检索结果-南通市图书馆

Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex:a prospective cohort study

引用

World Journal of Pediatrics 2024年第6期20卷 602-610页

作者： Shuo Dun Yang-Yang Wang Lin Wan qiu-Hong Wang qian lu Xiao-Yan Yang qi Zhang Hui-Min Chen lu-Peng qiu Li-Ping Zou Medical School of Chinese PLA Beijing 100853China Department of Pediatrics The First Medical CenterChinese PLA General HospitalBeijing 100853China Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Renal angiomyolipoma(RAML)is the most common kidney lesion in patients with tuberous sclerosis complex(TSC),affecting about 80%of *** is a benign tumor that grows over time,usually bilaterally,and can easily lead to kidney complications such as acute ***,we investigated the efficacy and safety of sirolimus in children with TSC-associated RAML and explored the factors affecting tumor disappearance under sirolimus treatment through subgroup *** A prospective cohort study was *** was initiated at 1 mg/(m^(2)×day),and dose adjustments were made by a 2-week titration period to attain a trough blood concentration of 5-10 ng/*** disappearance of RAML in chil-dren after sirolimus treatment was observed,and Cox regression was used to screen the factors affecting tumor *** One hundred and twenty-six patients who met the criteria were *** 3 months,6 months,12 months,and 24 months of follow-up,tumors disappeared in 18(14.3%),30(23.8%),39(31.0%),and 42(33.3%)children,*** disappeared in 50(39.7%)children by the last visit of each individual,and 30(60%)of them occurred within 6 *** multivariate Cox regression analysis showed that patients with a smaller maximum tumor diameter at baseline had a higher tumor disappearance ***-six(29%)patients had stomatitis during the entire treatment period,and no serious *** Sirolimus could promote the disappearance of TSC-related *** disappearance rate was correlated with the maximum diameter at baseline,and the smaller the tumor was,the higher the disappearance *** is well tolerated in the treatment of RAML associated with TSC.

关键词： Angiomyolipoma mTOR inhibitor Sirolimus Tuberous sclerosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Factor Structure and Longitudinal Invariance of the CES-D across Diverse Residential Backgrounds in Chinese Adolescents

引用

International Journal of Mental Health Promotion 2024年第4期26卷 261-269页

作者： Yanjing Cao Chenchen Xu qi Li Shan lu Jing Xiao Beijing Key Laboratory of Learning and Cognition and Department of Psychology Capital Normal UniversityBeijing100048China Center for Child Development Capital Normal UniversityBeijing100048China

Background:Valid and reliable measures of depressive symptoms are crucial for understanding risk factors,outcomes,and interventions across rural and urban *** this need,the longitudinal invariance of these measures over time remains *** research explores the structural components of the Center for Epidemiological Studies Depression Scale(CES-D)and examines its consistency across various living environments and temporal stability in a cohort of Chinese ***:In the initial phase,1,042 adolescents furnished demographic details and undertook the CES-D *** a three-month interval,967 of these participants repeated the CES-D *** study employed Confirmatory factor analysis(CFA)to scrutinize the scale’s structural *** investigated factorial invariance by conducting a twopronged CFA:one comparing urban *** backgrounds,and another contrasting the results from the initial assessment with those from the ***:The CES-D demonstrated adequate reliability in both rural and urban high school student *** preliminary four-factor model applied to the CES-D demonstrated a good fit with the collected *** tests,including multigroup analyses comparing rural and urban samples and longitudinal assessments,confirmed the scale’s ***:The results suggest that the CES-D serves as a reliable instrument for evaluating depressive symptoms among Chinese *** applicability is consistent across different living environments and remains stable over time.

