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Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 198-210页

作者： Long Wang qi Wu Zong-Wen zhang Hui zhang Hui Jin Xin-Liang Zhou Jia-Yin Liu Dan Li yan Liu Zhi-Song Fan Department of Oncology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Colony-stimulating factor 3(CSF3)and its receptor(CSF3R)are known to promote gastric cancer(GC)growth and ***,their effects on the immune microenvironment remain *** analysis indicated a potential link between CSF3R expression and the immunosuppressive receptor leukocyte immunoglobulin-like receptor B2(LILRB2)in *** hypothesized that CSF3/CSF3R may regulate LILRB2 and its ligands,angiopoietin-like protein 2(ANGPTL2)and human leukocyte antigen-G(HLA-G),contributing to *** To investigate the relationship between CSF3/CSF3R and LILRB2,as well as its ligands ANGPTL2 and HLA-G,in *** Transcriptome sequencing data from The Cancer Genome Atlas were analyzed,stratifying patients by CSF3R *** expressed genes and immune checkpoints were ***(IHC)was performed on GC *** analyses of CSF3R,LILRB2,ANGPTL2,and HLA-G were conducted using The Cancer Genome Atlas data and IHC *** cells were treated with CSF3,and expression levels of LILRB2,ANGPTL2,and HLA-G were measured by quantitative reverse transcriptase-polymerase chain reaction and western *** Among 122 upregulated genes in high CSF3R expression groups,LILRB2 showed the most significant *** results indicated high expression of LILRB2(63.0%),ANGPTL2(56.5%),and HLA-G(73.9%)in GC *** positive correlations existed between CSF3R and LILRB2,ANGPTL2,and HLA-G mRNA levels(P0.05).CSF3 increased LILRB2,ANGPTL2,and HLA-G expression in GC *** nuclear ribonucleoprotein H1 modulation significantly altered their expression,impacting CSF3’s regulatory *** The CSF3/CSF3R pathway may contribute to immunosuppression in GC by upregulating LILRB2 and its ligands,with heterogeneous nuclear ribonucleoprotein H1 playing a regulatory role.

关键词： Gastric cancer Immunosuppressive receptor Colony-stimulating factor 3 Colony-stimulating factor 3 receptor Leukocyte immunoglobulin-like receptor B2 Angiopoietin-like protein 2 Human leukocyte antigen-G Heterogeneous nuclear ribonucleoprotein H1

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The GECAM ground search system for gamma-ray transients

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Science China(Physics,Mechanics & Astronomy) 2025年第3期68卷 161-174页

作者： Ce Cai yan-qiu zhang Shao-Lin Xiong Ping Wang Jian-Hui Li Xiao-Bo Li Cheng-Kui Li Yue Huang Shi-Jie Zheng Li-Ming Song Shuo Xiao qi-Bin Yi Yi Zhao Sheng-Lun Xie Rui qiao yan-qi Du Zhi-Wei Guo Wang-Chen Xue Chao Zheng Jia-Cong Liu Chen-Wei Wang Wen-Jun Tan Yue Wang Jin-Peng zhang Chao-yang Li Guo-Ying Zhao Xiao-Yun Zhao Xiao-Lu zhang Zhen zhang Wen-Xi Peng Xiang Ma Jing-yan Shi Dong-Ya Guo Jin Wang Xin-qiao Li Xiang-yang Wen Zheng-Hua An Fan zhang College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang050024China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China University of Chinese Academy of Sciences Beijing100049China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang550001China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang550001China School of Physics and Optoelectronics Xiangtan UniversityXiangtan411105China School of Computer and Information Dezhou UniversityDezhou253023China Institute of Astrophysics Central China Normal UniversityWuhan430079China

