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Journal of Pharmaceutical Analysis 2024年第6期14卷 930-932页

作者： Xiao-lan Li Jian-qing Zhang Yun Li Xuan-jing Shen Huan-ya Yang Lin Yang Meng Xu qi-rui bi Chang-liang Yao De-an Guo Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China b University of Chinese Academy of Sciences Beijing100049China

Prescriptions are the main clinical application of traditional Chinese medicines(TCMs).Common forms include Chinese patent medicines,Kampo formulas,and hospital decoctions.A new pre-scription called“famous classical formulas”is recently developed and expected to boom in the *** constituent me-dicinal plants in prescriptions is critical for new drug development and quality control[1],which could avoid safety issues from adulteration or substandard ingredients,as seen in the notorious Longdan Xiegan Pill event.

关键词： medicines formulation prescription

Traditional Chinese Medicines Against COVID‑19:A Global Overview

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World Journal of Traditional Chinese Medicine 2022年第3期8卷 279-313页

作者： Chang‑Liang Yao Wen‑Long Wei Jian‑qing Zhang qi‑rui bi Jia‑Yuan Li Ikhlas Khan Rudolf Bauer De‑An Guo Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory Research Center for TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina National Center for Natural Products Research School of PharmacyUniversity of MississippiMSUSA Department of Pharmacognosy Institute of Pharmaceutical SciencesUniversity of GrazGrazAustria

Coronavirus disease 2019(COVID‑19),caused by the severe acute respiratory syndrome coronavirus 2,continues to be a global *** Chinese medicines(TCMs)are an important element of the fight against COVID‑19 in *** combined application of TCMs and conventional medicines in the treatment of COVID‑19 has achieved beneficial results,including the resolution of symptoms,prevention of disease progression,and reduced *** this review,we summarize and discuss the current applications of TCMs with respect to COVID‑19,as well as update the preclinical and clinical research,including chemical analysis,molecular mechanisms,quality control,drug development,and studies of clinical *** expectation is that a better understanding of the roles of TCMs against COVID‑19 will improve the response to COVID‑19,both in China and globally.

关键词： Coronavirus disease 2019 clinical efficacy molecular mechanism traditional Chinese medicine

The acceptance of traditional Chinese medicine among patients with Parkinson's disease:A hospital survey

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Journal of Integrative Medicine 2024年第2期22卷 180-187页

作者： Peng Wang Jing Hong Zhu-qian Tang bi-zhen Gong Xiao-rong qi Han Jiang Bo Pan qi Chen Postgraduate School Medical School of Chinese People’s Liberation ArmyBeijing 100853China Senior Department of Traditional Chinese Medicine the Sixth Medical Center of PLA General HospitalBeijing 100853China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Integrative Oncology the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Dermatology the First Clinical Medical CollegeAnhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

Objective:The efficacy of medications for Parkinson’s disease(PD)tend to decline over time,which has a serious impact on patients’health and quality of *** some extent,traditional Chinese medicine(TCM)can resolve the distressing problem of ineffective dopaminergic medication in PD *** purpose of this study was to investigate the attitude,acceptance,and independent predictors of TCM in PD patients admitted to the outpatient department of a tertiary ***:A cross-sectional study of PD patients was conducted in the outpatient department of a large tertiary hospital in Beijing from March 2022 to June 2023.A self-report questionnaire was developed to investigate PD patients’attitudes and acceptance of TCM based on the *** logistic regression analyses were also performed to further clarify the independent predictors influencing patients’adoption of TCM ***:A total of 397 patients completed the questionnaire,of which 78.09%were willing to be treated with TCM and 21.91%indicated that they were not willing to use *** logistic regression analysis showed that several parameters were correlated with a patient’s willingness to include TCM in their therapeutic *** included education level of a bachelor’s degree(odds ratio[OR)=8.554;95%confidence interval[CI]:4.112–17.794;P<0.001,vs junior high school education),living in an urban setting(OR=8.022;95%CI:4.577–14.060;P<0.001,vs rural),having other underlying diseases(OR=5.126;95%CI:3.078–8.537;P<0.001,vs none),having previously used TCM(OR=3.083;95%CI:1.852–5.134;P<0.001,vs not used),believing that TCM therapy is safe(OR=3.530;95%CI:1.446–8.616;P=0.006,vs not thought),believing that TCM therapy is effective(OR=3.859;95%CI:1.482–10.047;P=0.006,vs not understood),and being willing to discuss ongoing TCM therapy with an attending physician(OR=62.468;95%CI:30.350–128.574;P<0.001,vs not informed).Conclusion:This study initially investigated the acceptance

