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Two-weight Norm Inequalities for Local Fractional Integrals on Gaussian Measure Spaces

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Acta Mathematica Sinica,English Series 2022年第7期38卷 1203-1228页

作者： Bo Ning DI qian jun he Dun Yan YAN School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China School of Applied Science Beijing Information Science and Technology UniversityBeijing 100192P.R.China

In this paper,the authors establish the two-weight boundedness of the local fractional maximal operators and local fractional integrals on Gaussian measure spaces associated with the local *** precisely,the authors first obtain the two-weight weak-type estimate for the locala fractional maximal operators of orderαfrom L^(p)(v)to L^(q,∞)(u)with 1≤p≤qa A_(p,q,a)^(b') ,and then obtain the two-weight weak-type estimate for the local fractional *** addition,the authors obtain the two-weight strong-type boundedness of the local fractional maximal operators under a condition of(u,v)∈M_(p,q,a)^(6a+9√da^2) and the two-weight strong-type boundedness of the local fractional *** estimates are established by the radialization method and dyadic approach.

关键词： Local fractional integral local fractional maximal operator two-weight inequality Gaussian measure space

Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota

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Neural Regeneration Research 2022年第2期17卷 409-417页

作者： Yi-Tong Lin Qing-Qing Shi Lei Zhang Cai-Ping Yue Zhi-jun he Xue-Xia Li qian-jun he Qiong Liu Xiu-Bo Du College of Life Sciences and Oceanography Guangdong Provincial Key Laboratory for Plant EpigeneticsShenzhen UniversityShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringHealth Science CenterShenzhen UniversityShenzhenGuangdong ProvinceChina Shenzhen Bay Laboratory ShenzhenGuangdong ProvinceChina

Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic(3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months. The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg Alzheimer's disease mice. In addition, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These findings suggest that hydrogen-rich water is an effective hydrogen donor that can treat Alzheimer's disease. This study was approved by the Animal Ethics and Welfare Committee of Shenzhen University, China(approval No. AEWC-20140615-002) on june 15, 2014.

关键词： Alzheimer's disease amyloid-β anti-inflammation bioenergetics gut microbiota hydrogen therapy neurodegenerative disease neurofibrillary tangles

Recent advances in age-related metabolic dysfunction-associated steatotic liver disease

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World Journal of Gastroenterology 2024年第7期30卷 652-662页

作者： qian-jun he Yi-Fei Li Ling-Tong Zhao Chun-Tong Lin Chun-Yan Yu Dan Wang College of Basic Medicine Beihua UniversityJilin 132013Jilin ProvinceChina Department of Traumatic Surgery Jilin Central HospitalJilin 132001Jilin ProvinceChina

Metabolic dysfunction-associated steatotic liver disease(MASLD)affects approximately 25%of the world's population and has become a leading cause of chronic liver *** recent years,an increasing amount of data suggests that MASLD is associated with *** the population ages,age-related MASLD will become a major global health *** an aging will become a new approach to the treatment of *** paper reviews the current studies on the role of aging-related factors and therapeutic targets in MASLD,including:Oxidative stress,autophagy,mitochondrial homeostasis,bile acid metabolism homeostasis,and *** aim is to identify effective therapeutic targets for age-related MASLD and its progression.

关键词： Metabolic dysfunction-associated steatotic liver disease Aging Mitochondrial homeostasis Bile acid homeostasis Dysbiosis

The Mechanism of heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： GAO qian LI jun WANG Xianhui CAO Laifu GONG Jian LI Bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

Discovery of a new family member of arsenic–vanadium polyoxometalates with high catalytic performance for one-pot coupling of CO2, epoxides and amines

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Tungsten 2025年第1期7卷 80-87页

作者： Fang-qian Wang Yin Zhang Wei-Wei Wang Mei-qian Fu Hong-Bing Mo Wei-Dong Yu Chao Liu jun Yan College of Chemistry and Chemical Engineering Central South University junior Education Department Changsha Normal University School of Science Hunan University of Technology and Business

Arsenic-vanadium polyoxometalates（POMs） represent a family of tremendous potential catalysts owing to their peculiar physical and chemical *** in CO2conversion,using POMs to catalyze the conversion of CO2and epoxide into chemical intermediates is the research ***,A new family number of arsenic-vanadium POMs,[N（CH3）4]4[As8V12O38（H2O）]·2H2O({As8V12O38}),was reported and characterized by single-crystal X-ray diffraction,fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,*** from other allotropicity,{As8V12O38}shows a different structure pattern with an I-43d *** obtained {As8V12O38} was employed as a catalyst for the *** initial catalytic reaction confirmed that {As8V12O38} can catalyze the formation of epoxy carbonate by using 1.01 kPa CO2and epoxide at 70℃.Furtherly,when added amine in the catalytic system,oxazolidinone could be obtained by high yields,which provides an efficient way to convert CO2into profitable ***,a possible catalytic reaction mechanism was proposed by using different characterization analyses.{As8V12O38} first catalyzes the epoxide and CO2to form an epoxy carbonate and then catalyzes epoxy carbonate and benzylamine into oxazolidinone.