关键词： Depression factor structure measurement invariance Chinese adolescent longitudinal invariance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bending Failure Mode and Prediction Method of the Compressive Strain Capacity of A Submarine Pipeline with Dent Defects

引用

China Ocean Engineering 2024年第4期38卷 636-647页

作者： HOU Fu-heng JIA lu-sheng CHEN Yan-fei ZHANG qi ZHONG Rong-feng WANG Chun-sha School of Mechanical and Transportation Engineering China University of PetroleumBeijingBeijing 102249China CNOOC Research Institute Ltd.Beijing 100028 China

A dent is a common type of defects for submarine *** submarine pipelines,high hydrostatic pressure and internal pressure are the main *** pipelines bend due to complex subsea conditions,the compression strain capacity may be *** into the local buckling failure and accurate prediction of the compressive strain capacity are important.A finite element model of a pipeline with a dent is *** buckling failure under a bending moment is investigated,and the compressive strain capacity is *** effects of different parameters on pipeline local buckling are *** results show that the dent depth,external pressure and internal pressure lead to different local buckling failure modes of the pipeline.A higher internal pressure indicates a larger compressive strain capacity,and the opposite is true for external *** the ratio of external pressure to collapse pressure of intact pipeline is greater than 0.1,the deeper the dent,the greater the compressive strain capacity of the *** as the ratio is less than 0.1,the opposite is *** the basis of these results,a regression equation for predicting the compressive strain capacity of a dented submarine pipeline is proposed,which can be referred to during the integrity assessment of a submarine pipeline.

关键词： submarine pipeline dent defect bending load local buckling compressive strain capacity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In-situ thermal Raman mapping and stress analysis of CNT/CF/epoxy interfaces

引用

新型炭材料（中英文） 2024年第4期39卷 703-714页

作者： HE Jing-zong CHEN Shi MA Zheng-kun lu Yong-gen WU qi-lin State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

A study of the interfacial behavior and internal thermal stress distribution in fiber-reinforced composites is essential to assess their performance and ***/carbon fiber(CF)hybrid fibers were constructed using electrophoretic *** interfacial properties of CF/epoxy and CNT/CF/epoxy composites were statistically investigated and compared using in-situ thermal Raman mapping by dispersing CNTs as a Raman sensing medium(CNT_(R))in a *** associated local thermal stress changes can be simulated by capturing the G'band position distribution of CNT_(R) in the epoxy at different *** was found that the G'band shifted to lower positions with increasing temperature,reaching a maximum difference of 2.43 cm^(−1) at 100℃.The interfacial bonding between CNT/CF and the matrix and the stress distribution and changes during heat treatment(20-100℃)were investig-ated in *** work is important for studying thermal stress in fiber-reinforced composites by in-situ thermal Raman mapping technology.

关键词： Thermal Raman mapping Stress distribution Carbon fiber Carbon nanotube Interface

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Defective MnO2 functional separator coating as effective polysulfide mediators for lithium–sulfur batteries

引用

Tungsten 2024年第3期6卷 536-543页

作者： Yan-qi Feng qiong-qiong lu Hui Liu School of Materials & Environment Engineering Chengdu Technological University School of Materials Science and Engineering Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic Materials Shaanxi University of Science and Technology Institute of Materials Henan Key Laboratory of Advanced Conductor Materials Henan Academy of Sciences Institute of Materials Chemistry Leibniz Institute for Solid State and Materials Research (IFW) Dresden e.V.

Advanced energy storage systems are in urgent need nowadays due to the rising demand in mobile devices and electric vehicles [1]. Lithium–sulfur（Li–S） batteries are intensively studied due to the high theoretical specific capacity(1675 m Ah·g-1) and energy density(2600 Wh·kg-1), as well as natural abundant and environmentally friendly of sulfur.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Junshanyinzhen tea extract prevents obesity by regulating gut microbiota and metabolic endotoxemia in high-fat diet fed rats

引用

Food Science and Human Wellness 2024年第4期13卷 2036-2047页

作者： Jian Ouyang Xiuping Li Changwei Liu Danmin lu Jie Ouyang Fang Zhou qi Liu Jianan Huang Zhonghua Liu Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128China National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals Hunan Agricultural UniversityChangsha 410128China Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients Hunan Agricultural UniversityChangsha 410128China Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops Ministry of Agriculture and Rural AffairsHunan Agricultural UniversityChangsha 410128China

