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Malondialdehyde treatment reduced immunoreactivity of amandin and delayed its digestion

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Food Quality and Safety 2023年第2期7卷 277-290页

作者： Xin Luo Mingyan Ai Yongyan wu qia Wang Hongbo Song Qun Huang Jiankang Lu Production&Construction Group Key Laboratory of Special Agricultural Products Further Processing in Southern Xinjiang Tarim UniversityAla'erChina College of Food Science Fujian Agriculture and Forestry UniversityFuzhouChina School of Public Health The Key Laboratory of Environmental Pollution Monitoring and Disease ControlMinistry of EducationGuizhou Medical UniversityGuiyangChina wuhan Academy of Agricultural Sciences WuhanChina Institute for Egg Science and Technology School of Food and Biological EngineeringChengdu UniversityChengduChina Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangChina

Objectives:The secondary products of lipid oxidation are one of the main factors inducing protein *** effects of oxidation treatment with malondialdehyde(MDA)on the immunoreactivity of amandin and its digestion were *** and Methods:The rabbit IgG binding ability of amandin was analyzed by western blotting,and the changes in amandin oxidation and immunoreactivity during digestion of amandin with different degrees of oxidation were investigated in combination with an almond allergen enzyme-linked immunosorbent assay *** of linear epitopes of amandin by oxidation was investigated by liquid chromatography-tandemmass spectrometry(LC-MS/MS).Results:The results showed that the immunoreactivity of amandin was significantly reduced after 1 mmol/L MDA and 100 mmol/L MDA ***,the 1 mmol/L MDA treatment was owing to cleavage of linear epitope peptide in amandin and oxidation of the active amino *** 100 mmol/L MDA treatment was due to aggregation of amandin and significant decrease in its *** also reduced di-gestibility of amandin and significantly affected immunoreactivity during ***-MS/MS also identified four oxidation-prone methionine sites(aa 264-274,298-308,220-240,and 275-297)in gamma conglutinin ***:MDA treatment reduced the immunoreactivity of *** treatment also led to protein aggregation,which slowed down the digestion of amandin and altered the immunoreactivity of amandin during digestion.

关键词： Oxidation amandin immunoreactivity digestion LC-MS/MS

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给水污泥有机组分表征与碳排放核算探讨

供水技术 2024年第5期18卷 1-5页

作者：韩小蒙马艳叶辉武珉辉郭恰上海城市水资源开发利用国家工程中心有限公司上海 200082

给水污泥中的有机组分影响其资源化利用效果.选取4 座给水厂的污泥,对比了其有机组分的不同表征方法并探讨了碳排放核算参数.当以干基计量时,烧失量、总有机碳(TOC)、总化学需氧量(TCOD)、溶解性化学需氧量(SCOD)之间无显著相关性,但是... 详细信息

给水污泥中的有机组分影响其资源化利用效果.选取4 座给水厂的污泥,对比了其有机组分的不同表征方法并探讨了碳排放核算参数.当以干基计量时,烧失量、总有机碳(TOC)、总化学需氧量(TCOD)、溶解性化学需氧量(SCOD)之间无显著相关性,但是以湿基计量时,烧失量、TOC和TCOD两两之间显著相关,且含水率与SCOD也存在显著相关性.在计算给水污泥直接碳排放量时,不仅可以使用COD及其修正系数计算可降解有机碳(DOC),还可以通过TOC直接表征DOC.

关键词：给水污泥有机物碳排放烧失量总有机碳化学需氧量

Efficacy and safety of tacrolimus and low-dose prednisone in Chinese children with steroid-resistant nephrotic syndrome

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World Journal of Pediatrics 2020年第2期16卷 159-167页

作者： Hai-Xia Chen qia Cheng Fang Li Qing-Nan He Yan Cao Zhu-Wen Yi Xiao-Chuan wu Department of Pediatrics The Second Xiangya HospitalCentral South UniversityChangsha 410011China

