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Impact of baseline hepatitis B virus viral load on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2504-2519页

作者： Di Pan Hao-Nan liu Zhi-yuan Yao Xiao-Xiao Chen yu-qi li Jing-Jing Zhu Zheng-Xiang Han Xiao-Bing qin Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Although the combination of lenvatinib and PD-1 inhibitors has become the standard regimen for the treatment of advanced hepatocellular carcinoma(HCC),real data on the impact of baseline hepatitis B virus(HBV)-DNA levels on the clinical efficacy of this regimen is still *** To evaluate the effectiveness of camrelizumab combined with lenvatinib in patients with HCC at varying levels of *** One hundred and twenty patients with HCC who received camrelizumab and lenvatinib treatment were categorized into two cohorts:HBV-DNA≤2000(n=66)and HBV-DNA>2000(n=54).The main outcomes measured were overall survival(OS)and progression-free survival(PFS),while additional outcomes included the rate of objective response rate(ORR),disease control rate(DCR),and any negative *** proportional hazards regression analysis revealed independent predictors of OS,leading to the creation of a nomogram incorporating these *** The median PFS was 8.32 months for the HBV-DNA≤2000 group,which was similar to the 7.80 months observed for the HBV DNA>2000 group(P=0.88).likewise,there was no notable variation in the median OS between the two groups,with durations of 13.30 and 14.20 months respectively(P=0.14).The ORR and DCR were compared between the two groups,showing ORR of 19.70%vs 33.33%(P=0.09)and DCR of 72.73%vs 74.07%(P=0.87).The nomogram emphasized the importance of antiviral treatment as the main predictor of patient results,with portal vein tumor thrombus and Barcelona Clinic liver Cancer staging following closely *** The clinical outcomes of patients with HBV-associated HCC treated with camrelizumab in combination with lenvatinib are not significantly affected by HBV viral load.

关键词： Hepatitis B virus Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy

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Impact of baseline body mass index on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastroenterology 2024年第37期30卷 4132-4148页

作者： yu-qin Wang Di Pan Zhi-yuan Yao yu-qi li Peng-Fei Qu Run-Bang Wang qing-Hao Gu Jie Jiang Zheng-Xiang Han Hao-Nan liu Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina The First College of Clinical Medicine Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology Suining County People’s HospitalXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Primary liver cancer is the sixth most common cancer worldwide,with hepato-cellular carcinoma(HCC)being the most prevalent *** the current availability of multiple immune or immune combination treatment options,the prognosis is still poor,so how to identify a more suitable population is extremely *** To evaluate the clinical effectiveness of combining lenvatinib with camrelizumab for patients with hepatitis B virus(HBV)-related HCC in Barcelona Clinic liver Cancer(BCLC)stages B/C,considering various body mass index(BMI)in diffe-rent *** Retrospective data were collected from 126 HCC patients treated with lenvatinib plus *** were divided into two groups based on BMI:The non-overweight group(BMIline graph *** subgroup analyses for non-overweight(BMI:18.5-24.9 kg/m2),overweight(BMI:25-30 kg/m2),and obese(BMI≥30 kg/m2)patients.A Cox proportional hazards regression analysis identified independent prognostic factors for overall survival(OS),leading to the development of a column-line graph *** Median progression-free survival was significantly longer in the obese/overweight group compared to the non-overweight ***,the median OS was significantly prolonged in the obese/overweight group than in the non-overweight *** objective remission rate and disease control rate for the two groups of patients were,respectively,objective remission rate(5.88%vs 28.00%)and disease control rate(39.22%vs 62.67%).Fatigue was more prevalent in the obese/overweight group,while other adverse effects showed n

关键词： Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy Safety

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Environmental effects induced by excavation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 50-57页

作者： yu-qi li Jian ZHOU Kang-he XIE Department of Civil Engineering Shanghai University Shanghai 200072 China Department of Geotechnical Engineering Tongji University Shanghai 200092 China Institute of Geotechnical Engineering Zhejiang University Hangzhou 310027 China

Based on 3D Biot’s consolidation theory and nonlinear Duncan-Chang’s model, a 3D FEM (finite element method) program is developed considering the coupling of groundwater seepage and soil skeleton deformation during excavation. The comparison between the analysis result considering the variation of water head difference and that without considering it shows that the porewater pressure distribution of the former is distinctly different from that of the latter and that the foundation pit de- formations of the former are larger than those of the latter, so that the result without considering the variation of water head dif- ference is unreliable. The distribution rules of soil horizontal and vertical displacements around the pit and excess porewater pressure are analyzed in detail in time and space, which is very significant for guiding underground engineering construction and ensuring environment safety around the pit.

