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An Efficient Solid State Method for Deoximation under Mild Conditions

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Chinese Chemical Letters 2006年第12期17卷 1559-1562页

作者： Wang ZHOU qian He LI sha PENG Institute of Fine Catalysis and Synthesis Hunan Normal University Changsha 410080

Oximes of ketones and aldehydes are efficiently converted to the corresponding carbonyl compounds, using a combination of NaHSO4.H20 and paraformaldehyde in good to excellent yields under solid state conditions at roo... 详细信息

关键词： Solid state deoximation oxime carbonyl compound.

Zircon U-Pb geochronology of Archean high-grade metamorphic rocks from Xi Ulanbulang area,central Inner Mongolia

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Science China Earth Sciences 2012年第2期55卷 204-212页

作者： DONG XiaoJie XU ZhongYuan LIU ZhengHong sha qian College of Earth Science Jilin UniversityChangchun 130061China

The early Precambrian high-grade metamorphosed basement in the Xi Ulanbulang area, central Inner Mongolia of China, is composed mainly of intermediate granulites and charnockitic gneisses. Both types of the rocks are closely associated spatially and temporally, with a gradual variation between them. In order to understand timing of the high-grade metamorphism, we carried out SHRIMP U-Pb dating of zircons of the rocks. Zircons from the granulites and charnockitic gneisses are similar in structure and age. Zircon cores show magmatic zoning and have ages of 2507-2545 Ma. The ages are interpreted as the forming time of protolith of the granulites and charnockitic gneisses, indicating that a strong magmatism existed at that time in the Yinshan Block. The zircon mantles and rims show homogeneous structures and record a strong granulite facies metamorphism event around 2500 Ma, with a time interval between the metamorphism and magamatism being less than 50 Ma. These suggest that the Western Block was similar to the Eastern Block in tectono-thermal timing at the end of the Neoarchean.

关键词： Xi Ulanbulang high-grade metamorphic rocks zircon SHRIMP U-Pb dating

Association between Macroscopic-factors and Identified HIV/AIDS Cases among Injecting Drug Users: An Analysis Using Geographically Weighted Regression Model

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Biomedical and Environmental Sciences 2014年第4期27卷 311-318页

作者： XING Jian Nan GUO Wei qian sha sha DING Zheng Wei CHEN Fang Fang PENG Zhi Hang QIN qian qian WANG Lu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University

Drug use （DU）, particularly injecting drug use （IDU） has been the main route of transmission and spread of Human Immunodeficiency Virus （HIV）/Acquired Immune Deficiency Syndrome （AIDSJ among injecting drug users （IDUs）[1]. Previous studies have proven that needles or cottons sharing during drug injection were major risk factors for HIV/AIDS transmission at the personal level[z4]. Being a social behavioral issue, HIV/AIDS related risk factors should be far beyond the personal level. Therefore, studies on HIV/AIDS related risk factors should focus not only on the individual factors, but also on the association between HIV/AIDS cases and macroscopic-factors, such as economic status, transportation, health care services, etc[1]. The impact of the macroscopic-factors on HIV/AIDS status might be either positive or negative, which are potentially reflected in promoting, delaying or detecting HIV/AIDS epidemics.

关键词： AIDS HIV An Analysis Using Geographically Weighted Regression Model

ERK1/2 Activities Are Dispensable for Oocyte Growth but Are Required for Meiotic Maturation and Pronuclear Formation in Mouse

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Journal of Genetics and Genomics 2015年第9期42卷 477-485页

作者： Yin-Li Zhang Xiao-Man Liu Shu-Yan Ji qian-qian sha Jue Zhang Heng-Yu Fan Life Sciences Institute Zhejiang University

Previous studies revealed that extracellular regulated kinase-1 and -2 （ERK1/2） cascade plays pivotal roles in regulating oocyte meiotic cell cycle progression. However, most knowledge about the in vivo function of ERK1/2 in mammalian oocytes was indirectly obtained from analyzing the phenotypes of Mos knockout mice. In this study, we knocked out Erkl and Erk2 in mouse oocytes as early as the primordial follicle stage using the well-characterized Gdp-Cre mouse model, and for the first time directly investigated the in vivo function of ERK1/2 in mouse oocytes. In this novel mouse model, we observed that ERK1/2 activities in oocyte are dispensable for primordial follicle maintenance, activation and follicle growth. Different from the Mos null oocytes, the ERK1/2-deleted oocytes had well-assembled spindles at metaphase I （MI）, extruded polar body-I （PB1） with normal sizes, and did not undergo a full parthenogenetic activation characterized for pronuclear formation. However, the ovulated ERK1/2-deleted oocytes had poorly-assembled metaphase II （MII） spindles, spontaneously released polar body-2 （PB2）, and were arrested at another metaphase called metaphase III （MIII）. In addition, ERK1/2 deletion prevented male pronuclear formation after fertilization, and caused female infertility. In conclusion, these results indicate that ERK1/2 activities are required for not only MII-arrest maintenance, but also efficient pronuclear formation in mouse oocytes.

