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Improving the Conversion Success Rate of Hepatocellular Carcinoma: Focus on the Use of Combination Therapy with a High Objective Response Rate

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Journal of Clinical and Translational Hepatology 2024年第3期12卷 298-304页

作者： qi-feng chen Song chen Minshan chen Ning Lyu Ming Zhao Department of Minimally Invasive Interventional Therapy Liver Cancer Study and Service GroupSun Yat-sen University Cancer CenterGuangzhouGuangdongChina State Key Laboratory of Oncology in South China GuangzhouGuangdongChina Department of Liver Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdongChina

The high mortality rate in hepatocellular carcinoma(HCC)is partially due to the fact that a significant number of patients are diagnosed at an intermediate or advanced stage,with surgical treatment options *** therapy,which involves both locoregional and systemic treatments,has the potential to downstage tumors in selected patients with initially unresectable HCC,thereby making surgical treatment a possibility and potentially increasing long-term *** optimize the conversion rate,it is necessary to maximize successful conversions and clearly define the target population for conversion treatment through a collaborative *** this review article,we summarize the clinical experience and evidence for conversion therapy in patients with‘potentially resectable’HCC from four perspectives:1)defining the target population for conversion therapy,2)selecting the appropriate conversion strategy,placing emphasis on the utilization of combination therapy that exhibits a significant objective response rate,3)determining the timing and urgency of surgical resection,4)promoting the adoption of a multidisciplinary team *** authors are optimistic that with the continuous progress in treatment and a deeper understanding of HCC,the success rate of HCC conversion therapy will increase,and the overall survival of HCC patients will be prolonged.

关键词： Hepatocellular carcinoma Conversion therapy Conversion rate Targeted population Combination therapy

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Possible evidence of destroying small PAH particles by radiation from AGNs

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Research in Astronomy and Astrophysics 2015年第2期15卷 199-206页

作者： qi-chen feng Jing Wang Jian-Yan Wei National Astronomical Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences

The issue of destroying small polycyclic aromatic hydrocarbon （PAH） par- ticles by radiation from AGNs is examined through optical narrow-emission line ra- tios of a sample of type II AGNs. We find that narrow-line ratios [OI]λ6300/Ha and [SII]λ6716, λ6731/Hα have prominent correlations with the PAH 11.3/7.7 ratio in our selected sample of AGNs. Because of the marginal （and in some cases no） dependence of the PAH ratio on the gas metallicity, a possible explanation for the correlations is the destruction of small PAH particles by the hard ionizing field associated with the AGNs.

关键词： infrared: ISM quasars: emission lines galaxies: active galaxies: AGN methods: statistical

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The relationship between the properties of PAHs and AGN activities in type-I AGNs

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Research in Astronomy and Astrophysics 2015年第5期15卷 663-672页

作者： qi-chen feng Jing Wang Hua-Li Li Jian-Yan Wei National Astronomical Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Space Astronomy and Technology (NAOC CAS)

In order to explore the relationship between properties of Polycyclic Aromatic Hydrocarbons （PAHs） and AGN activities in Type-I AGNs, we compiled a sample of 47 Type-I AGNs with measured PAH 11.3 μm and 7.7 μm emission lines. The PAH emission and optical properties of these AGNs are taken from the literature. It is found that the equivalent width （EW） of 11.3 μm emission from PAHs shows a weak correlation with the ratio of the EWs of the FelI complex between λ4434 and A4684 to H/3 （RFe）. The PAH 11.3/7.7 ratio is correlated with various elements defined by the first eigenvector space, which are RFe, [OIII]A5007 luminosity and H/3 asymmetry. These correlations infer that AGNs with high RFe, weak [OIII] emission and a strong H/3 blue-wing are likely to have low PAH ionization, and hence a larger amount of neutral PAHs.

关键词： infrared ISM -- quasars emission lines -- galaxies active -- galaxies evolution -- methods statistical

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Sound event localization and detection based on deep learning

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Journal of Systems Engineering and Electronics 2024年第2期35卷 294-301页

作者： ZHAO Dada DING Kai qi Xiaogang chen Yu feng Hailin School of Mathematics and Statistics Xidian UniversityXi’an 710071China Science and Technology on Near-Surface Detection Laboratory Wuxi 214035China

Acoustic source localization(ASL)and sound event detection(SED)are two widely pursued independent research *** recent years,in order to achieve a more complete spatial and temporal representation of sound field,sound event localization and detection(SELD)has become a very active research *** paper presents a deep learning-based multioverlapping sound event localization and detection algorithm in three-dimensional ***-Mel spectrum and generalized cross-correlation spectrum are joined together in channel dimension as input *** features are classified and regressed in parallel after training by a neural network to obtain sound recognition and localization results *** channel attention mechanism is also introduced in the network to selectively enhance the features containing essential information and suppress the useless ***,a thourough comparison confirms the efficiency and effectiveness of the proposed SELD *** experiments show that the proposed algorithm is robust to reverberation and environment and can achieve higher recognition and localization accuracy compared with the baseline method.