Obesity is associated with gut dysbiosis and metabolic *** tea extract(JSTE)reduced fat accumulation and body weight in obese ***,the effects and mechanism of JSTE in preventing obesity were ***,we used different doses of JSTE(75,150 and 300 mg/(kg·day))to evaluate the effect on high-fat diet(HFD)-induced rats under 8 weeks of ***,our results showed that JSTE could significantly reduce body weight gain,blood lipid levels and fat accumulation,improve fatty damage in liver tissue(P<0.05).In addition,JSTE increased the expression of intestinal tight junction proteins(P<0.05),relieved metabolic endotoxemia(P<0.05)and chronic low-grade inflammation in HFD *** of fecal samples showed that JSTE could effectively reverse the microbial diversity and the ratio of Firmicutes to Bacteroidetes to normal levels in HFD-fed *** and Erysipelotrichaceae,which are positively related to obesity,were decreased by JSTE intervention(P<0.05).while Bifidobacteriaceae,Bacteroidaceae,Akkermansia,and Clostridium,which are negatively related to obesity,were ***,these results suggested that JSTE might effectively prevent obesity by modulating gut microbiota dysbiosis,intestinal barrier dysfunction,metabolic endotoxemia and chronic low-grade infl ammation in HFD-induced rats.

关键词： Junshanyinzhen tea Obesity Gut microbiota Gut barrier function Metabolic endotoxemia

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A N-CoSe/CoSe2-C@Cu hierarchical architecture as a current collector-integrated anode for potassium-ion batteries

引用

Rare Metals 2024年第8期43卷 3702-3712页

作者： Zi-Jie Mu Yan-Jun Gao Wen-shuai Dong Zong-You Li qing-Yi Song Han-Jiao Huang Li-Dong Xing Jian-Guo Zhang Wei Wang qi-Yao Yu State Key Laboratory of Explosion Science and Technology School of Mechatronical EngineeringBeijing Institute of Technology School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The highly reversible insertion/extraction of large-radius K+into electrode materials remains a tough goal,especially for con version-type ***,we design a current collector-integrated electrode（N-CoSe/CoSe2-C@Cu） as an advanced anode for potassium-ion battery（PIBs）.The conductive CoSe/CoSe2heterojunction with rich Se vacancy defects,conductive sp2N-doped carbon layer,and the elastic copper foil matrix can greatly accelerate the electron transfer and enhance the structural ***,the well-designed N-CoSe/CoSe2-C@Cu current collector-integrated electrode displays enhanced potassium storage performance with regard to a high capacity(325.1 mAh·g-1at 0.1 A·g-1after 200cycles),an exceptional rate capability(223.5 mAh·g-1at2000 mA·g-1),and an extraordinary long-term cycle stability(a capacity fading of only 0.019% per cycle over1200 cycles at 2000 mA·g-1).Impressively,ex situ scanning electron microscopy（SEM） characterizations prove that the elastic structure of copper foil is merged into the cleverly designed N-CoSe/CoSe2-C@Cu heterostructure,which buffers the deformation of structure and volume and greatly promotes the cycle life during the potassium/depotassium process.

关键词： Potassium-ion battery Integrated collector electrode CoSe CoSe 2 Heterojunction Copper foil matrix N-doped carbon

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Platycodin D inhibits angiogenic vascular mimicry in NSCLC by regulating the eIF4E-mediated RNA methylome

引用

Journal of Pharmaceutical Analysis 2024年第1期14卷 152-155页

作者： Shuyu Zheng Yanlin Xin Jiamin Lin Zejuan Xie Keyu Cheng Shanshan Wang Wenli lu Hao Yang Tianming lu Jun Li Ruogu qi Yuanyuan Guo Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative MedicineNanjing University of Chinese MedicineNanjing210023China Department of Neurosurgery The Second Affiliated HospitalZhejiang UniversityHangzhou310009China

The treatment of non-small cell lung cancer(NSCLC)remains a challenge due to tumor evolution during anti-angiogenesis therapies,in which the mechanism of vascular mimicry(VM)is believed to result in ineffective treatment[1].To conquer this challenge,substantial effort has recently been devoted to seeking out natural compounds on account of their multitarget *** a traditional herbal medicine,platycodin D(PD)is the major bioactive monomer derived from Platycodon grandiflorum(***)and is used as an expectorant for pulmonary disease in Asia[2].