关键词： Parkinson's disease Traditional Chinese medicine Cross-sectional study

Efficient and fair PPO-based integrated scheduling method for multiple tasks of SATech-01 satellite

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Chinese Journal of Aeronautics 2024年第2期37卷 417-430页

作者： qi SHI Lu LI Ziruo FANG Xingzi bi Huaqiu LIU Xiaofeng ZHANG Wen CHEN Jinpei YU Shanghai Satellite Network Research Institute CO. LTDShanghai 201210China Innovation Academy for Microsatellites of Chinese Academy of Sciences Shanghai 201306China University of Chinese Academy of Sciences Beijing 100039China

SATech-01 is an experimental satellite for space science exploration and on-orbit demonstration of advanced *** satellite is equipped with 16 experimental payloads and supports multiple working modes to meet the observation requirements of various *** to the limitation of platform power supply and data storage systems,proposing reasonable mission planning schemes to improve scientific revenue of the payloads becomes a critical *** this article,we formulate the integrated task scheduling of SATech-01 as a multi-objective optimization problem and propose a novel Fair Integrated Scheduling with Proximal Policy Optimization(FIS-PPO)algorithm to solve *** use multiple decision heads to generate decisions for each task and design the action mask to ensure the schedule meeting the platform *** results show that FIS-PPO could push the capability of the platform to the limit and improve the overall observation efficiency by 31.5%compared to rule-based plans currently ***,fairness is considered in the reward design and our method achieves much better performance in terms of equal task *** of its low computational complexity,our task scheduling algorithm has the potential to be directly deployed on board for real-time task scheduling in future space projects.

关键词： Satellite observatories SATech-01 Multi-modes platform Scheduling algorithms Reinforcement learning Proximal Policy Optimization(PPO)

Effect of crystal morphology of ultrahigh-nickel cathode materials on high temperature electrochemical stability of lithium ion batteries

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Journal of Energy Chemistry 2024年第1期88卷 327-335,I0008页

作者： bi Luo Hui Li Haoyu qi Yun Liu Chuanbo Zheng Weitong Du Jiafeng Zhang Lai Chen School of Metallurgy Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600JiangsuChina National Engineering Laboratory for High-Efficiency Recovery of Refractory Nonferrous Metals School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083HunanChina School of Materials Science and Engineering Beijing Key Laboratory of Environmental Science and EngineeringBeijing Institute of TechnologyBeijing 100081China

Higher nickel content endows Ni-rich cathode materials LiNi_(x)Co_yMn_(1-x-y)O_(2)(x>0.6)with higher specific capacity and high energy density,which is regarded as the most promising cathode materials for Li-ion ***,the deterioration of structural stability hinders its practical application,especially under harsh working conditions such as high-temperature *** these circumstances,it becomes particularly critical to clarify the impact of the crystal morphology on the structure and high-temperature performance as for the ultrahigh-nickel ***,we conducted a comprehensive comparison in terms of microstructure,high-temperature long-cycle phase evolution,and high-temperature electrochemical stability,revealing the differences and the working mechanisms among polycrystalline(PC),single-crystalline(SC)and Al doped SC ultrahigh-nickel *** results show that the PC sample suffers a severe irreversible phase transition along with the appearance of microcracks,resulting a serious decay of both average voltage and the energy *** the Al doped SC sample exhibits superior cycling stability with intact layered ***-situ XRD and intraparticle structural evolution characterization reveal that Al doping can significantly alleviate the irreversible phase transition,thus inhibiting microcracks generation and enabling enhanced ***,it exhibits excellent cycling performance in pouch-type full-cell with a high capacity retention of 91.8%after 500 cycles at 55℃.This work promotes the fundamental understanding on the correlation between the crystalline morphology and high-temperature electrochemical stability and provides a guide for optimization the Ni-rich cathode materials.

