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Bone Research 2024年第1期12卷 107-121页

作者： Feng Gao qimiao Hu Wenwei Chen Jilong Li Cheng qi Yiwen Yan Cheng qian Mei Wan James Ficke Junying zheng Xu Cao Department of Orthopedic Surgery Johns Hopkins University School of MedicineBaltimoreMaryland 21205USA Department of Biomedical Engineering Johns Hopkins University School of MedicineBaltimoreMaryland 21205USA

Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading ***,it is unclear whether the signals of bone cells in response to mechanical stress are processed and interpreted in the *** this study,we found that the hypothalamus of the brain regulates bone remodeling and structure by perceiving bone prostaglandin E2(PGE2)concentration in response to mechanical *** PGE2 levels are in proportion to their weight *** weight bearing changes in the tail-suspension mice,the PGE2 concentrations in bones change in line with their weight bearing *** of cyclooxygenase-2(COX2)in the osteoblast lineage cells or knockout of receptor 4(EP4)in sensory nerve blunts bone formation in response to mechanical ***,knockout of TrkA in sensory nerve also significantly reduces mechanical load-induced bone ***,mechanical loading induces cAMP-response element binding protein(CREB)phosphorylation in the hypothalamic arcuate nucleus(ARC)to inhibit sympathetic tyrosine hydroxylase(TH)expression in the paraventricular nucleus(PVN)for ***,we show that elevated PGE2 is associated with ankle osteoarthritis(AOA)and ***,our data demonstrate that in response to mechanical loading,skeletal interoception occurs in the form of hypothalamic processing of PGE2-driven peripheral signaling to maintain physiologic bone homeostasis,while chronically elevated PGE2 can be sensed as pain during AOA and implication of potential treatment.

关键词： pain elevated PGE2

Optimizing high-coordination shell of Co-based single-atom catalysts for efficient ORR and zinc-air batteries

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Journal of Energy Chemistry 2024年第8期95卷 306-314,I0007页

作者： Yugang qi qing Liang Kexin Song Xinyan Zhou Meiqi Liu Wenwen Li Fuxi Liu Zhou Jiang Xu Zou Zhongjun Chen Wei Zhang Weitao zheng Key Laboratory of Automobile Materials MOE School of Materials Science&Engineering Electron Microscopy Centerand International Center of Future ScienceJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsJilin UniversityChangchun 130012JilinChina Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Atom-level modulation of the coordination environment for single-atom catalysts(SACs)is considered as an effective strategy for elevating the catalytic *** the MNxsite,breaking the symmetrical geometry and charge distribution by introducing relatively weak electronegative atoms into the first/second shell is an efficient way,but it remains challenging for elucidating the underlying mechanism of ***,a practical strategy was reported to rationally design single cobalt atoms coordinated with both phosphorus and nitrogen atoms in a hierarchically porous carbon derived from metal-organic frameworks.X-ray absorption spectrum reveals that atomically dispersed Co sites are coordinated with four N atoms in the first shell and varying numbers of P atoms in the second shell(denoted as Co-N/P-C).The prepared catalyst exhibits excellent oxygen reduction reaction(ORR)activity as well as zinc-air battery *** introduction of P atoms in the Co-SACs weakens the interaction between Co and N,significantly promoting the adsorption process of ^(*)OOH,resulting in the acceleration of reaction kinetics and reduction of thermodynamic barrier,responsible for the increased intrinsic *** discovery provides insights into an ultimate design of single-atom catalysts with adjustable electrocatalytic activities for efficient electrochemical energy conversion.

关键词： Electrocatalytic Oxygen reduction reaction Single atom catalyst Shell coordination optimization

Establishment and evaluation of a prognostic model for patients with unresectable gastric cancer liver metastases

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World Journal of Clinical Cases 2024年第13期12卷 2182-2193页

作者： zheng-Yao chang Wen-Xing Gao Yue Zhang Wen Zhao Di Wu Lin Chen Department of General Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Endocrinology The First Medical Center of Chinese PLA General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China

