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How Do Deep Learning Forecasting Models Perform for Surface Variables in the South China Sea Compared to Operational Oceanography Forecasting Systems?

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Advances in Atmospheric Sciences 2025年第1期42卷 178-189页

作者： Ziqing ZU Jiangjiang XIA Xueming ZHU Marie DREVILLON Huier MO Xiao LOU qian zhou Yunfei ZHANG Qing YANG Key Laboratory of Marine Hazards Forecasting National Marine Environmental Forecasting CenterMinistry of Natural ResourcesBeijing 100081China Key Laboratory of Regional Climate-Environment for Temperate East Asia(RCE-TEA) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519000China Mercator Ocean International Ramonville Saint Agne 31400France

It is fundamental and useful to investigate how deep learning forecasting models(DLMs)perform compared to operational oceanography forecast systems(OFSs).However,few studies have intercompared their performances using an identical *** this study,three physically reasonable DLMs are implemented for the forecasting of the sea surface temperature(SST),sea level anomaly(SLA),and sea surface velocity in the South China *** DLMs are validated against both the testing dataset and the“OceanPredict”Class 4 *** show that the DLMs'RMSEs against the latter increase by 44%,245%,302%,and 109%for SST,SLA,current speed,and direction,respectively,compared to those against the ***,different references have significant influences on the validation,and it is necessary to use an identical and independent reference to intercompare the DLMs and *** the Class 4 dataset,the DLMs present significantly better performance for SLA than the OFSs,and slightly better performances for other *** error patterns of the DLMs and OFSs show a high degree of similarity,which is reasonable from the viewpoint of predictability,facilitating further applications of the *** extreme events,the DLMs and OFSs both present large but similar forecast errors for SLA and current speed,while the DLMs are likely to give larger errors for SST and current *** study provides an evaluation of the forecast skills of commonly used DLMs and provides an example to objectively intercompare different DLMs.

关键词： forecast error deep learning forecasting model operational oceanography forecasting system validation intercomparison

Sini decoction alleviates inflammation injury after myocardial infarction through regulating arachidonic acid metabolism

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Chinese Herbal Medicines 2025年第1期17卷 148-155页

作者： Cuiping Long qian zhou Min Xu Xin Ding Xingxing Zhang Ya Zhang Yuping Tang Guangguo Tan School of Pharmacy Shaanxi University of Chinese Medicine Department of Pharmacy Air Force Medical University Department of Traditional Chinese Medicine Xijing Hospital Air Force Medical University The Third Stationed Outpatient Department General Hospital of Central Theater Command of PLA

Objective:Myocardial inflammation during myocardial infarction(MI) could be inhibited by regulating arachidonic acid(AA) *** studies demonstrated that Sini Decoction(SND) was identified to be an effective prescription for treating heart failure(HF) caused by *** the anti-inflammatory mechanism of SND remained *** work was designed to investigate the anti-inflammato ry mechanism of SND through the AA metabolism pathway in vitro and in vivo ***:An inflammatory injury model of H9c2 cells was established by lipopolysaccharide(LPS)-stimulated macrophage-conditioned medium(CM).The MI model was built by the ligation of left anterior descending(LAD) branch of coronary artery in ***,the rats were divided into five groups:sham group,MI group,MI+Celecoxib group,MI+low-dose SND group(SND-L) and MI+high-dose SND group(SND-H).Cardiac function,histopathological changes and serum cytokines were examined four weeks *** blot analysis was conducted to verify the key enzymes levels in the AA metabolic pathway,including phospholipase A2(PLA2),cyclooxygenases(COXs) and lipoxygenases(LOXs).Results:These in vivo results demonstrated that SND could improve the cardiac function and pathological changes of rats with MI,and regulate the key inflammatory molecules in the AA metabolism pathway,including sPLA2,COX-1,COX-2,5-LOX and *** vitro,SND could decrease the release of proinflammatory cytokines including TNF-α and IL-6 and inhibit cell apoptosis in CM-induced H9c2 ***,SND could protect H9c2 cells from the damage of CM by regulating nuclear factor kappa-B(NF-κB) signal pathway and the expression of ***: SND may be a drug candidate for anti-inflammatory treatment during MI by regulating the multiple targets in the AA metabolism pathway.

