检索结果-南通市图书馆

MicroRNAs:A novel signature in the metastasis of esophageal squamous cell carcinoma

World Journal of Gastroenterology 2024年第11期30卷 1497-1523页

作者： qi-Ying Wei Feng Jin zhong-Yu Wang Bing-Jie Li wen-Bo Cao Zhi-Yan Sun Sai-Jun Mo Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Perioperative Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Division of Special Service Department of Basic OncologySchool of Basic MedicineZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Esophageal squamous cell carcinoma(ESCC)is a malignant epithelial tumor,characterized by squamous cell differentiation,it is the sixth leading cause of cancer-related deaths *** increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered,coupled with higher risk of metastasis,which is an exceedingly malignant charac-teristic of cancer,frequently leading to a high mortality ***,there is currently no specific and effective marker to predict and treat metastasis in ***(miRNAs)are a class of small non-coding RNA molecules,approximately 22 nucleotides in *** are vital in modulating gene expression and serve pivotal regulatory roles in the occurrence,progression,and prognosis of ***,we have examined the literature to highlight the intimate correlations between miRNAs and ESCC metastasis,and show that ESCC metastasis is predominantly regulated or regulated by genetic and epigenetic *** review proposes a potential role for miRNAs as diagnostic and therapeutic biomarkers for metastasis in ESCC metastasis,with the ultimate aim of reducing the mortality rate among patients with ESCC.

关键词： MicroRNAs Esophageal squamous cell carcinoma Metastasis Signaling pathway Epigenetics mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Topology optimization of chiral metamaterials with application to underwater sound insulation

引用

Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1119-1138页

作者： Chao WANG Honggang ZHAO Yang WANG Jie zhong Dianlong YU Jihong wen Laboratory of Science and Technology on Integrated Logistics Support National University of Defense TechnologyChangsha410073China

Chiral metamaterials have been proven to possess many appealing mechanical phenomena,such as negative Poisson's ratio,high-impact resistance,and energy *** work extends the applications of chiral metamaterials to underwater sound *** chiral metamaterials with low acoustic impedance and proper stiffness are inversely designed using the topology optimization *** acoustic impedance enables the metamaterials to have a high and broadband sound transmission loss(STL),while proper stiffness guarantees its robust acoustic performance under a hydrostatic *** proof-of-concept demonstrations,two specimens are fabricated and tested in a water-filled impedance *** results show that,on average,over 95%incident sound energy can be isolated by the specimens in a broad frequency range from 1 k Hz to 5 k Hz,while the sound insulation performance keeps stable under a certain hydrostatic *** work may provide new insights for chiral metamaterials into the underwater applications with sound insulation.

关键词： chiral metamaterial topology optimization underwater sound insulation low acoustic impedance sound transmission loss(STL)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Roles of combined femoral and acetabular anteversion in pathological changes of hip dysplasia and hip reconstructive surgery

引用

World Journal of Orthopedics 2024年第5期15卷 390-399页

作者： Can Liu Zheng Xu Jian-Fa Zeng Zhen-qi Song Yu-Yin Xie zhong-wen Tang Jie wen Sheng Xiao Department of Anatomy Hunan Normal University School of MedicineChangsha 410003Hunan ProvinceChina Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina

Combined femoral and acetabular anteversion is the sum of femoral and acetabular anteversion,representing their morphological relationship in the axial *** with the increasing understanding of hip dysplasia in recent years,numerous scholars have confirmed the role of combined femoral and acetabular anteversion in the pathological changes of hip *** present,the reconstructive surgery for hip dysplasia includes total hip replacement and redirectional hip preservation *** an important surgery index,combined femoral and acetabular anteversion have a crucial role in these ***,we discuss the role of combined femoral and acetabular anteversion in pathological changes of hip dysplasia,total hip replacement,and redirectional hip preservation surgery.

