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Genes & Diseases 2024年第5期11卷 91-93页

作者： Linzi Wei qian Yu Xueying Yang Department of Thoracic Surgery The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China

Lung cancer(Lc)is a prevalent and fatal malignancy,with high incidence and mortality rates.1 ATP binding cassette(ABc)transporters,a superfamily of integral membrane proteins,use ATP hydrolysis to facilitate substrate transport across cellular membranes.2 The pivotal role of ABc transporters in tumorigenesis was initially established by Mochida,3 who demonstrated that the loss of ABcB1 suppresses intestinal polyp formation and tumor progression in *** investigations have reported correlations between ABc transporters and the tumor microenvironment and cancer immunotherapy response,suggesting their modulatory effects on tumor progression and immunotherapy.

关键词： mortality adenocarcinoma Lung

Influence of Film Thickness on Nanofabrication of Graphene Oxide

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Nanomanufacturing and Metrology 2024年第2期7卷 13-25页

作者： chuan Tang Lei chen Linmao qian Tribology Research Institute The State Key Laboratory of Rail Vehicle SystemSchool of Mechanical EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Nanofabrication of two-dimensional materials through mechanical machining is normally influenced by not only process parameters such as load and velocity but also intrinsic properties such as strength and ***,we examined the effects of graphene oxide(GO)film thickness on nanofabrication on the plane surfaces and at the step edges using scanning probe microscope *** material removal of GO initiates at the load above a critical value,which strongly depends on film thickness and *** the increase in film thickness,the critical load decreases monotonically on the plane surfaces but increases gradually at the step ***,the critical load for the GO monolayer at the step edges is at least 25 times lower than that on the plane surfaces,and the gap decreases to around 3 times when GO thickness increases to four ***,mechanical nanofabrication initiating from the GO step edge allows producing various nanopatterns under extremely low loads around 1 ***,the GO nanostructures are deoxidized by annealing at 800°c in high-purity argon to restore their highly functionalized conjugated structures,which are supported by X-ray diffraction and Raman *** work provides a novel approach to fabricating graphene-like nanostructures by deoxidizing GO after nanofabrication,which holds significant potential for applications in graphene-based devices.

关键词： Graphene oxide Nanofabrication Film thickness step edge Nanopattern Deoxidized treatment

On the central Position of“chanting to Express One's Qing and Xing”in classical chinese Lyrical Poetics

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Frontiers of Literary Studies in china-Selected Publications from chinese Universities 2024年第2期18卷 119-152页

作者： qian Zhixi Department of chinese Language and Literature Peking UniversityBeijing 100871China

“chanting to express one's qing(emotions)and xing(natural inclination)”holds a central position in a series of lyrical theories in chinese classical *** on the philosophy of emotions and dispositions,this concept marks the development from the expression of aspirations and emotions in general and collective poetics prevalent in the pre-Qin period to the lyrical theory of individual *** poetry of literati in the Han and Wei dynasties originated from the view of“expressing aspirations”and gave rise to the view of“springing from emotions.”During the Southern and Northern dynasties,poetic thought centered on qing and xing began to be established,and people often associated poetry with“chanting to express one's qing and xing”in addition to the concepts of“expressing aspirations”and“springing from emotions.”The poetics of the Tang Dynasty absorbed the view of“Introduction to Mao's Version of The Book of Odes”on the ballads and court hymns composed in the decline of the Zhou Dynasty and the theory of qing and xing from the Southern and Northern *** fundamental assertion regarding poetry is“chanting to express one's qing and xing,”and it endowed the traditional theory of qing and xing with an emphasis on individuality and a reverence for natural *** advocating the didactic purpose,the poetics of the Tang Dynasty essentially aligned with the ballads composed in the decline of the Zhou Dynasty,“chanting to express one's qing and xing.”In the Song Dynasty,the theory of qing and xing was combined with individual ethical essence,serving as the ideological foundation of the emphasis on reason in Song *** the Ming and Qing dynasties,poets still followed the traditional theory of qing and xing,considering qing and xing as the foundation of *** them,the school of“expressing one's inner self”emphasized the natural expression of individuality and valued inspiration and innovation.

