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Strong Correlation of Abnormal Serum and Urinary Iodine Levels with Papillary Thyroid Cancer:A Case-control Study

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Biomedical and Environmental Sciences 2020年第1期33卷 62-67页

作者： XIU Cheng HE qian ZHAO Hong Jian YUAN Zhen Nan GUO Lun hua wang Feng qian YANG Xian Guang TIAN Qiu shi SUN Qi Hao MIAO Su Sheng SUN Ji FAN Li Jun JIA Shen shan Department of Head and Neck Oncology the Third Affiliated HospitalHarbin Medical UniversityHarbin 150030HeilongjiangChina Public Health College Shandong First Medical University&Shandong Academy of Medical SciencesTai’an 271016ShandongChina general Surgery Department People's Hospital of Chengwu CountyHeze 274200ShandongChina Public Health College Harbin Medical UniversityHarbin 150076HeilongjiangChina Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin 150076HeilongjiangChina

Thyroid cancer is the most common malignancy of the endocrine system,and its incidence is increasing *** China,its incidence has increased from 1.78/104 in 1988 to 10.58/104 *** cancers are mainly classified into papi... 详细信息

关键词： PTC Strong Correlation Abnormal Serum and Urinary Iodine Levels Papillary Thyroid Cancer:A Case-control Study

基于ComBat方法调谐^(18)F-FDG PET脑显像的初步研究

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中华核医学与分子影像杂志 2024年第7期44卷 412-416页

作者：焦方阳王丹朱毓华鲁佳荧琚紫昭徐蒨葛璟洁华涛吴平施匡宇管一晖左传涛复旦大学附属华山医院核医学/PET中心上海200235 陆军军医大学大坪医院核医学科重庆400042 瑞士伯尔尼大学核医学科伯尔尼3010

目的基于ComBat方法对同一厂家不同型号PET采集的脑显像数据进行影像调谐,探讨该同质化方法对数据中心效应的影响。方法用2台不同型号PET/CT仪(德国Siemens Biograph64 TruePoint与Biograph128 mCT)对三维(3D)Hoffman脑模型进行^(18)F-F... 详细信息

目的基于ComBat方法对同一厂家不同型号PET采集的脑显像数据进行影像调谐,探讨该同质化方法对数据中心效应的影响。方法用2台不同型号PET/CT仪(德国Siemens Biograph64 TruePoint与Biograph128 mCT)对三维(3D)Hoffman脑模型进行^(18)F-FDG PET显像;对14名健康受试者[男8名、女6名;年龄(57.7±9.5)岁]用Biograph64 TruePoint、12名健康受试者[男9名、女3名;年龄(55.8±10.5)岁]用Biograph128 mCT PET/CT仪行^(18)F-FDG PET脑显像(受试者来源:复旦大学附属华山医院;时间:2020年11月至2023年3月)。依据自动解剖标记(AAL)脑模板将全脑划分为116个脑区,应用ComBat同质化方法对采集的脑模型及健康受试者ROI内PET数据进行影像调谐。对2台PET/CT所得数据影像调谐前后的放射性计数、SUV比值(SUVR)进行Mann-Whitney U检验;对健康受试者的数据进行基于体素的统计参数图(SPM)两独立样本t检验。结果对于3D Hoffman脑模型,Biograph64 TruePoint和Biograph128 mCT PET/CT的调谐前放射性计数[5590.33(4961.67,6102.95)与6116.03(5420.97,6660.66);z=-9.35,P0.05;SUVR:1.04(1.01,1.09)~2.32(2.24,2.40);z值:-0.82~0,均P>0.05]。SPM分析显示调谐前2台PET/CT仪采集的健康受试者脑内葡萄糖代谢在大脑皮质、基底节、中脑及小脑存在差异,调谐后有差异的脑区明显减少。结论ComBat同质化方法可有效地消除同一厂家不同型号PET/CT间系统性技术差异,为多中心脑显像研究提供1种简单、易实现的调谐方法。

关键词：脑图像处理,计算机辅助正电子发射断层显像术氟脱氧葡萄糖F18

Anomalous displacement reaction for synthesizing above-room-temperature and air-stable vdW ferromagnet PtTe2ge1/3

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National Science Review 2023年第1期10卷 236-245页

作者： Wenxuan Zhu Cheng Song qian wang hua Bai Siqi Yin Feng Pan Key Laboratory of Advanced Materials School of Materials Science and Engineering Beijing Innovation Center for Future Chips Tsinghua University

