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Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin qi Huixian Zhu Kangli shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan xin Cao Liang Chen qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong Yang Haochen shen Xiaoming Xiao Zhichao Li qi Zhou Wei Yang Bin Jiang Yongli Sun Luhong Zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu xin-Yian Guo Jian-Gang shen Su-Hua qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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小型沼气工程建设与管理

工程建设与设计 2018年第6期 180-181页

作者：漆馨沈彩霞新疆兵团农业技术推广总站乌鲁木齐830011

在新农村逐步发展的今天,越来越多的地方都采用小型沼气。论文介绍小型沼气工程的建设与管理,并提出改善意见,旨在推动小型沼气工程持续健康发展。

关键词：小型沼气工程建设管理

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分布式网络存储管理系统的研究与实现

计算机科学 2003年第6期30卷 74-77页

作者：张凌蒋东兴刘启新周霖沈培华清华大学计算机与信息管理中心北京100084

The distributed network storage management system will effectively organize the users' storage spaces which are distributed and heterogeneous to provide the users with a piece of integrated and uniform virtual storage space. This paper summarily introduces the fundamental function and structure of the system,and mainly describes the related protocols and the method for realizing.

关键词：分布式网络存储管理系统信息安全数据存储计算机网络网络安全

The magnetic properties and magnetocaloric effects in binary R-T(R = Pr,Gd,Tb,Dy,Ho,Er,Tm;T = Ga,Ni,Co,Cu)intermetallic compounds

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Chinese Physics B 2017年第2期26卷 1-41页

作者： xin-qi Zheng Bao-Gen shen School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Institute of Physics Chinese Academy of Sciences and University of Chinese Academy of Sciences Beijing 100190 China

In this paper, we review the magnetic properties and magnetocaloric effects（MCE） of binary R–T（R = Pr, Gd, Tb,Dy, Ho, Er, Tm; T = Ga, Ni, Co, Cu） intermetallic compounds（including RGa series, RNi series, R_（12）Co_7 series, R_3 Co series and RCu_2series）, which have been investigated in detail in the past several years. The R–T compounds are studied by means of magnetic measurements, heat capacity measurements, magnetoresistance measurements and neutron powder diffraction measurements. The R–T compounds show complex magnetic transitions and interesting magnetic *** types of magnetic transitions are investigated and confirmed in detail by multiple approaches. Especially, most of the R–T compounds undergo more than one magnetic transition, which has significant impact on the magnetocaloric effect of R–T compounds. The MCE of R–T compounds are calculated by different ways and the special shapes of MCE peaks for different compounds are investigated and discussed in detail. To improve the MCE performance of R–T compounds,atoms with large spin（S） and atoms with large total angular momentum（J） are introduced to substitute the related rare earth atoms. With the atom substitution, the maximum of magnetic entropy change（？SM）, refrigerant temperature width（Twidth）or refrigerant capacity（RC） is enlarged for some R–T compounds. In the low temperature range, binary R–T（R = Pr, Gd,Tb, Dy, Ho, Er, Tm; T = Ga, Ni, Co, Cu） intermetallic compounds（including RGa series, RNi series,R_（12）Co_7 series, R_3 Co series and RCu_2series） show excellent performance of MCE, indicating the potential application for gas liquefaction in the future.

关键词： magnetocaloric effect magnetic entropy change magnetic property neutron diffraction magnetic structure

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上海地区屠宰场猪红斑丹毒丝菌的分离鉴定

中国畜牧兽医 2017年第1期44卷 227-235页

作者：徐锋王晓旭张维谊宁昆齐新永沈莉萍上海市动物疫病预防控制中心上海201103

为了解上海地区猪红斑丹毒丝菌在健康猪群中的带菌状况,本试验选择上海地区标准化屠宰场的上市猪为研究对象,采集鼻拭子、肺脏、扁桃体和下颌淋巴结等样本,进行猪红斑丹毒丝菌的分离,采用VITEK 2Compact系统和VITEK MS快速鉴定系统进行... 详细信息