Background Tacrolimus,a calcineurin inhibitor,is recommended by the recent guidelines from the Kidney Disease Improving Global Outcomes Group as the first-line treatment for steroid-resistant nephrotic syndrome(SRNS),but its clinical application in China is still *** investigated the efficacy and safety of tacrolimus combined with low-dose corticosteroids in a population of Chinese children with *** In this prospective non-randomized,non-controlled study,Chinese children with SRNS who failed the previous full-dose prednisone treatment were given tacrolimus(0.1 mg/kg/day)and low-dose prednisone(0.25-0.50 mg/kg/day).We compared the overall remission rate(ORR)and adverse events in the follow-up period with this therapeutic *** A total of 76 children were enrolled into the study with an average follow-up period of 18±6 months(maximum 36 months).ORR achieved by the first,third,and sixth months was 94.7%,94.7%,and 96.0%,*** patients who attained an initial tacrolimus trough concentration(FK506C0)>6 ng/mL(60.3%)achieved *** relative risk of relapse at FK506C0<3 ng/mL compared to 3-6 ng/mL,6-9 ng/mL,and 9-12 ng/mL was 2.3,3.2,and 16.9,*** the follow-up period,adverse effects that had been previously reported were *** Combination of tacrolimus and low-dose prednisone was safe and effective for the treatment of children with SRNS,with high remission rates observed as early as the first *** were infrequent,but tended to increase significantly with decreases in FK506C0.

关键词： Children Low-dose prednisone Steroid-resistant nephrotic syndrome Tacrolimus

Validation of the chinese version of the EORTC QLQ-CR29 in patients with colorectal cancer

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World Journal of Gastroenterology 2017年第10期23卷 1891-1898页

作者： Jin-bo Lin Lei Zhang Dong-Wen wu Zhou-Huan xi xue-Jun Wang yun-Shou Lin Wakana Fujiwara Jing-Ru Tian Min Wang Peng Peng Ai Guo Zhen Yang Le Luo Ling-Ya Jiang qia-qia Li xue-Ying Zhang yun-Feng Zhang Hou-Wei xu bing Yang xun-Lin Li Yi-xiong Lei School of Public Health Guangzhou Medical University Longgang Central Hospital of Shenzhen Department of Thoracic Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Lung Cancer Center Xiangya School of Medicine Central South University Department of Gastrointestinal Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Lung Cancer Center Tianjin Medical University School of Medicine Georgetown University Department of Radiation Oncology Tumor HospitalXiangya School of Medicine of Central South University Longgang District Peoples Hospital of Shenzhen1 Cancer Center of Guangzhou Medical University

AIM To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29 (EORTC QLQ-CR29) in Chinese patients with colorectal cancer (CRC). METHODS From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire (EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale (KPS). The reliability and validity of the questionnaires were assessed by Cronbach's proportional to coefficient, the Spearman correlation test and Wilcoxon rank sum test. RESULTS The EORTC QLQ-CR29 showed satisfactory reliability (proportional to > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability (proportional to = 0.608). The multitrait scaling analyses showed good convergent (r > 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups (KPS 80). Body image and most single- item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients. CONCLUSION The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients.

关键词： Colorectal cancer Health-related quality of life EORTC QLQ-CR29 China's Mainland

Matching Degree Analysis of the Requirements of Each Phase and the Characteristics of the Main Bodies of Public Crisis Management

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Matching Degree Analysis of the Requirements of Each Phase a...

2007 International Conference on Public Administration（ICPA 3rd）

作者： LI qia CHEN Xiao-jian wu Man-qing School of Management University of Science and Technology of China

In the public crisis management the network,we can divide the main bodies to core body,sub-core body and extension body according to the conditions to participate in the public crisis *** the process of setting up a public crisis management network,the analysis of the requirements of each phase and the characteristics of the main body of public crisis management is *** can provide us a direction instruction while we setting up cooperation network.

关键词： Public crisis Network management Phase Main body

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多酶复配合成海藻糖及其分离提取的研究

中国生物工程杂志 2019年第7期39卷 65-70页

作者：封金云宿玲恰吴敬江南大学食品科学与技术国家重点实验室无锡214122 江南大学生物工程学院工业生物技术教育部重点实验室无锡214122

以大米淀粉为原料,多酶复配制备海藻糖。确定了实验室条件下多酶复配生产海藻糖的最佳条件:以15%(m/V)大米淀粉为底物,催化温度45℃、pH 6. 0、DE值16、α/β-CGTase加量为1. 4U/ml、催化28h后糖化处理12h,海藻糖转化率由双酶法催化的50... 详细信息

