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Modulation of gut microbiota and serum metabolome by Apostichopus japonicus derived oligopeptide in high-fructose diet-induced hyperuricemia in mice

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Food Science and Human Wellness 2025年第1期14卷 161-174页

作者： Jun zhou Ziyan Wang Zhixuan Zhang Jiaojiao Han Ying Feng jing Zhang Zhen Zhang Ye Li Tinghong Ming Chenyang Lu Rixin Wang Xiurong Su State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingbo 315000China Key Laboratory of Aquacultural Biotechnology Ministry of EducationNingbo UniversityNingbo 315000China School of Marine Science Ningbo UniversityNingbo 315000China College of Life Sciences Tonghua Normal UniversityTonghua 134000China Faculty of Food Science Zhejiang Pharmaceutical CollegeNingbo 315000China

Fructose consumption has risen dramatically in recent decades due to the use of sucrose and high fructose corn syrup in beverages and processed foods,contributing to rising rates of *** purpose of this experiment was to explore the anti-hyperuricemia effects of an active oligopeptide(GPSGRP)derived from sea cucumber in fructose induced hyperuricemia mouse model,and to clarify the underlying mechanism in sight of gut microbiota and serum *** GPSGRP treatment rebalanced uric acid metabolism and alleviated inflammatory response in *** addition,treatment with GPSGRP decreased the abundance of Bacteroides and Proteobacteria at the phylum level,Muribaculum,Prevotella and Bacteroides at the genus level,and inhibited the related pathways of purine metabolism and glycolysis/gluconeogenesis ***,serum metabolites,including linoleic acid,indole and its derivatives,arachidonic acid and uridine,as well as related metabolic pathways,such as tricarboxylic acid cycle,ketone production and sugar production,were altered in response to GPSGRP *** study provides a valuable reference for the application and development of marine biological peptides in uric acid management.

关键词： Fructose Hyperuricaemia Oligopeptide Gut microbiota Serum metabolomics

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Transcriptome and single-cell profiling of the mechanism of diabetic kidney disease

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World Journal of Diabetes 2025年第2期16卷 216-236页

作者： Ying zhou Xiao Fang Lin-jing Huang Pei-Wen Wu Department of Endocrinology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Kidney Transplantation Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Endocrinology National Regional Medical Center Binhai Campus of the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350212Fujian ProvinceChina Clinical Research Center for Metabolic Diseases of Fujian Province The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Fujian Key Laboratory of Glycolipid and Bone Mineral Metabolism The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Diabetes Research Institute of Fujian Province The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina

BACKGROUND The NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome may play an important role in diabetic kidney disease(DKD).However,the exact link remains *** To investigate the role of the NLRP3 inflammasome in *** Using datasets from the Gene Expression Omnibus database,30 NLRP3 inflammasome-related genes were *** expressed genes were selected using differential expression analysis,whereas intersecting genes were selected based on overlapping differentially expressed genes and NLRP3 inflammasome-related ***,three machine learning algorithms were used to screen genes,and biomarkers were identified by overlapping the genes from the three *** biomarkers were validated by western blotting in a db/db mouse model of *** Two biomarkers,sirtuin 2(SIRT2)and caspase 1(CASP1),involved in the Leishmania infection pathway were *** biomarkers were expressed in endothelial ***-temporal analysis based on endothelial cells showed that DKD mostly occurs during the mid-differentiation *** blotting results showed that CASP1 expression was higher in the DKD group than in the control group(P<0.05),and SIRT2 content decreased(P<0.05).CONCLUSION SIRT2 and CASP1 provide a potential theoretical basis for DKD treatment.

关键词： Diabetic kidney disease Single-cell RNA sequencing analysis NOD-like receptor thermal protein domain associated protein 3 Sirtuin 2 Caspase 1

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基于动态建模方法的可靠性增长试验评定

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系统工程学报 2004年第4期19卷 435-440页

作者：刘琦冯静周经伦张金槐国防科技大学系统工程研究所湖南长沙410073

运用动态建模方法对可靠性增长试验下可靠性参数的先验分布进行分析.在任务可靠度先验分布确定的基础上,结合产品的少量现场试验数据,利用Bayes方法对系统的可靠性增长试验结果进行分析.首先给出了可靠性增长分析的动态模型,然后运用历... 详细信息

运用动态建模方法对可靠性增长试验下可靠性参数的先验分布进行分析.在任务可靠度先验分布确定的基础上,结合产品的少量现场试验数据,利用Bayes方法对系统的可靠性增长试验结果进行分析.首先给出了可靠性增长分析的动态模型,然后运用历次阶段试验中的可靠性增长数据建立动态参数的递推估计模型,在此基础上,给出各阶段可靠性增长试验中可靠性参数的Bayes估计.针对液体火箭发动机寿命分布为Weibull分布的特点,对Weibull寿命型系统的可靠性增长试验进行评定.通过一个实际例子说明了该方法的有效性.

