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Effect of SARS-CoV-2 infection on semenparameters in sperm bank volunteers with normalsperm concentration

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Asian Journal of Andrology 2024年第3期26卷 328-332页

作者： Li Wang wen-Kai Han Xiao-Hui Song qi-Lin Zhang An-Quan guan Yuan Gao Jin-Long Ma Center for Reproductive Medicine Shandong UniversityJinan 250001China State Key Laboratory of Reproductive Medicine and Offspring Health ShandongUniversityJinan 250001China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinan 250001China Shandong KeyLaboratory of Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250001China Shandong Provincial ClinicalResearch Center for Reproductive Health Jinan 250001China Shandong Technology Innovation Center for Reproductive Health Jinan 250001China NationalResearch Center for Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinan 250001China Research Unit of Gametogenesis andHealth of ART-Offspring Chinese Academy of Medical Sciences(No.2021RU001)Jinan 250001China.

In this study,we aimed to assess the effect of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection on semenparameters.The study comprised 110 sperm volunteers who self-reported SARS-CoV-2 infection from the Human Sperm Bank ofthe Center for Reproductive Medicine,Shandong University(Jinan,China).The volunteers had normal sperm concentration beforeinfection.Each volunteer provided semen samples before and after infection.We selected 90 days after infection as the cutoff point.Semen parameters within 90 days after infection of 109 volunteers(group A)were compared with semen parameters before infection.Moreover,semen parameters on or after 90 days after infection of 36 volunteers(group B)were compared with semen parameters beforeinfection.Furthermore,based on whether the volunteers had completed the three-dose SARS-CoV-2 vaccination booster,volunteersin group A and B were further divided into two subgroups separately.Semen parameters were compared before and after infection ineach subgroup.Our results showed that in this cohort population,the semen quality in volunteers with normal sperm concentrationsbefore infection decreased after SARS-CoV-2 infection within 90 days,while the semen quality returned to preinfection levels after 90days.The completion of a three-dose SARS-CoV-2 vaccination booster may exert a protective effect on semen quality after infection.

关键词： SARS-CoV-2 SARS-CoV-2 vaccination semen quality sperm donation sperm parameters

Boundary points, minimal L^(2) integrals and concavity property Ⅱ: Weakly pseudoconvex Kähler manifolds

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Science China Mathematics 2024年第7期67卷 1665-1718页

作者： qi’an guan Zhitong Mi Zheng Yuan School of Mathematical Sciences Peking UniversityBeijing100871China School of Mathematics and Statistics Beijing Jiaotong UniversityBeijing100044China Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing100190China

In this paper, we consider minimal L^(2) integrals on the sublevel sets of plurisubharmonic functions on weakly pseudoconvex K?hler manifolds with Lebesgue measurable gain related to modules at boundary points of the sublevel sets, and establish a concavity property of the minimal L^(2) integrals. As applications, we present a necessary condition for the concavity degenerating to linearity, a concavity property related to modules at inner points of the sublevel sets, an optimal support function related to modules, a strong openness property of modules and a twisted version, and an effectiveness result of the strong openness property of modules.

关键词： minimal L^(2)integrals plurisubharmonic functions boundary points weakly pseudoconvex K?hler manifold

Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in China

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World Journal of Psychiatry 2024年第4期14卷 523-532页

作者： Jing-wen Xu Xiao-Bo guan Xue-Ying Wang Yang Feng qi Zhang Jun-Juan Zhu Jian-Hua Chen Department of Medicine Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China The Fourth Sick Ward Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Psychotic DisordersShanghai 200030China The First Sick Ward Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China

BACKGROUND Prior studies have noted great variability in the plasma levels of risperidone(RIS).Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption,metabolism,and other predictors of metabolic dysregulation;however,these factors are poorly understood and the association between metabolic change and change in psychopathology is uncertain.AIM To ascertain the characteristics of chronic schizophrenic patients treated with RIS,and to assess their relationship with plasma RIS levels.METHODS This was a descriptive cross-sectional study of 50 patients with a diagnosis of schizophrenic psychosis treated with RIS in a psychiatric service.The plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone were determined by high performance liquid chromatography.The patients’demographic and clinical characteristics,and psychopathologies were assessed,and the associations between clinical variables and plasma levels of RIS were explored.RESULTS Male patients received higher doses of RIS than female ones,but plasma concentrations of RIS and risperidone+9-hydroxyrisperidone(active moiety)were higher in female patients.Age and the mean scores of the general psychopathology subscale of the Positive and Negative Syndrome Scale(PANSS)were significantly positively correlated with plasma concentrations of risperidone+9-hydroxyrisperidone adjusted for weight and dose in all 50 subjects.In male subjects,we found a statistically significant positive correlation between the concentrations of risperidone+9-hydroxyrisperidone in plasma/(dose×kg)and age,mean PANSS negative subscale scores,mean PANSS general psychopathology subscale scores,and mean PANSS total scores.CONCLUSION Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects.

