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Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 414-435页

作者： You-Wang Lu zhao-Li Ding Rui Mao Gui-Gang zhao Yu-qi He Xiao-Lu Li Jiang Liu Department of Dermatology and Venereology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Kunming Biological Diversity Regional Center of Large Apparatus and Equipments Public Technical Service CenterKunming Institute of ZoologyKunming 650223Yunnan ProvinceChina School of Stomatology Kunming Medical UniversityKunming 650500Yunnan ProvinceChina Genome Center of Biodiversity Kunming Institute of ZoologyChinese Academy of ScienceKunming 650223Yunnan ProvinceChina Department of Reproduction and Genetics The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Aberrant methylation is common during the initiation and progression of colorectal cancer(CRC),and detecting these changes that occur during early adenoma(ADE)formation and CRC progression has clinical *** To identify potential DNA methylation markers specific to ADE and *** Here,we performed SeqCap targeted bisulfite sequencing and RNA-seq analysis of colorectal ADE and CRC samples to profile the epigenomic-transcriptomic *** Comparing 22 CRC and 25 ADE samples,global methylation was higher in the former,but both showed similar methylation patterns regarding differentially methylated gene positions,chromatin signatures,and repeated ***-grade CRC tended to exhibit elevated methylation levels in gene promoter regions compared to those in low-grade *** with RNA-seq gene expression data,we identified 14 methylation-regulated differentially expressed genes,of which only AGTR1 and NECAB1 methylation had prognostic *** Our results suggest that genome-wide alterations in DNA methylation occur during the early stages of CRC and demonstrate the methylation signatures associated with colorectal ADEs and CRC,suggesting prognostic biomarkers for CRC.

关键词： Colorectal cancer Epigenomic alteration Transcriptome Methylation-regulated differentially expressed genes

Regio-and Stereoselective Polymerization of Bio-based Ocimene by Rare-Earth Metal Catalysts

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Chinese Journal of Polymer Science 2024年第2期42卷 223-229,I0008页

作者： qi-Yuan Wang Li-Peng Sang Zhen Zhang Yang Jiang Hui Tian Xia zhao Xiang Guo Shi-Hui Li State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechonologyXiangyang441003China Shanxi Coal Chemical Industry Technology Research Institute Xi’an710000China Hubei Institute of Aerospace Chemotechonology Xiangyang441003China

Coordination polymerization of renewable β-ocimene has been investigated using asymmetric diiminophosphinate lutetium complex1, β-diketiminate yttrium complex 2, bis(phosphino)carbazolide yttrium complex 3, half-sandwich benzyl fluorenyl scandium complex 4 and pyridyl-methylene-fluorenyl rare-metal complexes 5a–5c. Complexes 1, 4 and 5a–5c show trans-1,2-regioselectivities and high activities, of which 5c exhibits excellent isoselectivity(mmmm>99%). Conversely, complexes 2 and 3 promote β-ocimene polymerization to produce isotactic cis-1,4-polyocimenes(cis-1,4>99%, mm>95%). Diblock copolymers cis-1,4-PIP-block-cis-1,4-POc and cis-1,4-PBD-block-cis-1,4-POc are obtained in one-pot reactions of β-ocimene with isoprene and butadiene using complex 3. Epoxidation and hydroxylation of polyocimene afford functionalized polyolefins with enhanced T_(g)(from-20 ℃ to 79 ℃ and 74 ℃) and hydrophilicity.

关键词： Biobased monomer Terpenes Ocimene Rare-earths Polymerization Regio/stereoselectivity Elastomer

In Situ Atomic Reconstruction Engineering Modulating Graphene-Like MXene-Based Multifunctional Electromagnetic Devices Covering Multi-Spectrum

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Nano-Micro Letters 2024年第9期16卷 247-261页

作者： Ting‑Ting Liu qi Zheng Wen‑qiang Cao Yu‑Ze Wang Min Zhang Quan‑Liang zhao Mao‑Sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Department of Physics Beijing Technology and Business UniversityBeijing 100048People’s Republic of China School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144People’s Republic of China

