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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beijie qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

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住宅小区智能控制与管理系统

同济大学学报（自然科学版） 2001年第2期29卷 246-249页

作者：陈启军陈辉堂王月娟杨永零同济大学信息与控制工程系上海200092

介绍了一种住宅小区智能控制与管理系统的网络结构及其实现 .在此系统中 ,家庭自动化系统采用有线电缆与电力线载波通信相结合的机制 ;家庭自动化系统与大楼集中控制站之间的通信通过RS485实现 ;大楼集中控制站、公用设施控制站与小区... 详细信息

介绍了一种住宅小区智能控制与管理系统的网络结构及其实现 .在此系统中 ,家庭自动化系统采用有线电缆与电力线载波通信相结合的机制 ;家庭自动化系统与大楼集中控制站之间的通信通过RS485实现 ;大楼集中控制站、公用设施控制站与小区中央控制站之间的通信通过LONWORKS局部操作网实现 .

关键词：家庭自动化系统大楼集中控制站中央控制站电力线载波通信住宅小区智能控制管理系统

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi Wen Xin Xiong Ting Xu qi Wang Xiusheng chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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结合站点拓扑结构的页面视图分析

太原理工大学学报 2004年第4期35卷 414-417页

作者：张琦琪陈俊杰太原理工大学信息工程学院山西太原030024

在介绍用途数据挖掘预处理过程的基础上,结合站点的拓扑结构,详细分析了页面视图的识别过程,给出了站点结构的形式化表述和页面视图识别的算法,为Web用途挖掘找到了合适的挖掘粒度。最后总结了结构数据对用途挖掘的作用。

关键词： web用途挖掘日志预处理拓扑结构页面视图识别

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定向钻孔在高位瓦斯抽采中的应用

内蒙古煤炭经济 2019年第5期 6-7,100页

作者：祁晨君白刚胡振阳中煤科工集团西安研究院有限公司

德通煤矿工作面生产期间,瓦斯涌出量大,引起回风隅角瓦斯较高,预警现象时有发生。本文在分析采空区瓦斯运移规律的基础上,采用定向钻机施工高位定向钻孔,布置不同层位,探讨钻孔最优落点层位,为后期该区域瓦斯治理提供技术支撑。

关键词：瓦斯涌出高位钻孔定向钻进

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker chen chen Heqiao Dai qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

人类白细胞抗原高分辨等位基因及单倍型与北方汉族急性淋巴细胞白血病的关联性

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中华医学遗传学杂志 2017年第5期34卷 737-742页

作者：齐珺陈利萍王天菊王满妮王小芳武君华叶世辉陕西省血液中心中华骨髓库HLA高分辨分型确认实验室西安710061

目的探讨人类白细胞抗原（human leukocyte antigen，HLA）-A，-B，-DRB1高分辨等位基因及单倍型多态性与北方汉族急性淋巴细胞白血病（acutelymphoblastic leukemia，ALL）的相关性。方法以1241名正常非亲缘造血干细胞捐献者为对照，... 详细信息

目的探讨人类白细胞抗原（human leukocyte antigen，HLA）-A，-B，-DRB1高分辨等位基因及单倍型多态性与北方汉族急性淋巴细胞白血病（acutelymphoblastic leukemia，ALL）的相关性。方法以1241名正常非亲缘造血干细胞捐献者为对照，应用聚合酶链反应一测序分型（polymerase chain reaction-sequence-basedtyping，PCR-SBT）、序列特异寡核苷酸探针技术（sequence specific oligonucleotide probes，SSO）和组特异性引物扩增（sequence specificprimer，SSP）方法对170例ALL患者进行HLA-A、-B、-DRB1高分辨分型，用Arlequin3．5．2软件计算HLA基因频率和单倍型频率，计算疾病比值比（oddratio，OR）进行病例对照研究。结果经X2检验、连续校正显示，与对照组相比ALL患者的B＊13：01和B＊40：02频率升高（7．35％弧4．63％，P=0．030；2．94％vs．1．45％，P=0．042），而B＊35：03和B＊46：01频率降低（O．29％强1．69％，P=0．048；4．41％7iS．7．82％，P=0．025），但经Bonferroni校正后显示差异均无统计学意义。在ALL患者中频率增加的DRB1＊15组尽管经Bonferroni校正后差异无统计学意义，但其组内的DRB1＊15：01基因频率经Bonferroni校正后仍显著高于对照组（16．18％邯．10．19％，Pc’=0．041），与ALL呈正相关（OR=1．70，95％CI：1．24～2．33）。19种单倍型在ALL中的频率显著高于对照组，其中11种单倍型在对照组中未出现过，与白血病呈正相关。结论本研究获得了HLAA、-B、-DRB1高分辨等位基因及单倍型与北方汉族ALL相关性的资料，DRB1＊15：01与北方汉族ALL患者正相关，可能是北方汉族发生ALL的易感基因，并与其特定单倍型关联。

关键词：急性淋巴细胞白血病人类白细胞抗原北方汉族单倍型基因频率

优化条件下氧化锌对高硫铝土矿溶出过程脱硫的影响

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有色金属（冶炼部分） 2017年第1期 28-31页

作者：刘龙李军旗陈朝轶刘利魏国令贵州大学材料与冶金学院贵阳550025 贵州省冶金工程与过程节能重点实验室贵阳550025

研究在优化条件下添加氧化锌对一水硬铝石型高硫铝土矿溶出过程脱硫的影响。结果表明,优化溶出条件下高硫铝土矿溶出过程中加入氧化锌后,硫溶出率随氧化锌加入量增加而降低,氧化铝溶出率基本不变。溶出液中S2-含量随氧化锌加入量增加而... 详细信息

研究在优化条件下添加氧化锌对一水硬铝石型高硫铝土矿溶出过程脱硫的影响。结果表明,优化溶出条件下高硫铝土矿溶出过程中加入氧化锌后,硫溶出率随氧化锌加入量增加而降低,氧化铝溶出率基本不变。溶出液中S2-含量随氧化锌加入量增加而降低,其他价态硫不随氧化锌加入量变化。优化溶出条件下,不同硫含量矿样在添加氧化锌后溶出的氧化铝溶出率基本不变,而硫溶出率随着矿样硫含量的增加,不断增加。添加10%氧化锌适合处理硫含量在1.373%以下的高硫铝土矿。

关键词：高硫铝土矿氧化锌溶出脱硫

Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin qi Huixian Zhu Kangli Shen Ruiqi Liu chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan Xin Cao Liang chen qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease