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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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High Gain Lateral Semi-Insulating GaAs Photoconductive Switch Triggered by 1064nm Laser Pulses

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Chinese Physics Letters 2002年第3期19卷 351-354页

作者： Shi Wei zhang xian-Bin Li qi Chen Er-Zhu Zhao Wei Department of Applied Physics Xi'an University of Technology Xi'an 710048 State Key Laboratory of Transient Optics and Technology Xi'an Institute of Optics and Precision Mechanics Chinese Academy of Sciences Xi'an 710068

We report on the experimental results of a lateral semi-insulating GaAs photoconductive switch, with a gap of 8mm between two electrodes, triggered by 1064nm laser pulses at a wavelength beyond the GaAs absorption edge. Both the linear and nonlinear modes of the switch were observed when it was triggered by light pulses with an energy of 1.9mJ and a pulse width of 60ns, and operated at high voltages of 3 and 5kV. The results show that when the semi-insulating GaAs photoconductive switch operates under an electrical field of 4.37kV/cm, it will enter into the linear mode first, and then the switch will undergo the nonlinear mode (lock-on) after a delay of about 20-100ns. It is worth noticing that the delay time under high light energy is longer than that in the low optical energy. The non-intrinsic absorption mechanism is discussed. EL2 deep level defects and double-photon absorption in GaAs may play a key part in the absorption process.

关键词： Gallium arsenide

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Different efficiency toward the biomimetic aerobic oxidation of benzyl alcohol in microchannel and bubble column reactors: Hydrodynamic characteristics and gas–liquid mass transfer

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Chinese Journal of Chemical Engineering 2023年第3期55卷 84-92页

作者： qi Han Xin-Yuan zhang Hai-Bo Wu xian-Tai Zhou Hong-Bing Ji Fine Chemical Industry Research Institute School of Chemical Engineering and TechnologySun Yat-sen UniversityZhuhai 519082China Fine Chemical Industry Research Institute School of ChemistrySun Yat-sen UniversityGuangzhou 510275China Huizhou Research Institute Sun Yat-sen UniversityHuizhou 516081China

The selective aerobic oxidation of benzyl alcohol to benzaldehyde has attracted considerable attention because benzaldehyde is a high value-added product. The rate of this typical gas–liquid reaction is significantly affected by mass transfer. In this study, CoTPP-mediated(CoTPP: cobalt(II) mesotetraphenylporphyrin) selective benzyl alcohol oxidation with oxygen was conducted in a membrane microchannel(MMC) reactor and a bubble column(BC) reactor, respectively. We observed that 83% benzyl alcohol was converted within 6.5 min in the MMC reactor, but only less than 10% benzyl alcohol was converted in the BC reactor. Hydrodynamic characteristics and gas–liquid mass transfer performances were compared for the MMC and BC reactors. The MMC reactor was assumed to be a plug flow reactor,and the dimensionless variance was 0.29. Compared to the BC reactor, the gas–liquid mass transfer was intensified significantly in MMC reactor. It could be ascribed to the high gas holdup(2.9 times higher than that of BC reactor), liquid film mass transfer coefficient(8.2 times higher than that of BC reactor), and mass transfer coefficient per unit interfacial area(3.8 times higher than that of BC reactor). Moreover,the Hatta number for the MMC reactor reached up to 0.61, which was about 15 times higher than that of the BC reactor. The computational fluid dynamics calculations for mass fractions in both liquid and gas phases were consistent with the experimental data.

关键词： Membrane microchannel reactor Gas-liquid flow Mass transfer Benzyl alcohol Computational fluid dynamics(CFD) Bubble column reactor

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Well production optimization using streamline features-based objective function and Bayesian adaptive direct search algorithm

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Petroleum Science 2022年第6期19卷 2879-2894页

作者： qi-Hong Feng Shan-Shan Li xian-Min zhang Xiao-Fei Gao Ji-Hui Ni School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shandong Institute of Petroleum and Chemical Technology Dongying257061ShandongChina CNOOC China Limited Shenzhen BranchShenzhen518000GuangdongChina