关键词： Bayes分析可靠性增长动态建模方法

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论陶瓷艺术与绘画创作的共同点

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株洲工学院学报 2006年第5期20卷 6-8页

作者：漆竞舟戴勇红湖南工业大学湖南株洲412008

陶瓷艺术和绘画作为某种意识形态造型的一种表达方式,在空间的形式语言和表现特征上有共同点,在文化内涵上也保持千丝万缕的联系。在理论上探讨其共同点有助于艺术家保持一种开放、宽容的状态,不固守传统的创作规范和审美要求,自由应用... 详细信息

陶瓷艺术和绘画作为某种意识形态造型的一种表达方式,在空间的形式语言和表现特征上有共同点,在文化内涵上也保持千丝万缕的联系。在理论上探讨其共同点有助于艺术家保持一种开放、宽容的状态,不固守传统的创作规范和审美要求,自由应用各种媒介去表达。

关键词：绘画陶瓷艺术创作共同

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Self-reporting hypoxia-responsive supramolecular phototheranostic nanomaterials based on AIEgen and azocalixarene

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Science China Chemistry 2025年

作者： Xiao-Wen Han Guo-Ling Zhang Pu Chen jing Zhang Guo-Gang Shan Chun-Xuan qi Ben-Zhong Tang Hai-Tao Feng AIE Research Center Shaanxi Key Laboratory of Phytochemistry College of Chemistry and Chemical Engineering Baoji University of Arts and Sciences National & Local United Engineering Laboratory for Power Batteries Department of Chemistry Northeast Normal University School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong KongShenzhen (CUHK-Shenzhen)

Hypoxia is a significant feature in most of solid tumors. Hence, developing hypoxia-responsive phototheranostic system is still a challenge. In this contribution, a supramolecular assembly strategy based on sulfonate-functionalized azocalix[4]arene(SAC4A)and cationic aggregation-induced emission photosensitizer(namely TPA-H) was proposed for hypoxia-responsive bioimaging and photodynamic therapy(PDT). Upon supramolecular complexation of TPA-H and SAC4A through electrostatic interaction,the fluorescence and reactive oxygen species(ROS) generation of TPA-H were largely inhibited. In hypoxic tumors, the azo group of SAC4A can be reduced to aniline derivative and release the included TPA-H to recover its pristine fluorescence and ROS. Interestingly, the free TPA-H undergoes cell membrane-to-mitochondria translocation during cell imaging, achieving a real-time self-reporting PDT system. In vivo tumor imaging and therapy reveal that this as-prepared supramolecular complexes have good biosafety and efficient antitumor activity under hypoxia. Such hypoxia-responsive supramolecular photosensitizer system will enrich image-guided photodynamic therapy.

关键词： Hypoxia is a significant feature in most of solid tumors. Hence, developing hypoxia-responsive phototheranostic system is still a challenge. In this contribution, a supramolecular assembly strategy based on sulfonate-functionalized azocalixarene(SAC4A)and cationic aggregation-induced emission photosensitizer(namely TPA-H) was proposed for hypoxia-responsive bioimaging and photodynamic therapy(PDT). Upon supramolecular complexation of TPA-H and SAC4A through electrostatic interaction,the fluorescence and reactive oxygen species(ROS) generation of TPA-H were largely inhibited. In hypoxic tumors, the azo group of SAC4A can be reduced to aniline derivative and release the included TPA-H to recover its pristine fluorescence and ROS. Interestingly, the free TPA-H undergoes cell membrane-to-mitochondria translocation during cell imaging, achieving a real-time self-reporting PDT system. In vivo tumor imaging and therapy reveal that this as-prepared supramolecular complexes have good biosafety and efficient antitumor activity under hypoxia. Such hypoxia-responsive supramolecular photosensitizer system will enrich image-guided photodynamic therapy.

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内生真菌浸种对燕麦生长和根部内生真菌群落的影响

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草业学报 2025年第1期34卷 151-160页

作者：郭璟王越祁存英李静青海理工学院生态与环境科学学院青海西宁810016 青海省高原气候变化及其生态环境效应重点实验室青海西宁810016

内生真菌在促进植物生长、增强抗逆性、改变植物根部微生物群落结构等方面有着重大的研究和开发价值。本研究采用内生真菌(木霉菌ADK和黄绿卷毛菇AF)浸种燕麦的方法开展田间试验,通过测定燕麦生长指标、生理生化指标、根际土壤理化指标... 详细信息

