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Nebulized Mycobacterium vaccae protects against asthma by attenuating the imbalance of IRF4/IRF8 expression in dendritic cells

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Asian Pacific Journal of Tropical Biomedicine 2022年第12期12卷 520-529页

作者： qi-xiang sun Si-Yue Xu Lao-Dong Li Huan Xiao qian-Nan Zhang Chao-qian Li Department of Respiratory Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanningChina

Objective:To assess the effects of nebulized inhaled Mycobacterium vaccae on allergic airway inflammation,airway hyperresponsiveness,and Th1/Th2 cell imbalance in mice with ovalbumin(OVA)-induced ***:Mice received OVA sensitization and challenge for establishment of the asthmatic *** intervention,mice received Mycobacterium vaccae nebulization once every other day from the first day of sensitization to the day before *** challenge,pulmonary histological analysis and airway responsiveness measurement were *** addition,Th1/Th2 cytokines and OVA-specific IgE levels in bronchoalveolar lavage fluid were measured by ***1/Th2 subset ratios and the expression of interferon-regulatory factor 4(IRF4),IRF8 and Toll-like receptor 4(TLR4)in dendritic cells were evaluated by flow ***:Severe inflammatory infiltration and airway hyperresponsiveness were observed in OVA-induced asthmatic *** mice showed higher Th2 cytokine concentration and increased percentage of Th2 cells,along with lower Th1 cytokine concentration and reduced percentage of Th1 cells compared with the normal ***,an imbalance of IRF4^(+)and IRF8^(+)in dendritic cells was found in asthmatic *** inhaled Mycobacterium vaccae reduced airway hyperresponsiveness and inflammation in OVA-induced asthmatic *** addition,nebulized inhaled Mycobacterium vaccae enhanced TLR4 and IRF8 expression,and alleviated the imbalance of Th1/Th2 as well as IRF4^(+)and IRF8^(+)in dendritic ***:Nebulized inhaled Mycobacterium vaccae protects against asthma by alleviating the imbalance of Th1/Th2 and IRF4/IRF8 in OVA-induced asthmatic mice.

关键词： Mycobacterium vaccae Asthma Nebulization IRF4 IRF8 TLR4

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Design optimization and testing of a morphing leading-edge with a variable-thickness compliant skin and a closed-chain mechanism

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Chinese Journal of Aeronautics 2024年第7期37卷 285-300页

作者： Zhigang WANG Xiasheng sun Yu YANG Wenjie GE Daochun LI Jinwu xiang Panpan BAO qi WU Andrea DA RONCH School of Aeronautical Science and Engineering Beihang UniversityBeijing 100191China National Key Laboratory of Strength and Structural Integrity Aircraft Strength Research Institute of ChinaXi’an 710065China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China Faculty of Engineering and Physical Sciences University of SouthamptonSouthampton SO171JBUK

Climate warming and the increased demand in air travels motivate the aviation industry to urgently produce technological *** of the most promising innovations is based on the smoothly continuous morphing leading-edge *** study proposes a two-step process for the design of a morphing leading-edge,including the optimization of the outer variable-thickness composite compliant skin and the optimization of the inner kinematic *** the compliant skin design,an optimization of the variable thickness composite skin is proposed based on a laminate continuity model,with laminate continuity constraint and other manufacturing *** laminate continuity model utilizes a guiding sequence and a ply-drop sequence to describe the overall stacking sequence of plies in different thickness regions of the complaint *** the inner kinematic mechanism design,a coupled four-bar linkage system is proposed and optimized to produce specific trajectories at the actuation points on the stringer hats of the compliant skin,which ensures that the compliant skin can be deflected into the aerodynamically optimal ***,a morphing leading-edge is manufactured and *** results are compared with numerical predictions,confirming the feasibility of the morphing leading-edge concept and the overall proposed design approach.

关键词： Optimization Design Morphing wing Compliant skin Kinematics Leading-edge Control surfaces

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One-shot Face Reenactment with Dense Correspondence Estimation

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Machine Intelligence Research 2024年第5期21卷 941-953页

作者： Yunfan Liu qi Li Zhenan sun School of Artificial Intelligence University of Chinese Academy of SciencesBeijing100049China Center for Research on Intelligent Perception and Computing Institute of AutomationChinese Academy of SciencesBeijing100190China

One-shot face reenactment is a challenging task due to the identity mismatch between source and driving *** existing methods fail to completely eliminate the interference of driving subjects’identity information,which may lead to face shape distortion and undermine the realism of reenactment *** solve this problem,in this paper,we propose using a 3D morphable model(3DMM)for explicit facial semantic decomposition and identity *** of using 3D coefficients alone for reenactment control,we take advantage of the generative ability of 3DMM to render textured face *** proxies contain abundant yet compact geometric and semantic information of human faces,which enables us to compute the face motion field between source and driving images by estimating the dense *** this way,we can approximate reenactment results by warping source images according to the motion field,and a generative adversarial network(GAN)is adopted to further improve the visual quality of warping *** experiments on various datasets demonstrate the advantages of the proposed method over existing state-of-the-art benchmarks in both identity preservation and reenactment fulfillment.

