检索结果-南通市图书馆

Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

Genes & Diseases 2024年第1期11卷 218-233页

作者： Zanwen Zuo Zerong Zhou Yuzhou Chang Yan Liu Yuping Shen qizhang Li Lei Zhang Innovative Drug R&D Center College of Life SciencesHuaibei Normal UniversityHuaibeiAnhui 235000China National"111"Center for Cellular Regulation and Molecular Pharmaceutics Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)and School of Food and Biological EngineeringHubei University of TechnologyWuhanHubei 430068China Department of Biomedical Informatics The Ohio State UniversityColumbusOH 43210USA School of Agriculture and Biology and Engineering Research Center of Cell&Therapeutic AntibodyMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Bioengineering Hunan University of Science and EngineeringYongzhouHunan425199China Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China

Ribonucleotide reductase M2(RRM2)is a small subunit in ribonucleotide reduc-tases,which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides,maintaining the dNTP pools for DNA biosynthesis,repair,and replication.RRM2 performs a critical role in the malignant biological behaviors of cancers.The structure,regulation,and function of RRM2 and its inhibitors were discussed.RRM2 gene can produce two transcripts encoding the same ORF.RRM2 expression is regulated at multiple levels during the processes from transcription to translation.Moreover,this gene is associated with resistance,regulated cell death,and tumor immunity.In order to develop and design inhibitors of RRM2,appropriate strategies can be adopted based on different mechanisms.Thus,a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis,resistance in cancer,and tumor microenvironment.Moreover,RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis.

关键词： Function Inhibition Regulation Resistance RRM2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of delay interval on blasting efficiency of parallel hole cuts with an empty hole

引用

Journal of University of Science and Technology Beijing 2003年第4期10卷 12-15页

作者： qizhang DachaoLin DepartmentofCivilEngineering Xi‘anUniversityofScienceandTechnologyXi’an710054China DepartmentofEngineeringMechanics TsinghuaUniversityBeijing100084China

Time interval of short delay ignition is an important factor to affect theefficiency of blasting cuts. The motion process of rock pieces in the cut cavity is analyzed, amechanical model to calculate the delay time of parallel hole cuts is presented for tunnel blasting,and a theoretical method to determine the volume ratio (the clearage rate) of the rock pieceswithin the cut cavity at different moments is proposed for the blasting cut with an empty hole.Numerical analysis results show that the optimal delay interval is proportional to the boreholedepth. The suggested results are of practical value to the optimal design of the delay interval inmillisecond blasting related to the parallel hole cuts with an empty hole.

关键词： tunnel blasting millisecond blasting parallel hole cuts rock fragmentation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高速列车对综合交通枢纽中地下车站结构振动的影响

引用

铁道建筑 2024年第1期64卷 100-104页

作者：付琪璋中铁第一勘察设计院集团有限公司西安710043

以济南遥墙综合交通枢纽为工程案例,依托CRTSⅢ型板式无砟轨道建立车辆-轨道-车站结构振动耦合模型,利用时频域分析方法,分析了不同列车通过速度下轨道与车站结构间振动传递特征、不同减振垫层刚度下车站结构顶板振动响应特征和减振效... 详细信息

以济南遥墙综合交通枢纽为工程案例,依托CRTSⅢ型板式无砟轨道建立车辆-轨道-车站结构振动耦合模型,利用时频域分析方法,分析了不同列车通过速度下轨道与车站结构间振动传递特征、不同减振垫层刚度下车站结构顶板振动响应特征和减振效果。结果表明:列车通过速度80 km/h时,钢轨、轨道板、车站结构侧壁、车站结构顶板振动加速度绝对值依次减小,车站结构顶板振动加速度级峰值出现在100 Hz;车站结构侧壁和顶板的分频最大振级、最大Z振级均随列车通过速度增加而增大,并且最大Z振级的增幅大于分频最大振级;不同列车通过速度下车站结构侧壁的分频最大振级和最大Z振级均大于顶板;降低减振垫层刚度可有效减小车站结构顶板最大Z振级;列车以不同速度通过各股道时可通过采用不同减振垫层刚度的轨道结构达到同等减振效果。

关键词：高速列车综合交通枢纽数值模拟车站结构时频域最大Z振级减振垫刚度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer

引用

Protein & Cell 2016年第8期7卷 571-585页

作者： Jianzhen Shan Yanyan Xuan qizhang Chunpeng Zhu Zhen Liu Suzhan Zhang Department of Medical Oncology The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 China Cancer Institute of Zhejiang University School of Medicine Hangzhou 310009 China Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 China Department of Gastroenterology The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 China

