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Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide

Acta Pharmacologica Sinica 2004年第6期25卷 131-136页

作者： qi-zhen cao, zhi-bin lin1 department of pharmacology, health science center, Peking {3., beijing 100083, china department of pharmacology Health Science Center Peking University

AIM: To investigate the antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide (GLPP). METHODS: Antitumor effect of GLPP was observed in tumor-bearing mice in vivo. At the same time, the effects of GLPP on proliferation of tumor cells and human umbilical cord vascular endothelial cell (HUVEC) were detected by MTTassay in vitro. Subsequently, spleen lymphocytes proliferation of nude mice was stimulated by LPS or ConA. To investigate the anti-angiogenic effect of GLPP, GLPP 80 μg per disc and GLPP-treated serum 10 μL per disc were added to the chick chorioallantoic membrane (CAM) respectively in vivo. RESULTS: GLPP 50, 100, and 200 mg/kg inhibited growth of Sarcoma 180 in BALB/c mice markedly by 3..2 %, 45.2 %, and 61.9 %, respectively. GLPP which was directly added to the cultured medium did not inhibit PG cell proliferation in vitro; but GLPP-treated serum 50, 100, 200 mg/kg potently inhibited PG cell proliferation by 22.5 %, 26.8 %, and 3..3.%, respectively; and reduced the xenograft (human lung carcinoma cell PG) in BALB/c nude mice greatly in vivo by 55.5 %, 46.0 %, and 46.8 %, respectively. Lymphocytes proliferation of nude mice could be stimulated by LPS 5 mg/Lbut not by ConA 2.5 mg/L, indicating that GLPP could not promote the T lymphocyte proliferation and neutral red phagocytosis of peritoneal macrophages of nude mice. The CAM assay showed that GLPP and GLPP-treated serum had anti-angiogenic effect. GLPP (1, 10, and 100 mg/L) inhibited HUVEC proliferation in vitro with the inhibitory rate of 9.4 %, 15.6 %, and 40.4 %, respectively. CONCLUSION: GLPP has antitumor and anti- angiogenic activity. The anti-angiogenesis of GLPP may be a new mechanism underlying its anti-tumor effects.

关键词： Ganoderma lucidum polysaccharides sarcoma 180 adenocarcinoma lung neoplasms lympho- cyte proliferation peritoneal macrophages angiogenesis nude mice

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Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear science and Techniques 2024年第8期35卷 132-141页

作者： qiang Li Li‑Jiao Wang Xiang‑Biao qiu Jing‑Wen Li Wei Xu Tao Li Ze‑bin {3. Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun Jing‑Yu Tang Rong Zhang Han‑Tao Jing Bo Mei qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping cao qi‑Ping Chen zhen Chen Zeng‑qi Cui An‑Chuan Fan Chang‑qing Feng Fan‑zhen Feng Ke‑qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua Jia Hao‑Yu Jiang Wei Jiang zhi‑Jie Jiang zheng‑Yao Jin {3.g Kang Bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑bin Liu Guang‑Yuan Luan bin‑bin qi Jie Ren zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu Guo‑Hui Zhang {3.‑Hao Zhang Mo‑Han Zhang qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping Zhou zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source science center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the china Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 3.0 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan qiang Li Gong Li Dong Liu zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong Liu Han Yi Yang Li zhen Yang qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping cao qi-Ping Chen zhen Chen Zeng-qi Cui An-Chuan Fan Chang-qing Feng Fan-zhen Feng Ke-qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang zhi-jie Jiang ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-{13. Liu Guang-Yuan Luan Chang-Jun Ning {13.-{13. qi Jie Ren zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang lin-Hao Zhang Mo-Han Zhang qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source science center Dongguan 523803China School of Nuclear science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the china Spallation Neutron Source(CSNS)that provides neutrons in the eV to 3.0 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear science and Techniques 2024年第8期35卷 58-68页

作者： qiang Li Li‑Jiao Wang Jing‑Yu Tang Xiang‑Biao qiu zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan Wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑qing Feng Rong Zhang Xiao‑Yang Sun qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping cao qi‑Ping Chen Yong‑Hao Chen Zeng‑qi Cui An‑Chuan Fan Fan‑zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei Jiang zhi‑Jie Jiang zheng‑Yao Jin ling Kang Bo Li Gong Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑bin Liu Yi‑Na Liu Guang‑Yuan Luan Jie Ren zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng Wang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui Zhang Hang‑Chang Zhang lin‑Hao Zhang qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang zhi‑Yong Zhang zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source science center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China china Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of sciences Beijing 100049China china Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the china Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

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The Antitumor and Anti-angiogenic Activity of Ganoderma lucidum Polysaccharides

The Antitumor and Anti-angiogenic Activity of Ganoderma luci...