以大米淀粉为原料,多酶复配制备海藻糖。确定了实验室条件下多酶复配生产海藻糖的最佳条件:以15%(m/V)大米淀粉为底物,催化温度45℃、pH 6. 0、DE值16、α/β-CGTase加量为1. 4U/ml、催化28h后糖化处理12h,海藻糖转化率由双酶法催化的50%提高至73%。在底物浓度为25%(m/V)时,海藻糖产量最高达到182. 5g/L,随后对高浓度海藻糖进行分离提取,分别考察了活性炭脱色、离交分离、浓缩结晶等对海藻糖提取效率的响。

关键词：海藻糖多酶复配酶催化反应分离提取

提高源自Bacillus circulans 251的β-CGTase对麦芽糖亲和性及其在生产海藻糖中的应用

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中国生物工程杂志 2019年第5期39卷 96-104页

作者：杜立宿玲恰吴敬江南大学食品科学与技术国家重点实验室无锡214122 江南大学生物工程学院工业生物技术教育部重点实验室无锡214122 江南大学教育部食品安全国际合作联合实验室无锡214122

将B. circulans 251β-CGTase应用于海藻糖制备,海藻糖转化率从50. 4%提高至71. 9%。为进一步提高底物的转化率,运用易错PCR-高通量筛选技术筛选对以麦芽糖为歧化反应受体的亲和性提高的B. circulans 251β-CGTase突变体。利用低底物浓... 详细信息

将B. circulans 251β-CGTase应用于海藻糖制备,海藻糖转化率从50. 4%提高至71. 9%。为进一步提高底物的转化率,运用易错PCR-高通量筛选技术筛选对以麦芽糖为歧化反应受体的亲和性提高的B. circulans 251β-CGTase突变体。利用低底物浓度的96孔板4,6-亚乙基-对硝基苯-α-D-麦芽七糖苷(EPS)显色法,最终筛选得到了一株对麦芽糖亲和性提高的突变体M234I。将野生型β-CGTase和突变体酶M234I进行蛋白质纯化,测定其酶学性质。结果表明,突变体的比活为345. 25U/mg,野生型则为357. 63U/mg;突变体M234I对麦芽糖的K_m为0. 258 2mmol/L,仅为野生型(0. 474 9mmol/L)的54. 4%,对麦芽糖的亲和性显著提高;突变体的最适温度、最适p H较野生型未发生较大变化。以麦芽糊精(DE值16)为底物,将突变体M234I用于多酶复配体系生产海藻糖,酶反应结果表明海藻糖的转化率最高达74. 9%,较野生型β-CGTase提高约3%。

关键词： β-CGTase 易错PCR 分子改造亲和性海藻糖转化

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电压无功功率优化控制中不可行问题的研究

电网技术 1999年第9期23卷 19-22页

作者：丁恰李乃湖武寒南京电力自动化研究院南京210003 东南大学电气工程系南京210018 华东电力调度局上海200002

分析了电力系统电压无功实时优化控制中出现的不可行问题，通过引入模糊约束，从一个新的角度对不可行问题进行了处理，最终获得尽量靠近原不等式约束空间的解。文中结合原对偶内点法的特点提出了不可行问题的探测和处理方法，并用模型... 详细信息

分析了电力系统电压无功实时优化控制中出现的不可行问题，通过引入模糊约束，从一个新的角度对不可行问题进行了处理，最终获得尽量靠近原不等式约束空间的解。文中结合原对偶内点法的特点提出了不可行问题的探测和处理方法，并用模型系统和华东电力系统的实际数据进行了验算。结果表明，文中所提的方法可以有效地探测和处理优化过程中的不可行问题。

关键词：电压无功功率优化控制电力系统

Discussion on Feasibility of Adjustment Program for Jiangmen Chinese White Dolphin Provincial Nature Reserve

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Agricultural Science & Technology 2010年第5期11卷 144-147页

作者：吴洽儿李纯厚孙典荣 qia-er Chun-hou Dian-rong 中国水产科学研究院南海水产研究所广东广州510300

From the protection of Chinese white dolphin and living environment,and considering the industrial development in coastal areas,we put forward adjustment program for Jiangmen Chinese White Dolphin Provincial Nature Reserve. Meanwhile we analyzed the feasibility of this program by systematically focusing the effect of adjusted functional regions on Chinese white dolphin.

关键词： Chinese white dolphin Reserve Adjustment Feasibility