关键词： lyrical poetics chanting to express one's qing and xing expressing aspirations springingfrom emotions

Perspective for OER electrocatalysts:Lattice engineering of clay-like frameworks with near-surface cluster active sites

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Science china(Technological Sciences) 2024年第1期67卷 330-334页

作者： ZHANG DanTong qian BinBin XUE DongFeng Multiscale crystal Materials Research center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Near-surface cluster active centers(NScAc)are pivotal functional units in the catalysis of oxygen evolution reaction(OER),which exceeds the limitations imposed by the diverse coordination environments experienced in atomic and molecular active centers,thereby serving as an exceptional medium for exploring the dynamic catalytic processes of metal active sites[1,2].In the OER,the NScAc primarily consist of the catalytic site and the first neighboring coordinating *** investigation of NScAc surpasses the exclusive reliance on the electron state regulation mechanism at the atomic level.

关键词： cluster centers exceptional

Piecewise Acoustic Source Imaging with Unknown Speed of Sound Using a Level-Set Method

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communications on Applied Mathematics and computation 2024年第2期6卷 1070-1095页

作者： Guanghui Huang Jianliang qian Yang Yang Petroleum Geo-Services HoustonTX 77079USA Department of Mathematics Michigan State UniversityEast LansingMI 48824USA Department of computational Mathematics Science and EngineeringMichigan State UniversityEastLansingMI48824USA

We investigate the following inverse problem:starting from the acoustic wave equation,reconstruct a piecewise constant passive acoustic source from a single boundary temporal measurement without knowing the speed of *** the amplitudes of the source are known a priori,we prove a unique determination result of the shape and propose a level set algorithm to reconstruct the *** the singularities of the source are known a priori,we show unique determination of the source amplitudes and propose a least-squares fitting algorithm to recover the source *** analysis bridges the low-frequency source inversion problem and the inverse problem of *** proposed algorithms are validated and quantitatively evaluated with numerical experiments in 2D and 3D.

关键词： Inverse gravimetry Acoustic source imaging Inversion of sound speed Level-set method Inverse problem

An abundant valuable resource for salt-tolerance allele hunting in rice

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Plant communications 2024年第4期5卷 127-128页

作者： Nai-qian Dong Hong-Xuan Lin National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China University of the chinese Academy of Sciences Beijing 100049China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

Soil salinity is a major abiotic stressor that limits plant growth and crop productivity ***,soil salinity is predictably increasing owing to global climate change,over-fertilization,and various farm irrigation ***,there are more than 833 million hectares of salt-affected soils around the globe(8.7%of the planet),accounting for approximately 20%–50%of irrigated soils and posing a significant threat to food production and security for over 1.5 billion people worldwide as a result of salt-induced land degradation(FAO,2021;https://***/global-soil-partnership/resources/highlights/detail/en/c/1445579/).

关键词： soil salinity abundant

Amplified internal electric field of cs_(2)cuBr_(4)@WO_(3-x)S-scheme heterojunction for efficient cO_(2)photoreduction

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Journal of Energy chemistry 2024年第5期92卷 521-533页

作者： Zhijie Zhang Xuesheng Wang Junyi qian Jiayue Xu School of Materials Science and Engineering Shanghai Institute of TechnologyShanghai 201418China

Heterojunction construction,especially S-scheme heterojunction,represents an efficient universal strategy to achieve high-performance photocatalytic *** further performance stimulation of these well-designed heterojunctions,modulating the interfacial internal electric field(IEF)to steer dynamic charge transfer represents a promising ***,we realized the precise regulation of Fermi level(E_(F))of the oxidation semiconductor(mesoporous WO_(3-x))by tailoring the concentration of oxygen vacancies(V_(O)),maximizing the IEF intensity in cs_(2)cuBr_(4)@WO_(3-x)(ccB@WO_(3-x))S-scheme *** augmented IEF affords a robust driving force for directional electron delivery,leading to boosted charge ***,the developed ccB@WO_(3-x)S-scheme heterojunction demonstrated outstanding photocatalytic cO_(2)reduction performance,with the electron consumption rate(Relectron)up to 390.34μmol g^(-1)h^(-1),which is 3.28 folds higher than that of pure *** in-depth analysis of the S-scheme electron transfer mode was presented via theoretical investigations,electron spin resonance(ESR),photo-irradiated Kelvin probe force microscopy(KPFM),and in-situ X-ray photoelectron spectroscopy(XPS).Finally,the cO_(2)photoconversion route was explored in detail using in-situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)and DFT theoretical calculations.