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2002国际灵芝专题研讨会

作者： qi-zhen cao zhi-bin {3. department of pharmacology, Peking university health science center, beijing, china

Ganoderma lucidum, has been widely used as a medicine to promote health and longevity in china for thousands of years. A series of experiments have demonstrated that the antitumor activity of Ganoderma lucidum polysaccharides (Gl-PS) may be mediated to some extent by activation of host immune functions. In this study, we investigate the anti-angiogenic activity of Ganoderma lucidum polysaccharide (Gl-PS) on tumor growth, which maybe a new pathway of antitumor effect by *** present study, we investigated the antitumor activity of Gl-PS. BALB/c mice which implanted with Sarcoma 180 were administrated intragastrically with Gl-PS 50,100,200mg·kg-1 respectively for 10 days. At the end of experiment, the tumor were cut and weighted. The effect of Gl-PS and Gl-PS-treated serum on proliferation of human lung carcinoma cell line PG were detected by MTT assay;BALB/c nude mice were implanted with xenograft (human lung carcinoma cell line PG) . Gl-PS were given at the dose of 50,100,200mg·kg-1 intragastrically for 3. days, then the tumor were cut and weighted. At the same time, spleen lymphocytes of the nude mice were also prepared to observe the effect of Gl-PS on lymphocytes proliferation induced by 2.5μg·ml-1 ConA or 5μg·ml-1 *** influence of Gl-PS on neutral red phagocytosis of nude mice peritoneal maerophages were also investigated in vitro. Gl-PS 40,80μg·ml-1 and Gl-PS-treated serum 10μl were added to the CAM (chick embryo chorioallantoic membrane) respectively to investigate the anti-angiogenesis effect of *** result showed that Gl-PS inhibited the growth of Sarcoma 180 significantly which had been implanted in BALB/c mice in vivo. Gl-PS inhibited the growth of Sarcoma 180 in a dose-dependent manner. The inhibitory rates were 3..20% ,45.25% , 61.88%, respectively. Gl-PS directly adding to the cultured medium did not inhibit PG cell proliferation in vitro, but 50, 100, 200mg ·kg- 1 Gl-PS-treated serum significantly inhibited PG cell proliferation, the inhib

关键词： Ganoderma lucidum , polysaccharides, anti-tumor, angiogenesis

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Receptor subtype involved in α-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes

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Acta Pharmacologica Sinica 2007年第7期 968-974页

作者： Da-li LUO~(2,3.4),Jian GAO~2,lin-lin FAN~2,Yu TANG~2,You-yi ZHANG~3.qi-de HAN~3.2 {3. of pharmacology,School of Chemical Biology and Pharmaceutical sciences,Capital university of Medical sciences,beijing100069,china ~3.Institute of Cardiovascular science at the health science center,Peking university,beijing 100083,china

Aim:The enhancement of intracellular Ca2+signaling in response to α1-adrener-gic receptor （α1-AR） stimulation is an essential signal transduction event in theregulation of cardiac functions,such as cardiac growth,cardiac contraction,andcardiac adaptation to various *** present study was intended todetermine the role（s） of the α1-AR subtype（s） in mediating this ***:We evaluated the effects of subtype-specific agonists and antagonists of the α1-AR on the intracellular Ca2+signaling of neonatal rat ventricular myocytes usinga confocal ***:After being cultured for 48 h,the myocytesexhibited spontaneous local Ca2+release,sparks,and global Ca2+*** of the α1-AR with phenylephrine,a selective agonist of the α1-AR,dose-dependently increased the frequency of Ca2+transients with an EC50valueof 2.3.μmol/*** the α1A-AR subtype with 5-methylurapidil （5-Mu） inhi-bited the stimulatory effect of phenylephrine with an IC50value of 6.7 nmol/***,blockade of the α1B-AR and α1D-AR subtypes with chloroethylclonidineand BMY 73.8,respectively,did not affect the phenylephrine ***,thelocal Ca2+spark numbers were also increased by the activation of the α1-AR,andthis effect could be abolished selectively by *** importantly,A61603.anovel selective α1A-AR agonist,mimicked the effects of phenylephrine,but withmore potency (EC50value=6.9 nmol/L) in the potentiation of Ca2+transients,andblockade of the α1A-AR by 5-Mu caused abolishment of its ***:These results indicate that α1-adrenergic stimulation of intracellular Ca2+activityis mediated selectively by the α1A-AR.