关键词： Generative adversarial networks face image manipulation face image synthesis face reenactment 3D morphable model

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Advanced Materials for NH_(3)Capture:Interaction Sites and Transport Pathways

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Nano-Micro Letters 2024年第11期16卷 119-155页

作者： Hai‑Yan Jiang Zao‑Ming Wang Xue‑qi sun Shao‑Juan Zeng Yang‑Yang Guo Lu Bai Ming‑Shui Yao xiang‑Ping Zhang Key Laboratory of Green Process and Engineering State Key Laboratory of Mesoscience and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190People’s Republic of China School of Future Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China China University of Petroleum Beijing 102249People’s Republic of China Institute for Integrated Cell‑Material Sciences(iCeMS) Kyoto UniversitySakyo‑KuYoshidaKyoto 606‑8501Japan

Ammonia(NH3)is a carbon-free,hydrogen-rich chemical related to global food safety,clean energy,and environmental *** an essential technology for meeting the requirements raised by such issues,NH3 capture has been intensively explored by researchers in both fundamental and applied *** four typical methods used are(1)solvent absorption by ionic liquids and their derivatives,(2)adsorption by porous solids,(3)abadsorption by porous liquids,and(4)membrane *** in the development of advanced materials for NH3 capture,we conducted a coherent review of the design of different materials,mainly in the past 5 years,their interactions with NH3 molecules and construction of transport pathways,as well as the structure–property relationship,with specific examples ***,the challenges in current research and future worthwhile directions for NH3 capture materials are proposed.

关键词： Ammonia capture Solvents Porous solids Porous liquids Membranes

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Tendencies of alloyed engineering in BiOX-based photocatalysts:a state-of-the-art review

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Rare Metals 2024年第4期43卷 1488-1512页

作者： Yan-Dong sun Chao Zeng Xue Zhang Zi-qi Zhang Bo Yang Sheng-qi Guo Tianjin Key Laboratory of Clean Energy and Pollutant Control School of Energy and Environmental EngineeringHebei University of TechnologyTianjin300401China State-Province Joint Engineering Laboratory of Zeolite Membrane Materials Institute of Advanced MaterialsCollege of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang330022China Anhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation School of Physics and Electronic InformationAnhui Province Industrial Generic Technology Research Center for Alumics MaterialsHuaibei Normal UniversityHuaibei235000China

Energy-saving and environmentally friendly photocatalysis has emerged as a popular research area in response to issues with energy scarcity and environmental *** to the unique layer-like structure,BiOX(Cl,Br,I)is frequently used in ***,inherent flaws in BiOX,such as an inappropriate band gap and low carrier separation efficiency,restrict its capacity for *** to the tunable grouping layer,alloying engineering is employed to optimize the intrinsic properties of BiOX and alloyed BiOX becomes a promising photocatalytic *** review describes the structure of BiOX,where tunable halogen layers provide favorable conditions for the implementation of alloying engineering to improve intrinsic *** article compares the effects and mechanisms of alloying engineering on the optimization of the energy band structure and carrier behavior of BiOX,and lists various modification methods used to improve the optimization of the intrinsic properties by alloying engineering,including defect engineering,morphology control as well as the synergy between alloying and other modification methods(bismuth-rich strategies,cation doping,construction of heterojunctions and plasma resonance effects).Subsequently,applications of alloyed BiOX in energy and environmental fields are summarized,including contaminant degradation,antibacterial,CO_(2)reduction,nitrogen fixation and organic ***,we summarize the current challenges and future directions of alloyed *** is expected that this work will provide guidance and assistance for an in-depth study and understanding of the mechanisms of alloying engineering to optimize intrinsic properties and design alloyed BiOX with higher photocatalytic activity.