BACKGROUND Liver metastases(LM)is the primary factor contributing to unfavorable outcomes in patients diagnosed with gastric cancer(GC).The objective of this study is to analyze significant prognostic risk factors for patients with GCLM and develop a reliable nomogram model that can accurately predict individualized prognosis,thereby enhancing the ability to evaluate patient *** To analyze prognostic risk factors for GCLM and develop a reliable nomogram model to accurately predict individualized prognosis,thereby enhancing patient outcome *** Retrospective analysis was conducted on clinical data pertaining to GCLM(type III),admitted to the Department of General Surgery across multiple centers of the Chinese PLA General Hospital from January 2010 to January *** dataset was divided into a development cohort and validation cohort in a ratio of 2:*** the development cohort,we utilized univariate and multivariate Cox regression analyses to identify independent risk factors associated with overall survival in GCLM ***,we established a prediction model based on these findings and evaluated its performance using receiver operator characteristic curve analysis,calibration curves,and clinical decision curves.A nomogram was created to visually represent the prediction model,which was then externally validated using the validation *** A total of 372 patients were included in this study,comprising 248 individuals in the development cohort and 124 individuals in the validation *** on Cox analysis results,our final prediction model incorporated five independent risk factors including albumin levels,primary tumor size,presence of extrahepatic metastases,surgical treatment status,and chemotherapy *** 1-,3-,and 5-years Area Under the Curve values in the development cohort are 0.753,0.859,and 0.909,respectively;whereas in the validation cohort,they are observed to be 0.772,0.848,and ***,th

关键词： Gastric cancer Liver metastases Nomogram Prognostic model Survival analysis

Causality Between Gut Microbiota and Inflammatory Bowel Disease:A Bidirectional Mendelian Randomization Study

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Infectious Microbes & Diseases 2024年第2期6卷 93-99页

作者： qi zheng Yuetong Li Jiali Ni Yong Huang Jiajun Wu Xiang Xu Guoping Sheng Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province Shulan(Hangzhou)Hospital Affiliated to Shulan International Medical CollegeZhejiang Shuren UniversityHangzhouChina Zhejiang Chinese Medical University HangzhouChina

The exact relationship between inflammatory bowel disease(IBD)and gut microbiota(GM)is still *** study aimed to explore the cause-and-effect relationship between IBD and GM by Mendelian randomization *** IBD data used in this study were obtained from Genome-Wide Association *** GM data were from the Dutch Microbiome Project and included 207 taxa and 205 microbiota-associated *** Mendelian randomization analysis was performed to investigate the relationship between GM and *** results demonstrated that susceptibility to developing IBD is negatively correlated with class Clostridia(OR=0.80,P=0.003),family Sutterellacea(OR=0.87,P=0.014),genus Coprobacter(OR=0.90,P=0.009),order Clostridiales(OR=0.80,P=0.003),phylum Firmicutes(OR=0.82,P=0.002)and Coprobacter fastidiosus(OR=0.90,P=0.009).Conversely,the risk of developing IBD was positively correlated with the phosphopantothenate biosynthesis I pathway(OR=1.17,P=0.006),Bacteroides caccae(OR=1.14,P=0.021)and Bacteroides uniformis(OR=1.26,P=0.003).Reverse causality was found between the phosphopantothenate biosynthesis I pathway and IBD(OR=1.03,P=0.04),but not for the remaining specific GM *** conclusion,our study demonstrated a causal relationship between specific GM features and IBD.

关键词： gut microbiota inflammatory bowel disease Mendelian randomization

Mineralogical properties and co-sintering characteristics of fluxed iron ore with magnetite concentrates

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Journal of Iron and Steel Research International 2024年第2期31卷 318-328页

作者： Le-le Niu zheng-jian Liu Jian-liang Zhang Yao-zu Wang Zhen-xing Yang Si-da Li chang-dong Shan Ben Feng School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Institute of Artificial Intelligence University of Science and Technology BeijingBeijing100083China Xinxing Casting Pipe Xinjiang Co. Bayingol841300XinjiangChina

To investigate the feasibility of co-sintering of fluxed iron ore with magnetite concentrates, the mineralogical properties of a novel fluxed iron ore were studied using particle size analysis, microscopic morphology characterization, and X-ray diffraction Rietveld analysis. Following that, the experiments for granulation performance and basic sintering characteristics were designed under seven different fluxed iron ore ratios, and the integrated ranking of different fluxed iron ore ratios was determined using gray relation analysis. Finally, the results of the industrial trails were combined with the feasibility analysis. Test and experimental results show that the fraction of the fluxed iron ore particles larger than 0.5 mm can account for more than 48%, and the particles have two morphologies: spherical-rough and flaky-smooth. Ca elements are found in the form of calcite (CaCO3) and dolomite (CaMg(CO3)2). The average particle size of granules and powder removal rate can be improved from 2.50 to 3.16 mm and 39.60% to 24.20%, respectively, with the increase in the fluxed iron ore ratio. Furthermore, the fluxed iron ore can improve assimilability and liquid fluidity of magnetite concentrates. In terms of overall granulation performance and sintering characteristics, the fluxed iron ore ratios are graded from best to worst as follows: 12%, 15%, 9%, 18%, 21%, 6% and 3%. The industrial trails show that when the fluxed iron ore ratio is increased, the beneficial effect of the superior sintering characteristics of the fluxed iron ore itself is ideally balanced with the negative effect of the lower amount of additional CaO at 12% ratio, and thus, it is feasible to bring the fluxed iron ore into production at a level of roughly 12%.