关键词： Arsenic CO2 conversion Oxazolidinone Polyoxometalates Vanadium

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-qian Yang Chun-Hao Yang Shi-jun he Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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富血小板纤维蛋白应用于年轻恒牙牙髓血运重建术的临床研究

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北京大学学报（医学版） 2018年第4期50卷 672-679页

作者：陆瑾慧钱军刘鹤朱俊霞北京大学口腔医学院.口腔医院儿童口腔科国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081 北京大学口腔医学院.口腔医院第二门诊部北京100101

目的:比较富血小板纤维蛋白(platelet-rich fibrin,PRF)牙髓血运重建术和经典牙髓血运重建术对患儿年轻恒牙的临床治疗效果。方法:选择16例患儿的18颗牙髓坏死伴或不伴根尖病变的年轻恒牙,行PRF牙髓血运重建术,选择同期行经典牙髓血运... 详细信息

目的:比较富血小板纤维蛋白(platelet-rich fibrin,PRF)牙髓血运重建术和经典牙髓血运重建术对患儿年轻恒牙的临床治疗效果。方法:选择16例患儿的18颗牙髓坏死伴或不伴根尖病变的年轻恒牙,行PRF牙髓血运重建术,选择同期行经典牙髓血运重建术的20例患儿的22颗患牙作为对照组。所有观察患儿/患牙均符合纳入标准,术后定期复查,对其临床表现及X线片进行评估及测量。通过治疗前后的临床记录及影像学资料评价治疗的成功率,并测量和比较治疗前后X线片上患牙的牙根长度、根管壁厚度及根尖孔大小的变化。结果:复查时间6~16个月,两组患儿的大部分患牙症状消失,根尖周病变得到控制或愈合(研究组17/18,对照组21/22),研究组患牙治愈率(83.3%)和对照组患牙治愈率(68.2%)的差异无统计学意义(P=0.446)。影像学结果显示,两组患儿年轻恒牙牙根均有一定程度发育,表现为牙根继续增长,根管壁增厚,根尖孔缩小(研究组15/18,对照组15/22)。研究组患牙根管壁增厚程度较对照组明显(P=0.039),两组的牙根长度增加(P=0.411)及根尖孔大小缩小(P=0.737)的差异无统计学意义。在牙髓活力恢复(P=0.517)、根管内钙化(P=0.324)及牙冠变色(P=0.386)方面,两组间差异也无统计学意义。结论:PRF牙髓血运重建术和经典牙髓血运重建术对患儿年轻恒牙的治疗效果均较好,但PRF牙髓血运重建术促进患儿年轻恒牙根管壁增厚的效果优于经典牙髓血运重建术。

关键词：牙髓血运重建再生富血小板纤维蛋白年轻恒牙患儿

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng jun-Hong Wu Dan-Dan Xu Kang he Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu qian-qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

锥形束CT图像经Planmeca Romexis软件三维影像重建鲁西南地区汉族人下颌第一恒磨牙牙根及根管的变异

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中国组织工程研究 2017年第16期21卷 2521-2526页

作者：马海峰耿海霞钱君荣刘贺刘平济宁医学院附属医院口腔科山东省济宁市272000

背景:下颌第一恒磨牙牙根数目多,根管形态复杂,存在一定变异性且种族差异较大,研究该牙的牙根及根管变异对提高根管预备效果、减少根管遗漏具有重要的意义。目的:应用锥形束CT调查鲁西南地区汉族人下颌第一恒磨牙牙根及根管变异情况。方... 详细信息

背景:下颌第一恒磨牙牙根数目多,根管形态复杂,存在一定变异性且种族差异较大,研究该牙的牙根及根管变异对提高根管预备效果、减少根管遗漏具有重要的意义。目的:应用锥形束CT调查鲁西南地区汉族人下颌第一恒磨牙牙根及根管变异情况。方法:选取2012年9月至2015年10月在济宁医学院附属医院口腔科行锥形束CT扫描的患者656例,要求双侧下颌第一恒磨牙均在,且发育完全,外观形态完整,未经治疗。锥形束CT图像经Planmeca Romexis软件三维影像重建,观察鲁西南地区汉族人下颌第一恒磨牙牙根及根管变异特点。结果与结论:(1)在1 312颗下颌第一恒磨牙中,2个牙根的下颌第一恒磨牙发生率为70.66%(927/1 312),根管变异型以2个牙根3个根管为主,占48.09%(631/1 312);(2)远舌根的个体发生率为35.37%(232/656),远舌根在所有牙齿中的发生率为29.34%(385/1 312),远舌根的对称性发生率为68.95%(153/232),远舌根的发生率男性高于女性,差异有显著性意义(P<0.05),右侧高于左侧,差异有显著性意义(P<0.05);(3)鲁西南地区汉族人下颌第一恒磨牙大部分有2个牙根,2个牙根3个根管是主要的根管变异类型,远舌根的发生率较高。利用锥形束CT对牙根和根管变异进行分析,可以为临床根管治疗提供参考依据。

关键词：磨牙牙根牙髓腔体层摄影术,X线计算机组织工程组织构建骨组织工程锥形束CT 下颌第一恒磨牙根管形态远舌根