关键词： Environmental effect Excavation Deformation Excess porewater pressure

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Chemical additives affect sulfate reducing bacteria biofilm properties adsorbed on stainless steel 316L surface in circulating cooling water system

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Frontiers of Environmental Science & Engineering 2017年第2期11卷 143-156页

作者： yu qi Jin li Rui liang Sitong Ji Jianxiang li Meng liu Research Center for Aqueous Organic Pollutants Control and Water Quality Security Beijing Key Laboratory Beijing Jiaotong University Beijing 100044 China

This paper studied the biofilm properties and corrosion behavior of sulfate reducing bacteria （SRB） on stainless steel 316L （SS316L） surface in circulating cooling water system with and without additives including hydroxy ethyl fork phosphonic acid （HEDP）, dodecyl dimethyl benzyl anunonium chlotide （1227） and NaClO. Biochemical technique, electrochemical technology, X-ray photoelectron spectroscopy （XPS） and scanning electron microscope （SEM） were used. The results show that the extracellular polymeric substance （EPS） in biofilm attached on the SS316L surface mainly contain proteins and polysaccharides, the contents are 98 ***-2 and ***-2, respectively. The polysaccharides were cut by 1227 about 80%, while 55% by NaCIO. The proteins were reduced by NaCIO about 53%, while only 30% by 1227. The potentiodynamic polarization shows that the corrosion potential of SS316L was enhanced from -0.495 V to -0.390 V by the chemical additive delaying the occurrence of the corrosion. And the corrosion rate was also reduced from 5.19 × 10^-3 mm·a^-1 to 2.42 × 10^-3 mm＇a . But NaCIO stdl caused pitting corrosion after stenhzmg the bacteria, while 1227 can form a protective film on the surface of SS316L. Though HEDP contribute to the bacteria activity, it can enhance the breakdown potential. XPS results confirmed that 1227 can change the value of C：O in the biofilm attached on metal surface, and NaCIO can eliminate the existence of amidogen. This study would provide some recommendations for the selection of chemical additives in the thermal power plant.

关键词： Sulfate reducing bacteria (SRB)Chemical additivesBiofilmExtracellular polymeric substance (EPS)Microbe conosion

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AquaSee: Predict Load and Cooling System Faults of Supercomputers Using Chilled Water Data

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Journal of Computer Science & Technology 2020年第1期35卷 221-230页

作者： yu-qi li li-Quan Xiao Jing-Hua Feng Bin Xu Jian Zhang National Supercomputer Center in Tianjin Tianjin 300450China College of Computer National University of Defense TechnologyChangsha 410073China

An analysis of real-world operational data of Tianhe-1A(TH-1A)supercomputer system shows that chilled water data not only can reflect the status of a chiller system but also are related to supercomputer *** study proposes AquaSee,a method that can predict the load and cooling system faults of supercomputers by using chilled water pressure and temperature *** method is validated on the basis of real-world operational data of the TH-1A supercomputer system at the National Supercomputer Center in *** with various compositions are used to construct the prediction model,which is also established using different prediction sequence *** results show that the method that uses a combination of pressure and temperature data performs more effectively than that only consisting of either pressure or temperature *** best inference sequence length is two ***,an anomaly monitoring system is set up by using chilled water data to help engineers detect chiller system anomalies.

关键词： supercomputer chilled water data sensor network load prediction

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商业综合体项目建筑给排水设计要点探讨

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工程建设与设计 2024年第3期 52-54页

作者：戚玉丽戚凯锋冯佳颖卢豪嘉兴大学浙江嘉兴314001 绿城房地产建设管理集团有限公司杭州310020 中国建筑第二工程局有限公司杭州310020

阐述建筑给排水系统设计原则,从用水量取值、给水方式、设备房的位置、排水的畅通环保、消防给水安全设计、可再生能源选择等方面进行了设计要点的分析和探究,使商业综合体项目建筑给排水系统设计既能满足功能需求,又能最大限度地满足... 详细信息

阐述建筑给排水系统设计原则,从用水量取值、给水方式、设备房的位置、排水的畅通环保、消防给水安全设计、可再生能源选择等方面进行了设计要点的分析和探究,使商业综合体项目建筑给排水系统设计既能满足功能需求,又能最大限度地满足后期业态调整或维修要求,同时也能满足绿色建筑评价的要求。

关键词：商业综合体给水排水消防可再生能源

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Role of vascular endothelial growth factor B in nonalcoholic fatty liver disease and its potential value

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World Journal of Hepatology 2023年第6期15卷 786-796页

