检索结果-南通市图书馆

A review on cell damage,viability,and functionality during 3D bioprinting

Military Medical Research 2023年第5期10卷 620-635页

作者： he-qi xu Jia-Chen Liu Zheng-Yi Zhang Chang-xue xu Department of Industrial Manufacturingand Systems EngineeringTexas Tech UniversityLubbockTX79409USA School of Naval Architecture and Ocean Engineering Huazhong University of Science and TechnologyWuhan430074China

Three-dimensional(3D)bioprinting fabricates 3D functional tissues/organs by accurately depositing the bioink composed of the biological materials and living *** though 3D bioprinting techniques have experienced significant advancement over the past decades,it remains challenging for 3D bioprinting to artificially fabricate functional tissues/organs with high post-printing cell viability and functionality since cells endure various types of stress during the bioprinting ***,cell viability which is affected by several factors including the stress and the environmental factors,such as pH and temperature,is mainly determined by the magnitude and duration of the stress imposed on the cells with poorer cell viability under a higher stress and a longer duration *** maintenance of high cell viability especially for those vulnerable cells,such as stem cells which are more sensitive to multiple stresses,is a key initial step to ensure the functionality of the artificial tissues/*** addition,maintaining the pluripotency of the cells such as proliferation and differentiation abilities is also essential for the 3D-bioprinted tissues/organs to be similar to native tissues/*** review discusses various pathways triggering cell damage and the major factors affecting cell viability during different bioprinting processes,summarizes the studies on cell viabilities and functionalities in different bioprinting processes,and presents several potential approaches to protect cells from injuries to ensure high cell viability and functionality.

关键词： Three-dimensional bioprinting Cell damage Shear stress Cell viability Cell functionality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cultivated Cordyceps: A Tale of Two Treasured Mushrooms

引用

Chinese Medicine and Culture 2021年第4期4卷 221-227页

作者： Anawinla Ta Anyu Wen-Hui Zhang qi-he xu GKT School of Medical Education King’s College LondonLondon WC2R 2LS School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery Shanghai 201203China Renal Sciences and Integrative Chinese Medicine Laboratory Department of Inflammation BiologySchool of Immunology and Microbial SciencesFaculty of Life Sciences and MedicineWeston Education CentreKing’s College LondonLondon SE59RJUK

Ophiocordyceps sinensis and Cordyceps militaris both contain many bioactive compounds that confer potential therapeutic benefits. This review discusses the possible use of cultivated C. militaris as an effective substitute for native O. sinensis in the face of ever-increasing prices of O. sinensis because of its short supply. On the one hand, cultivated C. militaris contains higher levels of cordycepin when compared with that of wild-type O. sinensis and cultivation of C. militaris has been shown to be capable of reducing the risk of heavy metal contamination. On the other hand, there is a paucity of robust in vivo studies and randomized controlled tests comparing the pharmacology and use of C. militaris and O. sinensis. For extraction of cordycepin as western-style tablets, the use of cultivated C. militaris rather than O. sinensis represents the most appropriate future approach. For many other purposes, comparative pharmacology and clinical trials are in urgent needs.

关键词： Cordycepin cordyceps militaris ophiocordyceps sinensis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

herbal Medicines for Acute Kidney Injury: Evidence, Gaps and Frontiers

引用

World Journal of Traditional Chinese Medicine 2015年第3期1卷 47-66页

作者： Valérian Bunel Fan Qu Pierre Duez qi-he xu Laboratory of Experimental Nephrology Faculty of MedicineUniversité Libre de Bruxelles(ULB) Laboratory of Pharmacognosy Bromatology and Human NutritionFaculty of PharmacyULB Women’s Hospital School of MedicineZhejiang University Department of Therapeutic Chemistry and Pharmacognosy Université de Mons(UMONS) Centre for Integrative Chinese Medicine and Department of Renal Medicine King’s College London