Oxaliplatin is a key drug in chemotherapy of colorectal cancer （CRC）. However, its efficacy is unsatisfied due to drug resistance of cancer ceils. In this study, we tested whether a natural agent, ursolic acid, was able to enhance the efficacy of oxaliplatin for CRC. Four CRC cell lines including SW480, SW620, LoVo, and RKO were used as in vitro models, and a SW620 xenograft mouse model was used in further in vivo study. We found that ursolic acid inhibited proliferation and induced apoptosis of all four cells and enhanced the cytotoxicity of oxaliplatin. This effect was associated with down-regulation of Bcl-xL, Bcl-2, survivin, activation of caspase-3, 8, 9, and inhibition of KRAS expression and BRAF, MEKll2, ERK1/2, p-38, JNK, AKT, IKKa, IKBa, and p65 phosphorylation of the MAPK, PI3K/AKT, and NF-KB signaling pathways. The two agents also showed synergistic effects against tumor growth in vivo. In addition, ursolic acid restored liver function and body weight of the mice treated with oxaliplatin. Thus, we concluded that ursolic acid could enhance the therapeutic effects of oxaliplatin against CRC both in vitro and in vivo, which offers an effective strategy to minimize the burden of oxaliplatin-induced adverse events and provides the groundwork for a new clinical strategy to treat CRC.

关键词： ursolic acid colorectal cancer oxaliplatin,signaling pathways

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geometry dependent photoconductivity of In2S3 kinks synthesized by kinetically controlled thermal deposition

引用

Nano Research 2016年第12期9卷 3848-3857页

作者： Xing Xiong qizhang Lin Gan Xing Zhou Xiaonan Xing Huiqiao Li Tianyou Zhai State Key Laboratory of Material Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology (HUST) Wuhan 430074 China

High quality In2S3 kinks were synthesized via a kinetically controlled thermal deposition process and their optoelectronic characteristics were systematically explored. The growth mechanism was attributed to the combination of kinetic dynamic, crystal fadal energy, and surface roughness. Two trap induced emission bands were evidenced via a low temperature cathodoluminescence （CL） study. Furthermore, the nanowire junctions demonstrated a degenerative photodetection performance, as compared to the straight arms, attributed to a stress-induced extra series resistance measured from the kinked area. The well-controllable shape of the inorganic nanostructures and the detailed exploration of their optoelectronic properties are particularly valuable for their further practical applications.

关键词： geometry dependence photodetection In2S3 kinks thermal deposition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

引用

Nano Research 2017年第3期10卷 794-801页

作者： Yu Cai Weili Si Qianyun Tang Pingping Liang Chengwu Zhang Peng Chen qizhang Wei Huang Xiaochen Dong ing 211816 China School of Chemical and Biomedical Engineering Nanyang Technological University 70 Nanyang Drive N 1.3-B3-08 Singapore ingTech) 30 South Puzhu Road Naniing 211816 China

Therapeutic nanoparticles （NPs） based on the donor-acceptor-donor structured small organic molecule diketopyrrolopyrrole （SDPP） were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation （660 nm, 1.0 W.cm 2）, even at a low dose （0.16 mg.kg^-1）.

关键词： photothermal therapy,photoacoustic imaging,diketopyrrolopyrrole,donor-acceptor-donor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis attenuation through JAK/STAT signaling pathway,at least partially

引用

中国药理学与毒理学杂志 2015年第S1期29卷 47-48页

作者： Lin-linYIN Yong-yanCHEN ZhaoQU LiZHANG QiWANG qizhang LinLI Department of Pharmacology Xuan wu Hospital of Capital Medical University Beijing Geriatric Medical Research Center Key Laboratory for Neurodegenerative Diseases of Ministry of Education Beijing 100053 China School of Pharmaceutical Sciences Zhengzhou University Zhengzhou 450001 China Institute of Clinical Pharmacology Guangzhou University of Chinese Medicine Guangzhou 510405 China