作者： yu-qi li Lei Xin yu-Chi Zhao Shang-qi li Ya-Nuo li Department of Pathophysiology School of Basic MedicineBinzhou Medical UniversityYantai 264000Shandong ProvinceChina Department of Gastrointestinal Surgery Yantaishan HospitalYantai 264000Shandong ProvinceChina Department of Surgery Yantaishan HospitalYantai 264000Shandong ProvinceChina The First School of Clinical Medicine Binzhou Medical UniversityYantai 264000ShandongChinaYantai 264000Shandong ProvinceChina

Nonalcoholic fatty liver disease(NAFLD)refers to fatty liver disease caused by liver injury factors other than *** disease is characterized by diffuse fat infiltration,including simple steatosis(no inflammatory fat deposition),nonalcoholic fatty hepatitis,liver fibrosis,and so on,which may cause liver cirrhosis,liver failure,and even liver cancer in the later stage of disease *** present,the pathogenesis of NAFLD is still being ***"two-hit"theory,represented by lipid metabolism disorder and inflammatory reactions,is gradually enriched by the"multiple-hit"theory,which includes multiple factors,such as insulin resistance and adipocyte *** recent years,vascular endothelial growth factor B(VEGFB)has been reported to have the potential to regulate lipid metabolism and is expected to become a novel target for ameliorating metabolic diseases,such as obesity and type 2 *** review summarizes the regulatory role of VEGFB in the onset and development of NAFLD and illustrates its underlying molecular *** conclusion,the signaling pathway mediated by VEGFB in the liver may provide an innovative approach to the diagnosis and treatment of NAFLD.

关键词： Nonalcoholic fatty liver disease Vascular endothelial growth factor B "Twohit"theory "Multiple-hit"theory Obesity

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A novel TOA estimation method with effective NLOS error reduction

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The Journal of China Universities of Posts and Telecommunications 2008年第1期15卷 32-37页

作者： ZHANG Yi-heng CUI qi-mei li yu-xiang ZHANG Ping Key Laboratory of Universal Wireless Communications Beijing University of Posts and Telecommunications Ministry of Education Wireless Technology Innovation Institute (WTI) Beijing 100876 China

It is well known that non-line-of-sight （NLOS） error has been the major factor impeding the enhancement of accuracy for time of arrival （TOA） estimation and wireless positioning. This article proposes a novel method of TOA estimation effectively reducing the NLOS error by 60%, comparing with the traditional timing and synchronization method. By constructing the orthogonal training sequences, this method converts the traditional TOA estimation to the detection of the first arrival path （FAP） in the NLOS multipath environment, and then estimates the TOA by the round-trip transmission （RTT） technology. Both theoretical analysis and numerical simulations prove that the method proposed in this article achieves better performance than the traditional methods.

关键词： TOA estimation NLOS error B3G

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Recent progress in subatomic particle detection technology

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Frontiers of physics 2013年第5期8卷 548-554页

作者： Zhi-Huan li Jian-ling Lou qi-Te li yu-Cheng Ge Zhe-Wei Yin Yan-lin Ye School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China

Particle detection technologies have been largely advanced in ,boratory over the past decade. A neutron sphere was built to detect the decay neutron emitted from the implanted unstable nu eleus, whereas a multi-neutron correlation spectrometer was implemented to detect the forward moving neutrons resulting from breakup reactions. Charged particle telescopes are now equipped with double sided Silicon strip detectors which have excellent energy and position resolutions. Large size gas chambers, such as resistive plate chambers, have been developed in order to achieve high Derformances related to timing or position measurements. The advances of these technologies con tribute substantially to such large science project, as LHC-CMS, and to the experiments with the radioactive nucleus beams.

关键词： subatomic particles detection nuclear physics

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Propylene epoxidation coupled with furfural oxidation over Pt(Ⅱ?) TPP porphyrin with molecular oxygen

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Green Chemical Engineering 2024年第4期5卷 519-525页

作者： Hong-qi li Hai-Yang yu Yang li Xiao-qi He Xian-Tai Zhou Huizhou Research Institute Sun Yat-sen University School of Chemical Engineering and Technology Sun Yat-sen University

The development of green route for preparing propylene oxide (PO) with molecular oxygen is of significance both in academic and industrial. In this work, propylene epoxidation coupled with furfural oxidation catalyzed by platinum meso-tetraphenylporphyrin (Pt (II)TPP) has been developed. Propylene conversion and PO selectivity reached up to 56%and 83%, respectively. Meanwhile, furfural was almost completely converted to furoic *** on operando characterizations and electron paramagnetic resonance (EPR) tests, a mechanism involved high-valent Pt species was proposed. This work is expected to provide a potential application prospects for producing PO and furoic acid simultaneously in chemical industry.

关键词： Propylene Epoxidation Molecular oxygen Furfural Platinum porphyrins

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