关键词： Single-crystalline Ultrahigh-nickel cathode High-temperature performance Phase evolution

Differences in and factors controlling organic matter enrichment in the Ziliujing Formation shale in the Sichuan Basin

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Petroleum Science 2024年第1期21卷 77-86页

作者： Peng Li Zhong-Bao Liu He bi Tao Jiang rui-Kang bian Peng-Wei Wang Xiao-Yu Shang State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Efficient Development Beijing102206China Key Laboratory of Shale Oil/Gas Exploration and Production Technology SINOPECBeijing102206China Petroleum Exploration and Production Research Institute SINOPECBeijing102206China Research Institute of Petroleum Exploration and Development PetroChinaBeijing100083China Chinese Academy of Geological Sciences Beijing100037China No.4 Oil Production Plant in Daqing Oilfield Co Ltd. Daqing163511HeilongjiangChina

Lacustrine shale oil and gas are important fields for unconventional exploration and development in China,and organic-rich shale deposition lays down the critical foundation for hydrocarbon *** are two sets of shale,the Dongyuemiao and Da’anzhai Members,in the Ziliujing Formation in the Sichuan *** identify the differential enrichment characteristics of organic matter and clarify its controlling factors,geochemical analyses of organic and inorganic geochemical analyses were *** results showed that the total organic carbon content of the Dongyuemiao shale(1.36%)is slightly higher than that of the Da’anzhai shale(0.95%).The enrichment of organic matter in the two shales resulted from the comprehensive controls of paleoproductivity,paleoenvironment,and terrigenous input,but different factors have different *** addition,driven by climate,the change in the sulfate concentration in the bottom water further led to the different intensities of bacterial sulfate reduction in early *** made a great difference regarding organic matter accumulation in the two *** general,climate may have played a dominant role in organic matter enrichment in the two sets of shale.

关键词： Lacustrine shale Ziliujing Formation Sichuan Basin Enrichment mechanism of organic matter

Multi-wavelength Brillouin erbium-doped fiber laser with 40 GHz frequency shift interval assisted by Sagnac loop filter

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Optoelectronics Letters 2024年第5期20卷 265-271页

作者： qi Hexin ZHOU Xuefang ZHANG Yinghui YANG Guowei bi Meihua HU Miao School of Communication Engineering Hangzhou Dianzi UniversityHangzhou 310018China

A switchable and tunable multi-wavelength Brillouin erbium-doped fiber laser(MWBEFL) is designed and experimentally demonstrated. A Sagnac loop filter is employed as the switcher to obtain the double Brillouin frequency shift(BFS) of 0.172 nm(~20 GHz) and the quadruple BFS of 0.35 nm(~40 GHz). The working principles of the proposed laser are theoretically analyzed. The experimental results show that up to 8 Stokes lines with a wavelength interval of 0.172 nm can be obtained. When the Sagnac loop filter is used, two different output spectra with wavelength interval of 0.35 nm are obtained by adjusting the polarization controller(PC) and the optical signal-to-noise ratio(OSNR) is greater than 33 dB. By adjusting the Brillouin pump(BP) wavelength to investigate the tunability of the fiber laser, the output of 2—5 laser channels can be realized corresponding to 20 nm wavelength range. This approach is simple and can be employed for the microwave generation of other frequency ranges subject to the filtering shift of the Sagnac loop.

关键词： fiber laser filter

Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in Hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis

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Current Medical Science 2024年第3期44卷 503-511页

作者： Jian-gang bi qi LI Yu-sheng GUO Li-ping LIU Shi-yun BAO Ping XU Department of Hepatobiliary and Pancreatic Surgery Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Endocrinology Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China

Objective This study aimed to examine the role of long non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1)in the development of hepatocellular carcinoma(HCC).Methods A total of 62 pairs of HCC tissues and adjacent non-tumor tissues were obtained from 62 HCC *** interactions of PCED1B-AS1 and microRNA-34a(miR-34a)were detected by dual luciferase activity assay and RNA pull-down *** RNA expression levels of PCED1B-AS1,miR-34a and CD44 were detected by RT-qPCR,and the protein expression level of CD44 was determined by Western *** cell proliferation was detected by cell proliferation assay,and the cell invasion and migration by transwell invasion *** HCC tumor growth after PCED1B-AS1 was downregulated was determined by in vivo animal *** PCED1B-AS1 was highly expressed in HCC tissues,which was associated with poor survival of HCC ***,PCED1B-AS1 interacted with miR-34a in HCC cells,but they did not regulate the expression of each ***,PCED1B-AS1 increased the expression level of CD44,which was targeted by *** cell proliferation and invasion assay revealed that miR-34a inhibited the proliferation and invasion of HCC in vitro,while CD44 exhibited the opposite ***,PCED1B-AS1 suppressed the role of ***,the knockdown of PCED1B-AS1 repressed the HCC tumor growth in nude mice in *** PCED1B-AS1 may play an oncogenic role by regulating the miR-34a/CD44 axis in HCC.