Acute kidney injury(AKI) is a major health threat worldwide. The literature on herbal intervention in AKI was searched from English and Chinese databases and reports were critically analyzed in terms of preventing AKI, promoting repair and regeneration, enhancing extrarenal clearance of uremic toxins, and preventing progression to chronic kidney disease(CKD). Altogether, 16 herbal formulae and a few extracts derived from individual herbs were reported to prevent or mitigate AKI in animal models induced by renal ischemia/reperfusion, cisplastin,gentamicin, glycerol, adenine, sepsis or physical exhaustion. Four formulae and six individual herbs were reported to accelerate recovery and/or to prevent CKD in established AKI animal models. Intrarectal herbal medicines, with or without simultaneous oral administration, were reported in six clinical trials and in an animal model to increase extrarenal clearance of uremic toxins. Additional 13 clinical trials reported oral or intravenous herbal interventions in AKI of different etiologies. Despite recurring problems, notably poor compliance with good practice guidelines for clinical trials and for authentication, naming and quality control of herbal materials, accumulating experimental data on the preventive effects of herbal medicines in AKI look encouraging and urge for better, definitive trials to guide clinical practice. herbal enemas promoting extrarenal clearance of uremic toxins seem cost-effective, but better clinical evidence is certainly needed before any affirmative recommendation be made for AKI patients without access to dialysis. New frontiers, however, lie in those herbal remedies that promote repair/regeneration and prevent chronicity after AKI. Recent experimental data suggest that this may be possible.

关键词： Acute renal failure renoprotective traditional Chinese medicine herbal medicinal products traditional medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Different Concentrations of Sulfate Ions on Carbonate Crude Oil Desorption:Experimental Analysis and Molecular Simulation

引用

Fluid Dynamics & Materials Processing 2024年第8期20卷 1731-1741页

作者： Nannan Liu hengchen qi Hui xu Yanfeng he School of Petroleum and Natural Gas Engineering Changzhou UniversityChangzhou213164China

Low salinity water containing sulfate ions can significantly alter the surface wettability of carbonate ***,the impact of sulfate concentration on the desorption of oil film on the surface of carbonate rock is still *** study examines the variations in the wettability of the surface of carbonate rocks in solutions containing varying amounts of sodium sulfate and pure *** problem is addressed in the framework of molecular dynamics simulation(Material Studio software)and *** experiment’s findings demonstrate that sodium sulfate can increase the rate at which oil moisture is turned into water *** final contact angle is smaller than that of pure *** results of the simulations show that many water molecules travel down the water channel under the influence of several powerful forces,including the electrostatic force,the van der Waals force and hydrogen bond,crowding out the oil molecules on the calcite’s surface and causing the oil film to *** relative concentration curve of water and oil molecules indicates that the separation rate of the oil film on the surface of calcite increases with the number of sulfate ions.

关键词： Carbonate rocks wettability sulfate ions concentration molecular simulation desorption

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Taming the Fire of Nephrotoxic Botanicals

引用

World Journal of Traditional Chinese Medicine 2019年第3期5卷 151-168页

作者： Francesca Holden Vanisha Amin Dominic Kuek Jeffrey BKopp Bruce Mhendry qi-he xu Department of Renal Medicine Centre for Integrative Chinese MedicineSchool of Immunology and Microbial SciencesFaculty of Life Sciences and MedicineKing’s College LondonWestern Education Centre GKT School of Medical Education Faculty of Life Sciences and MedicineKing’s College LondonLondonUnited Kingdom Kidney Disease Section NIDDKNational Institutes of HealthBethesdaMDUSA

Criteria for diagnosing nephropathy and urothelial neoplasms induced by botanicals containing aristolochic acids(AAs) are well established. Highlights of recent research on AAs include mechanisms of AA intrarenal transport and metabolism and vigorous debate on whether AAs may also cause liver cancers. Many other botanicals may also cause renal injury, but a generalized framework for diagnosing botanical-induced kidney injury(BIKI) is lacking. Based on what we have learnt about the wide spectrum of phenotypes of BIKI attributed to AAs and a recently published standardized phenotypic framework of drug-induced kidney disease, we propose that BIKI may be categorized into six phenotypes(acute kidney injury, tubular dysfunction, glomerular disorders, nephrolithiasis, chronic kidney disease, and neoplasms) and four mechanistic types(A, predictable;B, idiosyncratic;C, chronic;and D, delayed). We call for international cooperation assembling a task force to develop, refine, and regularly appraise an online BIKI database, documenting botanical use, phenotypes, mechanisms, and levels of evidence. Once established, such a database may be linked with electronic patient records and pharmacovigilance channels to generate alerts, guide clinical decision-making, direct future research, and support evidence-based regulation of herbal medicines and education of healthcare professionals and the public. Finally, to prevent BIKI, we propose that a proactive approach integrating the triad of botanicals, users, and stakeholders will be needed.

