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Correction:Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3798-3798页

作者： Xia Li Mi Shao Xiangjun Zeng pengxu qian He Huang Bone Marrow Transplantation Center The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou People’s Republic of China Liangzhu Laboratory Zhejiang University Medical Center 1369 West Wenyi Road Hangzhou 311121 People’s Republic of China Institute of Hematology Zhejiang University Hangzhou Zhejiang People’s Republic of China Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy Hangzhou Zhejiang People’s Republic of China Center of Stem Cell and Regenerative Medicine Zhejiang University School of Medicine Hangzhou People’s Republic of China

Since the publication of this review1,the authors noticed one inadvertent mistake occurred in Fig.6c that needs to be *** correct Fig.6 is provided as *** detail,"Human-derived CAR-T cells"has been replaced by"Mouse-derived CAR-T cells"in the revised *** key findings of the article are not affected by these *** original review article has been corrected.

关键词： diseases cytokine release

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MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB

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Signal Transduction and Targeted Therapy 2024年第11期9卷 5267-5285页

作者： Xiujian Wang Xiao Tao Pengjie Chen Penglei Jiang Wenxiao Li Hefeng Chang Cong Wei Xinyi Lai Hao Zhang Yihan Pan Lijuan Ding Zuyu Liang Jiazhen Cui Mi Shao Xinyi Teng Tianning Gu Jieping Wei Delin Kong Xiaohui Si Yingli Han Huarui Fu Yu Lin Jian Yu Xia Li Dongrui Wang Yongxian Hu pengxu qian He Huang Bone Marrow Transplantation Center The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Liangzhu Laboratory Zhejiang University Medical Center1369 West Wenyi RoadHangzhou 311121China Institute of Hematology Zhejiang UniversityHangzhou 310003China Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy Hangzhou 310003China Center of Stem Cell and Regenerative Medicine Zhejiang University School of MedicineHangzhou 310058China Department of Hematology The Third Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325200China

Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T(CAR-T)***1/2 inhibitors(MEKIs),widely used in cancer treatment due to their ability to inhibit aberrant MAPK signaling,have shown potential synergistic effects when combined with ***,the impact and mechanisms of MEKIs on CAR-T cells remain uncertain and *** address this,we conducted a comprehensive investigation to determine whether MEKIs enhance or impair the efficacy of CAR-T *** findings revealed that MEKIs attenuated CAR-T cell exhaustion and terminal differentiation induced by tonic signaling and antigen stimulation,thereby improving CAR-T cell efficacy against hematological and solid ***,these effects were independent of the specific scFvs and costimulatory domains utilized in ***,analysis of bulk and single-cell transcriptional profiles demonstrates that the effect of MEK inhibition was related to diminish anabolic metabolism and downregulation of c-Fos and ***,the overexpression of c-Fos or JunB in CAR-T cells counteracted the effects of MEK ***,our Cut-and-Tag assay revealed that MEK inhibition downregulated the JunB-driven gene profiles associated with exhaustion,differentiation,anergy,glycolysis,and *** summary,our research unveil the critical role of the MAPK-c-Fos-JunB axis in driving CAR-T cell exhaustion and terminal *** mechanistic insights significantly broaden the potential application of MEKIs to enhance the effectiveness of CAR-T therapy.

关键词： JunB metabolism stimulation

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CCAR1 5′UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance

CCAR1 5′UTR as a natural miRancer of miR-1254 overrides tam...

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第九届全国核糖核酸学术讨论会

作者： Gaopeng Li Xiaoli Wu Wenchang qian Huayong Cai Xinbao Sun Weijie Zhang Sheng Tan Zhengsheng Wu pengxu qian Keshuo Ding Xuefei Lu Xiao Zhang Hong Yan Haifeng Song Shouhong Guang Qingfa Wu Peter E Lobie Ge Shan 朱涛中国科学技术大学 Hefei National Laboratory for Physical Sciences at Microscale Department of Pathology Anhui Medical University Stowers Institute for Medical Research Department of Pharmacology and Toxicology Beijing Institute of Radiation Medicine Cancer Science Institute of Singapore and Department of Pharmacology National University of Singapore

MicroRNAs(miRNAs)typically bind to unstructured miRNA-binding sites in targetRNAs,leading to a mutual repression of ***,we report that miR-1254interacts with structured elements in cell cycle and apoptosis regulator 1(CCAR1)5′untranslated region(UTR)and this interaction enhances the stability of both ***-1254 can also act as a repressor when binding to unstructured sites in its ***,structured miR-1254-targeting sites act as both a functional RNA motifsensing unit,and an independentRNA functional unit that enhances *** designed miRNA enhancers,termed"miRancers",can stabilize and enhance the activity of miRNAs of *** further demonstrate that CCAR1 5′UTR as a natural miRancer of endogenous miR-1254 re-sensitizes tamoxifen-resistant breast cancer cells to ***,our study presents a novel model of miRNA function,wherein highly structured miRancer-like motif-containing RNA fragments or miRancer molecules specifically interact with miRNAs,leading to reciprocal stabilization.

关键词： CCAR1 5’UTR miR-1254 mi Rancer tamoxifen

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河南省区域城市化与生态环境效应空间关系分析

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信阳师范学院学报（自然科学版） 2015年第3期28卷 377-381页

作者：鲁迪钱宏胜赵鹏飞耿鹏旭平顶山学院资源与环境科学学院河南平顶山467000 西北大学城市与环境学院陕西西安710127

运用熵权法对2012年河南省18个地市的城市化水平和生态环境效应进行综合评价,并在此基础上运用空间统计分析和GIS技术,探讨河南省区域城市化与生态环境效应的空间关系.结果表明:2012年河南省区域城市化水平与生态环境效应空间差异显著,... 详细信息

运用熵权法对2012年河南省18个地市的城市化水平和生态环境效应进行综合评价,并在此基础上运用空间统计分析和GIS技术,探讨河南省区域城市化与生态环境效应的空间关系.结果表明:2012年河南省区域城市化水平与生态环境效应空间差异显著,且呈现较明显的负相关对应关系;通过空间自相关与空间关联分析,区域城市化与生态环境效应呈现全局性显著的相似区域间"趋同"的集聚特征;运用K-Means聚类分析将2012年河南省区域城市化与生态环境响应关系划分为5种类型.

关键词：城市化生态环境效应熵权空间自相关空间关联河南省

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