内生真菌在促进植物生长、增强抗逆性、改变植物根部微生物群落结构等方面有着重大的研究和开发价值。本研究采用内生真菌(木霉菌ADK和黄绿卷毛菇AF)浸种燕麦的方法开展田间试验,通过测定燕麦生长指标、生理生化指标、根际土壤理化指标,评价内生真菌浸种对燕麦的促生效果,并利用高通量测序技术研究内生真菌浸种对燕麦根部内生真菌群落组成的影响。结果表明:2种内生真菌均能促进燕麦株高生长,增加根长、干重、鲜重等,其中,ADK对燕麦生长性状影响最显著(P<0.05),AF对燕麦产量增加最显著(P<0.05)。内生真菌对燕麦生理也有显著影响(P<0.05),ADK和AF组过氧化物酶(POD)活性和维生素C(Vc)含量较CK分别增加87.53、86.03%%和5.56%、58.11%,脯氨酸(Pro)和丙二醛(MDA)含量分别减少64.62%、72.85%和54.82%、63.85%。此外,ADK和AF能够提高土壤全磷含量,且AF显著(P<0.05)提高土壤有机碳含量。Illumina高通量测序结果表明内生真菌浸种增加了燕麦根部内生真菌的Shannon指数、Pielou指数以及特有OTU的数量,改变了燕麦根部内生真菌群落结构。主成分分析(PCA)结果显示ADK促进了燕麦生长,增加了燕麦根部内生真菌多样性;AF提高了燕麦产量,增强了燕麦抗逆性。本研究揭示出内生真菌浸种对燕麦有显著的促生效果,并能增强燕麦的抗逆性及改变燕麦根部内生真菌群落结构,为后期开发植物促生菌剂提供了菌种资源,也有助于开发木霉菌及黄绿卷毛菇在生物菌肥方面的潜能。

关键词：内生真菌燕麦浸种促生群落结构

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多模态可信度感知的情感计算

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软件学报 2025年第2期36卷 537-553页

作者：罗佳敏王晶晶周国栋苏州大学计算机科学与技术学院江苏苏州215006

多模态情感计算是情感计算领域一个基础且重要的研究任务,旨在利用多模态信号对用户生成的视频进行情感理解.尽管已有的多模态情感计算方法在基准数据集上取得了不错的性能,但这些方法无论是设计复杂的融合策略还是学习模态表示,普遍忽... 详细信息

多模态情感计算是情感计算领域一个基础且重要的研究任务,旨在利用多模态信号对用户生成的视频进行情感理解.尽管已有的多模态情感计算方法在基准数据集上取得了不错的性能,但这些方法无论是设计复杂的融合策略还是学习模态表示,普遍忽视了多模态情感计算任务中存在的模态可信度偏差问题.认为相较于文本,语音和视觉模态往往能更真实的表达情感,因而在情感计算任务中,语音和视觉是高可信度的,文本是低可信度的.然而,已有的针对不同模态特征抽取工具的学习能力不同,导致文本模态表示能力往往强于语音和视觉模态(例如:GPT3与ResNet),这进一步加重了模态可信度偏差问题,不利于高精度的情感判断.为缓解模态可信度偏差,提出一种模型无关的基于累积学习的多模态可信度感知的情感计算方法,通过为低可信度的文本模态设计单独的文本模态分支捕捉偏差,让模型在学习过程中从关注于低可信度文本模态的情感逐步关注到高可信度语音和视觉模态的情感,从而有效缓解低可信度文本模态导致的情感预测不准确.在多个基准数据集上进行实验,多组对比实验的结果表明,所提出的方法能够有效地突出高可信度语音和视觉模态的重要性,缓解低可信度文本模态的偏差;并且,该模型无关的方法显著提升了多模态情感计算方法的性能,这表明所提方法在多模态情感计算任务中的有效性和通用性.

关键词：多模态可信度感知多模态情感计算可信度偏差累积学习

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An Improved LZO Compression Algorithm for FPGA Configuration Bitstream Files

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Computers, Materials & Continua 2025年第2期82卷 3091-3109页

作者： Xiaoling Lai Jian Zhang Yangming Guo Ting Ju qi Zhu Guochang zhou School of Computer Science Northwestern Polytechnic UniversityXi’an710072China Xi’an Branch of China Academy of Space Technology Xi’an710100China

With the increase in the quantity and scale of Static Random-Access Memory Field Programmable Gate Arrays (SRAM-based FPGAs) for aerospace application, the volume of FPGA configuration bit files that must be stored has increased dramatically. The use of compression techniques for these bitstream files is emerging as a key strategy to alleviate the burden on storage resources. Due to the severe resource constraints of space-based electronics and the unique application environment, the simplicity, efficiency and robustness of the decompression circuitry is also a key design consideration. Through comparative analysis current bitstream file compression technologies, this research suggests that the Lempel Ziv Oberhumer (LZO) compression algorithm is more suitable for satellite applications. This paper also delves into the compression process and format of the LZO compression algorithm, as well as the inherent characteristics of configuration bitstream files. We propose an improved algorithm based on LZO for bitstream file compression, which optimises the compression process by refining the format and reducing the offset. Furthermore, a low-cost, robust decompression hardware architecture is proposed based on this method. Experimental results show that the compression speed of the improved LZO algorithm is increased by 3%, the decompression hardware cost is reduced by approximately 60%, and the compression ratio is slightly reduced by 0.47%.

