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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning zhang Zhou-Bo Guo Di Wang Zhao-Xian Li wei-qi zhang Yu-Ying Tan Li zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Rapid and specific detection of norepinephrine via a “hunting-shooting” strategy

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Science China Chemistry 2023年第4期66卷 923-925页

作者： qi-wei zhang Yang Tian Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China

Neurotransmitters are important endogenous chemicals in the central and sympathetic nervous system of organisms,which play an important role in maintaining physiological processes,such as the signaling,neuromodulation... 详细信息

关键词： metabolism endogenous sympathetic

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Variation in winter daily range area of red deer(Cervus elaphus xanthopygus) based on DNA extracted from fecal samples

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Journal of Forestry Research 2019年第5期30卷 1951-1958页

作者： Miao Yang Yue Sun wei qi zhang Hongyi Yuan Minghai zhang College of Wildlife Resources Northeast Forestry University

With environmental change and increased human activity,wild red deer(Cervus elaphus xanthopygus)populations and habitat area continue to *** deer is a main prey species of Amur tiger(Panthera tigris altaica).Factors affecting red deer winter home range in the Wanda montains of northeast China are not well *** this study,we aimed to better document red deer daily ranges to support conservation of red deer.A second objective was to develop a practical research method combining macro-and micro-technology for home range research on a variety of rare or endangered wild *** collected 105 fresh fecal samples of red deer in three different periods during winter from December 2012 to March 2013 in the Wandashan region,Heilongjiang Province,*** and sex identities were analyzed based on fecal DNA using microsatellite *** used samples from deer farms for correction and validation of our identifications from field *** used a combination of molecular scatology,3S techniques(GPS),and direct observation to estimate winter daily range *** on eleven microsatellite loci,we identified 18 individuals,10 females and 8 males,with a correction factor of 1.00 and sex ratio of 1:*** mean(±SE)number of alleles was 5.1±0.41,and mean polymorphism information content was 0.63±*** heterozygosity ranged from 0.46 to 0.81,with a mean of 0.69±0.03,and mean observed heterozygosity was 0.73±*** of mean daily ranges were 26.1±1.1 ha in December,89.3±1.6 ha in January,and 67.5±1.9 ha in March,indicating the following trend for daily range area:middle winter>late winter>early *** daily range area was insignificantly larger for males than for *** winter daily ranges were similar to those reported for *** combination of macro-and micro-technology proved useful for estimating winter home range areas of red deer.

关键词： Daily range Molecular scatology Red deer Temporal scale Winter

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Stomatal dynamics are regulated by leaf hydraulic traits and guard cell anatomy in nine true mangrove species

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Plant Diversity 2024年第3期46卷 395-405页

作者： Ya-Dong qie qi-wei zhang Scott A.M.McAdam Kun-Fang Cao State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of ForestryGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Forest Ecology and Conservation College of ForestryGuangxi UniversityNanning 530004China Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection Ministry of EducationGuangxi Normal UniversityGuilin 541001China Guangxi Key Laboratory of Landscape Resources Conservation and Sustainable Utilization in Lijiang River Basin Guangxi Normal UniversityGuilin 541001China Purdue Center for Plant Biology Department of Botany and Plant PathologyPurdue UniversityWest LafayetteIN 47907USA

Stomatal regulation is critical for mangroves to survive in the hyper-saline intertidal zone where water stress is severe and water availability is highly ***,very little is known about the stomatal sensitivity to vapour pressure deficit(VPD)in mangroves,and its co-ordination with stomatal morphology and leaf hydraulic *** measured the stomatal response to a step increase in VPD in situ,stomatal anatomy,leaf hydraulic vulnerability and pressure-volume traits in nine true mangrove species of five families and collected the data of genome *** aimed to answer two questions:(1)Does stomatal morphology influence stomatal dynamics in response to a high VPD in mangroves?with a consideration of possible influence of genome size on stomatal morphology;and(2)do leaf hydraulic traits influence stomatal sensitivity to VPD in mangroves?We found that the stomata of mangrove plants were highly sensitive to a step rise in VPD and the stomatal responses were directly affected by stomatal anatomy and hydraulic ***,denser stomata was correlated with faster stomatal closure at high VPD across the species of Rhizophoraceae,and stomata size negatively and vein density positively correlated with genome *** negative leaf osmotic pressure at the full turgor(πo)was related to higher operating steady-state stomatal conductance(gs);and a higher leaf capacitance(Cleaf)and more embolism resistant leaf xylem were associated with slower stomatal responses to an increase in *** addition,stomatal responsiveness to VPD was indirectly affected by leaf morphological traits,which were affected by site salinity and consequently leaf water *** results demonstrate that mangroves display a unique relationship between genome size,stomatal size and vein packing,and that stomatal responsiveness to VPD is regulated by leaf hydraulic traits and stomatal *** work provides a quantitative framework to better understand of stomatal regulation in mangroves