关键词： anti-inflammation arachidonic acid metabolism pathway conditioned medium myocardial infarction Sini Decoction

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空投艇动力系统特殊管路设计的技术方法研究

舰船科学技术 2025年第2期47卷 41-44页

作者：郭昂周谦中国船舶科学研究中心江苏无锡214082

针对空投艇在离机和着水过程中,柴油机燃油及滑油管路无法满足极限使用要求的技术问题,提出解决方案。采用常开式直动式电磁阀与通电延时继电器组合装置,以及设计倾斜的多孔隔板特殊管路,能够有效解决极限状态下动力管路渗流油和滑油产... 详细信息

针对空投艇在离机和着水过程中,柴油机燃油及滑油管路无法满足极限使用要求的技术问题,提出解决方案。采用常开式直动式电磁阀与通电延时继电器组合装置,以及设计倾斜的多孔隔板特殊管路,能够有效解决极限状态下动力管路渗流油和滑油产生气泡的难题,同时满足空投艇降落后动力系统远距离遥控启动的需求。通过刚性冲锋突击艇的实船应用和验证,表明这一改进措施不仅提升了空投艇的实用性能力,而且对实际设计工作具有重要的指导意义。

关键词：空投艇动力系统特殊管路

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湖北省基础研究资助发展现状及策略

科技和产业 2025年第2期25卷 241-249页

作者：周茜武汉商学院通识教育学院武汉430000

近年来,湖北省形成了基础研究资助规模提升、管理有序、途径增加的良好局面,但仍存在基础研究资助来源较为单一、财政资助规模相对较小、自然科学基金管理行政色彩较为浓厚、资助平台数字化建设相对滞后等问题。湖北省需要通过创造有利... 详细信息

近年来,湖北省形成了基础研究资助规模提升、管理有序、途径增加的良好局面,但仍存在基础研究资助来源较为单一、财政资助规模相对较小、自然科学基金管理行政色彩较为浓厚、资助平台数字化建设相对滞后等问题。湖北省需要通过创造有利于基础研究多元化资助的社会环境、加大财政对基础研究的资助力度、改善基金管理模式、加快资助平台数字化建设等方式,强化区域基础研究资助体系建设,为实现高水平科技自立自强提供区域治理方案。

关键词：基础研究资助现状策略

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日本孔子学院本土化发展路径研究

文化创新比较研究 2025年第1期9卷 156-160页

作者：周倩鲁东大学山东烟台264025

孔子学院实现汉语国际推广和文化传播的可持续健康发展,在世界多元文化中扎根开花,需要注重本土化建设。日本作为我国的近邻和重要合作伙伴,与我国有着悠久的历史文化渊源,增加交流和理解是中日实现合作共赢的重要基石。该文通过分析日... 详细信息

孔子学院实现汉语国际推广和文化传播的可持续健康发展,在世界多元文化中扎根开花,需要注重本土化建设。日本作为我国的近邻和重要合作伙伴,与我国有着悠久的历史文化渊源,增加交流和理解是中日实现合作共赢的重要基石。该文通过分析日本孔子学院发展现状、本土化建设面临的挑战和问题,结合当地发展实际,提出适应日本文化、语言表达习惯的思路,通过改革教材内容、教学方法、传播方式,充分利用大众传媒加强宣传,有效融入日本学校教学、社区和民众日常生活、日本国民教学体系,逐步实现教育内容和教育资源本土化,助力日本孔子学院本土化发展。

关键词：日本孔子学院本土化汉语国际推广文化传播发展路径

Yolk–shell Au@carbon nanospheres with photothermal and electronplunder sterilization for infected wound healing

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Science China Materials 2025年第2期68卷 597-609页

作者： Jin Chai Changzhen Qu Kunpeng Li Jiaheng Liang qian zhou Rong Zhuang Shuo Wang Fei Xu Qingyan Jia Peng Li Frontiers Science Center for Flexible Electronics(FSCFE) Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&Engineering(IBME)Northwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU)Xi’an 710072China

Highly pathogenic-resistant bacteria infectionsseriously hinder the wound healing process and induce a catastrophic threat to human health. Incorporating multipleantibacterial strategies into nanostructured materials has beenverified to possess paramount promise for amelioratingtherapeutic efficiency against resistant bacteria. Herein, amultifunctional yolk–shell nanocomposite (Au@HCN) comprised of an aurum (Au) core and hollow carbon nanosphere(HCN) shell was prepared via one-step copolymerization andcarbonization. The electron plunder by Au@HCN on thebacterial membrane leads to bacterial membrane depolarization and enhanced reactive oxygen species (ROS) metabolism,resulting in remarkable efficacy against drug-resistant bacteriaunder dark conditions. Moreover, the synergetic photothermaltherapy (PTT) displayed significant antibacterial properties(~98%) when exposed to near-infrared (NIR) irradiation invitro. Meanwhile, efficient eradication of drug-resistant bacteria in the infected wound in vivo was observed under NIRexposure, thereby promoting wound healing through theprominent antibacterial properties of Au@HCN. The yolk–shell Au@HCN possesses tremendous potential for combatingmultidrug resistance with high efficiency.