关键词： Bismuth oxyhalide Photocatalytic Alloyed engineering Microstructural regulation Application

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Solubility of iron(Ⅲ) and nickel(Ⅱ) acetylacetonates in supercritical carbon dioxide

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Chinese Journal of Chemical Engineering 2024年第1期65卷 29-34页

作者： Haixin sun Jianlei qi Jianfei sun Lin Li Kunpeng Yu Jintao Wu Jianzhong Yin State Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalian 116024China College of Chemical Engineering Inner Mongolia University of TechnologyHohhot 010051China

As a common precursor for supercritical CO_(2)(scCO_(2))deposition techniques,solubility data of organometallic complexes in scCO_(2)is crucial for the preparation of ***,metal acetylacetonates have shown great potential for the preparation of single-atom catalytic *** this study,the solubilities of iron(Ⅲ)acetylacetonate(Fe(acac)3)and nickel(Ⅱ)acetylacetonate(Ni(acac)2)were measured at the temperature from 313.15 to 333.15 K and in the pressure range of 9.5–25.2 MPa to accumulate new solubility *** was measured using a static weight loss *** semi-empirical models proposed by Chrastil and sung et *** used to correlate the solubility data of Fe(acac)3 and Ni(acac)*** equations obtained can be used to predict the solubility of the same system in the experimental range.

关键词： Iron(III)acetylacetonate Nickel(II)acetylacetonate Supercritical carbon dioxide Solubility measurement Correlation model Phase equilibrium

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Low-temperature chemistry in plasma-driven ammonia oxidative pyrolysis

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Green Energy & Environment 2024年第9期9卷 1477-1488页

作者： Mingming Zhang qi Chen Guangzhao Zhou Jintao sun He Lin School of Mechanical Electronic and Control Engineering Beijing Jiaotong University School of Mechanical Engineering Shanghai Jiao Tong University

Ammonia is gaining increasing attention as a green alternative fuel for achieving large-scale carbon emission reduction. Despite its potential technical prospects, the harsh ignition conditions and slow flame propagation speed of ammonia pose significant challenges to its application in engines. Non-equilibrium plasma has been identified as a promising method, but current research on plasma-enhanced ammonia combustion is limited and primarily focuses on ignition characteristics revealed by kinetic models. In this study, low-temperature and low-pressure chemistry in plasma-assisted ammonia oxidative pyrolysis is investigated by integrated studies of steady-state GC measurements and mathematical simulation. The detailed kinetic mechanism of NH3decomposition in plasma-driven Ar/NH3and Ar/NH3/O2mixtures has been developed. The numerical model has good agreements with the experimental measurements in NH3/O2consumption and N2/H2generation, which demonstrates the rationality of modelling. Based on the modelling results, species density profiles, path flux and sensitivity analysis for the key plasmaproduced species such as NH2, NH, H2, OH, H, O, O（1D）, O2（a1△g）, O2（b1∑g+）, Ar*, H-, Ar+, NH3+, O2-in the discharge and afterglow are analyzed in detail to illustrate the effectiveness of the active species on NH3excitation and decomposition at low temperature and relatively higher E/N values. The results revealed that NH2, NH, H as well as H2are primarily generated through the electron collision reactions e + NH3→ e + NH2+ H, e + NH3→ e + NH + H2and the excited-argon collision reaction Ar*+ NH3+ H → Ar + NH2+ 2H, which will then react with highly reactive oxidative species such as O2*, O*, O, OH, and O2to produce stable products of NOx and H2O. NH3→ NH is found a specific pathway for NH3consumption with plasma assistance, which further highlights the enhanced kinetic effects.

关键词： Non-equilibrium plasma Ammonia fuel Oxidative pyrolysis Pathway flux analysis Sensitivity analysis

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Atomically dispersed calcium as solid strong base catalyst with high activity and stability

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Green Energy & Environment 2024年第10期9卷 1619-1626页

作者： xiang-Bin Shao Zhi-Wei Xing Si-Yu Liu Ke-Xin Miao Shi-Chao qi Song-Song Peng Xiao-qin Liu Lin-Bing sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM)College of Chemical EngineeringNanjing Tech University30 South Puzhu Road