关键词： Combined anteversion Femoral anteversion Acetabular anteversion Hip dysplasia Hip preservation surgery Total hip replacement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effective time, correction speed and termination time of hemiepiphysiodesis in children

引用

World Journal of Orthopedics 2024年第1期15卷 1-10页

作者： Jian-Fa Zeng Yu-Yin Xie Can Liu Zhen-qi Song Zheng Xu zhong-wen Tang Jie wen Sheng Xiao Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina Department of Anatomy Hunan Normal University school of MedicineChangsha 410003Hunan ProvinceChina

In children with asymmetric growth on the medial and lateral side of limbs,if there still remains growth potential,the guided growth technique of hemiepiphysiodesis on one side of the epiphysis is recognized as a safe and effective ***,when the hemi-epiphysiodesis start to correct the deformities,how many degrees could hemi-epiphysiodesis bring every month and when to remove the hemi-epiphysiodesis implant without rebound phenomenon are still on *** article reviews the current studies focus on the effective time,correction speed and termination time of hemi-epiphysiodesis.

关键词： Hemi-epiphysiodesis Percutaneous epiphysiodesis Transphyseal screws Eight plate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pig H3K4me3,H3K27ac,and gene expression profiles reveal reproductive tissue-specific activity of transposable elements

引用

Zoological Research 2024年第1期45卷 138-151页

作者： Tao Jiang Zhi-Min Zhou Zi-qi Ling qing Zhang zhong-Zi Wu Jia-wen Yang Si-Yu Yang Bin Yang Lu-Sheng Huang National Key Laboratory of Pig Genetic Improvement and Germplasm Innovation Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Regulatory sequences and transposable elements(TEs)account for a large proportion of the genomic sequences of species;however,their roles in gene transcription,especially tissue-specific expression,remain largely *** serve as an excellent animal model for studying genomic sequence biology due to the extensive diversity among their wild and domesticated ***,we conducted an integrated analysis using H3K27ac ChIP-seq,H3K4me3 ChIP-seq,and RNA-seq data from 10 different tissues of seven fetuses and eight closely related adult *** aimed to annotate the regulatory elements and TEs to elucidate their associations with histone modifications and mRNA expression across different tissues and developmental *** on correlation analysis between mRNA expression and H3K27ac and H3K4me3 peak activity,results indicated that H3K27ac exhibited stronger associations with gene expression than ***,1.45%of TEs overlapped with either the H3K27ac or H3K4me3 peaks,with the majority displaying tissue-specific ***,a TE subfamily(LTR4C_SS),containing binding motifs for SIX1 and SIX4,showed specific enrichment in the H3K27ac peaks of the adult and fetal ***-seq analysis also revealed widespread expression of TEs in the exons or promoters of genes,including 4688 TE-containing transcripts with distinct development stage-specific and tissue-specific *** note,1967 TE-containing transcripts were enriched in the *** identified a long terminal repeat(LTR),MLT1F1,acting as a testis-specific alternative promoter in SRPK2(a cell cycle-related protein kinase)in our pig *** element was also conserved in humans and mice,suggesting either an ancient integration of TEs in genes specifically expressed in the testes or parallel evolutionary ***,our findings demonstrate that TEs are deeply embedded in the genome and exhibit important tissue-specific biological functions,particularly in the reproductive

关键词： Transposable elements Porcine Histone modification Alternative promoter TE-containing transcript

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MPI/OpenMP-Based Parallel Solver for Imprint Forming Simulation

引用

Computer Modeling in Engineering & Sciences 2024年第7期140卷 461-483页

作者： Yang Li Jiangping Xu Yun Liu wen zhong Fei Wang School of Mechanical Engineering Jiangsu UniversityZhenjiang212016China School of Mechanical Engineering Wuhan Polytechnic UniversityWuhan430023China Shenyang Mint Company Limited Shenyang110092China

