检索结果-南通市图书馆

Two missense STK11 gene variations impaired LKB1/adenosine monophosphate-activated protein kinase signaling in Peutz-Jeghers syndrome

引用

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1532-1546页

作者： Jin Liu Si-Cong Zeng An Wang Hai-Ying Cheng qian-jun zhang Guang-Xiu Lu Hunan Guangxiu Hospital Hunan Normal UniversityChangsha 410000Hunan ProvinceChina Scientific Research Department Reproductive and Genetic Hospital of Citic-XiangyaChangsha 410000Hunan ProvinceChina

BACKGROUND Peutz-Jeghers syndrome(PJS)is a rare hereditary neoplastic disorder mainly associated with serine/threonine kinase 11(STK11/LKB1)gene *** genetic testing can protect a patient’s offspring from mutated genes;however,some variations in this gene have been interpreted as variants of uncertain significance(VUS),which complicate reproductive decision-making in genetic *** To identify the pathogenicity of two missense variants and provide clinical *** Whole exome gene sequencing and Sanger sequencing were performed on the peripheral blood of patients with PJS treated at the Reproductive and Genetic Hospital of *** was employed to predict the protein structure,conservation,and pathogenicity of the two missense variation sites in patients with ***,plasmids were constructed and transfected into HeLa cells to observe cell *** differences in signal pathway expression between the variant group and the wild-type group were compared using western blot and *** analysis was performed using one-way analysis of variance.PG(***297Gly)and c.733C>T(***245Phe)]in 9 unrelated PJS families who were seeking reproductive *** two missense VUS were located in the catalytic domain of serine/threonine kinase,which is a key structure of the liver kinase B1(LKB1)*** vitro experiments showed that the phosphorylation levels of adenosine monophosphate-activated protein kinase(AMPK)at Thr172 and LKB1 at Ser428 were significantly higher in transfected variation-type cells than in wild-type *** addition,the two missense STK11 variants promoted the proliferation of HeLa *** immunohistochemical analysis showed that phosphorylated-AMPK(Thr172)expression was significantly lower in gastric,colonic,and uterine polyps from PJS patients with misse

关键词： Missense STK11 Peutz-Jeghers syndrome Rare disease Genetic counseling Assisted reproductive technique

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two-dimensional analysis of progressive delamination in thin film electrodes

引用

Acta Mechanica Sinica 2018年第2期34卷 359-370页

作者： Mei Liu Bo Lu Dong-Li Shi jun-qian zhang Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Department of Mechanics Shanghai University Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai University Materials Genome Institute Shanghai University

By employing the two-dimensional analysis, i.e.,plane strain and plane stress, a semi-analytical method is developed to investigate the interfacial delamination in electrodes. The key parameters are obtained from the governing equations, and their effects on the evolution of the delamination are evaluated. The impact of constraint perpendicular to the plane is also investigated by comparing the plane strain and plane stress. It is found that the delamination in the plane strain condition occurs easier, indicating that the constraint is harmful to maintain the structure stability. According to the obtained governing equations, a formula of the dimensionless critical size for delamination is provided, which is a function of the maximum volumetric strain and the Poisson’s ratio of the active layer.

关键词： Lithium-ion battery Thin film electrode Delamination Critical size

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of delamination in thin film electrodes under galvanostatic and potentiostatic operations with Li-ion diffusion from edge

引用

Acta Mechanica Sinica 2013年第3期29卷 348-356页

作者： Bo Lu Yi-Cheng Song Zhan-Sheng Guo jun-qian zhang Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Department of Mechanics Shanghai University Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai University

Progressive delamination driven by Li-ion diffusion in elastic disk-like thin film electrodes of Li-ion batteries is modeled based on the cohesive model. Axisymmetric diffusion model is considered under both galvanostatic and potentiostatic operations. The effect of edge diffusion on the delamination process is evaluated. It is found that the diffusion from edge leads to an earlier delamination initiation. The edge effect is significant for active disks with a small aspect ratio, but negligible for the case of large aspect ratio. The edge diffusion is weaker in the potentiostatic operation than in the galvanostatic operation.

