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Natural Products and Derivatives Targeting at Cancer Energy Metabolism:A Potential Treatment Strategy

Current Medical Science 2020年第2期40卷 205-217页

作者： qi-qi wangi Ming-xue LI Chen LI Xiao-xia GU Meng-zhu ZHENG Li-xia CHEN Hua LI Wuya College of Inovation School of Pharmaceutical EngineeringKey Laboratory of Structure-Based Drug Design&DiscoveryMinistry of EducationShenyang Pharmaceutical UniversiryShenyang 110016China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

In the 1920s,Dr Otto Warburg first suggested the significant difference in energy metabolism between malignant cancer cells and adjacent normal *** cells mainly adopt the glycolysis as energy source to maintain tumor cell growth and biosynthesis under aerobic *** on energy metabolism pathway in cancer cells has aroused the interest of cancer researchers all around the *** recent years,plentiful studics suggest that targeting the peculiar cancer energy metabolic pathways,including glycolysis,mitochondrial respiration,amino acid metabolism,and fatty acid oxidation may be an effective strategy to starve cancer cells by blocking essential *** products (NPs)are considered as the “treasure trove of small molecules drugs” and have played an extremely remarkable role in the discovery and development of anticancer *** numerous NPs have been reported to act on cancer energy metabolism ***,a comprehensive overview about cancer energy metabolism targets and their natural-occurring inhibitors is prepared.

关键词： cancer energy metabolism cancer therapy natural products binding targets,inhibitors

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Taxonomic revision of the genus Mesechinus (Mammalia Erinaceidae) with description of a new species

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Zoological Research 2018年第5期39卷 335-347页

作者： Huai-Sen Ai Kai He Zhong-Zheng Chen Jia-qi Li Tao Wan Quan Li Wen-Hui Nie Jin-Huan Wang Wei-Ting Su Xue-Long Jiang Gaoligongshan National Nature Reserve Baoshan Yunnan 678000 China Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China The Kyoto University Museum Kyoto University Kyoto 606-8501 Japan College of Life Sciences Anhui Normal University Wuhu Anhui 241000 China Nanjing Institute of Environmental Sciences Ministry of Environmental Protection Nanjing Jiangsu 210042 China

Hedgehogs in the genus Mesechinus （Family Erinaceidae）, which include two currently recognized species （ M. dauuricus and M. hughi）, are distributed from northeast Mongolia to the upper Amur Basin in Russia and adjacent areas in northeast and northern China. In recent years, a population of Mesechinus hedgehogs was discovered from Mt. Gaoligong, southwestern Yunnan, China, far from the known distribution range of the genus. Furthermore, these hedgehogs are the only known population to be distributed at elevations higher than 2 100 m and in sympatry with gymnures. To evaluate the taxonomic status of these hedgehogs, we examined specimens representing Mesechinus taxa in China and further conducted morphometric and karyotypic analyses. Our results supported the existence of four species in China. Specifically, we identified the hedgehogs from Mt. Gaoligong as a new species, Mesechinus wangi sp. nov., and recognized M. miodon, previously considered as a synonym of either M. dauuricus or M. hughi as a distinct species. Interestingly, we observed a supernumerary M4 on all specimens of Mesechinus wangi sp. nov., which is an extremely rare event in the evolution of mammalian dentition.

关键词： Mesechinus Taxonomy MorphometricsInhibitory cascade Karyotype New speciesSupernumerary molar

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贵州遵义地区早—中三叠世双壳类生物地层研究

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地质科技情报 2010年第6期29卷 7-14页

作者：熊鑫琪黄云飞童金南中国地质大学逸夫博物馆武汉430074 中国地质大学生物地质与环境地质教育部重点实验室武汉430074

遵义地区位于扬子板块上扬子台地中部,下、中三叠统发育良好,夜郎组、茅草铺组、松子坎组及狮子山组地层出露齐全。其中遵义巷口剖面是扬子台地区的经典下-中三叠统地层剖面之一,其产双壳类化石尤为丰富,是该沉积相区生物地层和生态系... 详细信息

遵义地区位于扬子板块上扬子台地中部,下、中三叠统发育良好,夜郎组、茅草铺组、松子坎组及狮子山组地层出露齐全。其中遵义巷口剖面是扬子台地区的经典下-中三叠统地层剖面之一,其产双壳类化石尤为丰富,是该沉积相区生物地层和生态系演化研究的关键剖面。迄今已发现双壳类15属55种(亚种)(本次研究鉴定出12属35种),多数属为世界性的分布类型,由下向上可划分出6个双壳类化石带:Pteriaussurica varibilis-Eumorphotis venetiana组合带,Claraiaconcentrica-Claraia wangi组合带,Eumorphotis multiformis顶峰带,Entolium discites microtis顶峰带,Myophoria(Costatoria)goldfussi mansuyi-Asoellaillyrica组合带和Plagiostoma radiata-Palaeoli ma subcostata组合带。其双壳类生态类群的演变与华南其他地区具有一致性。

关键词：早-中三叠世双壳类生物地层贵州遵义

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New species and new synonyms of Conaspidia Konow(Hymenoptera:Tenthredinidae) with keys to species of the Conaspidia bicuspis group and Japanese species

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Entomotaxonomia 2015年第3期37卷 221-233页

作者：祁立威牛耕耘刘婷魏美才中南林业科技大学经济林培育和保护教育部省部共建重点实验室湖南长沙410004

Conaspidia qinlingia Wei sp. nov. and C. wangi Wei sp. nov. are described from China. Characters of Conaspidia bicuspis group are briefly discussed and a key to the species of the group is provided. Conaspidia murotai Togashi, 1984 and Conaspidia ishikawai Togashi, 2005 are new synonyms of Conaspidia guttata （Matsumura, 1912）, the latter is briefly redescribed and illustrated. A key to Japanese species of Conaspidia is also provided.

关键词： Tenthredininae sawflies taxonomy key

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