关键词： Fluxed iron ore Magnetite concentrate Granulation performance Sintering characteristics Gray relation analysis

Serum carbohydrate antigen (CA) 19-9 as a prognostic factorin cholangiocarcinoma: A meta-analysis

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Frontiers of Medicine 2010年第4期4卷 457-462页

作者： Shang-Long LIU Zi-Fang SONG qing-Gang HU Duo SHAN Shao-Bo HU Jun LI qi-chang zheng Department of Hepatobiliary Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China

This study was performed to determine the prognostic role of preoperative serum carbohydrate antigen(CA)19-9 levels in the survival of patients with *** published up to June 1st,2010 that evaluated preoperative CA19-9 levels and the prognosis of cholangiocarcinoma were collected for *** required information for calculating indivi-dual relative risk(RR)was extracted from the studies,and a combined overall RR was *** eligible studies were *** study dealt with extra-hepatic cholangiocarcinoma,while the other eight studies analyzed intra-hepatic *** mean methodolo-gical quality score was 74.1%,ranging from 65.5%to 82.5%.The overall RR for the nine studies was 1.28(95%conﬁdence interval=1.10–1.46),and the Z-score for overall effect was 13.83(P<0.001).The association between serum CA19-9 level and lymph node involvement was also *** combined RR was 1.471(95%conﬁdence interval=0.411–5.264)and Z-score for overall effect was 0.59(P=0.553).CA19-9 levels were associated signiﬁcantly with the prognosis of patients with *** meta-analysis shows that elevation of preoperative CA19-9 levels is correlated with a poor prognosis of patients with ***,larger scale and randomized studies are needed to draw a more substantive conclusion.

关键词： cholangiocarcinoma prognostic factors serum carbohydrate antigen 19-9

Recombinant adeno-associated virus 8 vector in gene therapy:Opportunities and challenges

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Genes & Diseases 2024年第1期11卷 283-293页

作者： Liyuan Zhao Zixuan Yang Minhui zheng Lei Shi Mengyun Gu Gang Liu Feng Miao Yan chang Fanghua Huang Naping Tang Anhui University of Traditional Chinese Medicine HefeiAnhui 230000China Yangtze Delta Drug Advanced Research Institute Yangtze Delta Pharmaceutical CollegeNantongJiangsu226133China Shanghai Innostar Bio-Technology Co. LtdChina State Institute of Pharmaceutical IndustryShanghai 201203China Innostar Bio-tech Nantong Co. Ltd.NantongJiangsu 226133China Center for Drug Evaluation National Medical Products AdministrationBeijing 100022China

In recent years,significant breakthroughs have been made in the field of gene ***-associated virus(AAV)is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of *** the AAV vectors,AAV serotype 8(AAv8)has attracted much attention for its efficient and stable gene transfection into specific ***,recombinant AAv8 has been widely used in gene therapy research on a va-riety of diseases,including genetic diseases,cancers,autoimmune diseases,and viral diseases.

关键词： AAV8 Adeno-associated virus Gene therapy Primates

A review of integrated surface-subsurface numerical hydrological models

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Science China Earth Sciences 2024年第5期67卷 1459-1479页

作者： Lele SHU Hao CHEN Xianhong MENG Yan chang Litang HU Wenke WANG Longcang SHU Xuan YU Christopher DUFFY Yingying YAO Donghai zheng Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Water Sciences Beijing Normal UniversityBeijing 100038China School of Water and Environment Chang’an UniversityXi’an 710064China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Department of Civil and Environmental Engineering Pennsylvania State UniversityState CollegePA 16801USA Department of Earth and Environmental Science School of Human Settlements and Civil EngineeringXi’an Jiaotong UniversityXi’an 710049China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China