关键词： Oocyte Female reproduction Meiosis ERK1/2 Fertilization

Inhibitory effect of three biopolymer materials on scar formation following trabeculectomy

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International Journal of Ophthalmology(English edition) 2011年第4期4卷 380-383页

作者： sha, qian Jiao, Guang-Yu Cui, Hai-Bin Wang, Jie Sun, Li-Bin Chen, Ming Fu, Song-Bin Harbin Med Coll Harbin 150001 Heilongjiang Pr Peoples R China China Med Univ Shengjing Hosp Dept Ophthalmol Shenyang 110004 Liaoning Provin Peoples R China Eye Dis Prevent Inst Harbin 150001 Heilongjiang Pr Peoples R China Heilongjiang Prov Hosp Dept Ophthalmol Harbin 150001 Heilongjiang Pr Peoples R China

AIM: To investigate the inhibitory effects of amniotic membrane, polylactic acid membrane and chitosan membrane on scar formation following trabeculectomy. METHODS: A total of 24 New Zealand white rabbits (48 eyes) were randomly divided into 4 groups: amniotic membrane group, polylactic acid membrane group, chitosan membrane group, and control group, with 6 rabbits (12 eyes) in each group. The left eyes underwent routine trabeculectomy, and the right eyes were considered as controls. Amniotic membrane, polylactic acid membrane and chitosan membrane were respectively installed under sclera flap in three groups, but any treatment was not applied in control group. Intraocular pressure, conjunctival filtering bleb, and anterior chamber inflammation responses were monitored at day 1, 3, 7, 14, 28 and 56 post-operatively. Eyeball tissue underwent histopathological examination at day 56 post-operatively. RESULTS: Fibrocytes and inflammatory cells were reduced in amniotic membrane, polylactic acid membrane and chitosan membrane groups compared to that in control group. At day 1 post-operatively, intraocular pressure was decreased in three membrane groups compared to that in control group. At day 14 post-operatively, the intraocular pressure was decreased significantly, while it of three membrane groups was significantly lower than that of preoperative (P0.05). Filtering bleb of four groups was clearly observed at day 7 post-operatively, but there was no significant difference in pair-wise comparison. At day 28 and 56 post-operatively, filtering bleb in control group was significantly narrowed compared to that in three membrane groups (P <0.05), but there was no significant difference in pair-wise comparison of three membrane groups. CONCLUSION: All amniotic membrane, polylactic acid membrane and chitosan membrane can effectively inhibit scar formation following trabeculectomy, the effect of amnioti

关键词： amniotic membrane polylactic acid membrane chitosan membrane glaucoma filtration surgery

温度与差应力对岩石熔融程度的等效关系——以角闪变粒岩为例

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吉林大学学报（地球科学版） 2011年第1期41卷 106-110页

作者：沙茜马瑞吉林大学地球科学学院长春130061

为了探讨差应力和温度与岩石熔融程度的关系,利用角闪变粒岩进行高温高压条件下的岩石变形实验。包括差应力条件下的动态实验,围压100MPa,温度700℃,施加相当于差应力为0～25MPa,且以每5MPa为间隔进行天然块状岩石样品的动态熔融;在相... 详细信息

为了探讨差应力和温度与岩石熔融程度的关系,利用角闪变粒岩进行高温高压条件下的岩石变形实验。包括差应力条件下的动态实验,围压100MPa,温度700℃,施加相当于差应力为0～25MPa,且以每5MPa为间隔进行天然块状岩石样品的动态熔融;在相同的围压条件下,温度由700℃到900℃每50℃为间隔,进行无差应力条件下天然块状岩石的静态熔融实验,并进行对比研究。结果表明,在相同温度条件下,岩石的熔融程度随着差应力的增加明显增高。通过对斜率的对比分析表明:以700℃为基准,差应力每增加5MPa,其带来的影响与温度升高40℃的效果相当,也说明中性岩石的熔融对差应力的敏感程度比酸性岩要高。

关键词：差应力熔融程度温度变质岩

Simulated Method on the Release of Sediment Pollutants in the Temple Lake

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Meteorological and Environmental Research 2014年第1期5卷 51-54页

作者： sha qian Wang Haitao Zhang Weihao Wuhan Environmental Protection Sciences Research Institute Wuhan University

[ Objective] The research aimed to study simulated method on the release of sediment pollutants in the Temple Lake. [ Method] For existing pollution status of the Temple Lake, sediments and overlying water were sampled by the integrated device. Based on the technical route, through the orthogonal test, release processes of nitrogen and phosphorus from sediment were simulated, and their release speeds were estimated under different temperatures, pH and DO in the laboratory. Relationship between environmental factor and pollutant release was explored. [ Result] The integrated device of sediment sampling and test had simple structure, cheap cost and easy operation, and sediment pollution test could be conducted without disturbing sediment after collecting sediment. Among the studied three impact factors, temperature had the maximum influence on contaminant release process, which should be considered as the important factor of future research. [ Conclusion] Compared with routine research method of sediment contaminant release from other lakes, simulated method of contaminant release from sediment in the Temple Lake had many advantaqes, which was favorable for scientific research in latter period and actual lake control.

