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Safety and efficacy of thalidomide in patients with transfusiondependentβ-thalassemia:a randomized clinical trial

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3723-3729页

作者： Jiang-Ming Chen Wei-Jian Zhu Jie Liu Gui-Zhen Wang Xiao-qin Chen Yun Tan Wei-Wei Xu Li-Wei Qu Jin-Yan Li Huan-Ju yang Lan Huang Ning Cai Wei-Da Wang Ken Huang Jian-Quan Xu Guo-Hui Li Sheng He Tian-Ying luo Yi Huang Song-Hua Liu Wen-qiang Wu qi-yang lu Mei-Guang Zhou Shu-Ying Chen Rong-Lan Li Mei-Ling Hu Ying Huang Jin-Hua Wei Jun-Min Li Sai-Juan Chen Guang-Biao Zhou Department of Hematology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Department of Hematology Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 541000 GuangdongChina State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Reproductive Medicine The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000 HebeiChina State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhou 510060 GuangdongChina State Key Laboratory of Medical Genomics Shanghai Institute of HematologyNational Research Center for Translational MedicineRuijin Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200025China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences&University of Chinese Academy of SciencesBeijing 100101China Department of Pediatrics Affiliated Hospital of Youjiang Medical University for NationalitiesBaise City 533000 GuangxiChina Department of Hematology Yulin Guinan HospitalYulin 537005 GuangxiChina Department of neurology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Guangxi Key Laboratory of Basic Research on Birth Defects Prevention and Treatment Guangxi Zhuang Autonomous Region Women and Children Health Care HospitalNanning 530000 GuangxiChina Department of Hematology Guigang People’s HospitalGuigang 537100 GuangxiChina Department of Hematology Hospital of Traditional Chinese Medicine of Wuzhou CityWuzhou 543002 GuangxiChina Department of Hematology Wuzhou Red Cross HospitalWuzhou 543002 GuangxiChina Department of Hematology Hechi People’s HospitalHechi City 547000 GuangxiChina

Thalidomide inducesγ-globin expression in erythroid progenitor cells,but its efficacy on patients with transfusion-dependentβ-thalassemia(TDT)remains *** this phase 2,multi-center,randomized,double-blind clinical trial,we aimed to determine the safety and efficacy of thalidomide in TDT patients.A hundred patients of 14 years or older were randomly assigned to receive placebo or thalidomide for 12 weeks,followed by an extension phase of at least 36 *** primary endpoint was the change of hemoglobin(Hb)level in the *** secondary endpoints included the red blood cell(RBC)units transfused and adverse *** the placebo-controlled period,Hb concentrations in patients treated with thalidomide achieved a median elevation of 14.0(range,2.5 to 37.5)g/L,whereas Hb in patients treated with placebo did not significantly *** the 12 weeks,the mean RBC transfusion volume for patients treated with thalidomide and placebo was 5.4±5.0 U and 10.3±6.4 U,respectively(P<0.001).Adverse events of drowsiness,dizziness,fatigue,pyrexia,sore throat,and rash were more common with thalidomide than *** the extension phase,treatment with thalidomide for 24 weeks resulted in a sustainable increase in Hb concentrations which reached 104.9±19.0 g/L,without blood *** increase in Hb concentration and reduction in RBC transfusions were associated with nonβ0/β0 and HBS1L-MYB(rs9399137 C/T,C/C;rs4895441 A/G,G/G)*** results demonstrated that thalidomide is effective in patients with TDT.