为了解上海地区猪红斑丹毒丝菌在健康猪群中的带菌状况,本试验选择上海地区标准化屠宰场的上市猪为研究对象,采集鼻拭子、肺脏、扁桃体和下颌淋巴结等样本,进行猪红斑丹毒丝菌的分离,采用VITEK 2Compact系统和VITEK MS快速鉴定系统进行鉴定,并设计1对16SrRNA基因引物,对分离菌株进行PCR扩增,随机选取16株分离菌进行测序及16SrRNA同源性分析。结果显示,49.07%(105/214)的样本中分离到猪红斑丹毒丝菌,分离菌株同参考菌株及疫苗株之间16SrRNA同源性为99.6%~100.0%。本试验结果表明上海地区猪群中确实存在猪红斑丹毒丝菌的健康带菌状况。

关键词：屠宰场猪红斑丹毒丝菌分离鉴定

Monitoring Multiple Cropping Index of Henan Province, China Based on MODIS-EVI Time Series Data and Savitzky-Golay Filtering Algorithm

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Computer Modeling in Engineering & Sciences 2019年第5期119卷 331-348页

作者： Lihui Wang Feng qi xin shen Jinliang Huang Key Laboratory of Environment and Disaster Monitoring and Evaluation Institute of Geodesy and GeophysicsChinese Academy of SciencesWuhan430077China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan430079China Collaborative Innovation Center of Geospatial Technology Wuhan UniversityWuhan430079China.

Multiple cropping index(MCI)is a very important indicator in crop production and agricultural intensification,which represents the utilizing degree of agriculture resources at time scale and the effective utilization situation of arable *** objective of this paper is monitoring multiple cropping index of Henan province of China according to the time series of MODIS(Moderate-Resolution Imaging Spectroradiometer)EVI(Enhanced Vegetation Index)after Savitzky-Golay filter processing from the year 2006 to *** results revealed that this method could provide an effective way to monitor multiple cropping index,and the method of no additional authentication data is independent and *** result was accurate and stable,the slope of linear regression of the multiple cropping index between the statistical results and the remote sensing results was 1.0136(R2=0.779).The precision of sample areas validation was 97.91%.Suggesting that the time series MODIS-EVI which after Savitzky-Golay filtering processed,could provide an effective way to extract spatial information of multiple cropping index for management department of agriculture.

关键词： Multiple cropping index time Series of MODIS-EVI Savitzky-Golay filtering Henan Province

戊型肝炎病毒基因ORF3编码蛋白在大肠杆菌中的表达及鉴定

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微生物学免疫学进展 2003年第2期31卷 6-11页

作者：李启明沈心亮蒋琳雷清刘鹏兰州生物制品研究所兰州730046

实验以两种不同的表达策略构建了两个以大肠杆菌DE3为宿主的原核表达载体 ,由T7启动子启动外源基因的转录 ,在诱导剂IPTG诱导下成功地进行了戊肝病毒ORF3蛋白的原核表达。并通过SDS一聚丙烯酰胺凝胶电泳、免疫印迹、竞争抑制法酶联免疫... 详细信息

实验以两种不同的表达策略构建了两个以大肠杆菌DE3为宿主的原核表达载体 ,由T7启动子启动外源基因的转录 ,在诱导剂IPTG诱导下成功地进行了戊肝病毒ORF3蛋白的原核表达。并通过SDS一聚丙烯酰胺凝胶电泳、免疫印迹、竞争抑制法酶联免疫等一系列实验对两种表达产物进行了鉴定和分析。综合分析两种表达结果发现 ,在融合型表达中ORF3蛋白与其融合标签蛋白 (谷胱甘肽S一转移酶 )之间存在免疫交叉反应。

关键词：戊型肝炎病毒开读框架原核表达融合蛋白