关键词： Stomatal temporal kinetics Vapour-pressure deficit(VPD) Leaf water relations Leaf hydraulic vulnerability Leaf osmotic potential Genome size

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Explosion temperature mapping of emulsion explosives containing TiH_(2)powders with the two-color pyrometer technique

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Defence Technology（防务技术） 2022年第10期18卷 1834-1841页

作者： Yu-Le Yao Yang-Fan Cheng qi-wei zhang Yu Xia Fang-Fang Hu Quan Wang Yuan Chen State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan232001PR China School of Chemical Engineering Anhui University of Science and TechnologyHuainan232001PR China Anhui Engineering Laboratory of Explosive Materials and Technology Anhui University of Science and TechnologyHuainan232001PR China Quality Department The 38th Research Institute of China Electronics Technology Group CorporationHefei230088PR China

In the study,the two-color pyrometer technique was used to measure the transient temperature field of emulsion explosives with different contents of TiH_(2)*** experimental results showed that the introduction of TiH_(2)powders could significantly increase the explosion temperature and fireball duration of emulsion *** emulsion explosives were ignited,the average explosion temperature of pure emulsion explosive continuously decreased while emulsion explosives added with TiH_(2)powders increased at first and then *** the content of TiH_(2)powders was 6 mass%,the explosion average temperature reached its maximum value of 3095 K,increasing by 43.7%as compared with that of pure emulsion *** addition,the results of air blast experiment and explosion heat test showed that the variation trends of shock wave parameters,explosion heat and theoretical explosion temperature of emulsion explosives with different contents of TiH_(2)powders were basically consistent with that of explosion temperature measured by the two-color pyrometer *** conclusion,the two-color pyrometer technique would be conducive to the formula design of emulsion explosive by understanding the explosion temperature characteristics.

关键词： Two-color pyrometer Emulsion explosive Explosion temperature field Explosion heat

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Contrast sensitivity in 14 MeV fast neutron radiography

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Nuclear Science and Techniques 2017年第6期28卷 115-122页

作者： Chang-Bing Lu Jie Bao Ying Huang Peng Xu Xiong-Jun Chen qi-wei zhang Xi-Chao Ruan Key Laboratory of Nuclear Data China Institute of Atomic Energy Xi'an Institute of High Technology Science and Technology Information Center China Academy of Engineering Physics

Fast neutron radiography(FNR) is an effective non-destructive testing *** to the scattering effect and low detection efficiency,the detection limit of FNR under certain conditions cannot be *** order to obtain the minimum detectable thickness by FNR,we studied the contrast sensitivity of FNR lead samples,both theoretically and *** then clarified the relationship between pixel value and irradiation time,and sample materials and *** experiment,using a4-cm-thick lead sample,verified our theoretical expression of FNR contrast sensitivity.

关键词： Fast neutron radiography Contrast sensitivity Experimental research

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Study of neutron production and moderation for sulfur neutron capture therapy

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Nuclear Science and Techniques 2019年第1期30卷 59-66页

作者： Meng Peng Guo-Zhu He qi-wei zhang Bin Shi Hong-qing Tang Zu-Ying Zhou Key Laboratory of Nuclear Data China Institute of Atomic Energy College of Liberal Arts and Sciences National University of Defense Technology

Neutron capture therapy with Sulfur-33, similar to boron neutron capture therapy with Boron-10, is effective in treating some types of tumors including ocular melanoma. The key point in sulfur neutron capture therapy is whether the neutron beam flux and the resonance capture cross section of ^(33)S(n;α)^(30) Si reaction at 13.5 keV can achieve the requirements of radiotherapy. In this research,the authors investigated the production of 13.5 keV neutron production and moderation based on an accelerator neutron source. A lithium glass detector was used to measure the neutron flux produced via near threshold^7 Li(p,n)~7 Be reaction using the time-of-flight method. Furthermore, the moderation effects of different kinds of materials were investigated using Monte Carlo simulation.