关键词： Adverse effects database herbal kidney mechanisms phenotypes prevention

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inkjet 3D bioprinting for tissue engineering and pharmaceutics

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2022年第12期23卷 955-973页

作者： Deng-ke ZHAO he-qi xu Jun YIN Hua-yong YANG The State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China

3D bioprinting has the capability to create 3D cellular constructs with the desired shape using a layer-by-layer *** 3D bioprinting,as a key component of 3D bioprinting,relies on the deposition of cell-laden droplets to create native-like tissues/organs which are envisioned to be transplantable into human body for replacing damaged *** from its superiorities such as high printing resolution and deposition accuracy,inkjet 3D bioprinting has been widely applied to various areas,including,but not limited to,tissue engineering and drug screening in *** though inkjet 3D bioprinting has proved its feasibility and versatility in various fields,the current applications of inkjet 3D bioprinting are still limited by the printing technique and material *** review,which specifically focuses on inkjet 3D bioprinting,firstly summarizes the techniques,materials,and applications of inkjet 3D bioprinting in tissue engineering and drug screening,subsequently discusses the major challenges that inkjet 3D bioprinting is facing,and lastly summarizes potential solutions to those challenges.

关键词： Inkjet 3D bioprinting Biomaterials In vitro tissue models In vivo tissue substitutes Drug screening

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functional prediction of tomato PLATZ family members and functional verification of Sl PLATZ17

引用

Journal of Integrative Agriculture 2024年第1期23卷 141-154页

作者： Min xu Zhao Gao Dalong Li Chen Zhang Yuqi Zhang qian he Yingbin qi he Zhang Jingbin Jiang Xiangyang xu Tingting Zhao College of Horticulture and Landscape Architecture Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(Northeast Region) Ministry of Agriculture and Rural AffairsHarbin 150030China

PLATZ is a novel zinc finger DNA-binding protein that plays an important role in regulating plant growth and development and resisting abiotic ***,there has been very little research on the function of this family gene in tomatoes,which limits its application in germplasm resource ***,the PLATZ gene family was identified and analyzed in tomato,and its roles were predicted and verified to provide a basis for in-depth research on SlPLATZ gene *** this study,the PLATZ family members of tomato were identified in the whole genome,and 19 SlPLATZ genes were *** prediction was conducted based on gene and promoter structure analysis and RNA-seq-based expression pattern *** genes that responded significantly under different abiotic stresses or were significantly differentially expressed among multiple tissues were screened as functional gene ***17 was selected for functional verification by experiment-based *** results showed that the downregulation of SlPLATZ17 gene expression reduced the drought and salt tolerance of tomato *** plants overexpressing SlPLATZ17 had larger flower sizes and long,thin petals,adjacent petals were not connected at the base,and the stamen circumference was *** study contributes to understanding the functions of the SlPLATZ family in tomato and provides a reference for functional gene screening.

关键词： tomato PLATZ family abiotic stresses plant development

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fracture sealing performance of granular lost circulation materials at elevated temperature:A theoretical and coupled CFD-DEM simulation study

引用

Petroleum Science 2024年第1期21卷 567-581页

作者： Chong Lin qi-Cong xu Lie-Xiang Han Gao Li Hai he Hong-Ling Zhou Ji-Ping She CCDC Drilling&Production Technology Research Institute Guanghan618300SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina College of Materials Science and Engineering Chongqing UniversityChongqing400044China State Key Lab of Oil and Gas Reservoir Geology and Exploitation(Chengdu University of Technology) Chengdu610059SichuanChina College of Energy Chengdu University of TechnologyChengdu610059SichuanChina