关键词： Antipsychotics Risperidone 9-hydroxyrisperidone Plasma drug concentration monitoring Chronic schizophrenia

Colorectal cancer’s burden attributable to a diet high in processed meat in the Belt and Road Initiative countries

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 182-196页

作者： Gu Liu Chang-Min Li Fei Xie qi-Lai Li Liang-Yan Liao wen-Jun Jiang Xiao-Pan Li guan-Ming Lu Department of Gastrointestinal Surgery The First Affiliated HospitalJinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Gastrointestinal Surgery Chenzhou Third People’s HospitalChenzhou 423000Hunan ProvinceChina Department of Gastrointestinal Surgery Chenzhou First People’s Hospital and the First Affiliated Hospital of Xiangnan UniversityChenzhou423000 Hunan ProvinceChina Department of Breast and Thyroid Surgery the Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Health Management Center Zhongshan HospitalShanghai Medical College of Fudan UniversityShanghai 200032China

BACKGROUND Colorectal cancer(CRC)plays a significant role in morbidity,mortality,and economic cost in the Belt and Road Initiative(“B and R”)countries.In addition,these countries have a substantial consumption of processed meat.However,the burden and trend of CRC in relation to the consumption of a diet high in processed meat(DHPM-CRC)in these“B and R”countries remain unknown.AIM To analyze the burden and trend of DHPM-CRC in the“B and R”countries from 1990 to 2019.METHODS We used the 2019 Global Burden of Disease Study to collate information regarding the burden of DHPM-CRC.Numbers and age-standardized rates(ASRs)of deaths along with the disability-adjusted life years(DALYs)were determined among the“B and R”countries in 1990 and 2019.Using joinpoint regression analysis,the average annual percent change(AAPC)was used to analyze the temporal trends of age-standardized DALYs rate(ASDALR)from 1990 to 2019 and in the final decade(2010–2019).RESULTS We found geographical differences in the burden of DHPM-CRC among“B and R”countries,with the three highest-ranking countries being the Russian Federation,China,and Ukraine in 1990,and China,the Russian Federation,and Poland in 2019.The burden of DHPM-CRC generally increased in most member countries from 1990 to 2019(all P<0.05).The absolute number of deaths and DALYs in DHPM-CRC were 3151.15[95%uncertainty interval(UI)665.74-5696.64]and 83249.31(95%UI 15628.64-151956.31)in China in 2019.However,the number of deaths(2627.57-2528.51)and DALYs(65867.39-55378.65)for DHPM-CRC in the Russian Federation has declined.The fastest increase in ASDALR for DHPM-CRC was observed in Vietnam,Southeast Asia,with an AAPC value of 3.90%[95%confidence interval(CI):3.63%-4.16%],whereas the fastest decline was observed in Kyrgyzstan,Central Asia,with an AAPC value of-2.05%(95%CI:-2.37%to-1.73%).A substantial upward trend in ASR of mortality,years lived with disability,years of life lost,and DALYs from DHPM-CRC changes in 1990-2019 and the final decade(2010-2019)for most Maritime Silk Route memb

关键词： Belt and Road Initiative countries Colorectal cancer Burden of disease Dietary risk factors Processed meat Disability-adjusted life years Trend analysis

Deep Learning Blockchain Integration Framework for Ureteropelvic Junction Obstruction Diagnosis Using Ultrasound Images

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Tsinghua Science and Technology 2024年第1期29卷 1-12页

作者： Yu guan Pengceng wen Jianqiang Li Jinli Zhang Xianghui Xie Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Beijing Children’s Hospital Affiliated to Capital Medical University Beijing 100020China