Well production optimization is a complex and time-consuming task in the oilfield *** combination of reservoir numerical simulator with optimization algorithms is usually used to optimize well *** method spends most of computing time in objective function evaluation by reservoir numerical simulator which limits its optimization *** improve optimization efficiency,a well production optimization method using streamline features-based objective function and Bayesian adaptive direct search optimization(BADS)algorithm is *** new objective function,which represents the water flooding potential,is extracted from streamline *** only needs to call the streamline simulator to run one time step,instead of calling the simulator to calculate the target value at the end of development,which greatly reduces the running time of the *** the well production optimization model is established and solved by the BADS *** feasibility of the new objective function and the efficiency of this optimization method are verified by three *** demonstrate that the new objective function is positively correlated with the cumulative oil *** the BADS algorithm is superior to other common algorithms in convergence speed,solution stability and optimization ***,this method can significantly accelerate the speed of well production optimization process compared with the objective function calculated by other conventional *** can provide a more effective basis for determining the optimal well production for actual oilfield development.

关键词： Well production Optimization efficiency Streamline simulation Streamline feature Objective function Bayesian adaptive direct search algorithm

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Optimizing Heavy-duty Anticorrosive Performances of Coating Films Formed by Acrylate-vinylidene Chloride Copolymer Latexes through Twice-painting Technique

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Chinese Journal of Polymer Science 2015年第1期33卷 14-22页

作者： Ce Fu Tong-xian zhang Cheng-qi Ji Fa Cheng Wen-zhu Cui 陈宇 Department of Chemistry School of Sciences Tianjin University and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Jin Tian New Material Co. Ltd. COSCO Kansai Paint & Chemicals Co. Ltd.

Twice-painting technique was adopted to prepare heavy-duty anticorrosive coating films formed by aqueous latexes of copolymers of vinylidene chloride（VDC） with an acrylate, namely methyl acrylate（MA）, ethyl acrylate（EA）, butyl acrylate（BA） or 2-ethylhexyl acrylate（EHA）. Harsh salt-spray corrosion tests demonstrated that the optimized twicepainting technique was that the acidic latex solution was adjusted to p H 5-6 for the first painting, while it was utilized directly for the second painting. The test of 600 h of harsh salt-spray corrosion showed that MA-VDC85 coating could protect the steel excellently, whereas the other acrylate-VDC coatings with 75%-90% VDC content could not protect the steel so effectively. Further corrosion test showed that（1） MA-VDC85 coating protected steel from loss of metallic luster for at least 1000 h of salt-spray corrosion;（2） adhesion of MA-VDC85 coating to steel was excellent for at least 800 h of saltspray corrosion, but became very poor after 1000 h. Differential scanning calorimetry, thermogravimetric analysis, X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy were used to evaluate the corroded MA-VDC85 film.

关键词： Anticorrosion Coatings Vinylidene chloride Emulsion polymerization Acrylates.

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Informational uncertainties of risk assessment about accidents of chemicals

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Journal of Environmental Sciences 2001年第1期13卷 69-74页

作者： zhang Yi-xian Suzhou Institute of Urban Construction and Environmental Protection Suzhou 215011China

An analysis system of informational uncertainties for accidental risk assessment of chemicals is introduced. Statistical test methods and fuzzy sets method can do the quantitative analysis of the input parameters. The uncerainties of the model can be used by quantitative compared method for the leakage accidents of chemicals. The estimation of the leaking time is important for discussing accidental source term. The uncertain analyses of the release accident for pipeline gas (CO) liquid chlorine and liquid propane gas (LPG) have been discussed.

关键词： uncertainty risk assessment accident chemicals pipeline gas liquid chlorine LPG

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Metal nanoparticle-enhanced room temperature phosphorescence of diiodofluorescein on the filter paper substrate

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Chinese Chemical Letters 2010年第1期21卷 109-112页

作者： He, Mao Cai Li, Yu qi Zhu, Ya xian zhang, Yong Xiamen Univ Environm Sci Res Ctr State Key Lab Marine Environm Sci Xiamen 361005 Peoples R China Xiamen Univ Dept Chem Coll Chem & Chem Engn Xiamen 361005 Peoples R China

Metal-enhanced room temperature phosphorescence of diiodofluorescein was first observed on filter paper *** phosphorescence intensity is 2.5-fold brighter from diiodofluorescein on silver nanoparticles-deposited filter paper as compared with an identical control sample without silver ***,enhanced absorption was also observed for the same *** findings suggest that both singlet and triplet states can couple to surface plasmons and enhance phosphorescence quantum yields at ...