关键词： wound infection drug-resistant bacteria photothermal therapy electron transfer nanocarbon

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Castleman disease and TAFRO syndrome:To improve the diagnostic consciousness is the key

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World Journal of Clinical Cases 2022年第5期10卷 1536-1547页

作者： qian-Yun zhou Department of Critical Care Medicine Peking University Shougang HospitalBeijing 100144China

BACKGROUND Castleman disease(CD)and TAFRO syndrome are very rare in clinical *** clinicians,especially non-hematological clinicians,do not know enough about the two diseases,so it often leads to misdiagnosis or missed *** To explore the clinical features and diagnosis of CD and TAFRO *** We retrospectively collected the clinical and laboratory data of 39 patients who were diagnosed with CD from a single medical *** Clinical classification identified 18 patients(46.15%)with unicentric Castleman disease(UCD)and 21 patients(53.85%)with multicentric Castleman disease(MCD),the latter is further divided into 13 patients(33.33%)with idiopathic multicentric Castleman disease-not otherwise specified(iMCD-NOS)and 8 patients(20.51%)with TAFRO *** and iMCD are significantly different in clinical manifestations,treatment,and ***,a few patients with MCD were diagnosed as UCD in their early *** was a correlation between two of Thrombocytopenia,anasarca and elevated creatinine,which were important components of TAFRO *** UCD group,the pathologies of lymph modes were mostly hyaline vascular type(13/18,72.22%),however plasma cell type or mixed type could also *** iMCD-NOS group and TAFRO syndrome group,the pathologies of lymph mode shown polarity of plasma cell type and hyaline vascular type *** with patients with TAFRO syndrome,patients with iMCD-NOS were diagnosed more *** The clinical and pathological types of CD are not completely separate,there is an intermediate situation or mixed characteristics between two ends of clinical and pathological *** clinical manifestations of patients with CD are determined by their pathological *** syndrome is a special subtype of iMCD with unique clinical manifestations.

关键词： Castleman disease Diagnosis Lymph node biopsy TAFRO syndrome

Clinicopathological Characters of Triple Negative Breast Cancer

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Chinese Journal of Cancer Research 2010年第1期22卷 17-20页

作者： Xin zhou qian Liu Chongqing Cancer Institute Chongqing 400030 China

Objective： To study the clinicopathological characters Methods： A total of 629 patients with breast cancer of triple negative breast cancer （TNBC）. were reviewed, who were treated from 2003 to 2007 in Chongqing Cancer Institute. The comparison of clinicopathological features including TNM classification, histological type, tumor location, axillary lymphonodes status and neoadjuvant chemotherapy between TNBC and nontriple negative breast cancer （NTNBC） was performed. The overall response was evaluated by whether the patients achieve complete remission （CR） and partial remission （PR） after chemotherapy. Results： There were 69 TNBCs in the 629 patients with breast cancer. The premenopausal patients, which was found in 49/69 of TNBCs, was more than NTNBCs. The average diameter of tumor in TNBC group was 4.1 cm, lager than NTNBC group. TNBC with axillary nodes metastasis occurred in 21 cases, and the axillary nodes metastasis rate was lower than NTNBC. The positive expression rate of p53 in TNBC was 44.9%, and the overall response （CR＋PR） was 72.2%. No statistical differences were found regarding the positive expression rate of p53 and the overall response between TNBC and NTNBC. Conclusion： TNBC were a group of primary breast cancers with triple negative, tending to occur in premenopausal women, with larger tumors, lower axillary nodes metastasis rate. TNBC had worse clinical prognosis and currently lacked effective targeted therapies.

关键词： Breast cancer Triple negative Prognosis

Magnetized Micropillar-Enabled Wearable Sensors for Touchless and Intelligent Information Communication

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Nano-Micro Letters 2021年第12期13卷 132-147页

作者： qian zhou Bing Ji Fengming Hu Jianyi Luo Bingpu zhou Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeTaipaMacao 999078P.R.China School of Applied Physics and Materials Research Center of Flexible Sensing Materials and DevicesWuyi UniversityJiangmen 529020P.R.China

The wearable sensors have recently attracted considerable attentions as communication interfaces through the information perception,decoding,and conveying ***,it is still challenging to obtain a sensor that can convert detectable signals into multiple outputs for convenient,e cient,cryptic,and high-capacity information ***,we present a capacitive sensor of magnetic field based on a tilted flexible micromagnet array(t-FMA)as the proposed interaction *** the bidirectional bending capability of t-FMA actuated by magnetic torque,the sensor can recognize both the magnitude and orientation of magnetic field in real time with non-overlapping capacitance *** optimized sensor exhibits the high sensitivity of over 1.3 T-1 and detection limit down to 1 mT with excellent *** a proof of concept,the sensor has been successfully demonstrated for convenient,e cient,and programmable interaction systems,e.g.,touchless Morse code and Braille *** distinguishable recognition of the magnetic field orientation and magnitude further enables the sensor unit as a high-capacity transmitter for cryptic information interaction(e.g.,encoded ID recognition)and multi-control instruction *** believe that the proposed magnetic field sensor can open up a potential avenue for future applications including information communication,virtual reality device,and interactive robotics.

关键词： Electronic skin Human–machine interaction Cryptic information communication Magnetic field sensing Tilted magnetized micropillar