关键词： transfusion patients thalidomide

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论节约能源法的义务本位

学术交流 2004年第5期 37-41页

作者：田其云阳露昭中国海洋大学法学院山东青岛266071

不论是从合理利用有限能源和保护环境来看,还是从实现能源价值来看,节约能源法以义务本位是有益的,这也是我国自全球性能源危机以来开展节约能源法制建设实践的选择,并体现在节能技术法律制度、国家支持节能管理制度、建筑物节能管理制... 详细信息

不论是从合理利用有限能源和保护环境来看,还是从实现能源价值来看,节约能源法以义务本位是有益的,这也是我国自全球性能源危机以来开展节约能源法制建设实践的选择,并体现在节能技术法律制度、国家支持节能管理制度、建筑物节能管理制度、节约能源法律责任制度等节约能源法律制度中。

关键词：节约能源法义务本位法律制度

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie lu Yanwen Ding Shujun Liu Zhijie qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi lu Mingrui Cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong Zhu Guang yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

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砌体含参数本构关系统一模型研究

四川建筑科学研究 2016年第5期42卷 10-13页

作者：黄榜彪廖天权朱基珍张贝李治盛琪刘阳卢强广西科技大学土木建筑工程学院广西柳州545006 华中科技大学光学与电子信息学院湖北武汉430074

为建立一个含参数砌体本构关系统一模型,应用能量原理和损伤力学理论解释了砌体单轴受压过程中损伤能量与热量释放的关系,定义了损伤变量。通过选取的一个损伤函数,结合砌体轴压作用下应力-应变曲线的特征,提出了砌体受压含参数本构关... 详细信息

为建立一个含参数砌体本构关系统一模型,应用能量原理和损伤力学理论解释了砌体单轴受压过程中损伤能量与热量释放的关系,定义了损伤变量。通过选取的一个损伤函数,结合砌体轴压作用下应力-应变曲线的特征,提出了砌体受压含参数本构关系模型,并依据烧结页岩多孔砖砌体轴压试验结果,验证此含参数统一本构关系的正确性,对于不同材料的块体,只需结合其砌体轴压试验的峰值应力与应变,即可得到具体的本构关系表达式。

关键词：页岩多孔砖本构关系砌体抗压强度损伤

Spatiotemporal characteristics and influencing factors of vegetation water use efficiency on the Tibetan Plateau in 2001–2020

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Journal of Geographical Sciences 2025年第1期 39-64页

作者： HE Chenyang WANG Yanjiao YAN Feng lu qi School of Ecological and Environmental Science East China Normal University Institute of Ecological Conservation and Restoration Chinese Academy of Forestry National Climate Center China Meteorological Administration

Water use efficiency （WUE）,as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ***,in the context of global warming,WUE evolution and its primary drivers on the Tibetan Plateau remain *** study employed the ensemble empirical mode decomposition method and the random forest algorithm to decipher the nonlinear trends and drivers of WUE on the Tibetan Plateau in 2001–*** indicated an annual mean WUE of 0.8088 gC/mm·m2across the plateau,with a spatial gradient reflecting decrease from the southeast toward the *** manifesting monotonous trends of increase or decrease in WUE accounted for 23.64%and 9.69%of the total,***,66.67%of the region exhibited trend reversals,i.e.,39.94%of the area of the Tibetan Plateau showed transition from a trend of increase to a trend of decrease,and 26.73%of the area demonstrated a shift from a trend of decrease to a trend of *** factors accounted for 70.79%of the variability in *** leaf area index and temperature served as the major driving forces of WUE variation.

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腭帆提肌腭帆张肌开放咽鼓管作用的年龄解剖学和比较解剖学研究

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解剖学报 1993年第1期24卷 6-11页

作者：姜平童鑫康欧阳琦吕力为陈可胜镇江医学院解剖学教研室镇江212001 南京医学院解剖学教研室

以咽鼓管、腭帆提肌和腭帆张肌在颅底的附着点为依据,分别测量了成人、幼儿、新生儿、猴、犬和兔的颅骨。分析了腭帆提肌、腭帆张肌的解剖特点,与咽鼓管开放的相互关系以及与颅形的内在联系,并将测量数据与有关头部标本进行对照研究。... 详细信息