关键词： Sulfur Neutron capture therapy Boron neutron capture therapy 33S(n,α)3 Si resonance reaction 7Li(p,n)^7 Be neutron source

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Clival metastasis of renal clear cell carcinoma: Case report and literature review

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World Journal of Clinical Cases 2018年第9期6卷 301-307页

作者： wei-qi zhang Yue Bao Bo qiu Yong Wang Zhi-Peng Li Yi-Bao Wang Department of Neurosurgery First Affiliated Hospital of China Medical University

The clivus is an atypical metastatic site for renal clear cell carcinoma(RCCC). Here we report a 54 year old man with acute cavernous sinus syndrome. Brain magnetic resonance imaging identified a clival-based lesion with associated bony erosion. The patient underwent endoscopic endonasal biopsy and partial resection of the clival mass. Because histologic examination of the resected specimen resulted in a diagnosis of RCCC, contrast-enhanced computed tomography scan of the abdomen was performed and showed an enhanced left renal mass. The patient subsequently underwent laparoscopic left radical nephrectomy and gamma knife was planned for the residual clival lesion. We also retrospectively reviewed available published reports on clival metastases, specifically those from RCCC, since 1990.

关键词： Clival metastases Endoscopic skull base surgery Renal clear cell carcinoma Renal Carcinoma

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An origin of ultraslow spreading ridges for the Yarlung-Tsangpo ophiolites

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Fundamental Research 2022年第1期2卷 74-83页

作者： Chuan-Zhou Liu Fu-Yuan Wu Tong Liu Chang zhang wei-qi zhang Zhen-Yu zhang Zhen zhang Wu wei Yin-Zheng Lina State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China CAS Center for Excellence in Deep Earth Science Guangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China

As relics of ancient ocean lithosphere,ophiolites are the most important petrological evidence for marking the sutures and also play a key role in reconstructing plate *** also provide valuable windows for studying crustal accretion and mantle processes occurring at modem ocean *** ophiolites are distributed along the Yarlung-Tsangpo suture and represent the relics of ocean lithosphere of the *** are characterized by an incomplete litho-stratigraphy,of which the mantle section is much thicker than the crustal *** crustal rocks outcropped in the Yarlung-Tsangpo ophiolites are much thinner than normal ocean crusts(~7 km)or even *** settings from which the Yarlung-Tsangpo ophiolites originated remain highly controversial,although an origin of the supra-subduction zone is ***,their incomplete litho-stratigraphy has been commonly attributed to tectonic dismemberment during the late-stage emplacement after their ***,such an incompleteness resembles the ocean lithosphere generated at modem ultraslow spreading ridges,such as the Southwest Indian Ridge(SWIR).In this paper,we present several lines of evidence that support the formation of the Yarlung-Tsangpo ophiolites at ultraslow spreading ridges,during which detachment faults were *** suggests that the Yarlung-Tsangpo ophiolites might represent the ocean core complexes(OCC)in the Neo-Tethys *** OCC with high topography in the seafloor were clogged in the trench and preserved as ophiolites through Indo-Eurasia *** clogging resulted in the demise of an old subduction and a new subduction was re-initiated beneath the clogged OCC.

关键词： Yarlung-Tsangpo ophiolites Tibetan plateau Ultraslow spreading ridges Subduction re-initiation

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A Quantitative Method for Simultaneous Determination of Four Anthraquinones with One Marker in Rhei Radix et Rhizoma

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Chinese Herbal Medicines 2012年第2期4卷 157-163页

作者： Jing-jing ZHU[a][b] Zhi-min WANG[a][b] Xin-yu MA[a] wei-hong FENG[a][b] qi-wei zhang[a][b] Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines Beijing 100700 China

Objective To develop a quantitative method for simultaneously determining multi-components in Rhei Radix et Rhizoma using one chemical reference *** The contents of multi-components were calculated by the UV relative correction factors(RCFs)of chrysophanol,physcion,and rhein to *** The values of RCFs at 274 nm for rhein,chrysophanol,and physcion to emodin were 0.712,0.674,and *** calibration curves were linear over the ranges of 0.02-4.08,0.02-4.12,0.07-12.92,and 0.02-3.68μg/mL for rhein,emodin, chrysophanol,and physcion,*** contents of emodin in 18 samples were determined by the external standard method,and the contents of the other three anthraquinone aglycones were calculated according to their RCFs. Conclusion No significant difference is found in comparison with the classical method,indicating that the RCFs have high reliability within their linear ranges and could be used in quality control of Rhei Radix et *** quantitative analysis of multi-component with a single marker is especially suitable for herbal medicines containing unstable or hard to be purified components as quality control markers.

关键词： anthraquinone multi-component quantitative analysis quality control Rhei Radix et Rhizoma UV relative correction factor

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