Solid strong base catalysts are highly attractive for diverse reactions owing to their advantages of neglectable corrosion,facile separation,and environmental ***,their widespread applications are impeded by basic components aggregation and low *** this work,we fabricate single calcium atoms on graphene （denoted as Ca1/G） by use of a redox strategy for the first time,producing solid strong base catalyst with high activity and *** precursor Ca（NO3）2is first reduced to CaO at 400℃ by the support graphene,forming CaO/G with conventional basic sites,and the subsequent reduction at 850℃ results in the generation of Ca1/G with atomically dispersed *** characterizations reveal that Ca single atoms are anchored on graphene in tetra-coordination （Ca–C2–N2） where N is in situ doped from Ca（NO3）*** atomically dispersed Ca,along with their anchoring on the support,endow Ca1/G with high activity and stability toward the transesterification reaction of ethylene carbonate with *** turnover frequency value reaches 128.0 h-1on Ca1/G,which is much higher than the traditional counterpart CaO/G and various reported solid strong bases (2.9–46.2 h-1).Moreover,the activity of Ca1/G is well maintained during 5 cycles,while 60% of activity is lost for the conventional analogue CaO/G due to the leaching of Ca.

关键词： Solid strong base Single Ca atoms Heterogeneous catalysts Transesterification Reaction

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Heparin-binding protein as a predictor of mortality in patients with diabetes mellitus and community-acquired pneumonia in intensive care unit:a propensity score matched study

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World Journal of Emergency Medicine 2024年第4期15卷 263-272页

作者： Yuhan sun Baoqing sun Zhigang Ren Mingshan Xue Changju Zhu qi Liu Translational Medicine Center Department of Emergency Medicinethe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Infectious Disease the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan Medical Key Laboratory of Emergency and Trauma Research Department of Emergency Medicinethe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

BACKGROUND:Patients with diabetes mellitus(DM)are vulnerable to community-acquired pneumonia(CAP),which have a high mortality *** aimed to investigate the value of heparin-binding protein(HBP)as a prognostic marker of mortality in patients with DM and ***:This retrospective study included CAP patients who were tested for HBP at intensive care unit(ICU)admission from January 2019 to April *** were allocated to the DM or non-DM group and paired with propensity score *** characteristics and clinical outcomes up to 90 days were *** primary outcome was the 10-day *** operating characteristic(ROC)curves,Kaplan-Meier analysis,and Cox regression were used for statistical ***:Among 152 enrolled patients,60 pairs were successfully *** was no significant difference in 10-day mortality,while more patients in the DM group died within 28 d(P=0.024)and 90 d(P=0.008).In the DM group,HBP levels at ICU admission were higher in 10-day non-survivors than in 10-day survivors(median 182.21[IQR:55.43-300]ng/ml *** 66.40[IQR:34.13-107.85]ng/mL,P=0.019),and HBP levels could predict the 10-day mortality with an area under the ROC curve of *** cut-off value,sensitivity,and specificity were 160.6 ng/mL,66.7%,and 90.2%,*** Cox regression analysis indicated that HBP was an independent prognostic factor for 10-day(HR 7.196,95%CI:1.596-32.455,P=0.01),28-day(HR 4.381,95%CI:1.449-13.245,P=0.009),and 90-day mortality(HR 4.581,95%CI:1.637-12.819,P=0.004)in patients with ***:Plasma HBP at ICU admission was associated with the 10-day,28-day,and 90-day mortality,and might be a prognostic factor in patients with DM and CAP.

关键词： Community-acquired pneumonia Diabetes mellitus Heparin-binding protein Propensity score match

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Multi-locomotion transition of tensegrity mobile robot under different terrains

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Science China(Technological Sciences) 2024年第2期67卷 536-557页

作者： YANG qi LIU XinYu WANG PanFeng SONG YiMin sun Tao Key Laboratory of Mechanism Theory and Equipment Design(Tianjin University) Ministry of EducationTianjin UniversityTianjin 300350China

Knowing how to make a multi-locomotion robot achieve locomotion transition under different terrains is a challenging problem,especially for tensegrity robots with multi-locomotion *** this study,a motion planning method for the transition of a multi-locomotion tensegrity robot(hereafter TJUBot)under different terrains is *** robot can achieve four locomotion modes:earthworm-like,inchworm-like,tumbling,and sliding locomotion with only two *** models of the four locomotion modes under five typical terrains,including flat ground,confined space,obstacle,gap,and descending slope,are established using the energy ***,the kinematic characteristics(driving law and initial position)of the robot under these terrains are *** this basis,motion planning for the locomotion transition of TJUBot is conducted,which includes a perception strategy based on three laser sensors and a transition strategy under different *** driving laws of the two motors that can ensure the effective locomotion transition of TJUBot under different terrains are naturally ***,experiments are *** demonstrate that the robot can achieve effective locomotion transition when the motion planning method is used.

关键词： multi-locomotion robot tensegrity kinematic modeling locomotion transition

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