关键词： Silver nanoparticle Enhancement Diiodofluorescein Room temperature phosphorescence

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Inverse-preserving Linear Maps Between Spaces of Matrices over Fields

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Acta Mathematica Sinica,English Series 2006年第3期22卷 873-878页

作者： xian zhang School of Mathematical Science Heilongjiang University

Suppose F is a field different from F2, the field with two elements. Let Mn（F） and Sn（F） be the space of n × n full matrices and the space of n ×n symmetric matrices over F, respectively. For any G1, G2 ∈ {Sn（F）, Mn（F）}, we say that a linear map f from G1 to G2 is inverse-preserving if f（X）^-1 = f（X^-1） for every invertible X ∈ G1. Let L （G1, G2） denote the set of all inverse-preserving linear maps from G1 to G2. In this paper the sets .L（Sn（F）,Mn（F））, L（Sn（F）,Sn（F））, L （Mn（F）,Mn（F）） and L（Mn （F）, Sn （F）） are characterized.

关键词： Field Inverse-preserving linear map Space of full matrices Space of symmetric matrices

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Synthesis and electrochemical properties of a chiral silyl-substituted tetrathiafulvalene derivative

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Chinese Chemical Letters 2014年第4期25卷 579-582页

作者： Guo-qi Liang Zhong-Bao zhang Hong-qi Li Ya-Ping Wang Chun-Ying xian College of Chemistry Chemical Engineering and BiotechnologyDonghua University

A new chiral tetrathiafulvalene （TTF） derivative and related silyl-substituted 1,3-dithiole-2-（thi）one compounds were synthesized and characterized by 1H NMR, 13C NMR, MS and IR spectra. Single crystal structure of the silyl-substituted 1,3-dithiole-2-one revealed the high degree of conjugation of the five- membered ring moiety in the compound. The electrochemical properties of the new TTF derivative were studied by cyclic voltammetry and the results indicated that the electron-donating ability of the chiral TI＂F derivative was similar to that of BEDT-TTF. The AE value for the new TTF derivative was smaller than those for TTF and BEDT-TrF, indicative of decreased Coulombic repulsion in the dicationic redox state. Formation of charge-transfer （CT） complex between the new donor and electron acceptor 2,3-dichloro-5,6-dicvano-1,4-benzocluinone （DDO） was demonstrated.

关键词： Tetrathiafulvalene Chiral Silyl Electrochemistry

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Comprehensive evaluation of surface air temperature reanalysis over China against urbanization-bias-adjusted observations

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Advances in Climate Change Research 2021年第6期12卷 783-794页

作者： zhang Si-qi REN Guo-Yu REN Yu-Yu zhang Ying-xian XUE Xiao-Ying Department of Atmospheric Science School of Environmental StudiesChina University of GeosciencesWuhan430074China Laboratory for Climate Studies National Climate CenterChina Meteorological AdministrationBeijing100081China Key Laboratory for Cloud Physics China Meteorological AdministrationBeijing100081China

The reanalysis datasets (CRA40) have now been developed in China Meteorological Administration. We aim to compare the differences in surface air temperature (SAT) between observational that has been adjusted for urbanization bias and reanalysis data (NCEPV1, NCEPV2, ERA5, CFSR, MERRA, JRA55, 20CRV3 and CRA40) over China's Mainland during 1961–2015. The main results are presented as follows. The correlation and standard deviation between the reanalysis data and observations exhibit highly consistent interannual variability and dispersion, with the interannual SAT variability in JRA55 being closest to the observations for 1961–2015 and that of ERA5 for 1979–2015;the dispersions of 20CRV3 is most consistent with the observations for 1961–2015 and that of NCEPV1 for 1979–2015. Although annual mean SAT of the reanalysis is generally 0–2.0 ℃ lower than the observations, the bias in the SAT climatology of 20CRV3 is the least for 1961–2015 in all reanalysis datasets and that of CRA40 is the least for 1979–2015. The trends of NCEPV1 is closer to the observations than other reanalysis for 1961–2015 and that of 20CRV3 for 1979–2015. The biases in terms of interannual variability, dispersion, climatology, and linear trend are increase with altitude. Overall, in terms of the similarity of multiple measures to the urbanization bias-adjusted observations, JRA55 and CRA40 show the best performances for the periods 1961–2015 and 1979–2015 respectively in reproducing various aspects of climatological and climate change features in China's Mainland.

关键词： Temperature Reanalysis data Urbanization bias Adjusted observations Comparison Evaluation China

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