UreteroPelvic Junction Obstruction(UPJO)is a common hydronephrosis disease in children that can result in an even progressive loss of renal function.Ultrasonography is an economical,radiationless,noninvasive,and high noise preliminary diagnostic step for UPJO.Artificial intelligence has been widely applied to medical fields and can greatly assist doctors'diagnostic abilities.The demand for a highly secure network environment in transferring electronic medical data online,therefore,has led to the development of blockchain technology.In this study,we built and tested a framework that integrates a deep learning diagnosis model with blockchain technology.Our diagnosis model is a combination of an attention-based pyramid semantic segmentation network and a discrete wavelet transformation-processed residual classification network.We also compared the performance between benchmark models and our models.Our diagnosis model outperformed benchmarks on the segmentation task and classification task with MloU=87.93,MPA=93.52,and accuracy=91.77%.For the blockchain system,we applied the InterPlanetary File System protocol to build a secure and private sharing environment.This framework can automatically grade the severity of UPJO using ultrasound images,guarantee secure medical data sharing,assist in doctors'diagnostic ability,relieve patients'burden,and provide technical support for future federated learning and linkage of the Internet of Medical Things(loMT).

关键词： data mining image processing and computer vision machine learning medical information systems

The temporal-spatial expression and functional analysis of three gustatory receptor genes in Solenopsis invicta using sweet and bitter compounds

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Insect Science 2024年第2期31卷 448-468页

作者： Muhammad Irfan Waris Yanyuan Lei Guojun qi Ziying guan Abdul Rashied Jie Chen Lihua Lyu Institute of Plant Protection Guangdong Academy of Agricultural SciencesGuangdong Provincial Key Laboratory of High Technology for Plant ProtectionGuangzhouChina Department of Entomology College of Plant ProtectionSouth China Agricultural UniversityGuangzhouChina

The insect gustatory system participates in identifying potential food sources and avoiding toxic compounds.During this process,gustatory receptors(GRs)recognize feeding stimulant and deterrent compounds.However,the GRs involved in recognizing stimulant and deterrent compounds in the red imported fire ant,Solenopsis invicta,remain unknown.Therefore,we conducted a study on the genes SinvGR1,SinvGR32b,and SinvGR28a to investigate the roles of GRs in detecting feeding stimulant and deterrent compounds.In this current study,we found that sucrose and fructose are feeding stimulants and the bitter compound quinine is a feeding deterrent.The fire ant workers showed significant behavior changes to avoid the bitter taste in feeding stimulant compounds.Reverse transcription quantitative real-time polymerase chain reaction results from developmental stages showed that the SinvGR1,SinvGR32b,and SinvGR28a genes were highly expressed in fire ant workers.Tissue-specific expression profiles indicated that SinvGR1,SinvGR32b,and SinvGR28a were specifically expressed in the antennae and foreleg tarsi of workers,whereas SinvGR32b gene transcripts were also highly accumulated in the male antennae.Furthermore,the silencing of SinvGRI or SinvGR32b alone and the co-silencing of both genes disrupted worker stimulation and feeding on sucrose and fructose.The results also showed that SinvGR28a is required for avoiding quinine,as workers with knockdown of the SinvGR28a gene failed to avoid and fed on quinine.This study first identified stimulant and deterrent compounds of fire ant workers and then the GRs involved in the taste recognition of these compounds.This study could provide potential target gustatory genes for the control of the fire ant.

关键词： behavioral responses feeding assays gustatory receptors RNA interference Solenopsis invicta temporal-spatial expression

Differences in vascular endothelial function and serum proteome between obese people with phlegm-dampness constitution and balanced constitution

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Journal of Traditional Chinese Medicine 2024年第1期44卷 188-196页

作者： ZHU Linghui SUN Ziwei guan Yuanyuan LIU Meiyi ZHENG Yi YU Ruoxi WANG qi LI Lingru School of Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China National Institute of TCM Constitution and Preventive Medicine Beijing University of Chinese MedicineBeijing 100029China