关键词： Lithium-ion battery · Thin film electrode · De-lamination · Diffusion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Diminishing the Perception Bias in the Working Environment Using a Network Generation-Based Framework

引用

Tsinghua Science and Technology 2024年第3期29卷 671-683页

作者： jun qian Tongda zhang Xiao Sun Yueting Chai Department of Automation Tsinghua UniversityBeijing 100084China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055Chinaand with Systems Optimization LaboratoryStanford UniversityPalo AltoCA 94305USA

Income inequality is widespread in human society and has important implications for human ***’s perception of the environment bridges income inequality and individual behavioral *** research suggests that social income inequality is usually biased,either overestimated or ***,such phenomena have not been fully explored with quantitive prove,especially in the working environment based on performance data of actual *** fact,the correct perception of people is the basis of a fair environment for their production ***,the perception bias may weaken the adaptability and competitiveness of a company in the *** paper first confirms the prevalence of individual perception bias of income inequality within the working environment based on actual production *** results show that people tend to underestimate income inequity around them,and this underestimation grows with the real unfairness of the working ***,this paper proposes a network generation-based framework with a three-layer structure to correct perception bias using a cooperative network reengineering *** the framework,a homophily-based generative network model is proposed as the key *** simulation results show that our proposed framework effectively reduces individuals’perception bias of income inequality.

关键词： income inequality perception bias Gini coefficient factory production cooperative networkreengineering homophily-based generative network model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

引用

Light(Science & Applications) 2024年第2期13卷 333-346页

作者： Yifan Sun qian Li Ling-jun Kong Xiangdong zhang Key Laboratory of advanced optoelectronic quantum architecture and measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081BeijingChina

Compared with electrical neural networks,optical neural networks(ONNs)have the potentials to break the limit of the bandwidth and reduce the consumption of energy,and therefore draw much attention in recent *** far,several types of ONNs have been ***,the current ONNs cannot realize the acceleration as powerful as that indicated by the models like quantum neural *** to construct and realize an ONN with the quantum speedup is a huge ***,we propose theoretically and demonstrate experimentally a new type of optical convolutional neural network by introducing the optical *** is called the correlated optical convolutional neural network(COCNN).We show that the COCNN can exhibit“quantum speedup”in the training *** character is verified from the two *** is the direct illustration of the faster convergence by comparing the loss function curves of the COCNN with that of the traditional convolutional neural network(CNN).Such a result is compatible with the training performance of the recently proposed quantum convolutional neural network(QCNN).The other is the demonstration of the COCNN’s capability to perform the QCNN phase recognition circuit,validating the connection between the COCNN and the ***,we take the COCNN analog to the 3-qubit QCNN phase recognition circuit as an example and perform an experiment to show the soundness and the feasibility of *** results perfectly match the theoretical *** proposal opens up a new avenue for realizing the ONNs with the quantum speedup,which will benefit the information processing in the era of big data.

关键词： process quantum convolution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Novel Sesquiterpenoid from Glechoma longituba

引用

Chinese Chemical Letters 2006年第3期17卷 355-357页

作者： qian jun zhang Xiao Sheng YANG Hal Yan ZHU Ye WANG Xiao Jiang HAO Bao An SONG The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences Guiyang 550002 Research and Development Center of Fine Chemicals Guizhou Univerisity Guiyang 550025

A novel sesquiterpenoid was isolated from the whole plant of Glechoma longituba. Its structure was elucidated as 1, 8-epoxy-7（11）-germacren-5-one-12, 8-olide 1 on the basis of spectral evidences.

关键词： Glechoma longituba sesquiterppenoid 1,8-epoxy-7(11)-germacren-5-one- 12,8-olide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluating the tumor stratification with a lysosomal pH sensitive-probe by fluorescence lifetime imaging

引用

Chinese Chemical Letters 2024年第3期35卷 262-267页

作者： jun Yan Xing Liang qian zhang Luolin Wang Weiying Lin Guangxi Key Laboratory of Electrochemical Energy Materials Institute of Optical Materials and Chemical BiologySchool of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China

Owing to the anaerobic metabolism in the tumor,abundant acidic metabolites are produced and accumulated in the ***,the cells in different tumor layers are directly linked to the pH ***,due to the lack of robust tools,the high-efficient evaluation of the acidic micro-environment of tumor stratification faces the challenge of accurate *** designed a new pH sensitive fluorescent lifetime probe target to *** we expected,the fluorescence lifetime of PLN possesses a good linear fit to the pH value,which could detect the pH change at a single lysosome level in real time,and then evaluate the different acidity of tumor *** probe PLN is successfully used to evaluate the tumor stratification by fluorescence lifetime imaging microscopy(FLIM)for the first time,which is of great significance in the preoperative diagnosis of clinical tumor treatment or evaluation of drug delivery effect.