In the era of time-domain,multi-messenger astronomy,the detection of transient events on the high-energy electromagnetic sky has become more important than *** gravitational wave high-energy electromagnetic counterpart all-sky monitor(GECAM)is a dedicated mission to monitor gamma-ray transients,launched in December,2020.A real-time on-board trigger and location software,using the traditional signal-to-noise ratio(SNR)method for blind search,is constrained to relatively bright signals due to the limitations in on-board computing resources and the need for real-time *** this work,we developed a ground-based pipeline for GECAM to search for various transients,especially for weak bursts missed by on-board *** pipeline includes both automatic and manual mode,offering options for blind search and targeted *** targeted search is specifically designed to search for interesting weak bursts,such as gravitational wave-associated gamma-ray bursts(GRBs).From the ground search of the data in the first year,GECAM has been triggered by 54 GRBs and other transients,including soft gamma-ray repeaters,X-ray binaries,solar flares,terrestrial gamma-ray *** report the properties of each type of triggers,such as trigger time and light *** this search pipeline and assuming a soft Band spectrum,the GRB detection sensitivity of GECAM is increased to about 1.1×10^(-8)erg cm^(-2)s^(-1)(10-1000 ke V,burst duration of 20 s).These results demonstrate that the GECAM ground search system(both blind search and targeted search)is a versatile pipeline to recover true astrophysical signals which were too weak to be found in the on-board search.

关键词： gamma-ray sources gravitational waves data analysis gamma-ray telescopes

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Hydraulic conductivity over a wide suction range of loess with different dry densities

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 481-492页

作者： Xiaokun Hou Shengwen qi yan Li Fangcui Liu Tonglu Li Hua Li State Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China University of Chinese Academy of Sciences Beijing100049China Innovation Academy for Earth Science Beijing100029China School of Civil Engineering University of A CoruñaA Coruña15071Spain Department of Geological Engineering Chang’an UniversityXi’an710054China School of Civil Engineering and Architecture Xi’an Jiaotong University of City CollegeXi’an710018China

Experimental research into the hydraulic conductivity curve (HCC) of unsaturated soil is limited due to the inherent challenge associated with labor, cost, and time. Typically, the HCC is estimated using the soil water characteristic curve (SWCC) based models and saturated hydraulic conductivity (SHC). However, the efficiency of the SWCC-based model is rarely assessed, and the influence of soil density and pore structure on HCC remains incomplete due to limited experimental data. To address this gap, this study employs an innovative filter-paper-based column method, which can measure the HCC over a wide suction range (e.g. 0−105 kPa), to capture the HCCs of both intact and compacted specimens with varying dry densities. The efficiency of two typical SWCC-based models is assessed using the measured data. Meanwhile, the mercury intrusion porosity (MIP) technique is employed to obtain the pore characteristic (i.e. pore size distribution (PSD)) and a method of predicting the HCC using the PSD data is proposed, emphasizing the dominant role of the pore structure in shaping the HCC. The results reveal that the dry density's influence on the HCC is primarily observed within the low suction range, corresponding to variations in the dominant and large pores. In the high suction range, the HCCs align along a linear trajectory when plotted in a log-log format. A notable finding is the overestimation of the HCC obtained from the SWCC-based models using the measured SHC. When the SHC is regarded as a fitting parameter, good agreement is achieved. The adjusted SHC value is typically 0-1 order of magnitude lower than the measured value, and this discrepancy diminishes as dry density increases. On the other hand, the proposed PSD-based model performs well with the measured SHC data. Caution is exercised when using the SHC to estimate the HCC for modeling water movement in partially saturated soil.

关键词： Hydraulic conductivity curve Wide suction range Dry density Pore size distribution Saturated hydraulic conductivity

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sRNA113 regulates Pseudomonas plecoglossicida motility to affect immune response against infection in pearl gentian grouper

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Zoological Research 2025年第01期 152-164页

作者： Li He Mei-qin Mao Ling-Min Zhao qi Li Hui Ge Jiao-Nan zhang Jiao-Lin zhang qing-Pi yan Fisheries College Jimei University Fisheries Research Institute of Fujian Key Laboratory of Special Aquatic Feed for Fujian Fujian Tianma Technology Company Limited