关键词： α1-adrenergic receptor subtype cardiomyocyte Ca2+ signaling A61603

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Regulation on Maturation and Function of Cultured Murine Dendritic Cells in vitro by Ganoderma Lucidum Polysaccharide

Regulation on Maturation and Function of Cultured Murine Den...

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2002全国青年药理学英文学术会议

作者： cao Li-zhen, lin {3.-bin department of pharmacology, Peking university health science center, beijing, 100083

AIM: To study the regulation effects of Ganoderma lucidum polysaccharide (Gl-PS) on maturation and function of cultured murine bone-marrow derived dendritic cells (DC) in vitro. METHODS: 1). Generation of mature DC: Murine bone-marrow derived DC was cultured with rmGM-CSF (20ng/ml) and rmlL-4 (20ng/ml) in vitro and stimulated by LPS on day 5. Non-adherent cells and culture supematants were harvested on day 7. Cell surface phenotype was analyzed by flow cytometry with anti-mouse CD 11c and anti-mouse I-A/I-E antibodies;The mRNA and protein expression of cytokine IL-12 P40 were detected with

关键词： Ganoderma lucidum polysaccharide (Gl-PS) dendritic cells (DC) cytotoxic T lymphocytes (CTL)

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The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023

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Cancer Communications 2024年第1期44卷 127-172页

作者： Feng-Hua Wang Xiao-Tian Zhang Lei Tang qi Wu Mu-Yan Cai Yuan-Fang Li Xiu-Juan Qu Hong qiu Yu-Jing Zhang Jie-Er Ying Jun Zhang ling-Yu Sun Rong-Bo lin Chang Wang Hao Liu Miao-zhen qiu Wen-Long Guan Sheng-Xiang Rao Jia-Fu Ji Yan Xin Wei-qi Sheng Hui-Mian Xu zhi-Wei Zhou Ai-Ping Zhou Jing Jin Xiang-lin Yuan Feng Bi Tian-Shu Liu Han Liang Yan-qiao Zhang Guo-Xin Li Jun Liang Bao-Rui Liu lin Shen Jin Li Rui-Hua Xu department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China department of Radiology Peking University Cancer HospitalBeijingP.R.China department of Endoscopy center Peking University Cancer HospitalBeijingP.R.China department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor center The First Hospital of Jilin UniversityChangchunJilinP.R.China department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China department of

The 2023.update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in{3.,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2023.CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of{3.,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

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Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： Zi-Yuan Zou Tian-Yi Ren Jia-qi Li Ting-Ying Jiao Meng-Yu Wang Lei-Jie Huang Shuang-Zhe lin Yuan-Yang Wang Xiao-zhen Guo Ye-Yu Song Rui-Xu Yang Cen Xie Jian-Gao Fan center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina university of Chinese Academy of sciences BeijingChina Human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53.knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53.long after the resolution of the hepatic phenotype through dietary *** levels of P53.might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53.knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53.may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53.AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53.AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets

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Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen Huang Fu-Jie Yu qi Zhao Xin-Dong Zhu Tao Feng Yao Jiang Xiao-Ming Li Xue-Fei Miao He Zhu Si Lan Xue-qian Wang Bao-Long Shen Zhe Jia Feng-qi Zhang Wei Wang qi Liu Yang Ren Xun-Li Wang Xiao-Ya Cui Xiao-Yang Wang Ya-Nan Chen bing-bing Fan Meng-Ru Li qi-Long Gao Jia-Ming Guo Zeng-Bao Jiao zhi-Min Guo Yu-Ping Zhao qian Yu Rui Huang ling-Kun Zhang Yi-Ping Lu Xu-Bo Li Huai-Jun lin Yan Ma Wei-Ming Yang zhi-Hua Shen Hai-Yan He Yong-Gang Sun Yong-Jiang Huang De-Zhuang Wang qing-Feng Liu Fei-Yang Wang Hui Liu Hong-Hui Wu Li-qiang Wang Yang Lu Nan Wang Tian-Li Wang Wei-bing Liao Yi-Han Wang Yuan Wu Yu-zhen Yin Jie Pan Yi Zhang qing Wang Jian-Yang Zhang Tao Yang Yasir Sohail Jin-Yu Zhang Hua Ji qiang Li Wei-Di Liu zhi-Gang Chen Xiong-Jun Liu Wen Ma Liang Mao zhen-Duo Wu School of Materials science and Engineering Nanjing University of Science and Technology Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University department of Physics City University of Hong Kong School of Materials science and Engineering Tianjin University School of Physics and Microelectronics Zhengzhou University department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical sciences Great Bay University School of Materials science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University beijing Advanced Innovation center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University department of Materials science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

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