Emerging van der Waals（vdW） magnets provide a paradise for the exploration of magnetism in the ultimate two-dimensional（2D） limit,and the construction of integrated spintronic devices,and have become a research frontier in the field of low-dimensional *** date,prototypical vdW magnets based on metals of the first transition series（e.g.V,Cr,Mn and Fe） and chalcogen elements suffer from rapid oxidation restricted by the Hard-Soft-Acid-Base principle,as well as low Curie temperatures（TC）,which has become a generally admitted challenge in 2D ***,starting from air-unstable Cr2ge2Te6vdW thin flakes,we synthesize ge-embedded PtTe2(namely PtTe2ge1/3) with superior air stability,through the displacement reaction in the Cr2ge2Te6/Pt *** this process,the anomalous substitution of Cr with Pt in the thermal diffusion is inverse to the metal activity order,which can be attributed to the compatibility between soft-acid（Pt） and soft-base（Te） ***,the layered uniform insertion of ge unbalances Pt-Te bonds and introduces long-range ordered ferromagnetism with perpendicular magnetic anisotropy and a Curie temperature above room *** work demonstrates the anti-metal-activity-order reaction tendency unique in 2D transition-metal magnets and boosts progress towards practical 2D spintronics.

关键词： vdW magnets room-temperature ferromagnetism air stability HSAB PtTe2ge1/3

Impact of Traffic Emissions on Local Air Quality and the Potential Toxicity of Traffic-related Particulates in Beijing, China

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Biomedical and Environmental Sciences 2012年第6期25卷 663-671页

作者： TIAN Lei ZHANG Wei LIN Zhi qing ZHANG hua shan XI Zhu ge CHEN Jian hua wang Wei Laboratory for Environmental and Food Safety Risk Monitoring Technology Institute of Health and EnvironmentalMedicine Tianjin 300050 China Chinese Academy of Environmental Sciences Beijing 100012 China

Objective Air-borne particulates from different sources could have different physicochemical properties and inflammatory potentials. This study aims to characterize the chemical compositions and the toxicity of ambient particulate matter （PM） associated with traffic emissions. Methods The concentrations of trace elements, organic carbon （OC）, elemental carbon （EC） and polycyclic aromatic hydrocarbons （PAHs） in PM2.5 and PMlo were measured in samples collected at sites in Beijing, China. Their toxic effects on the pulmonary system of rats were investigated. Biochemical parameters （LDH, T-AOC, TP） and inflammatory cytokine（IL-6, IL-1, TNF-a） levels were measured in the lungs of rats exposed to traffic-related PM. Oxidative damage was observed. PM samples were taken from a near road site and an off road site in summer time in 2006. Results The concentrations of the USEPA priority pollutant PAHs in both PMlo and PM2.s were higher （299.658 and 348.412） at the near road site than those （237.728 and 268.472） at the off road site. The similar trend was observed for the concentrations of trace elements in PM. Compared to coarse particles （PM^0）, fine particles （PM2.s） have a greater adsorption capacity to enrich toxic elements than inhalable particles. Decrease in antioxidant capacity and an increase in the amount of lipid peroxidation products in rat lung tissues was observed. Conclusion The findings of the present study suggest that the differing inflammatory responses of PM collected from the two road sites might have been mediated by the differing physicochemical characteristics.

关键词： Traffic-related PM, PAHs Trace elements Pulmonary toxicity

神经营养因子赖氨酸激酶受体1型基因突变致先天性无痛无汗症1例并文献复习

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安徽医药 2024年第2期28卷 383-386页

作者：王晓宇曹芳罗明鑫华山安徽省儿童医院呼吸科安徽合肥230022

目的报告先天性无痛无汗症(CIPA)1例并文献复习,增加其病因及临床特点的了解,减少误诊误治。方法采集2021年12月安徽省儿童医院收治的病儿及其父母外周血进行医学全外显子组基因检测,并对候选基因变异进行Sanger测序验证。结果基因... 详细信息

目的报告先天性无痛无汗症(CIPA)1例并文献复习,增加其病因及临床特点的了解,减少误诊误治。方法采集2021年12月安徽省儿童医院收治的病儿及其父母外周血进行医学全外显子组基因检测,并对候选基因变异进行Sanger测序验证。结果基因分子遗传学分析结果提示病儿在神经营养因子赖氨酸激酶受体1型(NTRK1)中存在2个分别来自父母双方的杂合突变(c.575-19G>A和c.444C>A),结合病儿临床表现符合CIPA。结论 CIPA为单基因遗传病,临床罕见,基因分子遗传学分析有助于诊断。

关键词：遗传性感觉和自主神经性神经病先天性无痛无汗症罕见病基因突变神经营养因子赖氨酸激酶受体1型

Effects of lifestyle interventions on rural patients with type 2 diabetes mellitus

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World Journal of Diabetes 2020年第6期11卷 261-268页

作者： Bo wang Xiao-Li Mu Juan Zhao Hai-Ping Jiang shan-shan Li ge Yan Ying-Ying hua Xue-Yi Ren Li-Xia Xing Yan liang Shu-Dong Zhang Yu-Chi Zhao Department of Internal Medicine Yantaishan HospitalYantai 264025Shandong ProvinceChina Department of Osteoarthropathy Yantaishan HospitalYantai 264025Shandong ProvinceChina