OBJECTIVE:To evaluate the extent of vascular endothelial dysfunction and preliminary identify serum protein biomarkers associated with obese individuals at risk for cardiovascular disease(CVD).METHODS:Fifteen obese volunteers with the phlegmdampness constitution or balanced constitution were recruited for this study respectively.The clinical baseline data was collected,and the vascular endothelial function was evaluated using the EndoPAT?.Blood samples were collected for the serum proteome analysis.The differences in the serum protein expression levels between the two groups were detected and the protein interaction network analysis,correlation analysis,receiver operating characteristic(ROC)curve analysis,and random forest model investigation were conducted.RESULTS:There were no statistical differences found in the baseline data.For vascular endothelial function,the reactive hyperemia index(RHI)of the phlegm-dampness constitution obese group was significantly lower than that of the balanced constitution obese group(1.46±0.30 vs 2.82±0.78,P<0.0001),indicating vascular endothelial dysfunction.There are 66 differentially expressed serum proteins between the two groups.apolipoprotein A2(Apo A2),angiotensin-converting enzyme 2(ACE-2),interleukin-33(IL-33),and forkhead box P3(FoxP3)showed significant differences and area under curve values of their ROC curves were greater than 0.7 and correlated significantly with RHI.CONCLUSION:Vascular endothelial dysfunction was present in the phlegm-dampness constitution obese group.Thus,alterations in the expression levels of key serum proteins,including Apo A2,ACE-2,IL-33,and Fox P3 could serve as potential biomarkers in the obese population at risk of CVD.

关键词： obesity phlegm-dampness constitution vascular endothelial function proteome reactive hyperemia index

Mechanistic insight into lysyl oxidase in vascular remodeling and angiogenesis

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Genes & Diseases 2023年第3期10卷 771-785页

作者： Zhao-Jun Wang qi-wen guan Hong-Hao Zhou Xiao-Yuan Mao Fang-Hui Chen Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Institute of Clinical Pharmacology Central South UniversityHunan Key Laboratory of PharmacogeneticsChangshaHunan 410078China Engineering Research Center of Applied Technology of Pharmacogenomics Ministry of EducationChangshaHunan 410078China National Clinical Research Center for Geriatric Disorders ChangshaHunan 410008China Department of Pharmacy The First Affliated Hospital of Gannan Medical UniversityGanzhouJiangxi 341000China

Vascular remodeling and angiogenesis are two key processes in the maintenance of vascular homeostasis and involved in a wide array of vascular pathologies. Following these processes, extracellular matrix (ECM) provides the mechanical foundation for vascular walls. Lysyl oxidase (LOX), the key matrix-modifying enzyme, has been demonstrated to significantly affect structural abnormality and dysfunction in the blood vessels. The role of LOX in vascular remodeling and angiogenesis has always been the subject in the current medical research. Therefore, we presently make a summarization of the biosynthesis of LOX and the mechanisms involved in vascular remodeling and angiogenesis, as well as the role of LOX in diseases associated with vascular abnormalities and the therapeutic potential via targeting LOX. In particular, we give a proposal that LOX likely reshapes matrisome-associated genes expressions in the regulation of vascular remodeling and angiogenesis, which serves as a mechanistic insight into the critical role of LOX in these two aspects. Additionally, LOX has also dual effects on the vascular dysfunction, namely, inhibition of LOX for improving hypertension, restenosis and malignant tumor while activation of LOX for curing arterial aneurysm and dissection. LOX-targeted therapy may provide a promising therapeutic strategy for the treatment of various vascular pathologies associated with vascular remodeling and angiogenesis.

关键词： Angiogenesis Disease pathology Lysyl oxidase Therapeutic target Vascular homeostasis Vascular remodeling

The size effect and analogous boundary states in a circular non-Hermitian chain

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Communications in Theoretical Physics 2024年第2期76卷 157-165页

作者： Xin-Yu Ma Yi-Han guan qiao-Nan Li Ai-Lei He Lu qi School of Physical Science and Technology Yangzhou UniversityYangzhou 225002China

We investigate the size effect and boundary states based on a circular non-Hermitian chain under the nonreciprocal intra-cell coupling and inter-cell coupling regimes.We find that the circular non-Hermitian chain exhibits an even–odd effect on the unit cell corresponding to a large chain,which is different from the open non-Hermitian chain only exhibiting the same effect for a small chain.Moreover,we find that the originally localized bulk states become totally extended via designing the boundary coupling strength appropriately.The extended bulk states reveal the fact of the disappearance of the non-Hermitian skin effect.In particular,we show that the circular non-Hermitian chain also possesses the analogous edge states under some parameter regimes,which is pretty counterintuitive since the circular chain usually cannot define a boundary.Our investigations supply the different non-Hermitian phenomena in a circular non-Hermitian chain.

关键词： boundary states non-Hermitian chain topological state