关键词： Sediment Contaminant release Integrated device Simulated method China

纳米二氧化钛胶体分离富集-氢化物原子荧光光谱法测定水中超痕量锗

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光谱学与光谱分析 2012年第5期32卷 1397-1400页

作者：钱沙华鲁敏张旭武汉大学资源与环境科学学院生物质资源化学与环境生物技术湖北省重点实验室湖北武汉430079

提出了用纳米TiO2胶体富集,氢化物原子荧光光谱法测定水样中超痕量锗的新方法。当溶液的pH为6.0～8.0时,纳米TiO2胶体对Ge((Ⅳ)吸附率为97.0～99.0%,并且吸附速度快。利用纳米TiO2胶体良好的吸附性能对水样中超痕量Ge((Ⅳ)进行富集,离心... 详细信息

提出了用纳米TiO2胶体富集,氢化物原子荧光光谱法测定水样中超痕量锗的新方法。当溶液的pH为6.0～8.0时,纳米TiO2胶体对Ge((Ⅳ)吸附率为97.0～99.0%,并且吸附速度快。利用纳米TiO2胶体良好的吸附性能对水样中超痕量Ge((Ⅳ)进行富集,离心后,弃去上清液,用少量盐酸将富集了Ge((Ⅳ)的沉积物(纳米二氧化钛)转化成胶体,用氢化物原子荧光光谱法直接测定胶体中的锗。该法检出限(3σ)低(0.060μg.L-1),精密度好(相对标准偏差(RSD)为2.0%),简单、快速(省去了繁琐的过滤和脱附过程),用于实际水样中超痕量锗的测定,结果满意。

关键词：纳米二氧化钛胶体分离富集超痕量锗氢化物原子荧光光谱

Huangqin decoction alleviates lipid metabolism disorders and insulin resistance in nonalcoholic fatty liver disease by triggering Sirt1/NF-κB pathway

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World Journal of Gastroenterology 2023年第31期29卷 4744-4762页

作者： Bao-Fei Yan Lan-Fen Pan Yi-Fang Quan qian sha Jing-Zheng Zhang Yi-Feng Zhang Li-Bing Zhou Xi-Long qian Xiao-Mei Gu Feng-Tao Li Ting Wang Jia Liu Xian Zheng College of Pharmacy Jiangsu Health Vocational CollegeNanjing 211800Jiangsu ProvinceChina Department of Pathology Affiliated Kunshan Hospital of Jiangsu UniversityKunshan 215300Jiangsu ProvinceChina Department of Education and Science The First People's Hospital of TaicangKunshan 215400Jiangsu ProvinceChina Department of Pharmacy Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221006Jiangsu ProvinceChina School of Pharmacy Nantong UniversityNantong 226019Jiangsu ProvinceChina Department of Pharmacy Affiliated Kunshan Hospital of Jiangsu UniversityKunshan 215300Jiangsu ProvinceChina School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a clinicopathological entity characterized by intrahepatic ectopic *** a consequence of increased consumption of high-calorie diet and adoption of a sedentary lifestyle,the incidence of NAFLD has surpassed that of viral hepatitis,making it the most common cause of chronic liver disease *** decoction(HQD),a Chinese medicinal formulation that has been used clinically for thousands of years,has beneficial outcomes in patients with liver diseases,including ***,the role and mechanism of action of HQD in lipid metabolism disorders and insulin resistance in NAFLD remain poorly *** To evaluate the ameliorative effects of HQD in NAFLD,with a focus on lipid metabolism and insulin resistance,and to elucidate the underlying mechanism of *** High-fat diet-induced NAFLD rats and palmitic acid(PA)-stimulated HepG2 cells were used to investigate the effects of HQD and identify its potential mechanism of *** in HQD were analyzed by highperformance liquid chromatography(HPLC)to identify the key *** Ten primary chemical components of HQD were identified by HPLC *** vivo,HQD effectively prevented rats from gaining body and liver weight,improved the liver index,ameliorated hepatic histological aberrations,decreased transaminase and lipid profile disorders,and reduced the levels of pro-inflammatory factors and insulin *** vitro studies revealed that HQD effectively alleviated PA-induced lipid accumulation,inflammation,and insulin resistance in HepG2 ***-depth investigation revealed that HQD triggers Sirt1/NF-κB pathwaymodulated lipogenesis and inflammation,contributing to its beneficial actions,which was further corroborated by the addition of the Sirt1 antagonist EX-527 that compromised the favorable effects of *** In summary,our study confirmed that HQD mitigates lipid metabolism disorders and insulin resistance i

关键词： Nonalcoholic fatty liver disease Huangqin decoction Lipid metabolism disorders Insulin resistance Sirt1/NF-κB pathway