晶粒数目对纯铜箔流动应力的影响,提出临界晶粒数目的判断准则。预测结果表明,当t/d大于某一临界值时,厚度方向晶粒数目对流动应力的影响可以忽略;而由于临界晶粒数目的影响,晶粒尺寸和厚度分别与流动应力的变化曲线也都出现了明显的转折点。基于以上分析,建立了一个综合的材料本构模型。该模型同时考虑了以上4个因素对金属箔流动应力的影响。将模型的计算结果与已有文献中高纯度镍的实验数据进行对比。结果表明,预测结果与实验数据相吻合且具有相同的变化趋势。特别是随着t/d比值的减小,Hall-Petch关系以及真实应力的变化曲线都具有2个明显的转折点。

关键词：本构模型流动应力微成形尺寸效应

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin ling Qiao-Nan Shan Xu-Yong Wei Rui wang Chang-Ku Jia li Zhuang Tian Shen li-Min Ding Zhi-Dan Xu Lai-Bang Luo li-Bo Sun Guang-ming li Tai-Shi Fang Nan Jiang Kun zhang Zhao-Jie Su Zhi-hai Peng Ren Lang Tao Jiang qiang he lin-Sen Ye Yang Yang Yu-Ting he Wen-Zhi Guo liu-Gen Lan Xu-Yong Sun dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi Bo wang Jiang liu qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen wang lin Zhong Jing-Sheng Ma Qi-Gen li Sheng-dong Wu Chang-Jiang Lu Cai-De Lu dong-Hua zhang Xuan wang Zi-qiang li Mu-Jian Teng Jun-Jie li Wen-Tao Jiang Jian-Hua li Quan-Bao zhang Ning-Qi Zhu Zheng-Xin wang Kang he qiang Xia Shao-Hua Song Zhi-Ren Fu Wei Qiu Guo-Yue Lv Rui-Peng Song Ji-Zhou wang Zheng wang Jian Zhou Gang Chen Ying-Peng Zhao li li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin Xie Xiao-Shun he Zhi-Yong Guo Shu-Sen Zheng Xiao Xu Department of hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents hepatocellular carcinoma liver transplantation Conversion