关键词： long non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1) hepatocellular carcinoma microRNA-34a(miR-34a) CD44 proliferation invasion

Detection and analysis of landslide geomorphology based on UAV vertical photogrammetry

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Journal of Mountain Science 2024年第4期21卷 1190-1214页

作者： bi rui GAN Shu YUAN Xiping LI Kun LI Raobo LUO Weidong CHEN Cheng GAO Sha HU Lin ZHU Zhifu School of Land and Resources Engineering Kunming University of Science and TechnologyKunming 650093China Plication Engineering Research Center of Spatial Information Surveying and Mapping Technology in Plateau and Mountainous Areas Set by Universities in Yunnan Province Kunming 650093China West Yunnan University of Applied Sciences Key Laboratory of Mountain Real Scene Point Cloud Data Processing and Application for Universities in Yunnan ProvinceDali 671006China

High-resolution landslide images are required for detailed geomorphological analysis in complex topographic environment with steep and vertical landslide *** study proposed a vertical route planning method for unmanned aerial vehicles(UAVs),which could achieve rapid image collection based on strictly calculated route *** effectiveness of this method was verified using a DJI Mavic 2 Pro,obtaining high-resolution landslide images within the Dongchuan debris flow gully,in the Xiaojiang River Basin,Dongchuan District,Yunnan,China.A three-dimensional(3D)model was constructed by the structure-from-motion and multi-view stereo(SfM-MVS).Micro-geomorphic features were analyzed through visual interpretation,geographic information system(GIS),spatial analysis,and mathematical statistics *** results demonstrated that the proposed method could obtain comprehensive vertical information on landslides while improving measurement *** 3D model was constructed using the vertically oriented flight route to achieve centimeter-level accuracy(horizontal accuracy better than 6 cm,elevation accuracy better than 3 cm,and relative accuracy better than 3.5 cm).The UAV technology could further help understand the micro internal spatial and structural characteristics of landslides,facilitating intuitive acquisition of surface *** slope of landslide clusters ranged from 36°to 72°,with the majority of the slope facing east and *** elevation levels were relatively consistent while middle to lower elevation levels gradually decreased from left to right with significant variations in lower elevation *** the rainy season,surface runoff was abundant,and steep topography exacerbated changes in surface *** route method is suitable for unmanned aerial vehicle(UAV)landslide surveys in complex mountainous *** geomorphological analysis methods used will provide references for identifying and describing topographic

关键词： UAV Landslide Vertical route SfM-MVS Topographic features

Enhanced Precision Therapy of Multiple Myeloma Through Engineered biomimetic Nanoparticles with Dual Targeting

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Engineering 2024年第5期36卷 178-192页

作者： Ruogu qi Shanshan Wang Jiayi Yu Tianming Lu Zhiqiang bi Weibo Liu Yuanyuan Guo Yong bian Jianliang Shen Xuesong Zhang Wenhao Hu School of Medicine Nanjing University of Chinese MedicineNanjing 210023China Laboratory Animal Center Nanjing University of Chinese MedicineNanjing 210023China Key Laboratory of Carcinogenesis and Translational Research Ministry of Education/BeijingDepartment of Radiation OncologyBeijing Cancer HospitalBeijing 100142China Department of Orthopedics The Fourth Medical CenterThe Chinese People’s Liberation Army General HospitalBeijing 100853China State Key Laboratory of Ophthalmology Optometry and Vision ScienceSchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027China

Multiple myeloma(MM)is the second most prevalent hematological *** MM treatment strategies are hampered by systemic toxicity and suboptimal therapeutic *** study addressed these limitations through the development of a potent MM-targeting chemotherapy strategy,which capitalized on the high binding affinity of alendronate for hydroxyapatite in the bone matrix and the homologous targeting of myeloma cell membranes,termed T-PB@*** results from our investigations highlight the considerable bone affinity of T-PB@M,both in vitro and in ***,this material demonstrated a capability for drug release triggered by low pH ***,T-PB@M induced the generation of reactive oxygen species and triggered cell apoptosis through the poly(ADP-ribose)polymerase 1(PARP1)-Caspase-3-B-cell lymphoma-2(Bcl-2)pathway in MM ***,T-PB@M preferentially targeted bone-involved sites,thereby circumventing systemic toxic side effects and leading to prolonged survival of MM orthotopic ***,this designed target-MM nanocarrier presents a promising and potentially effective platform for the precise treatment of MM.

关键词： Multiple myeloma Bortezomib Drug delivery Dual targeting Controlled release