Hydrological modeling,leveraging mathematical formulations to represent the hydrological cycle,is a pivotal tool in representing the spatiotemporal dynamics and distribution patterns inherent in *** models serve a dual purpose:they validate theoretical robustness and applicability via observational data and project future trends,thereby bridging the understanding and prediction of natural *** rapid advancements in computational methodologies and the continuous evolution of observational and experimental techniques,the development of numerical hydrological models based on physicallybased surface-subsurface process coupling have *** in micro-scale conservation principles and physical equations,these models employ numerical techniques to integrate surface and subsurface hydrodynamics,thus replicating the macro-scale hydrological responses of *** hydrological models have emerged as a leading and predominant trend in hydrological modeling due to their explicit representation of physical processes,heightened by their spatiotemporal resolution and reliance on interdisciplinary *** article focuses on the theoretical foundation of surface-subsurface numerical hydrological *** includes a comparative and analytical discussion of leading numerical hydrological models,encompassing model architecture,numerical solution strategies,spatial representation,and coupling ***,this paper contrasts these models with traditional hydrological models,thereby delineating the relative merits,drawbacks,and future directions of numerical hydrological modeling.

关键词： Numerical Hydrological Models Surface-Subsurface Process Coupling Numerical Methods Hydrological Modeling

Tough Semi-interpenetrating Polyvinylpyrrolidone/Polyacrylamide Hydrogels Enabled by Bioinspired Hydrogen-bonding Induced Phase Separation

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Chinese Journal of Polymer Science 2024年第5期42卷 591-603,I0006页

作者： qiong-Jun Xu Zhao-Yang Yuan chang-Cheng Wang Hao Liang Yu Shi Hai-Tao Wu Hu Xu Jing zheng Jin-Rong Wu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China

Semi-interpenetrating(semi-IPN)hydrogels formed by the continuous interpenetration of cross-linked polymer network and linear non-crosslinked polymer with multifunctionality are widely used in biomedical and other ***,the negative impact of linear polymer on the homogeneity of the cross-linked network often leads to a decrease in the mechanical properties of semi-IPN hydrogels and severely limits their ***,a bioinspired hydrogen-bonding induced phase separation strategy is presented to construct the tough semi-IPN polyvinylpyrrolidone/polyacrylamide hydrogels(named PVP/PAM hydrogels),including the linear polymer polyvinylpyrrolidone(PVP)and cross-linked polyacrylamide(PAM)*** resultant PVPx/PAM hydrogels exhibit unique phase separation induced by the hydrogen bonding between PVP and PAM and affected by the amount of substance of ***,the phase separation of PVPx/PAM hydrogels results in excellent mechanical properties with a strain of 2590%,tensile strength of 0.28 MPa and toughness of 2.17 MJ/m^(3).More importantly,the hydrogen bonding between PVP and PAM firstly disrupts to dissipate energy under external forces,so the PVPx/PAM hydrogels exhibit good self-recovery properties and outperform chemically cross-linked PAM hydrogels in impact resistance and damping *** is believed that the PVPx/PAM hydrogels with hydrogen-bonding induced phase separation possess more potential application prospects.

关键词： Tough Semi-interpenetrating networks Polyvinylpyrrolidone/polyacrylamide Hydrogels Phase separation

Discovery of the Significant Impacts of Swell Propagation on Global Wave Climate change

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Journal of Ocean University of China 2024年第3期23卷 594-604页

作者： zheng Chongwei Dalian Naval Academy Dalian 116018China Marine Resources and Environment Research Group on the Maritime Silk Road Dalian 116018China

This study compared the differences in the wave climate in the South China Sea and North Indian Ocean under these two datasets:ERA-40 wave reanalysis and Mei’s hindcast wave *** the numerical calculation of regional ocean waves,the wave climate characteristics exhibited significant bias if the influence of external swells(swells from afar)was not fully considered,which may provide an incorrect basis for global climate change analysis.1)The trends of the significant wave height(SWH)obtained from the two datasets showed significant differences,such as those of the Bay of Bengal and the Java Sea in *** the past 45 years,SWH from ERA-40(SWH-ERA)exhibited a significant annual increase in low-latitude waters of the North Indian Ocean(0.2-0.6 cm yr^(-1))and South China Sea(0.2-0.8 cm yr^(-1)).2)In the Bay of Bengal,the SWH-ERA in each month was generally 0.5 m higher than the SWH from Mei’s hindcast wave data(SWH-Mei)and can reach 1.0 m higher in some months.3)In the Bay of Bengal,SWH-ERA and SWH-Mei increased significantly at annual rates of 0.13 and 0.27 cm yr^(-1),*** increasing trend was mainly reflected after ***-ERA showed a trough in 1975(1.33 m)and a crest in 1992(1.83 m),which were not reflected in SWH-Mei.

关键词： wave climate climatic trend monthly variation annual variation external swell