Small RNAs(sRNAs) are a class of molecules capable of perceiving environmental changes and exerting posttranscriptional regulation over target gene expression,thereby influencing bacterial virulence and host immune responses. Pseudomonas plecoglossicida is a pathogenic bacterium that poses a significant threat to aquatic animal health. However, the regulatory mechanisms of sRNAs in P. plecoglossicida remain unclear. This study focused on sRNA113, previously identified as a potential regulator of the fliP gene, a key component of the lateral flagellar type III secretion system. To investigate the effects of sRNA113on P. plecoglossicida virulence, as well as its role in regulating pathogenic processes and host immune responses, mutant strains lacking this sRNA were generated and analyzed. Deletion of sRNA113 resulted in the up-regulation of lateral flagellar type III secretion system-related genes in P. plecoglossicida, which enhanced bacterial swarming motility, biofilm formation,and chemotaxis ability in vitro. In vivo infection experiments with pearl gentian grouper revealed that sRNA113 deletion enhanced the pathogenicity of ***. This heightened virulence was attributed to the up-regulation of genes associated with the lateral flagellar type III secretion system, resulting in higher bacterial loads within host tissues. This amplification of pathogenic activity intensified tissue damage, disrupted immune responses, and impaired the ability of the host to clear infection, ultimately leading to mortality. These findings underscore the critical role of sRNA113 in regulating the virulence of P. plecoglossicida and its interaction with host immune defenses. This study provides a foundation for further exploration of sRNAmediated mechanisms in bacterial pathogenesis and hostpathogen interactions, contributing to a deeper understanding of virulence regulation and immune evasion in aquatic pathogens.

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Electrospun nanofibers for electrochemical reduction of CO_(2): From spinning fabrication techniques to electrocatalyst design

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Nano Research 2025年第2期18卷 80-100页

作者： yanbiao Liu Ping Feng Zhenzhen Wang yan yan Yong Zheng Yu zhang Mingkai Liu Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110004China Institute for Technical Chemistry and Environmental Chemistry Friedrich-Schiller-Universitat JenaJena 07743Germany School of Chemistry&Chemical Engineering Anhui University of TechnologyMa’anshan 243002China College of Materials and Chemical Engineering Key Laboratory of inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China

Electrochemical reduction of CO_(2)(ECO_(2)RR)into value-added fuels and chemicals presents a promising avenue for mitigating CO_(2) emissions while simultaneously contributing to economic growth,thereby addressing critical environmental and energy ***,the large-scale implementation of ECO_(2)RR is significantly impeded by the necessity to design efficient catalysts that exhibit both high activity and *** catalysts must overcome the sluggish kinetics associated with ECO_(2)RR as well as the competing hydrogen evolution *** recent decades,electrospun nanofibers have garnered considerable attention as potential catalysts for ECO_(2)RR,attributable to their high surface area with abundant active sites,tunable functionalities,and enhanced *** review comprehensively examines the rational design of ECO_(2)RR catalysts utilizing electrospinning *** commence with an in-depth exploration of the principles underlying the electrospinning process and subsequently summarize key factors influencing this process,including solution parameters,environmental conditions,and electrospinning operational ***,we discuss recent advancements in ECO_(2)RR catalysts synthesized through electrospinning,encompassing carbon nanofibers,composite nanofibers,and metal ***,we delineate future perspectives and the challenges that electrospun materials face in the context of ECO_(2)RR *** review aims to inspire high-quality research directed toward the advancement of electrospun materials for improved performance in ECO_(2)RR.

关键词： CO_(2)reduction reaction catalyst design electrospinning single-atom catalysts

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Stress anisotropy regulated wrinkling pattern evolution on a core-shell soft cylinder

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 132-144页

作者： yan Zhao Zhipan Jie Yilong zhang Guo-yang Li yanping Cao Chao Jiang State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing 100871China Institute of Biomechanics and Medical Engineering AMLDepartment of Engineering MechanicsTsinghua UniversityBeijing100084China

Diverse wrinkling patterns can occur on curved bilayer systems under differential growth or *** such systems,stress anisotropy is frequently encountered,and the coupling effect of curvature and stress anisotropy on the pattern evolution remains largely *** this study,we investigate the evolution of wrinkling patterns on a cylinder core-shell system with stress anisotropy leveraging both theoretical analysis and finite element *** buckling analysis has identified three distinct critical buckling modes regulated by the stress anisotropy,i.e.,axial sinusoidal mode,checkerboard mode,and circumferential sinusoidal *** finite element simulations,along with post-buckling analysis,reveal seven distinct evolutionary paths stemming from the three critical buckling *** present phase diagrams for both the critical buckling modes and their evolutionary paths,which are determined by dimensionless curvature and stress *** results not only expand the theoretical research on surface wrinkling of a core-shell soft cylinder but also introduce stress anisotropy as a significant parameter for regulating the wrinkling patterns and their evolutionary paths in curved bilayer *** revelation of a multitude of wrinkling patterns and their evolutionary pathways holds great potential for advancing applications that leverage tunable wrinkle surfaces.