关键词： NSCLC eIF4E treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions

引用

Genes & Diseases 2024年第2期11卷 874-889页

作者： Yancheng Lai Xiaole lu Yankai Liao Pei Ouyang Hai Wang Xian Zhang Guanglong Huang Songtao qi Yaomin Li Department of Neurosurgery Institute of Brain DiseaseNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Laboratory for Precision Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Glioblastoma(GBM)is the most common intrinsic and aggressive primary brain tumor in adults,with a median survival of approximately 15 *** heterogeneity is considered responsible for the treatment resistance and unfavorable ***-mesenchymal transition(PMT)represents GBM malignant progression and recurrence,which might be a breakthrough to understand GBM heterogeneity and overcome treatment *** is a complicated process influenced by crosstalk between GBM and tumor microenvironment,depending on intricate ligand-receptor *** this review,we summarize the autocrine and paracrine pathways in the GBM microenvironment and related ligand-receptor interactions inducing *** also discuss the current therapies targeting the PMT-related autocrine and paracrine ***,this review offers a comprehensive understanding of the failure of GBM-targeted therapy and ideas for future tendencies of GBM treatment.

关键词： Autocrine Glioblastoma Ligand-receptor interaction Microenvironment Paracrine Proneural-mesenchymal transition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tourmaline guiding the electric field and dechlorination pathway of 2,3-dichlorophenol by Desulfitobacterium hafniense

引用

Journal of Environmental Sciences 2024年第1期135卷 262-273页

作者： Yue lu Fangyi Liang Fanzhi qin Linrui Zhong Jianhong Jiang qi Liu Shoujuan Zhang Ming Yan Changzheng Fan Haoran Dong College of Environmental Science and Engineering Hunan UniversityChangsha 410082China Shenzhen Research Institute Hunan UniverisyShenzhen 510082China Key Laboratory of Environment Biology and Pollution Control Hunan UniversityMinistry of EducationChangsha 410082China China Machinery International Engineering Design&Research Institute Co. Ltd.Changsha 410007China Hunan Engineering Research Center for Water Treatment Process&Equipment Changsha 410007China

The dehalogenation of organohalides has been a research hotspot in bioremediation field;however,the influence of tourmaline,a natural ore that can generate spontaneous electric field,on organohalide-respiring bacteria(OHRB)and their dechlorination process is not well *** this study,the effect and mechanism of tourmaline on the reductive dechlorination of 2,3-dichlorophenol(2,3-DCP)by Desulfitobacterium hafniense DCB-2Twere *** characterization results confirmed that tourmaline had good stability and the optimal dosage of tourmaline was 2.5 g/L,which shortened the total time required for dechlorination reaction to 72 ***,tourmaline amendment also increased the proportion of 2-chlorophenol(2-CP)from 18%to 30%of end products,while that of 3-CP decreased *** theoretical calculations showed that the bond charge of the orthosubstituted chlorine declined from-0.179 to-0.067,and that of meta-substituted chlorine increased from-0.111 to-0.129,which indicated that the spontaneous electric field of tourmaline affected the charge distribution of 2,3-DCP and was more conducive to the generation of ***,tourmaline with the spontaneous electric field affected the reductive dechlorination pathway of Desulfitobacterium,and the tourmaline-OHRB combining system might serve as a novel strategy for the bioremediation of environments polluted with chlorinated phenols.

关键词： Reductive dechlorination Desulfitobacterium hafniense Tourmaline Electric field 2 3-dichlorophenol

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：