In this research,we present the pure open multi-processing(OpenMP),pure message passing interface(MPI),and hybrid MPI/OpenMP parallel solvers within the dynamic explicit central difference algorithm for the coining process to address the challenge of capturing fine relief features of approximately 50 *** such precision demands the utilization of at least 7 million tetrahedron elements,surpassing the capabilities of traditional serial programs previously *** mitigate data races when calculating internal forces,intermediate arrays are introduced within the OpenMP *** helps ensure proper synchronization and avoid conflicts during parallel ***,in the MPI implementation,the coins are partitioned into the desired number of *** division allows for efficient distribution of computational tasks across multiple *** simulation examples are conducted to compare the three solvers with serial programs,evaluating correctness,acceleration ratio,and parallel *** results reveal a relative error of approximately 0.3%in forming force among the parallel and serial solvers,while the predicted insufficient material zones align with experimental ***,speedup ratio and parallel efficiency are assessed for the coining process *** pureMPI parallel solver achieves a maximum acceleration of 9.5 on a single computer(utilizing 12 cores)and the hybrid solver exhibits a speedup ratio of 136 in a cluster(using 6 compute nodes and 12 cores per compute node),showing the strong scalability of the hybrid MPI/OpenMP programming *** approach effectively meets the simulation requirements for commemorative coins with intricate relief patterns.

关键词： Hybrid MPI/OpenMP parallel computing MPI OpenMP imprint forming

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improved forecasting via physics-guided machine learning as exemplified using“21·7”extreme rainfall event in Henan

引用

Science China Earth Sciences 2024年第5期67卷 1652-1674页

作者： qi zhong Zhicha ZHANG Xiuping YAO Shaoyu HOU Shenming FU Yong CAO Linguo JING China Meteorological Administration Training Center Beijing 100081China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Zhejiang Meteorological Observatory Hangzhou 310017China Hebei Provincial Weather Modification Center Shijiazhuang 050020China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China National Meteorological Center Beijing 100081China School of Computer Science Chengdu University of Information TechnologyChengdu 610225China

As a natural disaster,extreme precipitation is among the most destructive and influential,but predicting its occurrence and evolution accurately is very challenging because of its rarity and *** the example of the“21·7”extreme precipitation event(17–21 July 2021)in Henan Province,this study explores the potential of using physics-guided machine learning to improve the accuracy of forecasting the intensity and location of extreme *** physics-guided ways of embedding physical features,fusing physical model forecasts and revised loss function are used,i.e.,(1)analyzing the anomalous circulation and thermodynamical factors,(2)analyzing the multi-model forecast bias and the associated underlying reasons for it,and(3)using professional forecasting knowledge to design the loss function,and the corresponding results are used as input for machine learning to improve the forecasting *** results indicate that by learning the relationship between anomalous physical features and heavy precipitation,the forecasting of precipitation intensity is improved significantly,but the location is rarely adjusted and more false alarms *** reasons for this are as *** anomalous features used here mainly contain information about large-scale systems and factors which are consistent with the model precipitation deviation;moreover,the samples of extreme precipitation are sparse and so the algorithm used here is ***,by combining“good and different”multi models with machine learning,the advantages of each model are extracted and then the location of the precipitation center in the forecast is improved ***,by combining the appropriate anomalous features with multi-model fusion,an integrated improvement of the forecast of the rainfall intensity and location is ***,this study is a novel exploration to improve the refined forecasting of heavy precipitation with extreme intensity and high variability,

关键词： Extreme precipitation event Refined assessment Anomalous physical features Multi-model fusion Machine learning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research on the navigation method of large-scale differential tail-control improvised guided munitions based on rotational speed constraints

引用

Defence Technology（防务技术） 2024年第8期38卷 155-170页

作者： Ning Liu wenjiang Zhao Yao Wang Kai Shen zhong Su wenhao qi Yuedong Xie Beijing Key Laboratory of High Dynamic Navigation Technology Beijing Information Science and Technology UniversityBeijing100192China Hua an Industry Group Co. Ltd.Qiqihar161006China Integrated Navigation and Intelligent Navigation Laboratory Beijing Institute of TechnologyBeijing100081China Beijing Institute of Technology Beijing100081China