OBJECTIVE In order to investigate whether cornel iridoid glycoside(CIG),the main component extracted from Cornus officinalis,can treat demyelinating diseases of the central nervous system(CNS)such as multiple sclerosis(MS).METHODS CIG(30,60 and 120mg·kg-1)or vehicle was intragastrically administered once daily to rats,starting immediately after purified myelin basic protein(MBP)68-86 peptides immunization until day 20 post immunization(p.i.).Histopathological staining,enzyme-linked immunosorbent assay,biochemical methods and Western blotting approaches were used to evaluate the disease incidence and severity,neuroinflammatory and neurotrophic response in the CNS.RESULTS Neurological deficit and proportion of incidence seen in EAE rats were significantly reduced by CIG treatment in a dose-dependent manner.Histopathological staining showed that CIG treatment alleviated demyelination and inflammatory infiltration,increased the number of oligodendrocytes,enhanced the expression of brain-derived neurotrophic factor(BDNF).Production of proinflammatory molecules such as interleukin-1β(IL-1β),tumour necrosis factor-αand interferon-γwere also inhibited by CIG administration.CIG could ameliorate phosphorylation of STAT1,STAT3 and JAK1 as well as IL-6/IL-6 Rexpression,which involved in immune response and inflammation.CONCLUSION Our results demonstrated that CIG may ameliorate EAE rats through down-regulation of JAK/STAT signaling pathway.This study gave new insight into the novel regulatory mechanism of CIG and highlight novel therapeutic targets and a potential therapeutic agent for the treatment of MS.

关键词： experimental autoimmune encephalomyelitis cornel i

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Sinai San decoction on the development of non-alcoholic steatohepatitis in rats

引用

World Journal of Gastroenterology 2005年第9期11卷 1392-1395页

作者： qizhang YanZhao Deng-BenZhang Li-JunSun KeyLaboratoryofEnvironmentandGenesRelatedtoDiseases MinistryofEducation DepartmentofPhysiology SchoolofMedicineXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina DepartmentofBasicMedicineinTraditionalChineseMedicine ShaanxiCollegeofTCMXianyang712083ShaanxiProvinceChina

AIM: To explore the effect of Sinai san decoction on the development of non-alcoholic steatohepatitis induced by CCL4 combined with a fat-rich diet in rats.METHODS: Twenty-seven Sprague-Dawley rats were divided into three groups randomly: control group (n = 9),model group (n = 9) and treatment group (n = 9). The rats of model group and treatment group were given small dosage of CCL4 combined with a fat-rich diet, andthose of control group were given normal diet. After four weeks of fat-rich diet feeding, the rats of treatment group were given Sinai san decoction. The serum levels of aminotransferase and lipid were measured, and the pathology of livers was observed by HE staining after the rats were sacrificed at eight weeks.RESULTS: The rats' livers presented the pathology of steatosis and inflammation with higher serum levels of ALT and AST in the model group. In the treatment group the serum ALT and AST levels decreased significantly and were close to the control group. The hepatic inflammation scores also decreased markedly, but were still higher than those of control group. And the degree of hepatocyte steatosis was similar to that of model group.CONCLUSION: Sinai san decoction may ameliorate the hepatic inflammation of rats with steatohepatitis induced by small dosage of CCL4 combined with a fat-rich diet,but does not prevent the development of hepatocyte steatosis.

关键词：脂肪肝小鼠动物模型中药制剂饮食营养

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on Pollution Level and Sources Distribution of Polychlorinated Naphthalenes in City Sewage

引用

International Journal of Technology Management 2015年第5期 53-55页

作者： qizhang Weifang University of Science and Technology ShouguangWeifangShandong 262700 China

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

嵌入式实验室门禁人脸识别系统设计

引用

现代计算机 2024年第4期30卷 99-103,108页

作者：翟丽邹琦璋南京审计大学实验中心南京211815 南京审计大学经济学院南京211815

为加强对实验室门禁系统的控制,降低门禁程序的误检率,对嵌入式实验室门禁人脸识别系统进行设计与验证。简述系统的构建需求,有针对性地进行嵌入式系统总体结构设计。基础电路中接入0K6410核心板,关联前后识别端口的同时,植入图像采集装... 详细信息

为加强对实验室门禁系统的控制,降低门禁程序的误检率,对嵌入式实验室门禁人脸识别系统进行设计与验证。简述系统的构建需求,有针对性地进行嵌入式系统总体结构设计。基础电路中接入0K6410核心板,关联前后识别端口的同时,植入图像采集装置,完成系统硬件的设计;建立嵌入式交叉识别编译环境,对所识别的图像预处理并设计定位指令,关联ORL嵌入式人脸数据库,完成系统软件的设计。系统测试结果表明:针对于静态检测识别环境和动态检测识别环境下的测试,在50名用户的识别测验后,得出的误检率均控制在15%以下,表明在实际嵌入式人脸识别过程中,识别误差小、可控、识别速度快、更易调整,具有实际的应用价值。

关键词：人脸识别嵌入式系统设计实验室门禁识别程序远程监测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：