BACKGROUND The prevalence of type 2 diabetes mellitus(T2DM)is rising rapidly in rural areas,and lifestyle interventions can effectively reduce the blood glucose levels of patients with ***,current dietary and exercise guidelines are still at experimental stages and are difficult for subjects to understand and *** Human Metabolism Analyzer provides real life interventions for the prevention and treatment of T2DM,and our pilot research has demonstrated its effectiveness and good *** To investigate the effect of and compliance with lifestyle interventions in rural patients with *** A total of ten rural villages were randomly selected in Chaoshui Township,Penglai City,shandong Province,China,to conduct health screening among residents aged 50 years or *** rural village represented a group,and 12 patients with T2DM were randomly selected from each group(total:120)to participate in this study and receive real life lifestyle interventions and medication *** interventions included changing the meal order(A),postprandial activities(B),resistance exercise(C),and reverse abdominal breathing(D).Diabetes education was conducted at least once a month with a weekly phone follow-up to monitor exercise and *** circumference,blood pressure,body mass index(BMI),motor function,body composition,fasting blood glucose,and glycated hemoglobin(HbA1c)were analyzed before and 3 mo after the ***,patient compliance and adjustments of hypoglycemic drugs were *** A total of 109 subjects completed the *** compliance rates for lifestyle interventions A,B,C,and D were 57.79%,60.55%,64.22%,and 75.23%,*** the subjects who received hypoglycemic drugs,the dose was reduced 2 to 3 times based on blood glucose in 54(67.50%)subjects and was tapered and discontinued in 5(6.25%)subjects within 3 mo,with no significant fluctuations in blood glucose after dose reduction and *** l

关键词： Type 2 diabetes mellitus Lifestyle interventions Body mass index

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen shanhong Chen shanzhen Chen Shao-Long Chen Shaomin Chen shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of geosciences Beijing China University of geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 geV Linac,a 1.1 geV Damping Ring,a Booster capable of achieving energies up to 180 geV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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分形理论及其在机械工程中的应用

煤矿机械 2005年第6期26卷 123-125页

作者：钱善华葛世荣朱华中国矿业大学可靠性研究所江苏徐州221008

分形理论为研究机械工程问题开辟了一条新的有效途径。在介绍分形的基本概念及其表征方法的基础上,阐述了分形理论在机械设备状态监测、故障诊断和摩擦学等领域的应用问题,并对分形理论在机械工程中的应用前景进行了展望。

关键词：分形理论机械工程摩擦学

Capecitabine combined with weekly docetaxel in Chinese patients 〉65 years with anthracycline-resistant metastatic breast cancer

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Chinese Medical Journal 2010年第22期123卷 3212-3216页

作者： wang hua-qing qian Zheng-zi LIU Xian-ming ZHANG Hui-lai LI Lan-fang QIU Li-hua HOU Yun ZHOU shi-yong HAO Xi-shan XIE Cong-hua Department of Medical Oncology Tianjin Medical University Cancer Hospital and Institute Key Laboratory of Breast Cancer Prevention and Therapy Ministry of Education Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 China Department of Radiation and Medical Oncology Zhongnan Hospital Hubei Cancer Clinical Study Center Wuhan University Wuhan Hubei 430071 China

Background There are no data on more tolerable capecitabine doses in elderly patients in Chinese population. The aim of this study was to evaluate the activity and safety of capecitabine combined with weekly docetaxel for the treatment of anthracycline-resistant metastatic breast cancer （MBC） in older Chinese patients. Methods MBC patients aged 〉65 years pretreated with 1-5 prior chemotherapy regimens, including an anthracycline, received oral capecitabine 825 mg/m^2 twice daily, days 1-14, plus docetaxel 30 mg/m^2 on days 1 and 8 every 21 days. All 41 enrolled patients received at least 1 dose of treatment and were evaluable for safety; 38 received at least 2 cycles （median 4, range 2-8） and were evaluable for efficacy. Results The overall objective response rate was 47%, including complete responses in 8% of patients. Median time to progression was 8.9 months. Median overall survival was 17.6 months. The most common side effects were haematological and gastrointestinal toxicities and hand-foot syndrome. The only grade 3/4 adverse events were neutropenia （12%）, alopecia （7%）, grade 3 nausea and vomiting （2%） and grade 3 nail toxicity （2%）. Conclusions Capecitabine 825 mg/m^2 twice daily plus weekly docetaxel is active with an acceptable safety profile in Chinese women 〉65 years with anthracycline-resistant MBC. Efficacy and tolerability compare favourably with previously reported trials evaluating higher capecitabine doses in combination with 3-weekly or weekly docetaxel.

关键词： capecitabine weekly docetaxel metastatic breast cancer anthracycline elderly tolerability