关键词： cs_(2)cuBr_(4) WO_(3-x) Oxygen vacancy S-scheme heterojunction Internal electricfield

A path planning algorithm for a crop monitoring fixed-wing unmanned aerial system

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Science china(Information Sciences) 2024年第8期67卷 5-23页

作者： Longhao qian Yi Lok LO Hugh Hong-tao LIU Institute of Aerospace Studies University of Toronto Department of Mechanical Engineering The University of Hong Kong

With the growing demand for automation in agriculture, industries increasingly rely on drones to perform crop monitoring and surveillance. In this regard, fixed-wing unmanned aerial systems(UASs)are viable platforms for scanning a large crop field, given their payload capacity and range. To achieve maximum coverage without landing for battery replacement, an algorithm for producing a minimal required energy survey path is essential. Hence, an energy-aware coverage path planning algorithm is proposed *** constraints for a fixed-wing UAS to fly at low altitudes while achieving full coverage of the crop field are first analyzed. Then, the full path is decomposed into straight-line and U-turn primitives. Finally, an algorithm to calculate a combination of straight-line segments and U-turns is proposed to obtain the path with minimum required energy consumption. The genetic algorithm is used to efficiently determine the order of the straight-line paths to traverse. case studies show that the proposed algorithm can produce planning results for a convex-polygon-shaped crop field.

关键词： path planning genetic algorithm energy minimization fixed-wing UAS aerial survey

Therapeutic advances in atrial fibrillation based on animal models

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 135-152页

作者： qian GONG Xuan LE Pengcheng YU Lenan ZHUANG Institute of Genetics and Reproduction College of Animal SciencesZhejiang UniversityHangzhou310058China Key Laboratory of cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou310016China

Atrial fibrillation(AF)is the most prevalent sustained cardiac arrhythmia among humans,with its incidence increasing significantly with *** the high frequency of AF in clinical practice,its etiology and management remain *** develop effective treatment strategies,it is imperative to comprehend the underlying mechanisms of AF;therefore,the establishment of animal models of AF is vital to explore its *** spontaneous AF is rare in most animal species,several large animal models,particularly those of pigs,dogs,and horses,have proven as invaluable in recent years in advancing our knowledge of AF pathogenesis and developing novel therapeutic *** review aims to provide a comprehensive discussion of various animal models of AF,with an emphasis on the unique features of each model and its utility in AF research and *** data summarized in this review provide valuable insights into the mechanisms of AF and can be used to evaluate the efficacy and safety of novel therapeutic interventions.

关键词： Atrial fibrillation Animal model Therapeutic

Monitoring and evaluation of the water quality of the Lower Neches River, Texas, USA

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Water Science and Engineering 2024年第1期17卷 21-32页

作者： Qin qian Mengjie He Frank Sun Xinyu Liu Department of civil and Environmental Engineering Lamar UniversityBeaumontTX 77710USA Department of Industry Engineering Lamar UniversityBeaumontTX 77710USA Department of computer Science Lamar UniversityBeaumontTX 77710USA

Increasing bacteria levels in the Lower Neches River caused by Hurricane Harvey has been of a serious *** study is to analyze the historical water sampling measurements and real-time water quality data collected with wireless sensors to monitor and evaluate water quality under different hydrological and hydraulic *** statistical and Pearson correlation analysis on historical water samples determines that alkalinity,chloride,hardness,conductivity,and pH are highly correlated,and they decrease with increasing flow rate due to *** flow rate has positive correlations with Escherichia coli,total suspended solids,and turbidity,which demonstrates that runoff is one of the causes of the elevated bacteria and sediment loadings in the *** correlation between *** and turbidity indicates that turbidity greater than 45 nephelometric turbidity units in the Neches River can serve as a proxy for *** to indicate the bacterial outbreak.A series of statistical tools and an innovative two-layer data smoothing filter are developed to detect outliers,fill missing values,and filter spikes of the sensor *** correlation analysis on the sensor data illustrates that the elevated sediment/bacteria/algae in the river is either caused by the first flush rain and heavy rain events in December to March or practices of land use and land ***,utilizing sensor measurements along with rainfall and discharge data is recommended to monitor and evaluate water quality,then in turn to provide early alerts on water resources management decisions.

关键词： Water quality Pearson correlation analysis Lower Neches River YSI wireless sensors Non-point pollution