With the diversified development of big data,detection and precision guidance technologies,electromagnetic(EM)functional materials and devices serving multiple spectrums have become a hot *** the multispectral response of materials is a challenging and meaningful scientific *** this study,MXene/TiO_(2)hybrids with tunable conduction loss and polarization relaxation are fabricated by in situ atomic reconstruction *** importantly,MXene/TiO_(2)hybrids exhibit adjustable spectral responses in the GHz,infrared and visible spectrums,and several EM devices are constructed based on *** antenna array provides excellent EM energy harvesting in multiple microwave bands,with|S11|up to−63.2 dB,and can be tuned by the degree of *** ultra-wideband bandpass filter realizes a passband of about 5.4 GHz and effectively suppresses the transmission of EM signals in the *** infrared stealth device has an emissivity of less than 0.2 in the infrared spectrum at wavelengths of 6-14μ*** work can provide new inspiration for the design and development of multifunctional,multi-spectrum EM devices.

关键词： Graphene-like MXene hybrids Multi-spectral response Multi-function antenna Ultra-wideband bandpass filter Electromagnetic device

Visible-light-driven photocatalysis degradation of antibiotic pollutants by La-doped CeO2 nanorods:synergy of La doping and oxygen vacancy

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Rare Metals 2024年第7期43卷 3134-3145页

作者： Shi-Hai Cao Jing-Ru Qu Yu-qi zhao Yun-Tong Sun Wen-Tong Gao Bing Han Yao Lu College of Environmental Engineering Nanjing Institute of Technology School of Materials Science and Engineering Nanjing Institute of Technology School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological University Institute of Environmental Health and Ecological Security School of Environment and Safety EngineeringJiangsu University Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment Suzhou University of Science and Technology

Elemental doping is an effective strategy to enhance photocatalytic activity and extend the light absorption range of single-component *** this work,a series of La-doped CeO2nanorods（La-CeO2-x） with La content of 1 wt%-15 wt% are synthesized by a simple hydrothermal method and further used as photocatalyst for sulfamerazine（SMR） *** prepared La-CeO2-x nanorods exhibit a great improvement in electron-hole pair migration and visible-light response due to the synergistic effect of abundant oxygen vacancies and heterogeneous elements（La）.Consequently,La-CeO2-x exhibited excellent visible-light photocatalytic performances and chemical stability for SMR degradation,the La-CeO2-5 sample achieved the highest SMR degradation rate of 81%,which was 3.4 times higher than that of the original ***,three possible degradation pathways of SMR in La-CeO2photocatalytic reactions were proposed by liquid chromatography-mass spectrometry ***,density functional theory calculations were carried out to provide an in-depth understanding of the structure-performance *** its excellent properties and better photocatalytic performance,this study demonstrates that La doping in CeO2is an effective way to increase oxygen vacancy and improve the photochemical properties of photocatalysts.

关键词： CeO 2 nanorod La-doped Photocatalysis Oxygen vacancy Sulfamerazine

Numerical study on local scour characteristics around submarine pipelines in the Yellow River Delta silty sandy soil under waves and currents

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Deep Underground Science and Engineering 2024年第2期3卷 182-196页

作者： Peng Yu Ruigeng Hu Jike Zhang qi Yang Jieru zhao Lei Cao Chenghao Zhu Key Laboratory of Geological Safety of Coastal Urban Underground Space Ministry of Natural ResourcesQingdaoChina qingdao Geo-Engineering Surveying Institute(qingdao Geological Exploration Development Bureau) QingdaoChina Sinopec Petroleum Engineering Corporation DongyingChina State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijingChina Department Civil and Environmental Engineering Politecnico di MilanoMilanItaly College of Environmental Science and Engineering Ocean University of ChinaQingdaoChina

Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource *** to the interaction of waves,currents,seabed,and pipeline structures,the soil around submarine pipelines is prone to local scour,severely affecting their operational *** the Yellow River Delta as the research area and based on the renormalized group(RNG)k-εturbulence model and Stokes fifth-order wave theory,this study solves the Navier-Stokes(N-S)equation using the finite difference *** volume of fluid(VOF)method is used to describe the fluid-free surface,and a threedimensional numerical model of currents and waves-submarine pipeline-silty sandy seabed is *** rationality of the numerical model is verified using a self-built waveflow *** this basis,in this study,the local scour development and characteristics of submarine pipelines in the Yellow River Delta silty sandy seabed in the prototype environment are explored and the influence of the presence of pipelines on hydrodynamic features such as surrounding flow field,shear stress,and turbulence intensity is *** results indicate that(1)local scour around submarine pipelines can be divided into three stages:rapid scour,slow scour,and stable *** maximum scour depth occurs directly below the pipeline,and the shape of the scour pits is asymmetric.(2)As the water depth decreases and the pipeline suspension height increases,the scour becomes more intense.(3)When currents go through a pipeline,a clear stagnation point is formed in front of the pipeline,and the flow velocity is positively correlated with the depth of *** study can provide a valuable reference for the protection of submarine pipelines in this area.

关键词： local scour numerical simulation submarine pipelines Yellow River Delta

Anomalous{1012}tensile twinning and subsequent detwinning in a friction stir processed carbon fiber-reinforced Mg composite

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Journal of Magnesium and Alloys 2024年第4期12卷 1511-1517页

作者： Wei zhao Zhihao Jiang Xiang Wu Yujing Liu Haokun Yang Jun Wang qi Liu Xiaochun Liu Institute of Metals College of Materials Science and EngineeringChangsha University of Science&TechnologyChangsha 410114China Department of Mechanical Engineering City University of Hong KongHong KongChina Smart manufacturing division Hong Kong Productivity CouncilHong Kong SAR 999077China Institute for Frontier Materials Deakin UniversityGeelongVIC 3216Australia Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHong KongChina

*** text Owing to their low density and high specific strength,magnesium alloys and magnesium-based composites have great potential as structure metal materials in applications where lightweight matters[1–4].Deformation twins[5],especially the{1012}tension twins(also called tensile or extension twins)with a low critical resolved shear stress(CRSS)[6],are commonly observed in Mg *** can provide the much-needed deformation along the c-axis in their hcp structure resulting from the very few easily activated slip systems in this crystal structure[7].The tensile twinning activation usually follows the macroscopic Schmid factor law[2],i.e.,the twin variant with the highest Schmid factor occurs,and it only appears when its Schmid factor is positive.

关键词： friction deformation magnesium

Mechanical response and dilatancy characteristics of deep marble under different stress paths:A sight from energy dissipation

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Journal of Central South University 2024年第6期31卷 2070-2086页

作者： LIU Xiao-hui HAO qi-jun ZHENG Yu ZHANG zhao-peng XUE Yang Key Laboratory of Fluid and Power Machinery Ministry of EducationXihua UniversityChengdu 610039China School of Energy and Power Engineering Xihua UniversityChengdu 610039China College of Water Resource and Hydropower Sichuan UniversityChengdu 610065China State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering Sichuan UniversityChengdu 610065China Southwest Municipal Engineering Design&Research Institute of China Chengdu 610036China MOE Key Laboratory of Deep Earth Science and Engineering Sichuan UniversityChengdu 610065China

Dilatancy is a fundamental volumetric growth behavior observed during loading and serves as a key index to comprehending the intricate nonlinear behavior and constitutive equation structure of *** study focuses on Jinping marble obtained from the Jinping Underground Laboratory in China at a depth of 2400 *** uniaxial and triaxial tests at different strain rates,along with constant confining pressure tests and reduced confining pressure tests under different confining pressures were conducted to analyze the mechanical response and dilatancy characteristics of the marble under four stress ***,a new empirical dilatancy coefficient is proposed based on the energy dissipation *** results show that brittle failure characteristics of marble under uniaxial compression are more obvious with the strain rate increasing,and plastic failure characteristics of marble under triaxial compression are gradually ***,compared to the constant confining pressure,the volume expansion is relatively lower under unloading *** energy dissipation is closely linked to the process of dilatancy,with a rapid increase of dissipated energy coinciding with the beginning of dilatancy.A new empirical dilatancy coefficient is defined according to the change trend of energy dissipation rate curve,of which change trend is consistent with the actual dilatancy response in marble under different stress *** existing empirical and theoretical dilatancy models are analyzed,which shows that the empirical dilatancy coefficient based on the energy background is more universal.