关键词： wrinkling pattern evolutionary path stress anisotropy dimensionless curvature core-shell soft cylinder

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu yan Xie Jian Yu Kun-Ning zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-qi zhang Yu-Ying Tan Li zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Spherical Magnetic Fe-Alginate Microgels Fabricated by Droplet-Microfluidics Combining with an External Crosslinking Approach and the Study of Their pH Dependent Fe^(3+) Release Behaviors

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Chinese Journal of Polymer Science 2025年第2期43卷 289-302页

作者： Jie Chen Run-Yu Yu ai-qi Wang Zhe-Yu zhang Arezoo Ardekani Yuan-Du Hu Department of Materials Science and Engineering School of Physics Science and EngineeringBeijing Jiaotong UniversityBeijing100044China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing South China University of TechnologyGuangzhou510641China State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai200438China Department of Mathematics School of Mechanical EngineeringPurdue University585 Purdue MallWest LafayetteIN47907-2088USA

Due to the rapid development and potential applications of iron(Ⅲ)-alginate(Fe-Alg)microgels in biomedical as well as environmental engineering,this study explores the preparation and characterization of spherical Fe-Alg microgels using droplet microfluidics combined with an external ionic crosslinking *** study focused on the role of Fe^(3+)and examined its effects on the physical/chemical properties of microgels under different ionic conditions and reduced or oxidized *** pH-dependent release behavior of Fe^(3+)from these microgels demonstrates their potential biomedical and environmental ***,the microgels can exhibit magnetism simply by utilizing in situ oxidation,which can be further used for targeted drug delivery and magnetic separation technologies.

关键词： Fe-alginate microgels Droplet microfluidics In situ oxidation Magnetism

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Support effect and confinement effect of porous carbon loaded tin dioxide nanoparticles in high-performance CO_(2) electroreduction towards formate

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Chinese Chemical Letters 2025年第1期36卷 597-602页

作者： Xingxing Jiang Yuxin Zhao yan Kong Jianju Sun Shangzhao Feng Xin Lu qi Hu Hengpan yang Chuanxin He College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

Leveraging the interplay between the metal component and the supporting material represents a cornerstone strategy for augmenting electrocatalytic efficiency,e.g.,electrocatalytic CO_(2)reduction reaction(CO_(2)RR).Herein,we employ freestanding porous carbon fibers(PCNF)as an efficacious and stable support for the uniformly distributed SnO_(2)nanoparticles(SnO_(2)PCNF),thereby capitalizing on the synergistic support effect that arises from their strong *** one hand,the interaction between the SnO_(2)nanoparticles and the carbon support optimizes the electronic configuration of the active *** interaction leads to a noteworthy shift of the d-band center toward stronger intermediate adsorption energy,consequently lowering the energy barrier associated with CO_(2)*** a result,the Sn O_(2)PCNF realizes a remarkable CO_(2)RR performance with excellent selectivity towards formate(98.1%).On the other hand,the porous carbon fibers enable the uniform and stable dispersion of SnO_(2)nanoparticles,and this superior porous structure of carbon supports can also facilitate the exposure of the SnO_(2)nanoparticles on the reaction interface to a great ***,adequate contact between active sites,reactants,and electrolytes can significantly increase the metal utilization,eventually bringing forth a remarkable7.09 A/mg mass *** work might provide a useful idea for improving the utilization rate of metals in numerous electrocatalytic reactions.

关键词： CO_(2)electroreduction Support effect Porous carbon fiber Formate Mass activity

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Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang Yali Liu Shanshan qi Biao Shi Ying Zhao Xiaodan zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage CenterState Key Laboratory of Photovoltaic Materials and CellsNankai UniversityTianjin 300350China Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Tianjin 300350China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Tianjin 300350China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells(IPSCs),which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid(5-MVA)was introduced as a strain buffer to release the residual strain of CsPbI_(2.85)Br_(0.15)*** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb^(2+)through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI_(2.85)Br_(0.15)perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI_(2.85)Br_(0.15),resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency(PCE)of NiOxbased inverted IPSCs increased from 19.25%to 20.82%with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI_(2.85)Br_(0.15)perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

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