关键词： sound event localization and detection(SELD) deep learning convolutional recursive neural network(CRNN) channel attention mechanism

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Determination of levodopa in pharmaceutical preparations by irreversible biamperometry

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Chinese Chemical Letters 2008年第6期19卷 703-706页

作者： Li Jun Li qi feng chen Hao cheng Lai Bo Yu Jian Ling Wu Department of Biological and Chemical Engineering Guangxi University of Technology Liuzhou 545006 China College of Chemistry and Chemical Engineering Guangxi University Nanning 530004China

Based on the electrocatalytic oxidation of levodopa at gold electrode and the reduction of permanganate at platinum electrode, a novel flow injection irreversible biamperometric method is developed for the determination of levodopa under the potential difference of 0 V imposed between two electrodes. In H2SO4 solution, the linear relationships between currents and the concentrations of levodopa are obtained in the range from 0.04 mg/L to 20 mg/L with the detection limit of 0.012 mg/L. The proposed method is applied to the determination of levodopa in pharmaceutical preparations.

关键词： Flow injection Levodopa Irreversible biamperometry Gold electrode Platinum electrode

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基于微控制器的光伏发电与并网系统优化设计

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机械研究与应用 2024年第5期37卷 127-131,136页

作者：彭磊吴丫丫祁琛峰李天钰刘硕国网甘肃省电力公司陇南供电公司甘肃陇南746000 兰州理工大学计算机与通信学院甘肃兰州730050

针对光伏发电数据采集不准确以及光伏设备出现故障而导致并网系统产生安全问题的情况与实际需求,提出了一种基于微控制器的创新设计方案,将电子机械技术、物联网技术和传感器技术相结合,对光伏发电系统进行系统化的软硬件设计。通过设... 详细信息

针对光伏发电数据采集不准确以及光伏设备出现故障而导致并网系统产生安全问题的情况与实际需求,提出了一种基于微控制器的创新设计方案,将电子机械技术、物联网技术和传感器技术相结合,对光伏发电系统进行系统化的软硬件设计。通过设计和实验完成了主控模块、分模块数据采集和通信模块之间的连接,验证了系统的完整性和准确性,成功解决了光伏发电系统数据采集不准确的问题,为光伏发电系统的智能化和并网安全性提供了可靠的解决方案。针对光伏发电与并网系统可能出现的低压穿越问题,采用撬棍电路进行电路保护,并对整体电网进行改造。这一设计在提升电力设备智能化和并网智能水平方面具有显著的应用价值。

关键词：电子机械光伏发电传感器技术物联网并网系统

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Eight key long non-coding RNAs predict hepatitis virus positive hepatocellular carcinoma as prognostic targets

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 983-997页

作者： Zi-Lin Huang Wang Li qi-feng chen Pei-Hong Wu Lu-Jun Shen Department of Medical Imaging and Interventional Radiology Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Hepatitis B virus,together with hepatitis C virus,has been recognized as the leading causes of hepatocellular carcinoma(HCC).Long non-coding RNAs(lncRNAs)have been suggested in increasing studies to be the potential prognostic factors for ***,the role of combined application of lncRNAs in estimating overall survival(OS)for hepatitis virus positive HCC(VHCC)is *** To construct an lncRNA signature related to the OS of VHCC patients to enhance the accuracy of prognosis *** The expression patterns of lncRNAs,as well as related clinical data were collected from 149 VHCC patients from The Cancer Genome Atlas *** R package was adopted to obtain the differentially expressed lncRNAs(DElncRNAs).LncRNAs significantly associated with OS were screened by means of univariate Cox regression analysis,so as to construct a least absolute shrinkage and selection operator(LASSO)***,the constructed lncRNA signature was developed and ***,the prognostic nomogram was established,which combined the as-established lncRNA signature as well as the clinical ***,subgroup analysis stratified by the virus type was also ***,the above-mentioned lncRNAs were enriched to corresponding pathways according to the markedly coexpressed *** A total of 1420 DElncRNAs were identified,among which 406 were significant in univariate Cox regression *** regression confirmed 8 out of the 406 lncRNAs,including AC005722.2,AC107959.3,AL353803.1,AL589182.1,AP000844.2,AP002478.1,FLJ36000,and ***,the prognostic risk score was *** results displayed a significant association between the risk model and the OS of VHCC[hazard ratio=1.94,95%confidence interval(CI):1.61-2.34,log-rank P=2e-10].The inference tree suggested that the established lncRNA signature was useful in the risk stratification of ***,a nomogram was plotted,and the concordance index of interna

关键词： Long non-coding RNAs Hepatitis virus Hepatocellular carcinoma Prognostic signature Least absolute shrinkage and selection operator

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Significance of tumor-infiltrating immunocytes for predicting prognosis of hepatitis B virus-related hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第35期25卷 5266-5282页

作者： qi-feng chen Wang Li Pei-Hong Wu Lu-Jun Shen Zi-Lin Huang Department of Medical Imaging and Interventional Radiology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine

BACKGROUND Hepatitis B virus (HBV) has been recognized as a leading cause of hepatocellular carcinoma (HCC). Numerous reports suggest that immune infiltration can predict the prognosis of HCC. Nonetheless, no creditable markers for prognosis of HBV-related HCC have been established by systematically assessing the immune-related markers based on tumor transcriptomes. AIM To establish an immune-related marker based on the cell compositions of immune infiltrate obtained based on tumor transcriptomes, so as to enhance the prediction accuracy of HBV-related HCC prognosis. METHODS RNA expression patterns as well as the relevant clinical data of HCC patients were obtained from The Cancer Genome Atlas. Twenty-two immunocyte fraction types were estimated by cell type identification by estimating relative subsets of RNA transcripts. Subsequently, the least absolute shrinkage and selection operator (LASSO) Cox regression model was employed to construct an immunoscore based on the immunocyte fraction types. Afterwards, the receiver operating characteristic (ROC) curve, Kaplan-Meier, and multivariate Cox analyses were performed. Additionally, a nomogram for prognosis that integrated the immunoscore as well as the clinical features was established. Meanwhile, the correlation of immunoscore with immune genes was also detected, and gene set enrichment analysis (GSEA) of the immunoscore was conducted. RESULTS A total of 22 immunocyte fraction types were predicted and compared among the tumor as well as non-tumor samples. An immunoscore was constructed through adopting the LASSO model, which contained eight immunocyte fraction types. Meanwhile, the areas under the ROC curves for the immunoscore biomarker prognostic model were 0.971, 0.912, and 0.975 for 1-, 3-, and 5-year overall survival (OS), respectively. Difference in OS between the high-immunoscore group and the low-immunoscore group was statistically significant [hazard ratio (HR)= 66.007, 95% confidence interval (CI): 8.361-52

关键词： Immune risk score Hepatitis B virus Hepatocellular carcinoma Prognostic signature Cell type identification by estimating relative subsets of RNA transcripts

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Determination of chlorogenic acid by flow injection irreversible biamperometry

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Chinese Chemical Letters 2007年第4期18卷 431-434页

作者： Li Jun Li qi feng chen Lai Bo Yu Zhao Heng Zhong Jun feng Hao cheng Hong Xing Kong Jian Ling Wu Department of Biological and Chemical Engineering Guangxi University of Technology Liuzhou 545006 China College of Chemistry and Chemical Engineering Guangxi University Nanning 530004 China

A flow injection irreversible biamperometric method for the determination of chlorogenic acid is described. The proposed method is based on the electrochemical oxidation of chlorogenic acid at pretreated platinum electrode and the reduction of permanganate at another electrode to form an irreversible biamperometric detection system. Under the external potential difference （z^v） of 0 V, in the 0.05 mol/L sulfuric acid, chlorogenic acid can be determined over the range 0.8-120 mg/L with a sample measurement frequency of 80 samples/h. The detection limit is 0.18 mg/L. The proposed method exhibits the satisfactory reproducibility with a relative standard derivation （R.S.D.） of 2.21% for 19 successive determinations of 40 mg/L.

关键词： Flow injection Irreversible biamperometry Chlorogenic acid Honeysuckle

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Iterative Signal Detection Based Soft Interference Cancellation for Satellite-Terrestrial Downlink NOMA Systems

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China Communications 2024年第8期21卷 249-263页

作者： Sun Meng Zhang qi Yao Haipeng Gao Ran Xin Xiangjun Tian feng feng Weiying chen Dong School of Electronic Engineering Beijing University of Posts and Telecommunications(BUPT)Beijing 100876China Beijing Key Laboratory of Space-Ground Interconnection and Convergence State Key Laboratory of Information Photonics and Optical CommunicationsSchool of Electronic EngineeringBeijing University of Posts and Telecommunications(BUPT)Beijing 100876China School of Information and Communication Engineering Beijing University of Posts and Telecommunications(BUPT)Beijing 100876China Beijing Institute of Technology Beijing 100081China Beihang University Beijing 100191China China Academy of Space Technology(CAST) Beijing 100094China

To improve the bit error rate(BER)performance of multi-user signal detection in satelliteterrestrial downlink non-orthogonal multiple access(NOMA)systems,an iterative signal detection algorithm based on soft interference cancellation with optimal power allocation is *** that power allocation has a significant impact on BER performance,the optimal power allocation is obtained by minimizing the average BER of NOMA *** to the allocated powers,successive interference cancellation(SIC)between NOMA users is performed in descending power *** each user,an iterative soft interference cancellation is performed,and soft symbol probabilities are calculated for soft *** improve detection accuracy and without increasing the complexity,the aforementioned algorithm is optimized by adding minimum mean square error(MMSE)signal estimation before detection,and in each iteration soft symbol probabilities are utilized for soft-decision of the current user and also for the update of soft interference of the previous *** results illustrate that the optimized algorithm ***-IDBSIC significantly outperforms joint multi-user detection and SIC detection by 7.57dB and 8.03dB in terms of BER performance.

关键词： non-orthogonal multiple access(NOMA) resource allocation satellite-terrestrial communication signal detection soft interference cancellation

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