关键词： FLIM pH Fluorescence imaging Lysosome Tumor imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental and numerical investigation of the impacts of rotor tip-rake on excitation forces of pump-jet propulsors

引用

Journal of Hydrodynamics 2024年第1期36卷 142-157页

作者： Xue-qin Ji Xiao-song zhang Chen-jun Yang Xiao-qian Dong State Key Laboratory of Ocean Engineering Marine Numerical Experiment CentreSchool of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China CSSC Shanghai Marine Energy Saving Technology Co. Ltd.Shanghai200011China China Ship Scientific Research Center Shanghai Branch Shanghai200011China

The tip-clearance flow in a pump-jet propulsor exerts great impacts on the fluctuating pressures and resultant unsteady forces,which are important sources of structural vibrations and radiated noise *** blade geometry close to the tip is an important factor determining the vortex strength in the tip-clearance *** the open-water condition,the effects of raking the rotor tips on the duct-surface fluctuating pressures and the resultant unsteady forces acting on different components of the propulsor are investigated via physical model experiments and the numerical solution of Reynolds-averaged Navier-Stokes(RANS)equations coupled with the SST k-ωturbulence *** measured and simulated results of hydrodynamic pressures are consistent to each other,and the simulated flows help better understand why the fluctuating pressures change with the tip *** strong fluctuations of duct-surface pressures are caused by intensive tip separation *** duct-surface pressure fluctuations are effectively reduced by using the rake distribution near the tip towards blade back side and,for the combination of the five-bladed rotor and the seven-bladed stator,the resultant unsteady horizontal(and vertical)forces acting on the duct and stator are also reduced;while increasing rake leads to negative effect on pressure fluctuations and unsteady horizontal(and vertical)forces acting on all the components of the propulsor.

关键词： Pump-jet tip-clearance tip-rake fluctuating pressures excitation forces

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Supermassive Primordial Black Holes for Nano-Hertz Gravitational Waves and High-redshift JWST Galaxies

引用

Research in Astronomy and Astrophysics 2024年第9期24卷 3-8页

作者： Hai-Long Huang Yong Cai jun-qian Jiang jun zhang Yun-Song Piao School of Physical Sciences University of Chinese Academy of Sciences Institute for Astrophysics School of Physics Zhengzhou University International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced Study UCAS Institute of Theoretical Physics Chinese Academy of Sciences

Recently, observational hints for supermassive black holes have been accumulating, prompting the question: Can primordial black holes（PBHs） be supermassive, particularly with masses M?10～9M⊙? A supercritical bubble,containing an inflating baby universe, that nucleated during inflation can evolve into a PBH in our observable universe. We find that when the inflaton slowly transitions past a neighboring vacuum, the nucleation rate of supercritical bubbles inevitably peaks, leading to a mass distribution of multiverse PBHs with a peak mass up to M?1011M⊙. Thus, our mechanism naturally provides a primordial origin for supermassive black holes.

关键词： (cosmology:) early universe (cosmology:) inflation (galaxies:) quasars: supermassive black holes

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cytoplasmic FKBPs are involved in molting and metamorphosis through regulating the nuclear localization of EcR

引用

Insect Science 2024年第3期31卷 759-772页

作者： Xian zhang Qiao-Ran Wang qian Wu jun Gu Li-Hua Huang Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology School of Life SciencesSouth China Normal UniversityGuangzhouChina Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouChina

Molting and metamorphosis are important physiological processes in insects that are tightly controlled by ecdysone receptor(EcR)through the 20-hydroxyecdysone(20E)signaling *** is a steroid nuclear receptor(SR).Several FK506-binding proteins(FKBPs)have been identified from the mammal SR complex,and are thought to be involved in the subcellular trafficking of ***,their roles in insects are poorly *** explore whether FKBPs are involved in insect molting or metamorphosis,we injected an FKBP inhibitor(FK506)into a lepidopteran insect,Spodoptera litura,and found that molting was inhibited in 61.11%of the larvae,and that the time for larvae to pupate was significantly extended.A total of 10 FKBP genes were identified from the genome of *** and were clustered into 2 distinct groups,according to their subcellular localization,with FKBP13 and FKBP14 belonging to the endoplasmic reticulum(ER)group and with the other members belonging to the cytoplasmic(Cy)*** the CyFKBPs were significantly upregulated in the prepupal or pupal stages,with the opposite being observed for the ER group ***506 completely blocked the transfer of EcR to the nucleus under 20E induction,and significantly downregulated the transcriptional expression of many 20E signaling genes.A similar phenomenon was observed after RNA interference of2 CyFKBPs(FKBP45 and FKBP12b),but not for *** together,our data indicate that the cytoplasmic FKBPs,especially FKBP45 and FKBP12b,mediate the nuclear localization of EcR,thereby regulating the 20E signaling and ultimately affecting molting and metamorphosis in insects.

关键词： EcR FKBP metamorphosis molting RNAi subcellular localization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：