关键词： FPGA configuration bitstream file LZO compression decompression

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Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 198-210页

作者： Long Wang qi Wu Zong-Wen Zhang Hui Zhang Hui Jin Xin-Liang zhou Jia-Yin Liu Dan Li Yan Liu Zhi-Song Fan Department of Oncology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Colony-stimulating factor 3(CSF3)and its receptor(CSF3R)are known to promote gastric cancer(GC)growth and ***,their effects on the immune microenvironment remain *** analysis indicated a potential link between CSF3R expression and the immunosuppressive receptor leukocyte immunoglobulin-like receptor B2(LILRB2)in *** hypothesized that CSF3/CSF3R may regulate LILRB2 and its ligands,angiopoietin-like protein 2(ANGPTL2)and human leukocyte antigen-G(HLA-G),contributing to *** To investigate the relationship between CSF3/CSF3R and LILRB2,as well as its ligands ANGPTL2 and HLA-G,in *** Transcriptome sequencing data from The Cancer Genome Atlas were analyzed,stratifying patients by CSF3R *** expressed genes and immune checkpoints were ***(IHC)was performed on GC *** analyses of CSF3R,LILRB2,ANGPTL2,and HLA-G were conducted using The Cancer Genome Atlas data and IHC *** cells were treated with CSF3,and expression levels of LILRB2,ANGPTL2,and HLA-G were measured by quantitative reverse transcriptase-polymerase chain reaction and western *** Among 122 upregulated genes in high CSF3R expression groups,LILRB2 showed the most significant *** results indicated high expression of LILRB2(63.0%),ANGPTL2(56.5%),and HLA-G(73.9%)in GC *** positive correlations existed between CSF3R and LILRB2,ANGPTL2,and HLA-G mRNA levels(P0.05).CSF3 increased LILRB2,ANGPTL2,and HLA-G expression in GC *** nuclear ribonucleoprotein H1 modulation significantly altered their expression,impacting CSF3’s regulatory *** The CSF3/CSF3R pathway may contribute to immunosuppression in GC by upregulating LILRB2 and its ligands,with heterogeneous nuclear ribonucleoprotein H1 playing a regulatory role.

关键词： Gastric cancer Immunosuppressive receptor Colony-stimulating factor 3 Colony-stimulating factor 3 receptor Leukocyte immunoglobulin-like receptor B2 Angiopoietin-like protein 2 Human leukocyte antigen-G Heterogeneous nuclear ribonucleoprotein H1

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Evaluating large language models as patient education tools for inflammatory bowel disease:A comparative study

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World Journal of Gastroenterology 2025年第6期31卷 34-43页

作者： Yan Zhang Xiao-Han Wan qing-zhou Kong Han Liu Jun Liu jing Guo Xiao-Yun Yang Xiu-Li Zuo Yan-qing Li Department of Gastroenterology Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Laboratory of Translational Gastroenterology Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Robot Engineering Laboratory for Precise Diagnosis and Therapy of GI Tumor Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Shandong Provincial Clinical Research Center for Digestive Disease Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Inflammatory bowel disease(IBD)is a global health burden that affects millions of individuals worldwide,necessitating extensive patient *** language models(LLMs)hold promise for addressing patient information ***,LLM use to deliver accurate and comprehensible IBD-related medical information has yet to be thoroughly *** To assess the utility of three LLMs(ChatGPT-4.0,Claude-3-Opus,and Gemini-1.5-Pro)as a reference point for patients with *** In this comparative study,two gastroenterology experts generated 15 IBD-related questions that reflected common patient *** questions were used to evaluate the performance of the three *** answers provided by each model were independently assessed by three IBD-related medical experts using a Likert scale focusing on accuracy,comprehensibility,and ***,three patients were invited to evaluate the comprehensibility of their ***,a readability assessment was *** Overall,each of the LLMs achieved satisfactory levels of accuracy,comprehensibility,and completeness when answering IBD-related questions,although their performance *** of the investigated models demonstrated strengths in providing basic disease information such as IBD definition as well as its common symptoms and diagnostic ***,when dealing with more complex medical advice,such as medication side effects,dietary adjustments,and complication risks,the quality of answers was inconsistent between the ***,Claude-3-Opus generated answers with better readability than the other two *** LLMs have the potential as educational tools for patients with IBD;however,there are discrepancies between the *** optimization and the development of specialized models are necessary to ensure the accuracy and safety of the information provided.

关键词： Inflammatory bowel disease Large language models Patient education Medical information accuracy Readability assessment

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