In the process of launching guided projectile under the conventional system, it is difficult to effectively obtain the precise navigation parameters of the projectile in the high dynamic environment. Aiming at this problem, this paper describes a new system of guided ammunition based on tail spin reduction. After analyzing the mechanism of the ammunition's tail spin reduction, a navigation method of large scale difference tail control simple guided ammunition based on speed constraint is proposed. In this method,the corresponding navigation constraints can be carried out by combining the rotation speed state of the ammunition itself, and the optimal solution of navigation parameters during the flight of the missile can be obtained by Extended Kalman Filter(EKF). Finally, the performance of the proposed method was verified by the simulation environment, and the hardware-in-the-loop simulation test and flight test were carried out to verify the performance of the method in the real environment. The experimental results show that the proposed method can achieve the optimal estimation of navigation parameters for simple guided ammunition with large-scale difference tail control. Under the conditions of simulation test and hardware-in-loop simulation test, the position and velocity errors calculated by the method in this paper converged. Under the condition of flight test, the spatial average error calculated by the method described in this paper is 6.17 m, and the spatial error of the final landing point is 3.50 *** this method, the accurate acquisition of navigation parameters in the process of projectile launching is effectively realized.

关键词： Guided projectiles Tail spin reduction RPM constraints Combined navigation Extended Kalman filter(EKF)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CrossLinkNet: An Explainable and Trustworthy AI Framework for Whole-Slide Images Segmentation

引用

Computers, Materials & Continua 2024年第6期79卷 4703-4724页

作者： Peng Xiao qi zhong Jingxue Chen Dongyuan Wu Zhen qin Erqiang Zhou Network and Data Security Key Laboratory of Sichuan Province University of Electronic Science and Technology of ChinaChengdu610054China Faculty of Data Science City University of MacaoMacao999078China

In the intelligent medical diagnosis area,Artificial Intelligence(AI)’s trustworthiness,reliability,and interpretability are critical,especially in cancer *** neural networks,while excellent at processing natural images,often lack interpretability and adaptability when processing high-resolution digital pathological *** limitation is particularly evident in pathological diagnosis,which is the gold standard of cancer diagnosis and relies on a pathologist’s careful examination and analysis of digital pathological slides to identify the features and progression of the ***,the integration of interpretable AI into smart medical diagnosis is not only an inevitable technological trend but also a key to improving diagnostic accuracy and *** this paper,we introduce an innovative Multi-Scale Multi-Branch Feature Encoder(MSBE)and present the design of the CrossLinkNet *** MSBE enhances the network’s capability for feature extraction by allowing the adjustment of hyperparameters to configure the number of branches and *** CrossLinkNet Framework,serving as a versatile image segmentation network architecture,employs cross-layer encoder-decoder connections for multi-level feature fusion,thereby enhancing feature integration and segmentation *** quantitative and qualitative experiments on two datasets demonstrate that CrossLinkNet,equipped with the MSBE encoder,not only achieves accurate segmentation results but is also adaptable to various tumor segmentation tasks and scenarios by replacing different feature ***,CrossLinkNet emphasizes the interpretability of the AI model,a crucial aspect for medical professionals,providing an in-depth understanding of the model’s decisions and thereby enhancing trust and reliability in AI-assisted diagnostics.

关键词： Explainable AI security trustworthy CrossLinkNet whole slide images

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

渭南黄土剖面中的稀土元素

引用

海洋地质与第四纪地质 2000年第4期20卷 57-61页

作者：刁桂仪文启忠中国科学院广州地球化学研究所广州510640

对渭南黄土 -古土壤序列中稀土元素含量和分布特征的研究结果表明 :古土壤比黄土层的 ΣREE表观丰度高 ,这主要是古土壤中碳酸盐遭到强烈淋滤造成的相对富集。实际上 ,在成土过程中稀土元素本身有淋失。黄土层和古土壤层的稀土元素组合... 详细信息

对渭南黄土 -古土壤序列中稀土元素含量和分布特征的研究结果表明 :古土壤比黄土层的 ΣREE表观丰度高 ,这主要是古土壤中碳酸盐遭到强烈淋滤造成的相对富集。实际上 ,在成土过程中稀土元素本身有淋失。黄土层和古土壤层的稀土元素组合模式彼此相似 ,并且与黄河中游黄土也极相似 ,这反映了中国黄土的物质来自于相似的源区。黄土中稀土元素对古气候变化的响应主要表现在 Ce的异常程度、各种稀土的组成和稀土总量的表观丰度上。因而 ,δCe、Σ Ce/ Σ Y和 ΣREE也能从一个方面反映古气候环境的变化。

关键词：稀土元素古气候黄土剖面土壤序列

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：