关键词： deep marble stress paths dilatancy energy dissipation empirical dilatancy coefficient

Degradation of warm permafrost and talik formation on the qinghai-Tibet Plateau in 2006-2021

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Advances in Climate Change Research 2024年第2期15卷 275-284页

作者： qi-Hang MEI Ji CHEN You-qian LIU Shou-Hong ZHANG Jing-Yi zhao Tian-Chun DONG Jun-Cheng WANG Yao-Jun zhao Beiluhe Observation and Research Station of Frozen Soil Engineering and Environment Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environmental and ResourcesChinese Academy of SciencesLanzhou 730000China China Railway qinghai-Tibet Group Co.Ltd Xining 810007China University of Chinese Academy of Sciences Beijing 100049China

Permafrost is degrading globally,particularly those with low thermal stability on the qinghai-Tibet Plateau,owing to climate ***,the inadequacy of direct research on permafrost degradation based on in-situ monitoring limits the prediction of permafrost degradation and engineering *** study explored the processes and modes of permafrost degradation into talik by analyzing ground temperature data from five points in the hinterland of the qinghai-Tibet Plateau from 2006 to *** results showed that the degradation of the warm permafrost layer with a geothermal gradient of zero occurred simultaneously in the top and bottom *** rate of permafrost degradation from the top down and bottom up increase during the degradation process,but the increase of the former is more drastic after the formation of thawed ***,the construction of the qinghai-Tibet Railway changed the degradation modes of the permafrost in adjacent natural sites through horizontal heat transfer,particularly after through talik formation under the *** findings suggest that taking countermeasures before or immediately after forming thawed interlayer is more *** evaluating the thermal impact of projects in warm permafrost regions,special attention should be given to the horizontal heat transfer process that may result from the formation of a through talik.

关键词： Warm permafrost Degradation Talik qinghai-Tibet Plateau Climate change

Large-scale physical simulation of injection and production of hot dry rock in Gonghe Basin,qinghai Province,China

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Petroleum Exploration and Development 2024年第3期51卷 741-752页

作者： zhao Peng ZHU Haiyan LI Gensheng CHEN Zuo CHEN Shijie SHANGGUAN Shuantong qi Xiaofei State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu 610059China College of Energy Chengdu University of TechnologyChengdu 610059China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing 102249China Sinopec Research Institute of Petroleum Engineering Co.Ltd. Beijing 102206China The Second Geological Team of Hebei Coal Field Geology Bureau(Hebei Hot Dry Rock Research Center) Xingtai 054000China

Based on the independently developed true triaxial multi-physical field large-scale physical simulation system of in-situ injection and production,we conducted physical simulation of long-term multi-well injection and production in the hot dry rocks of the Gonghe Basin,qinghai Province,NW *** multi-well connectivity experiments,the spatial distribution characteristics of the natural fracture system in the rock samples and the connectivity between fracture and wellbore were *** injection and production wells were selected to conduct the experiments,namely one injection well and two production wells,one injection well and one production *** variation of several physical parameters in the production well was analyzed,such as flow rate,temperature,heat recovery rate and fluid *** results show that under the combination of thermal shock and injection pressure,the fracture conductivity was enhanced,and the production temperature showed a downward *** larger the flow rate,the faster the *** the local closed area of the fracture was gradually activated,new heat transfer areas were generated,resulting in a lower rate of increase or decrease in the mining *** heat recovery rate was mainly controlled by the extraction flow rate and the temperature difference between injection and production *** the conductivity of the leak-off channel increased,the fluid recovery of the production well rapidly *** influence mechanisms of dominant channels and fluid leak-off on thermal recovery performance are *** former limits the heat exchange area,while the latter affects the flow rate of the produced *** of them are important factors affecting the long-term and efficient development of hot dry rock.

关键词： hot dry rock simulation of injection and production heat extraction performance conductivity dominant channel fluid leak-off