Lost circulation is a common downhole problem of drilling in geothermal and high-temperature,high-pressure(HTHP)*** circulation material(LCM)is a regular preventive and remedial measure for lost ***,conventional LCMs seem ineffective in high-temperature *** may be due to the changes in the mechanical properties of LCMs and their sealing performance under high-temperature *** understand how high temperature affects the fracture sealing performance of LCMs,we developed a coupled computational fluid dynamics-discrete element method(CFD-DEM)model to simulate the behavior of granular LCMs in *** summarized the literature on the effects of high temperature on the mechanical properties of LCMs and the rheological properties of drilling *** conducted sensitivity analyses to investigate how changing LCM slurry properties affected the fracture sealing efficiency at increasing *** results show that high temperature reduces the size,strength,and friction coefficient of LCMs as well as the drilling fluid ***,softer,and less frictional LCM particles have lower bridging probability and slower bridging *** particles tend to form dual-particle bridges rather than single-particle *** result in a deeper,tighter,but unstable sealing *** drilling fluid viscosity leads to faster and shallower sealing zones.

关键词： Geothermal well drilling HTHP formationLost circulation material CFD-DEM Fracture sealing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Highly Conductive Ag/pCF/MVQ Composite Rubber for Efficient Electromagnetic Interference Shielding

引用

Chinese Journal of Polymer Science 2024年第6期42卷 864-873页

作者： Yang Chen Xiao-Ming Shao Liang he Yi-Nuo xu qi-Yuan Yao Ding Feng Wen-Cai Wang State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Key Laboratory of Beijing City for Preparation and Processing of Novel Polymer Materials Beijing University of Chemical TechnologyBeijing100029China Sino-german School of Engineering Qingdao University of Science and TechnologyQingdao266400China

In this study,flexible and highly conductive composite rubber at low filler content was successfully prepared through polydopamine-assisted electroless silver plating plus mechanical ***,carbon fibers(CF)were activated by polydopamine(PDA)to improve the surface activity by self-polymerization ***,because of the metal chelating ability of PDA,silver layer was firmly deposited on the surface of CF through a facile electroless silver plating ***,flexible silver-plated carbon fibers(Ag/pCF)silicone rubber composites prepared by mechanical *** using X-ray photoelectron spectroscopy(XPS)and X-ray diffraction(XRD),the chemical composition and crystal structure of Ag/pCF were examined,and scanning electron microscopy(SEM)was used to assess the surface morphology of the Ag/*** results showed that a uniform and dense silver layer was formed on the surface of the CF,and the conductivity of the Ag/pCF could reach 7885 S/*** was noteworthy that the composite rubber filled with only 45 phr Ag/pCF had a high electromagnetic interference shielding effectiveness(100 dB)due to the low density and high aspect ratio of Ag/*** composite rubber has excellent potential for application in the field of electromagnetic interference shielding.

关键词： Carbon fibers Polydopamine Electroless plating Silver Electromagnetic interference shielding

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Predictors of Adverse Pregnancy Outcomes Following Traumatic Injuries

引用

Current Medical Science 2024年第3期44卷 642-647页

作者： Wan-rong LU Ping WU Gong SONG Mei-qi GU Zhe xu Li he National Clinical Research Center for Gynecology and Obstetrics Cancer Biology Research CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Traumatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective After traumatic injury in pregnant women,providing timely and appropriate management for high-risk patients is crucial for both pregnant women and *** study aimed to identify risk factors that predict adverse pregnancy outcomes after traumatic *** A retrospective cohort study including 317 pregnant patients who experienced trauma was *** collected data included general demographics,injury mechanisms and adverse pregnancy *** were divided into two subgroups based on the absence or presence of trauma-related adverse pregnancy *** and multivariate logistic regressions were conducted to estimate the associations between clinical variables and adverse pregnancy *** A total of 41(12.93%)patients experienced adverse pregnancy outcomes within the first 24 h *** study revealed that age>35 years(OR=14.995,95%CI:5.024–44.755,Phe probability of posttraumatic adverse pregnancy *** age,gestational age at delivery,vaginal bleeding and positive FAST results were risk factors for abnormal *** Advanced maternal age,third trimester,and positive FAST results should alert multidisciplinary trauma teams to closely monitor patients to prevent adverse pregnancy outcomes.

关键词： adverse pregnancy outcomes predictive factors abnormal delivery trauma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：