以咽鼓管、腭帆提肌和腭帆张肌在颅底的附着点为依据,分别测量了成人、幼儿、新生儿、猴、犬和兔的颅骨。分析了腭帆提肌、腭帆张肌的解剖特点,与咽鼓管开放的相互关系以及与颅形的内在联系,并将测量数据与有关头部标本进行对照研究。腭帆提肌位于咽鼓管后下方,成人的腭帆提肌与正中矢状面和腭水平面夹角明显大于新生儿和动物的,提示成人腭帆提肌上抬咽鼓管后内壁的能力比新生儿和动物强,腭帆张肌位于咽鼓管前方,成人为垂直下降到达翼钩,新生儿及动物向前倾斜,提示两者对咽鼓管具有不同作用。由于人类和动物的脑颅骨与面颅骨位置关系不同,以及成人与新生儿呼吸、咀嚼功能发育不一,使成人、小儿和动物的颅形出现明显差异,导致腭帆提肌、腭帆张肌的方位改变。本文结果表明,咽鼓管开放在成人以腭帆提肌为主,新生儿和动物以腭帆张肌为主,幼儿则处于腭帆张肌尚作用减弱,腭帆提肌尚未发育完善,其功能尚未有效发挥的过渡阶段。

关键词：咽鼓管腭帆提肌张肌颅骨

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《庄子》同心圆寓言初探

重庆文理学院学报（社会科学版） 2008年第3期27卷 48-51页

作者：刘玉丽杨启鲁青海民族学院文学院青海西宁810007

围绕同一寓意而组织起来的若干篇寓言，即同心圆寓言。在对同心圆寓言作了界定的同时，对《庄子》同心圆寓言也进行了分析，认为《庄子》同心圆寓言可分为平列式、嵌入式和公转式三种类型。《庄子》同心圆寓言，既可以形象地表达思想，... 详细信息

围绕同一寓意而组织起来的若干篇寓言，即同心圆寓言。在对同心圆寓言作了界定的同时，对《庄子》同心圆寓言也进行了分析，认为《庄子》同心圆寓言可分为平列式、嵌入式和公转式三种类型。《庄子》同心圆寓言，既可以形象地表达思想，也能鞭辟入里地进行论辩，还有利于保存寓言珍品。

关键词：庄子同心圆寓言平列式嵌入式公转式

Rural-urban Migration, Rural Household Income and Local Geographical Contexts——A Case of Northwestern Guangxi, China

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Chinese Geographical Science 2008年第1期18卷 17-23页

作者： yang Chunyue lu qi XIE Lishuang Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China Central University for Nationalities Beijing 100081 China

This paper aims to examine New Economics of Labor Migration (NELM) in the northwestern Guangxi, China and investigate the relationships among rural-urban migration, rural household income and local geographical contexts. Stratified sampling and typical case study were adopted and 236 questionnaires were collected from four vil- lages, Daxin, Lixin, Longhe and Yongchang. We analyzed the rural-urban migration rate, household income and local geographical factors, focusing on the ratio of remittance income to total household income. Data descriptions and sta- tistical methods, such as Pearson Chi-square test, Contingency coefficient, Eta, Pearson correlation coefficient, t-test, multiple comparisons (LSD test, Tamhane T2, Dunnett T3 and Dunnet C test) were used. The results are as follows. Rural households’ income is diversified in survey villages so the motivation of rural-urban migration in the study area can be partly explained by NELM. The migration rate of households (the percentage of households with migrants in survey households) in survey villages varies from 50% to 86%, while the proportion of remittance income to house- hold income is in the range of 30% to 80%. In the village of Yongchang, with the least average arable land area per household, the remittance income plays a vital role in household income (80%). And the statistical findings show that the proportion is significantly and negatively correlated with arable land area per household. The conclusion is that di- rect effect of migration, i.e., the contribution of remittance to household income, is negatively correlated with the con- tribution of resources to local income.

关键词： rural-urban migration household income local geographical contexts northwestern Guangxi